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Article: Cognitive mechanisms and neurological foundations of companion animals' role in enhancing human psychological well-being.

Liu, Heng / Lin, Jingyuan / Lin, Wuji

2024 Volume 15, Page(s) 1354220

Abstract: The impact of companion animals on human psychological health has garnered widespread attention. Research demonstrates that companion animals contribute positively in various ways, including reducing depression, anxiety, stress, and fostering positive ... ...

Abstract	The impact of companion animals on human psychological health has garnered widespread attention. Research demonstrates that companion animals contribute positively in various ways, including reducing depression, anxiety, stress, and fostering positive emotions in humans. Recent studies have revealed significant changes in the activity levels of human emotion-related cortical areas (such as the frontal cortex and amygdala) and neurotransmitter (e.g., oxytocin, cortisol) secretion due to interaction with companion animals. However, research in this domain is still in a nascent stage, with many unknowns in the cognitive neural mechanisms involved. This paper proposes that to understand the cognitive mechanisms through which companion animals affect human psychological health, we need to examine changes in emotional cognitive processing. It aims to uncover the neurological underpinnings of how companion animals enhance human psychological well-being from the perspective of brain connectivity. This approach is expected to provide theoretical support and direction for future research and practical applications in this field.
Language	English
Publishing date	2024-04-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1354220
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Article: Identification, Expression and Evolutional Analysis of Two

Wang, Yajun / Lin, Jingyuan / Li, Wenjin / Ji, Guangdong / Liu, Zhenhui

Animals : an open access journal from MDPI

2024 Volume 14, Issue 8

Abstract: The mechanism of sex determination and differentiation in animals remains a central focus of reproductive and developmental biology research, and the regulation of sex differentiation in amphioxus remains poorly understood. Cytochrome P450 Family 19 ... ...

Abstract	The mechanism of sex determination and differentiation in animals remains a central focus of reproductive and developmental biology research, and the regulation of sex differentiation in amphioxus remains poorly understood. Cytochrome P450 Family 19 Subfamily A member 1 (
Language	English
Publishing date	2024-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14081140
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Article ; Online: Multi-modular metabolic engineering and efflux engineering for enhanced lycopene production in recombinant Saccharomyces cerevisiae.

Huang, Guangxi / Li, Jiarong / Lin, Jingyuan / Duan, Changqing / Yan, Guoliang

Journal of industrial microbiology & biotechnology

2024 Volume 51

Abstract: Lycopene has been widely used in the food industry and medical field due to its antioxidant, anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of lycopene using chassis cells on an industrial scale remains a major ... ...

Abstract	Lycopene has been widely used in the food industry and medical field due to its antioxidant, anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of lycopene using chassis cells on an industrial scale remains a major challenge. Herein, we attempted to integrate multiple metabolic engineering strategies to establish an efficient and balanced lycopene biosynthetic system in Saccharomyces cerevisiae. First, the lycopene synthesis pathway was modularized to sequentially enhance the metabolic flux of the mevalonate pathway, the acetyl-CoA supply module, and lycopene exogenous enzymatic module. The modular operation enabled the efficient conversion of acetyl-CoA to downstream pathway of lycopene synthesis, resulting in a 3.1-fold increase of lycopene yield. Second, we introduced acetate as an exogenous carbon source and utilized an acetate-repressible promoter to replace the natural ERG9 promoter. This approach not only enhanced the supply of acetyl-CoA but also concurrently diminished the flux toward the competitive ergosterol pathway. As a result, a further 42.3% increase in lycopene production was observed. Third, we optimized NADPH supply and mitigated cytotoxicity by overexpressing ABC transporters to promote lycopene efflux. The obtained strain YLY-PDR11 showed a 12.7-fold increase in extracellular lycopene level compared to the control strain. Finally, the total lycopene yield reached 343.7 mg/L, which was 4.3 times higher than that of the initial strain YLY-04. Our results demonstrate that combining multi-modular metabolic engineering with efflux engineering is an effective approach to improve the production of lycopene. This strategy can also be applied to the overproduction of other desirable isoprenoid compounds with similar synthesis and storage patterns in S. cerevisiae. One-sentence summary: In this research, lycopene production in yeast was markedly enhanced by integrating a multi-modular approach, acetate signaling-based down-regulation of competitive pathways, and an efflux optimization strategy.
MeSH term(s)	Lycopene/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Metabolic Engineering/methods ; Carotenoids/metabolism ; Acetyl Coenzyme A/metabolism ; Mevalonic Acid/metabolism ; Biosynthetic Pathways ; Promoter Regions, Genetic ; NADP/metabolism ; Metabolic Networks and Pathways/genetics ; Acetates/metabolism
Chemical Substances	Lycopene (SB0N2N0WV6) ; Carotenoids (36-88-4) ; Acetyl Coenzyme A (72-89-9) ; Mevalonic Acid (S5UOB36OCZ) ; NADP (53-59-8) ; Acetates
Language	English
Publishing date	2024-04-15
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1482484-X
ISSN	1476-5535 ; 1367-5435
ISSN (online)	1476-5535
ISSN	1367-5435
DOI	10.1093/jimb/kuae015
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Article ; Online: Electrophysiological evidence for the effectiveness of images versus text in warnings.

