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Article ; Online: Efficient and durable MoFeNi hydroxide anode: Room temperature recrystallization regulated morphology-, valence- and crystallinity-dependent water oxidation performance

Yang, Yang / Lin, Meihong / Guo, Donggang / Liu, Lu

Journal of Colloid And Interface Science. 2024 Jan., v. 653 p.627-633

2024

Abstract: The formation of crystal-amorphous (c-a) interfaces by modulating the crystallinity of the material is a promising strategy for the oxygen evolution reaction (OER). Herein, a recrystallization growth at room temperature to regulate the crystallinity of ... ...

Abstract	The formation of crystal-amorphous (c-a) interfaces by modulating the crystallinity of the material is a promising strategy for the oxygen evolution reaction (OER). Herein, a recrystallization growth at room temperature to regulate the crystallinity of catalysts is reported. The MoFeNi hydroxide precursor was synthesized by the solvothermal method, and then the crystallinity of the material was controlled by adjusting the concentration of Na₂S in the immersion solution. These c-a heterogeneous interfaces significantly improved the OER activity of the catalysts while ensuring structural stability. The best catalyst exhibited a low overpotential of 195 mV to reach 10 mA cm⁻² in 1 M KOH. It also showed good stability, operating stably at high current densities for 96 h without significant degradation. In addition, the anode of the two-electrode water splitting electrolyzer required only 1.46 V to reach 10 mA cm⁻² and operated for a long time without significant degradation. This method will provide new insights and perspectives for developing efficient and stable OER catalysts.
Keywords	ambient temperature ; anodes ; catalysts ; crystal structure ; crystallization ; oxidation ; oxygen production ; Hydroxides ; Crystal-amorphous heterostructures ; Electrocatalysis ; Oxygen evolution reaction ; Nanosheets ; HER ; OER ; LDH ; XRD ; LSV ; CV ; RHE ; TEM ; XPS ; EIS ; ECSA
Language	English
Dates of publication	2024-01
Size	p. 627-633.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.09.107
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Article ; Online: Efficient and durable MoFeNi hydroxide anode: Room temperature recrystallization regulated morphology-, valence- and crystallinity-dependent water oxidation performance.

Yang, Yang / Lin, Meihong / Guo, Donggang / Liu, Lu

Journal of colloid and interface science

2023 Volume 653, Issue Pt A, Page(s) 627–633

Abstract	The formation of crystal-amorphous (c-a) interfaces by modulating the crystallinity of the material is a promising strategy for the oxygen evolution reaction (OER). Herein, a recrystallization growth at room temperature to regulate the crystallinity of catalysts is reported. The MoFeNi hydroxide precursor was synthesized by the solvothermal method, and then the crystallinity of the material was controlled by adjusting the concentration of Na
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.09.107
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Article ; Online: Insecticidal Activity and Molecular Target by Morphological Analysis, RNAseq, and Molecular Docking of the Aryltetralin Lignan Lactone Helioxanthin, Isolated from

Bi, Xiaoyang / Lin, Meihong / Zhou, Yifeng / Li, Dandan / Xu, Zuowei / Zhou, Lijuan / Huang, Jiguang

Journal of agricultural and food chemistry

2024 Volume 72, Issue 10, Page(s) 5133–5144

Abstract: Botanical insecticides are considered an environmentally friendly approach to insect control because they are easily biodegraded and cause less environmental pollution compared to traditional chemical pesticides. In this study, we reported the ... ...

