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  1. Article ; Online: Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp.

    Zhou, Bangdi / Chen, Dianming / Zhang, Tingyan / Song, Chenggui / Zhang, Xianwu / Lin, Leying / Huang, Jiuzhong / Peng, Xiaopeng / Liu, Yuanchang / Wu, Gaorong / Li, Jingyuan / Chen, Weiming

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 171, Page(s) 116180

    Abstract: The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds ...

    Abstract The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds directed against SARS-CoV-2 RdRp, exhibit a unique and highly effective mechanism, effectively overcoming various factors contributing to drug resistance against nucleoside inhibitors (NIs). This review investigates various NNIs, including both natural and synthetic inhibitors, that closely interacting with the SARS-CoV-2 RdRp with valid evidences from in vitro and in silico studies.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; RNA-Dependent RNA Polymerase ; Antiviral Agents/pharmacology ; Molecular Docking Simulation
    Chemical Substances RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Antiviral Agents
    Language English
    Publishing date 2024-01-23
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Camellia oleifera Abel shells as a new biosorbent to remove methylene blue from aqueous solutions.

    Lu, Yudong / Lin, Leying / You, Ruiyun / Wu, Zonghua

    Water science and technology : a journal of the International Association on Water Pollution Research

    2011  Volume 64, Issue 7, Page(s) 1566–1571

    Abstract: This study aimed at investigating the feasibility of using Camellia oleifera Abel shell (COAS), an agriculture product in middle-west region in China, for the adsorption of methylene blue (MB), a cationic dye. Batch adsorption experiments were carried ... ...

    Abstract This study aimed at investigating the feasibility of using Camellia oleifera Abel shell (COAS), an agriculture product in middle-west region in China, for the adsorption of methylene blue (MB), a cationic dye. Batch adsorption experiments were carried out to evaluate the effects of contact time, pH, adsorbent dosage, temperature and initial concentration on the adsorption of MB. Adsorption equilibrium studies showed that MB adsorption followed Langmuir model with a maximum adsorption capacity of 454.54 mg/g. The results demonstrated that the COAS is a promising adsorbent in the removal of MB from aqueous solutions.
    MeSH term(s) Adsorption ; Camellia ; China ; Coloring Agents/isolation & purification ; Hydrogen-Ion Concentration ; Kinetics ; Methylene Blue/isolation & purification ; Solutions ; Water Purification/methods
    Chemical Substances Coloring Agents ; Solutions ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2011
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764273-8
    ISSN 1996-9732 ; 0273-1223
    ISSN (online) 1996-9732
    ISSN 0273-1223
    DOI 10.2166/wst.2011.657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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