Lin, Wuji / Li, Zhuoyu / Zhang, Xukai / Gao, Yuan / Lin, Jingyuan

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1278

Abstract: Warning sign plays an important role in risk avoidance. Many studies have found that images are better warnings than text, while others have revealed flaws of image-only warning signs. To better understand the factors underlying the effectiveness of ... ...

Abstract	Warning sign plays an important role in risk avoidance. Many studies have found that images are better warnings than text, while others have revealed flaws of image-only warning signs. To better understand the factors underlying the effectiveness of different types of warning signs (image only, text only, or image and text), this study adopted event-related potential technology to explore the differences at the neurocognitive level using the oddball paradigm and the Go/No-go paradigm. Together, the behavioral and electroencephalogram results showed that text-only warnings had the lowest effectiveness, but there was little difference between the image-only and image-and-text warnings. The differences in the effects of the three warning signs were mainly in the areas of attention and cognitive control, implying differences in the underlying cognitive processes. Therefore, in the design of warning signs, the effects of different design attributes on cognitive processing should be taken into account based on actual needs in order to improve the effectiveness of the signs.
MeSH term(s)	Product Labeling/methods ; Smoking/psychology ; Smoking Cessation/psychology ; Mental Processes ; Attention
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-28230-x
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Article ; Online: Looking back on life: An updated meta-analysis of the effect of life review therapy and reminiscence on late-life depression.

Lin, Jingyuan / Zhao, Ruiying / Li, Hong / Lei, Yi / Cuijpers, Pim

Journal of affective disorders

2023 Volume 347, Page(s) 163–174

Abstract: Background: Twenty years ago, we confirmed the effectiveness of life review therapy and reminiscence (LRT-REM) to treat late-life depression in a meta-analysis. In the current study, we aimed to examine the most updated evidence on the effects of LRT- ... ...

Abstract	Background: Twenty years ago, we confirmed the effectiveness of life review therapy and reminiscence (LRT-REM) to treat late-life depression in a meta-analysis. In the current study, we aimed to examine the most updated evidence on the effects of LRT-REM in older adults with depression. Methods: We systematically searched records in English and Chinese databases up to December 2022 and included randomized controlled studies comparing LRT-REM with control conditions in older adults with depression. Outcomes included depression, anxiety, quality of life, and life satisfaction. Effect sizes (Hedges' g) at post-treatment were pooled with random effects meta-analyses. Results: 42 studies with 3361 depressed older adults (≥60 years) met the selection criteria. We found a significant and large effect of LRT-REM (g = 1.41, p < 0.001) on late-life depression, corresponding to a number-needed-to-treat (NNT) of 1.98. Heterogeneity shrunk from high (I Limitations: The quality of many included studies was not optimal, with a high risk of bias. Conclusions: LRT-REM may be effective for treating late-life depression, but long-term effects are unclear. More research is needed on the effects of LRT-REM, especially when guided by (para)professional or lay therapists in low- and middle-income countries.
MeSH term(s)	Aged ; Humans ; Anxiety/therapy ; Anxiety Disorders ; Depression/therapy ; Memory ; Quality of Life
Language	English
Publishing date	2023-11-22
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.11.050
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Article ; Online: Harm or protection? Two-sided consequences of females' susceptible responses to multiple threats.

Lin, Jingyuan / Cuijpers, Pim / Li, Hong / Lei, Yi

The Behavioral and brain sciences

2022 Volume 45, Page(s) e141

Abstract: The target article presented a plausible argument that females' susceptibility to threats might be self-protection ... ...

Abstract	The target article presented a plausible argument that females' susceptibility to threats might be self-protection for
MeSH term(s)	Bias ; Female ; Humans
Language	English
Publishing date	2022-07-25
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	423721-3
ISSN	1469-1825 ; 0140-525X
ISSN (online)	1469-1825
ISSN	0140-525X
DOI	10.1017/S0140525X22000607
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Article: The relationship between Chinese college students' mate preferences and their parents' education level.

