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Article ; Online: Efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke: a meta-analysis.

Huang, Huanjia / Zhang, Jian / Lin, Jinmei / Shi, Shengliang

2024 Volume 24, Issue 1, Page(s) 48

Abstract: Objective: This meta-analysis and systematic review were conducted to comprehensively evaluate the efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke.: Method: We conducted a manual search of electronic databases, ... ...

Abstract	Objective: This meta-analysis and systematic review were conducted to comprehensively evaluate the efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke. Method: We conducted a manual search of electronic databases, including PubMed, Embase, the Cochrane Library, and Web of Science, with a search deadline set for February 1, 2023. Data analysis was performed using Stata version 15.0. Result: A total of 9 randomized controlled studies were included, involving a total of 316 people, including 159 mesenchymal stem cells and 147 control groups. Results of meta-analysis: Compared to a placebo group, the administration of mesenchymal stem cells resulted in a significant reduction in the National Institutes of Health Stroke Scale (NIHSS) scores among patients diagnosed with acute ischemic stroke [SMD=-0.99,95% CI (-1.93, -0.05)]. Compared to placebo, barthel index [SMD = 0.48,95% CI (-0.55,1.51)], modified rankin score [SMD = 0.45, 95% CI (1.11, 0.21)], adverse events (RR = 0.68, 95% CI (0.40, 1.17)] the difference was not statistically significant. Conclusion: Based on current studies, mesenchymal stem cell transplantation can ameliorate neurological deficits in patients with ischemic stroke to a certain extent without increasing adverse reactions. However, there was no significant effect on Barthel index and Modified Rankin score.
MeSH term(s)	United States ; Humans ; Stroke/drug therapy ; Ischemic Stroke ; Mesenchymal Stem Cell Transplantation/adverse effects
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-024-03542-1
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Article ; Online: Study on particle movement characteristics in sandblast cylinder based on PIV technology

Hui Zhiquan / Wu Feng / Duan Haojie / Yang Bo / Lin Jinmei / Wang Lian / Huang Si

Polish Journal of Chemical Technology, Vol 22, Iss 3, Pp 38-

2020 Volume 47

Abstract: PIV technology was used to investigate the influence of the particles’ relevant parameters on the instantaneous movement characteristics in the sandblast cylinder under the circumstance of different particle sizes, different section heights and different ...

Abstract	PIV technology was used to investigate the influence of the particles’ relevant parameters on the instantaneous movement characteristics in the sandblast cylinder under the circumstance of different particle sizes, different section heights and different stacking conditions. As the diameter increased, particles had a greater velocity and energy when approaching the wall, which would cause a serious abrasion. The influence of test selection factors on the particles’ radial velocity of particles was greater than that on axial velocity. The radial velocity and axial velocity on the surface of the cylindrical section were all reduced to a lower level when the particles approach the tank wall. When r > 0.3 R, the particle velocity maintained at a higher level, but then decreased slowly when r > 0.7 R. Therefore, the abrasion of the conical section of the sandblast cylinder when r > 0.3 R should be paid more attention to.
Keywords	piv technology ; sandblast cylinder ; particles ; movement characteristics ; Chemistry ; QD1-999
Subject code	532
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: A novel cell-wall polysaccharide derived from the stipe of Agaricus bisporus inhibits mouse melanoma proliferation and metastasis

Wu, Qi-Ci / Zhang, Yin-Ying / Li, Yun-Bing / Alitongbieke, Gulimiran / Xue, Yu / Li, Xiu-Min / Lin, Zhi-Chao / Huang, Jia-Fu / Pan, Tao / Pan, Xiao-Ming / You, Jing-Ping / Lin, Jin-Mei / Pan, Yu-Tian

Archives of Biochemistry and Biophysics. 2023 Aug., v. 744 p.109678-

2023

Abstract: Malignant melanoma is an invasive and highly aggressive skin cancer that—if diagnosed—poses a serious threat to the patient's health and life. In this work, a novel purified cell-wall polysaccharide (termed Abwp) was obtained from the discarded stipe of ... ...