Abstract	Botanical insecticides are considered an environmentally friendly approach to insect control because they are easily biodegraded and cause less environmental pollution compared to traditional chemical pesticides. In this study, we reported the insecticidal activities of the ingredients from
MeSH term(s)	Animals ; Insecticides/chemistry ; Molecular Docking Simulation ; Lignans/pharmacology ; Plant Extracts/chemistry ; Larva ; Aedes
Chemical Substances	helioxanthin ; Insecticides ; Lignans ; Plant Extracts
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c06384
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Article ; Online: Insecticidal Triterpenes in Meliaceae: Plant Species, Molecules, and Activities: Part II (

Lin, Meihong / Bi, Xiaoyang / Zhou, Lijuan / Huang, Jiguang

International journal of molecular sciences

2022 Volume 23, Issue 10

Abstract: Plant-originated triterpenes are important insecticidal molecules. Research on the insecticidal activity of molecules from Meliaceae plants has always been a hotspot due to the molecules from this family showing a variety of insecticidal activities with ... ...

Abstract	Plant-originated triterpenes are important insecticidal molecules. Research on the insecticidal activity of molecules from Meliaceae plants has always been a hotspot due to the molecules from this family showing a variety of insecticidal activities with diverse mechanisms of action. In this paper, we discussed 116 triterpenoid molecules with insecticidal activity from 22 plant species of five genera (
MeSH term(s)	Insecticides/pharmacology ; Limonins/chemistry ; Melia ; Meliaceae/chemistry ; Triterpenes/pharmacology
Chemical Substances	Insecticides ; Limonins ; Triterpenes
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23105329
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Article ; Online: Insecticidal Triterpenes in Meliaceae: Plant Species, Molecules and Activities: Part Ⅰ (

Lin, Meihong / Yang, Sifan / Huang, Jiguang / Zhou, Lijuan

International journal of molecular sciences

2021 Volume 22, Issue 24

Abstract: Plant-originated triterpenes are important insecticidal molecules. The research on insecticidal activity of molecules from Meliaceae plants has always received attention due to the molecules from this family showing a variety of insecticidal activities ... ...

Abstract	Plant-originated triterpenes are important insecticidal molecules. The research on insecticidal activity of molecules from Meliaceae plants has always received attention due to the molecules from this family showing a variety of insecticidal activities with diverse mechanisms of action. In this paper, we discuss 102 triterpenoid molecules with insecticidal activity of plants of eight genera (
MeSH term(s)	Insecticides/chemistry ; Insecticides/pharmacology ; Limonins/chemistry ; Limonins/pharmacology ; Meliaceae/chemistry ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Triterpenes/chemistry ; Triterpenes/pharmacology
Chemical Substances	Insecticides ; Limonins ; Plant Extracts ; Triterpenes ; azadirachtin (O4U1SAF85H)
Language	English
Publishing date	2021-12-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222413262
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Article ; Online: Rational design of bifunctional hydroxide/sulfide heterostructured catalyst for efficient electrochemical seawater splitting.

Yang, Yang / Lin, Meihong / Wu, Yue / Chen, Ruotong / Guo, Donggang / Liu, Lu

Journal of colloid and interface science

2023 Volume 647, Page(s) 510–518

Abstract: Heterostructure engineering is one of the most promising strategies for efficient water splitting by electrocatalysts. However, it remains challenging to design heterostructured catalysts to achieve the desired goals in both hydrogen evolution reaction ( ... ...

Abstract	Heterostructure engineering is one of the most promising strategies for efficient water splitting by electrocatalysts. However, it remains challenging to design heterostructured catalysts to achieve the desired goals in both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in seawater splitting. Here, particulate heterostructures of FeCoNi hydroxide/sulfide supported on nickel foams were prepared by hydrothermal methods to achieve a high-performance bifunctional catalyst. The synthesized FeCoNi hydroxide/sulfide exhibited excellent electrocatalytic performance, requiring an overpotential of 195 mV for OER and 76 mV for HER to achieve a current density of 10 mA cm
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.05.090
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Vitro Assessment of Transporter Mediated Perpetrator DDIs for Several Hepatitis C Virus Direct-Acting Antiviral Drugs and Prediction of DDIs with Statins Using Static Models.

