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Article ; Online: Associations Between Temporomandibular Disorders and Brain Imaging-Derived Phenotypes.

Lin, Jun / Cao, Dong-Yuan

2024

Abstract: Objective: Temporomandibular disorders (TMD) affect the temporomandibular joint and associated structures. Despite its prevalence and impact on quality of life, the underlying mechanisms of TMD remain unclear. Magnetic resonance imaging studies suggest ... ...

Abstract	Objective: Temporomandibular disorders (TMD) affect the temporomandibular joint and associated structures. Despite its prevalence and impact on quality of life, the underlying mechanisms of TMD remain unclear. Magnetic resonance imaging studies suggest brain abnormalities in patients with TMD. However, these lines of evidence are essentially observational and cannot infer a causal relationship. This study employs Mendelian randomisation (MR) to probe causal relationships between TMD and brain changes. Methods: Genome-wide association study (GWAS) summary statistics for TMD were collected, along with brain imaging-derived phenotypes (IDPs). Instrumental variables were selected from the GWAS summary statistics and used in bidirectional 2-sample MR analyses. The inverse-variance weighted analysis was chosen as the primary method. In addition, false discovery rate (FDR) correction of P value was used. Results: Eleven IDPs related to brain imaging alterations showed significant causal associations with TMD (P-FDR < .05), validated through sensitivity analysis. In forward MR, the mean thickness of left caudal middle frontal gyrus (OR, 0.76; 95% CI, 0.67-0.87; P-FDR = 1.15 × 10 Conclusions: This study provides genetic evidence supporting the bidirectional causal associations between TMD and brain IDPs, shedding light on potential neurobiological mechanisms underlying TMD development and its relationship with brain structure.
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	218262-2
ISSN	1875-595X ; 0020-6539
ISSN (online)	1875-595X
ISSN	0020-6539
DOI	10.1016/j.identj.2024.01.008
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Article: Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1.

Lin, Jun-Jun / Lu, Ye-Cai

World journal of gastrointestinal oncology

2024 Volume 16, Issue 3, Page(s) 1006–1018

Abstract: Background: Colorectal cancer (CRC) is one very usual tumor together with higher death rate. Ubiquitin-specific protease 21 (USP21) has been confirmed to take part into the regulation of CRC progression through serving as a facilitator. Interestingly, ... ...

Abstract	Background: Colorectal cancer (CRC) is one very usual tumor together with higher death rate. Ubiquitin-specific protease 21 (USP21) has been confirmed to take part into the regulation of CRC progression through serving as a facilitator. Interestingly, the promotive function of USP21 has also discovered in the progression of CRC. ZEB1 has illustrated to be modulated by USP7, USP22 and USP51 in cancers. However, the regulatory functions of USP21 on ZEB1 in CRC progression need more investigations. Aim: To investigate the relationship between USP21 and ZEB1 in CRC progression. Methods: The mRNA and protein expressions were assessed through RT-qPCR, western blot and IHC assay. The interaction between USP21 and ZEB1 was evaluated through Co-IP and GST pull down assays. The cell proliferation was detected through colony formation assay. The cell migration and invasion abilities were determined through Transwell assay. The stemness was tested through sphere formation assay. The tumor growth was evaluated through Results: In this work, USP21 and ZEB1 exhibited higher expression in CRC, and resulted into poor prognosis. Moreover, the interaction between USP21 and ZEB1 was further investigated. It was demonstrated that USP21 contributed to the stability of ZEB1 through modulating ubiquitination level. In addition, USP21 strengthened cell proliferation, migration and stemness through regulating ZEB1. At last, through Conclusion: For the first time, these above findings manifested that USP21 promoted tumorigenicity and stemness of CRC by deubiquitinating and stabilizing ZEB1. This discovery suggested that USP21/ZEB1 axis may provide novel sights for the treatment of CRC.
Language	English
Publishing date	2024-04-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v16.i3.1006
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Article ; Online: Structural Damage Detection Based on the Correlation of Variational Autoencoder Neural Networks Using Limited Sensors.

Lin, Jun / Ma, Hongwei

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 8

Abstract: Identifying the structural state without baseline data is an important engineering problem in the field of structural health monitoring, which is crucial for assessing the safety condition of structures. In the context of limited accelerometers available, ...

Abstract	Identifying the structural state without baseline data is an important engineering problem in the field of structural health monitoring, which is crucial for assessing the safety condition of structures. In the context of limited accelerometers available, this paper proposes a correlation-based damage identification method using Variational Autoencoder neural networks. The approach involves initially constructing a Variational Autoencoder network model for bridge damage detection, optimizing parameters such as loss functions and learning rates for the model, and ultimately utilizing response data from limited sensors for model training analysis to determine the structural state. The contribution of this paper lies in the ability to identify structural damage without baseline data using response data from a small number of sensors, reducing sensor costs and enhancing practical applications in engineering. The effectiveness of the proposed method is demonstrated through numerical simulations and experimental structures. The results show that the method can identify the location of damage under different damage conditions, exhibits strong robustness in detecting multiple damages, and further enhances the accuracy of identifying bridge structures.
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24082616
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Article: Design of Two-Dimensional Transient Circular Thermal Cloaks with Imperfect Interfaces.