Abstract	Malignant melanoma is an invasive and highly aggressive skin cancer that—if diagnosed—poses a serious threat to the patient's health and life. In this work, a novel purified cell-wall polysaccharide (termed Abwp) was obtained from the discarded stipe of Agaricus bisporus (A. bisporus) and characterized to be a novel homogeneous polysaccharide consisted of a β-(1 → 4)- glucosyl backbone with β-(1 → 2) and (1 → 6)-d-glucosyl side-chains. The anti-melanoma effects of Abwp and its associated mechanisms in mice were then explored using in vitro and in vivo approaches. In vitro results showed that Abwp inhibited B16 melanoma cell proliferation and promoted their apoptosis in both time- and dose-dependent manners. In B16 cells induced with tumor necrosis factor (TNF-α), Abwp significantly decreased the protein expression of inflammatory-related signaling pathway (e.g., p38 MAPK and NF-κB) in time-, concentration-, and dose-dependent manners. Moreover, Abwp blocked nuclear entry of NF-κB-p65. In an in vivo mouse model featuring neoplasm transplantation with B16 melanoma cells, Abwp significantly inhibited the growth and proliferation of mouse melanoma. Hematoxylin staining showed that the invasion of melanoma cells into the lung tissue of the Abwp-treated group was significantly reduced. Immunohistochemical analysis showed that the expression of proliferation cell nuclear antigen (PCNA), N-cadherin, MMP-9, and Snail in the lung of mouse was significantly inhibited. Immunofluorescence showed that Abwp significantly interfered with the nuclear transcription of NF-κB-p65 in a dose-dependent manner. Collectively, these results showed that Abwp mediated p38 MAPK and NF-κB signaling pathways to inhibit the inflammatory response and malignant proliferation and metastasis of melanoma in mice.
Keywords	Agaricus bisporus ; apoptosis ; biophysics ; cadherins ; cell proliferation ; dose response ; fluorescent antibody technique ; immunohistochemistry ; inflammation ; lungs ; melanoma ; metastasis ; mice ; mitogen-activated protein kinase ; patients ; polysaccharides ; proliferating cell nuclear antigen ; protein synthesis ; skin neoplasms ; tumor necrosis factors ; Polysaccharide ; TNF-α ; p38 MAPK ; NF-κB
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2023.109678
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Article ; Online: A novel cell-wall polysaccharide derived from the stipe of Agaricus bisporus inhibits mouse melanoma proliferation and metastasis.

Wu, Qi-Ci / Zhang, Yin-Ying / Li, Yun-Bing / Alitongbieke, Gulimiran / Xue, Yu / Li, Xiu-Min / Lin, Zhi-Chao / Huang, Jia-Fu / Pan, Tao / Pan, Xiao-Ming / You, Jing-Ping / Lin, Jin-Mei / Pan, Yu-Tian

Archives of biochemistry and biophysics

2023 Volume 744, Page(s) 109678

Abstract: Malignant melanoma is an invasive and highly aggressive skin cancer that-if diagnosed-poses a serious threat to the patient's health and life. In this work, a novel purified cell-wall polysaccharide (termed Abwp) was obtained from the discarded stipe of ... ...