Lin, Wuji / Wang, Jie / Liu, Yutong / Li, Zhuoyu / Lin, Jingyuan

Frontiers in psychology

2022 Volume 13, Page(s) 907315

Abstract: Parents have an influence on the formation of their children's mate preferences. This research conducted two studies to test the relationship between parents' education level and the gender role characteristics (masculinity and femininity) of ideal mate ... ...

Abstract	Parents have an influence on the formation of their children's mate preferences. This research conducted two studies to test the relationship between parents' education level and the gender role characteristics (masculinity and femininity) of ideal mate for college students, and the moderating role of urban-rural residence on this relationship. In study 1, 1,033 participants (627 females) reported their explicit attitude toward gender role characteristics for an ideal mate
Language	English
Publishing date	2022-11-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.907315
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Article ; Online: Dual regulation of lipid droplet-triacylglycerol metabolism and ERG9 expression for improved β-carotene production in Saccharomyces cerevisiae.

Bu, Xiao / Lin, Jing-Yuan / Duan, Chang-Qing / Koffas, Mattheos A G / Yan, Guo-Liang

Microbial cell factories

2022 Volume 21, Issue 1, Page(s) 3

Abstract: Background: The limitation of storage space, product cytotoxicity and the competition for precursor are the major challenges for efficiently overproducing carotenoid in engineered non-carotenogenic microorganisms. In this work, to improve β-carotene ... ...

Abstract	Background: The limitation of storage space, product cytotoxicity and the competition for precursor are the major challenges for efficiently overproducing carotenoid in engineered non-carotenogenic microorganisms. In this work, to improve β-carotene accumulation in Saccharomyces cerevisiae, a strategy that simultaneous increases cell storage capability and strengthens metabolic flux to carotenoid pathway was developed using exogenous oleic acid (OA) combined with metabolic engineering approaches. Results: The direct separation of lipid droplets (LDs), quantitative analysis and genes disruption trial indicated that LDs are major storage locations of β-carotene in S. cerevisiae. However, due to the competition for precursor between β-carotene and LDs-triacylglycerol biosynthesis, enlarging storage space by engineering LDs related genes has minor promotion on β-carotene accumulation. Adding 2 mM OA significantly improved LDs-triacylglycerol metabolism and resulted in 36.4% increase in β-carotene content. The transcriptome analysis was adopted to mine OA-repressible promoters and IZH1 promoter was used to replace native ERG9 promoter to dynamically down-regulate ERG9 expression, which diverted the metabolic flux to β-carotene pathway and achieved additional 31.7% increase in β-carotene content without adversely affecting cell growth. By inducing an extra constitutive β-carotene synthesis pathway for further conversion precursor farnesol to β-carotene, the final strain produced 11.4 mg/g DCW and 142 mg/L of β-carotene, which is 107.3% and 49.5% increase respectively over the parent strain. Conclusions: This strategy can be applied in the overproduction of other heterogeneous FPP-derived hydrophobic compounds with similar synthesis and storage mechanisms in S. cerevisiae.
MeSH term(s)	Farnesyl-Diphosphate Farnesyltransferase/genetics ; Gene Expression Regulation, Fungal ; Lipid Droplets/metabolism ; Metabolic Engineering/methods ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Triglycerides/genetics ; Triglycerides/metabolism ; beta Carotene/analysis ; beta Carotene/biosynthesis ; beta Carotene/genetics
Chemical Substances	Saccharomyces cerevisiae Proteins ; Triglycerides ; beta Carotene (01YAE03M7J) ; ERG9 protein, S cerevisiae (EC 2.5.1.21) ; Farnesyl-Diphosphate Farnesyltransferase (EC 2.5.1.21)
Language	English
Publishing date	2022-01-04
Publishing country	England
Document type	Journal Article
ISSN	1475-2859
ISSN (online)	1475-2859
DOI	10.1186/s12934-021-01723-y
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Article: [Impact assessment of new sick clothes in patients with electrocardiogram monitoring].

Lin, Shouhong / Lin, Jingyuan / Lu, Haiyan / Yang, Meiling

Zhonghua wei zhong bing ji jiu yi xue

2019 Volume 31, Issue 3, Page(s) 355–358

Abstract: Objective: To design a new modified sick clothes for electrocardiogram (ECG) monitoring, and to observe its clinical application effect.: Methods: In order to overcome the shortcomings of the existing modified ECG monitoring clothes, a new type of ... ...