Lin, Jun-Hong / Chen, Tungyang

Materials (Basel, Switzerland)

2023 Volume 16, Issue 6

Abstract: In this paper, analytic modeling for the design of a transient thermal invisibility cloak with imperfect interfaces is presented together with numerical simulations. In contrast to steady-state conditions, it is shown that an object can only be made ... ...

Abstract	In this paper, analytic modeling for the design of a transient thermal invisibility cloak with imperfect interfaces is presented together with numerical simulations. In contrast to steady-state conditions, it is shown that an object can only be made partially invisible under a transient-state condition with either ideal or imperfect interfaces. The thermal visibility of an object to the external region can be optimally suppressed under certain conditions referred to as the "weak invisibility conditions" for the transient response, which are different from the "strong invisibility conditions" that can completely conceal an object in a steady state. In the formulation, a homogeneous metamaterial with constant volumetric heat capacity and constant anisotropic conductivity tensor is employed. It can be demonstrated that the interface's bonding conditions will have a significant effect on the design of metamaterials. Two typical types of imperfect interfaces, referred to as low-conductivity- and high-conductivity-type interfaces, are considered. Conditions, that render an object mostly undetectable, are analytically found and expressed in simple forms under quasi-static approximations. Within the quasi-static limit, the thermal localization in the target region can be tuned with the anisotropy of the conductivity tensor. Thermal shielding or concentrating effects in the target region are exemplified based on finite element simulations to demonstrate the manipulation of heat flux in the target region. The present findings make new advances in theoretical fundamentals and numerical simulations on the effect of the imperfect interface in the transient regime and can serve as guidelines in the design of thermal metamaterials through the entire conduction process.
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16062297
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Article ; Online: ASO Author Reflections: Conditional Survival of Patients with Limited-Stage Small Cell Lung Cancer After Surgery-A National Real-World Cohort Study.

Lin, Jun-Peng / Liu, Shuo-Yan / Wang, Feng

Annals of surgical oncology

2024

Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-024-15062-w
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Article ; Online: Blind self-rescue in acute dyspnea: A rare case report.

Huang, Yangzhou / Zhu, Daobin / Zhao, Hong / Lin, Jun

Asian journal of surgery

2024

Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.03.164
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Article ; Online: Deep neural network uncertainty estimation for early oral cancer diagnosis.

Lin, Huiping / Chen, Hanshen / Lin, Jun

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

2024

Abstract: Background: Early diagnosis in oral cancer is essential to reduce both morbidity and mortality. This study explores the use of uncertainty estimation in deep learning for early oral cancer diagnosis.: Methods: We develop a Bayesian deep learning ... ...

Abstract	Background: Early diagnosis in oral cancer is essential to reduce both morbidity and mortality. This study explores the use of uncertainty estimation in deep learning for early oral cancer diagnosis. Methods: We develop a Bayesian deep learning model termed 'Probabilistic HRNet', which utilizes the ensemble MC dropout method on HRNet. Additionally, two oral lesion datasets with distinct distributions are created. We conduct a retrospective study to assess the predictive performance and uncertainty of Probabilistic HRNet across these datasets. Results: Probabilistic HRNet performs optimally on the In-domain test set, achieving an F1 score of 95.3% and an AUC of 96.9% by excluding the top 30% high-uncertainty samples. For evaluations on the Domain-shift test set, the results show an F1 score of 64.9% and an AUC of 80.3%. After excluding 30% of the high-uncertainty samples, these metrics improve to an F1 score of 74.4% and an AUC of 85.6%. Conclusion: Redirecting samples with high uncertainty to experts for subsequent diagnosis significantly decreases the rates of misdiagnosis, which highlights that uncertainty estimation is vital to ensure safe decision making for computer-aided early oral cancer diagnosis.
Language	English
Publishing date	2024-04-17
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1021270-x
ISSN	1600-0714 ; 0904-2512
ISSN (online)	1600-0714
ISSN	0904-2512
DOI	10.1111/jop.13536
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Article ; Online: Antimicrobial resistance: from basic science to translational innovation.

Lin, Jun

Animal health research reviews

2018 Volume 18, Issue 2, Page(s) 85–86

Abstract: The rise in antimicrobial resistance (AMR) poses a major threat to animal agriculture and human health. To summarize and update current and emerging AMR issues that are significant for animal health and food safety, this issue presents a virtual AMR ... ...