Abstract	Malignant melanoma is an invasive and highly aggressive skin cancer that-if diagnosed-poses a serious threat to the patient's health and life. In this work, a novel purified cell-wall polysaccharide (termed Abwp) was obtained from the discarded stipe of Agaricus bisporus (A. bisporus) and characterized to be a novel homogeneous polysaccharide consisted of a β-(1 → 4)- glucosyl backbone with β-(1 → 2) and (1 → 6)-d-glucosyl side-chains. The anti-melanoma effects of Abwp and its associated mechanisms in mice were then explored using in vitro and in vivo approaches. In vitro results showed that Abwp inhibited B16 melanoma cell proliferation and promoted their apoptosis in both time- and dose-dependent manners. In B16 cells induced with tumor necrosis factor (TNF-α), Abwp significantly decreased the protein expression of inflammatory-related signaling pathway (e.g., p38 MAPK and NF-κB) in time-, concentration-, and dose-dependent manners. Moreover, Abwp blocked nuclear entry of NF-κB-p65. In an in vivo mouse model featuring neoplasm transplantation with B16 melanoma cells, Abwp significantly inhibited the growth and proliferation of mouse melanoma. Hematoxylin staining showed that the invasion of melanoma cells into the lung tissue of the Abwp-treated group was significantly reduced. Immunohistochemical analysis showed that the expression of proliferation cell nuclear antigen (PCNA), N-cadherin, MMP-9, and Snail in the lung of mouse was significantly inhibited. Immunofluorescence showed that Abwp significantly interfered with the nuclear transcription of NF-κB-p65 in a dose-dependent manner. Collectively, these results showed that Abwp mediated p38 MAPK and NF-κB signaling pathways to inhibit the inflammatory response and malignant proliferation and metastasis of melanoma in mice.
MeSH term(s)	Animals ; Mice ; NF-kappa B/metabolism ; Melanoma, Experimental/metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; Cell Proliferation ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; p38 Mitogen-Activated Protein Kinases/metabolism ; Cell Line, Tumor
Chemical Substances	NF-kappa B ; Tumor Necrosis Factor-alpha ; Polysaccharides ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2023-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2023.109678
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Article: Anthracnose Disease of Carpetgrass (

Zhang, Wu / Damm, Ulrike / Crous, Pedro W / Groenewald, Johannes Z / Niu, Xueli / Lin, Jinmei / Li, Yuting

Plant disease

2020 Volume 104, Issue 6, Page(s) 1744–1750

Abstract: Carpetgrass ( ...

Abstract	Carpetgrass (
MeSH term(s)	China ; Colletotrichum ; Phylogeny ; Plant Diseases ; Poaceae
Language	English
Publishing date	2020-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-10-19-2183-RE
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Article: Agaricus bisporus-Derived Glucosamine Hydrochloride Facilitates Skeletal Injury Repair through Bmp Signaling in Zebrafish Osteoporosis Model

Peng, Wei / Zhang, Wenjuan / Wu, Qici / Cai, Shunyou / Jia, Tingting / Sun, Jiarui / Lin, Zhichao / Alitongbieke, Gulimiran / Chen, Yixuan / Su, Yi / Lin, Jinmei / Cai, Lisheng / Sun, Yuqin / Pan, Yutian / Xue, Yu

Journal of natural products. 2021 Feb. 26, v. 84, no. 4

2021

Abstract: Glucosamine hydrochloride (GAH), one of the most basic and important derivatives of chitin, is obtained by hydrolysis of chitin in concentrated hydrochloric acid. At present, little is known about how GAH functions in skeletal development. In this report, ...

Abstract	Glucosamine hydrochloride (GAH), one of the most basic and important derivatives of chitin, is obtained by hydrolysis of chitin in concentrated hydrochloric acid. At present, little is known about how GAH functions in skeletal development. In this report, we demonstrate that GAH, extracted from the cell wall of Agaricus bisporus, acts in a dose-dependent manner to promote not only cartilage and bone development in larvae but also caudal fin regeneration in adult fish. Furthermore, GAH treatment causes a significant increase in expression of bone-related marker genes, indicating its important role in promoting skeletal development. We show that in both larval and adult osteoporosis models induced by high iron osteogenic defects are significantly ameliorated after treatment with GAH, which regulates expression of a series of bone-related genes. Finally, we demonstrate that GAH promotes skeletal development and injury repair through bone morphogenetic protein (Bmp) signaling, and it works at the downstream of the receptor level. Taken together, our findings not only provide a strong research foundation and strategy for the screening of natural osteoporosis drugs and product development using a zebrafish model but also establish the potential for the development of Agaricus bisporus-derived GAH as a new drug for osteoporosis treatment.
Keywords	Agaricus bisporus ; Danio rerio ; adults ; bone formation ; bone morphogenetic proteins ; cartilage ; cell walls ; chitin ; dose response ; fins ; fish ; glucosamine ; hydrochloric acid ; hydrolysis ; larvae ; models ; osteoporosis ; skeletal development
Language	English
Dates of publication	2021-0226
Size	p. 1294-1305.
Publishing place	American Chemical Society and American Society of Pharmacognosy
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.1c00002
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Article ; Online: Characterization of a halophilic heterotrophic nitrification-aerobic denitrification bacterium and its application on treatment of saline wastewater.