Abstract	Objective: To design a new modified sick clothes for electrocardiogram (ECG) monitoring, and to observe its clinical application effect. Methods: In order to overcome the shortcomings of the existing modified ECG monitoring clothes, a new type of modified sick clothes was designed on the basis of the traditional sick clothes, and a national utility model patent was obtained. 408 conscious patients with ECG monitoring admitted to department of neurology of the First Affiliated Hospital of Fujian Medical University from January 2015 to June 2018 were enrolled, and they were randomly divided into three groups according to the order of admission for comparing the wearing effect of three kinds of sick clothes. 133 patients dressed traditional clothes, while 139 patients dressed modified ECG monitoring clothes. According to the method reported in the literature, the pockets were removed on the basis of the traditional patient clothes, and a circular hole 5 cm in diameter was made at the position of the electrodes for ECG monitoring, which was used to pass through the lead wire and the electrodes. 136 patients dressed the new modified sick clothes. In view of the inconvenience of ECG monitoring and stimulation of patients' thoracic and abdominal skin by traditional sick clothes, the existing modified ECG monitoring clothes were not easy to operate, the location of electrodes sticking was not easy to judge and the lead line was messy, the new modified sick clothes were still based on the traditional ones. The three circular holes of the existing modified ECG monitoring clothes were made into incisions about 12 cm in length to facilitate the ECG monitoring lead line and electrodes sticking. A compression band or a simple patch was added to each side near the shoulder for tidying up the fixed lead. The self-evaluation of patient's comfort, the operation time of ECG monitoring by nurses, skin allergy rate and lead damage rate were recorded and compared among the three groups. Results: Compared with the traditional sick clothes and the modified ECG monitoring clothes groups, the patients in the new modified sick clothes group had higher comfort [the proportion of no discomfort: 11.0% (15/136) vs. 0% (0/133), 5.8% (8/139); the proportion of severe discomfort: 0% (0/136) vs. 4.5% (6/133), 0.7% (1/139), all P < 0.05], the installation and disassembly time of ECG monitoring by nurses was significantly shortened [installation time (s): 69.12±16.47 vs. 96.74±3.89, 88.24±9.83; disassembly time (s): 50.24±4.54 vs. 75.76±4.98, 66.54±7.86, all P < 0.01], and the skin allergies rate [3.7% (5/136) vs. 15.8% (21/133), 8.6% (12/139)] and the insulation loss rate of the lead wires [2.9% (4/136) vs. 15.8% (21/133), 7.9% (11/139)] were significantly lowered (all P < 0.05). Conclusions: The ECG monitoring patients using new modified sick clothes could increase their comfort, reduce the workload of nurses, save medical consumables, and have beautiful appearance and high practicability, which was worthy of clinical application.
MeSH term(s)	Clothing ; Electrocardiography ; Electrodes ; Humans ; Monitoring, Physiologic
Language	Chinese
Publishing date	2019-03-11
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.issn.2095-4352.2019.03.019
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Article ; Online: Conditional automaticity: interference effects on the implicit memory retrieval process.

Lin, Jingyuan / Meng, Yingfang / Lin, Wuji

Psychological research

2019 Volume 85, Issue 1, Page(s) 223–237

Abstract: Many studies have indicated that executing a secondary task during encoding has little influence on implicit memory (priming effect). However, relatively few studies have discussed the effect of interference on implicit memory during retrieval. Our ... ...

Abstract	Many studies have indicated that executing a secondary task during encoding has little influence on implicit memory (priming effect). However, relatively few studies have discussed the effect of interference on implicit memory during retrieval. Our previous studies found asymmetry between implicit encoding and retrieval processes, with the priming effect disrupted by retrieval interference. Therefore, the present study investigated why and how the priming effect is affected by interference at retrieval. We adopted a dual-task paradigm, with a lexical decision task as the memory task and an odd-even decision task as the interference task. The effect of interference during retrieval was assessed by comparing the performance in the interference condition with that in the full-attention condition. In Experiment 1, we observed that the priming effect was absent in the synchronous retrieval interference condition. In Experiment 2, asynchronous interference was also found to block the priming effect. To verify the assumption that the priming effect is sensitive to attentional resource competition during retrieval, we used two different manipulations (an extended stimulus interval in the dual-task paradigm, Experiment 3, and an interference inhibition manipulation, Experiment 4) known to reduce attentional distraction. In these experiments, the priming effect was protected from interference effects. We suggest that implicit memory retrieval could be regarded as a conditional automatic process that depends on a configuration of the cognitive system by attention and task sets. If the limited resources are occupied by another task, the implicit retrieval process can be impacted.
MeSH term(s)	Adolescent ; Adult ; Attention/physiology ; China ; Female ; Humans ; Inhibition, Psychological ; Male ; Memory/physiology ; Young Adult
Language	English
Publishing date	2019-07-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1463034-5
ISSN	1430-2772 ; 0340-0727
ISSN (online)	1430-2772
ISSN	0340-0727
DOI	10.1007/s00426-019-01228-9
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