Abstract	The rise in antimicrobial resistance (AMR) poses a major threat to animal agriculture and human health. To summarize and update current and emerging AMR issues that are significant for animal health and food safety, this issue presents a virtual AMR symposium consisting of seven review papers. These reviews cover a newly described AMR mechanism in Campylobacter, effects of AMR and microbiome on Campylobacter infection, plasmid-mediated colistin resistance in food-producing animals, the impact of point source or antibiotic residues on the environmental resistome, and potential factors influencing horizontal gene transfer in the intestines of food animals. These papers also identify significant knowledge gaps in AMR research and provide new directions for the development of innovative and effective strategies to mitigate AMR in the animal production system.
MeSH term(s)	Animals ; Drug Resistance, Bacterial ; Food Safety ; Humans
Language	English
Publishing date	2018-03-27
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2072117-1
ISSN	1475-2654 ; 1466-2523
ISSN (online)	1475-2654
ISSN	1466-2523
DOI	10.1017/S1466252317000172
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Article ; Online: Novel connections and physical implications of thermal metamaterials with imperfect interfaces.

Chen, Tungyang / Lin, Jun-Hong

Scientific reports

2022 Volume 12, Issue 1, Page(s) 2734

Abstract: Thermal metamaterials are of great importance in advanced energy control and management. Previous studies mainly focused on interfaces with perfect bonding conditions. In principle, imperfectness always exists across interface and the effect is ... ...

Abstract	Thermal metamaterials are of great importance in advanced energy control and management. Previous studies mainly focused on interfaces with perfect bonding conditions. In principle, imperfectness always exists across interface and the effect is intriguingly important with small-length scales. This work reports the imperfect interface effect in thermal metamaterials thoroughly. Low conductivity- and high conductivity-type interfaces are considered. We show that an object can always be made thermally invisible, with the effect of imperfect interface, as that of a homogeneous background material. This unprecedented condition is derived in an exact and analytic form, systematically structured, with much versatile and physical implications. Conditions for thermal shielding and enhancements are analytically found and numerically exemplified, highlighting the specific role of material and geometric parameters. We find that both types of interfaces are complementing with each other which, all together, will constitute a full spectrum to achieve the thermal invisibility. The analytic finding offers a general perception that adds to the understanding of heat transport mechanism across interfaces in thermal metamaterials, in ways that drastically distinct from that of ideal interfaces. This finding opens up new possibilities for the control and management of thermal metamaterials with imperfect bonding interfaces.
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06719-1
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Article: [Double-pulley combined with suture bridge technique for fixation of comminuted fractures of distal patella pole].

Shi, Lin-Jun / Wu, Cong-Cong

Zhongguo gu shang = China journal of orthopaedics and traumatology

2022 Volume 36, Issue 3, Page(s) 247–250

Abstract: Objective: To investigate the clinical effect of double pulley combined with suture bridge in the treatment of comminuted fracture of the lower pole of the patella.: Methods: From January 2018 to June 2020, 15 patients with comminuted fracture of the ...

Abstract	Objective: To investigate the clinical effect of double pulley combined with suture bridge in the treatment of comminuted fracture of the lower pole of the patella. Methods: From January 2018 to June 2020, 15 patients with comminuted fracture of the lower pole of the patella were treated with double pulley and suture bridge technology, including 9 males and 6 females, aged 28 to 68 years old with an average of (42.4±9.6) years old. All patients had obvious knee joint pain and limited movement after injury. All knee joints were examined by X-ray and CT, which confirmed that they were all comminuted fractures at the lower level of the patella. After operation, X-ray films of the knee joint were taken regularly to understand the fracture healing, the Insall Salvati index was measure, the range of motion of the joint was recorded, and the function of the knee joint was evaluateed by the Bostman scoring system. Results: All the 15 patients were followed up for 7 to 24 months with an average of (11.4±4.2) months, and there was no obvious anterior knee pain. At the last follow-up, the knee joint range of motion of the affected limb was 105° to 140° with an average of (128.5±12.8) °, and the Insall Salvati index was 0.79 to 1.12 with an average of (0.92±0.18). The X-ray film showed that the patella was bone healing, and no anchor fell off, broken, or displaced fracture block was found. Bostman patellar fracture function score was 27.85±2.06, 13 cases were excellent, 2 cases were good. Conclusion: Double pulley technique combined with suture bridge technique is reliable for reduction and fixation of comminuted fracture of the lower pole of patella, and patients can start functional exercise early after operation.
MeSH term(s)	Male ; Female ; Humans ; Adult ; Middle Aged ; Aged ; Fractures, Comminuted/surgery ; Fracture Fixation, Internal/methods ; Patella/surgery ; Patella/injuries ; Bone Wires ; Fractures, Bone/surgery ; Sutures ; Treatment Outcome
Language	Chinese
Publishing date	2022-12-21
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1003-0034
ISSN	1003-0034
DOI	10.12200/j.issn.1003-0034.2023.03.010
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