Duan, Jinming / Fang, Hongda / Su, Bing / Chen, Jinfang / Lin, Jinmei

Bioresource technology

2015 Volume 179, Page(s) 421–428

Abstract: A novel halophilic bacterium capable of heterotrophic nitrification-aerobic denitrification was isolated from marine sediments and identified as Vibrio diabolicus SF16. It had ability to remove 91.82% of NH4(+)-N (119.77 mg/L) and 99.71% of NO3(-)-N (136. ...

Abstract	A novel halophilic bacterium capable of heterotrophic nitrification-aerobic denitrification was isolated from marine sediments and identified as Vibrio diabolicus SF16. It had ability to remove 91.82% of NH4(+)-N (119.77 mg/L) and 99.71% of NO3(-)-N (136.43 mg/L). The nitrogen balance showed that 35.83% of initial NH4(+)-N (119.77 mg/L) was changed to intracellular nitrogen, and 53.98% of the initial NH4(+)-N was converted to gaseous denitrification products. The existence of napA gene further proved the aerobic denitrification ability of strain SF16. The optimum culture conditions were salinity 1-5%, sodium acetate as carbon source, C/N 10, and pH 7.5-9.5. When an aerated biological filter system inoculated with strain SF16 was employed to treat saline wastewater, the average removal efficiency of NH4(+)-N and TN reached 97.14% and 73.92%, respectively, indicating great potential of strain SF16 for future full-scale applications.
MeSH term(s)	Aerobiosis ; Ammonium Compounds/isolation & purification ; Base Sequence ; Biodegradation, Environmental ; Biological Oxygen Demand Analysis ; Bioreactors/microbiology ; Carbon/analysis ; DNA, Ribosomal/genetics ; Denitrification ; Genes, Bacterial ; Heterotrophic Processes ; Hydrogen-Ion Concentration ; Nitrification ; Nitrogen/isolation & purification ; Phylogeny ; Salinity ; Vibrio/genetics ; Vibrio/metabolism ; Waste Water/microbiology ; Water Purification/methods
Chemical Substances	Ammonium Compounds ; DNA, Ribosomal ; Waste Water ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
Language	English
Publishing date	2015-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2014.12.057
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Article ; Online: Agaricus bisporus

Journal of natural products

2021 Volume 84, Issue 4, Page(s) 1294–1305

Abstract	Glucosamine hydrochloride (GAH), one of the most basic and important derivatives of chitin, is obtained by hydrolysis of chitin in concentrated hydrochloric acid. At present, little is known about how GAH functions in skeletal development. In this report, we demonstrate that GAH, extracted from the cell wall of
MeSH term(s)	Agaricus/chemistry ; Animals ; Bone Morphogenetic Proteins/metabolism ; Bone and Bones/drug effects ; Disease Models, Animal ; Glucosamine/pharmacology ; Larva/drug effects ; Osteoporosis/drug therapy ; Regeneration ; Signal Transduction/drug effects ; Skeleton/drug effects ; Zebrafish
Chemical Substances	Bone Morphogenetic Proteins ; Glucosamine (N08U5BOQ1K)
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.1c00002
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Article: Simultaneous removal of NH4(+) and PO4(3-) at low concentrations from aqueous solution by modified converter slag.

Duan, Jinming / Fang, Hongda / Lin, Jinmei / Lin, Jianqing / Huang, Zhiyong

Water environment research : a research publication of the Water Environment Federation

2013 Volume 85, Issue 6, Page(s) 530–538

Abstract: In this study, modified converter slag (CS) was characterized in relation to its physicochemical structure, and used for the simultaneous removal of NH4(+) and PO4(3-) at low concentrations from aqueous solutions. The effects of contact time, pH, ... ...

Abstract	In this study, modified converter slag (CS) was characterized in relation to its physicochemical structure, and used for the simultaneous removal of NH4(+) and PO4(3-) at low concentrations from aqueous solutions. The effects of contact time, pH, adsorbent dosage, and temperature on the adsorption process were studied in batch experiments. The results showed that the adsorption capacity of modified converter slag was found to sharply increase as a result of modification. The optimum pH is 5-8. The adsorption process was able to reach equilibrium in 90 minutes. Kinetic data were best described by the pseudo-second-order model. The sorption isotherms were a good fit with the Langmuir model. The maximum adsorption capacities of modified converter slag for NH4(+) and PO4(3-) were 2.59 mg/g and 1.185 mg/g, respectively. Thermodynamic studies indicated that the adsorption was a spontaneous and endothermic process. The calculated values of enthalpy change indicated that ligand exchange, chemical reactions, and precipitation are dominating mechanisms of PO4(3-) removal, while physisorption and ion-exchange are major mechanisms of NH4(+) removal.
MeSH term(s)	Adsorption ; Ammonia/analysis ; Ammonia/isolation & purification ; Kinetics ; Microscopy, Electron, Scanning ; Models, Theoretical ; Phosphates/analysis ; Phosphates/isolation & purification ; Spectrometry, X-Ray Emission ; Thermodynamics ; Water/chemistry ; X-Ray Diffraction
Chemical Substances	Phosphates ; Water (059QF0KO0R) ; Ammonia (7664-41-7)
Language	English
Publishing date	2013-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1098976-6
ISSN	1554-7531 ; 1061-4303 ; 1047-7624
ISSN (online)	1554-7531
ISSN	1061-4303 ; 1047-7624
DOI	10.2175/106143013x13596524516860
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Article: Design of an ultra-sensitive gold nanorod colorimetric sensor and its application based on formaldehyde reducing Ag+

Lin, Jin-Mei / Huang, Yi-Qun / Lin, Chang-Qing / Liu, Jia-Ming / Liu, Zhen-bo / Ma, Xudong

RSC advances. 2015 Nov. 23, v. 5, no. 121

2015

Abstract: Formaldehyde (HCHO) could reduce Ag+ to Ag on the surface of gold nanorods (AuNRs) to form Au core–Ag shell nanorods (Au@AgNRs) in a AuNRs–Ag+–HCHO system, which caused the dielectric function to change, the longitudinal plasmon absorption band (LPAB) of ...

Abstract	Formaldehyde (HCHO) could reduce Ag+ to Ag on the surface of gold nanorods (AuNRs) to form Au core–Ag shell nanorods (Au@AgNRs) in a AuNRs–Ag+–HCHO system, which caused the dielectric function to change, the longitudinal plasmon absorption band (LPAB) of AuNRs to redshift (ΔλLPAB) and the color of the solution to change obviously. Thus, a responsive, simple, sensitive and selective AuNRs colorimetric sensor for the determination of HCHO has been developed based on the linear relationship between ΔλLPAB and the concentration of HCHO. The limit of detection (LOD) of this sensor is 6.3 × 10−11 (g mL−1), which is much lower than that of surface-enhanced Raman spectroscopy (SERS), showing its high sensitivity. What's more, the sensor has been applied to the detection of HCHO in water samples with the results agreeing well with resonance fluorescence spectrometry, showing its great practicality. Furthermore, the morphological changes of AuNRs and Au@AgNRs were characterized by transmission electron microscopy (TEM) and the sensing mechanism for the detection of HCHO was also discussed.
Keywords	absorption ; color ; colorimetry ; detection limit ; fluorescence emission spectroscopy ; formaldehyde ; gold ; nanogold ; nanorods ; nanosilver ; Raman spectroscopy ; silver ; transmission electron microscopy
Language	English
Dates of publication	2015-1123
Size	p. 99944-99950.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c5ra16266a
Database	NAL-Catalogue (AGRICOLA)

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