Chu, Xiaoyan / Chan, Grace Hoyee / Houle, Robert / Lin, Meihong / Yabut, Jocelyn / Fandozzi, Christine

The AAPS journal

2022 Volume 24, Issue 3, Page(s) 45

Abstract: Inhibitory effects of asunaprevir, daclatasvir, grazoprevir, paritaprevir, simeprevir, and voxilaprevir, direct-acting antiviral (DAA) drugs for the treatment of chronic hepatitis C virus (HCV) infection, were evaluated in vitro against a range of ... ...

Abstract	Inhibitory effects of asunaprevir, daclatasvir, grazoprevir, paritaprevir, simeprevir, and voxilaprevir, direct-acting antiviral (DAA) drugs for the treatment of chronic hepatitis C virus (HCV) infection, were evaluated in vitro against a range of clinically important drug transporters. In vitro inhibition studies were conducted using transporter transfected cells and membrane vesicles. The risk of clinical drug-drug interactions (DDIs) was assessed using simplified static models recommended by regulatory agencies. Furthermore, we refined and developed static models to predict complex DDIs with several statins (pitavastatin, rosuvastatin, atorvastatin, and pravastatin) by mechanistically assessing differential inhibitory effects of perpetrator drugs on multiple transporters, such as organic anion transporting polypeptides (OATP1B), breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), organic anion transporter 3 (OAT3), and cytochrome P450 CYP3A enzyme, as they are known to contribute to absorption, distribution, metabolism and excretion (ADME) of above statins. These models successfully predicted a total of 46 statin DDIs, including above DAA drugs and their fix-dose combination regimens. Predicted plasma area under curve ratio (AUCR) with and without perpetrator drugs was within ~ 2-fold of observed values. In contrast, simplified static R-value model resulted in increased false negative and false positive predictions when different prediction cut-off values were applied. Our studies suggest that mechanistic static model is a promising and useful tool to provide more accurate prediction of the risk and magnitude of DDIs with statins in early drug development and may help to improve the management of clinical DDIs for HCV drugs to ensure effective and safe HCV therapy. GRAPHICAL ABSTRACT.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Antiviral Agents ; Drug Interactions ; Hepacivirus/metabolism ; Hepatitis C, Chronic/drug therapy ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Membrane Transport Proteins/metabolism ; Neoplasm Proteins/metabolism
Chemical Substances	ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Antiviral Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Membrane Transport Proteins ; Neoplasm Proteins
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-021-00677-8
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Article: Near-infrared responsive sulfur vacancy-rich CuS nanosheets for efficient antibacterial activity via synergistic photothermal and photodynamic pathways

Mo, Shudi / Song, Yunhua / Lin, Meihong / Wang, Jianling / Zhang, Ze / Sun, Jingyu / Guo, Donggang / Liu, Lu

Journal of colloid and interface science. 2022 Feb. 15, v. 608

2022

Abstract: Defect engineering has been proven to be an effective approach for electronic structure modulation and plays an important role in the photocatalytic performance of nanomaterials. In this study, a series of CuS nanosheet sulfur vacancies (VS) are ... ...

Abstract	Defect engineering has been proven to be an effective approach for electronic structure modulation and plays an important role in the photocatalytic performance of nanomaterials. In this study, a series of CuS nanosheet sulfur vacancies (VS) are constructed by a simple hydrothermal synthesis method. The CuS with the highest VS concentration exhibits strong antibacterial performance, achieving bactericidal rates of 99.9% against the Gram-positive Bacillus subtilis and Gram-negative Escherichia coli bacteria under 808 nm laser irradiation. Under illumination, the temperature of the catalyst increases from 23.5 °C to 53.3 °C, and with a high photothermal conversion efficiency of 41.8%. For E. coli and B. subtilis, the reactive oxygen species (ROS) production that is induced by the CuS group is 8.6 and 9.6 times greater, respectively, than that of the control group. The presence of VS facilitates the enhancement of the light absorption capacity and the separation efficiency of electron-hole pairs, thereby resulting in improved photocatalytic performance. The synergistic effect of photothermal therapy (PTT) and photodynamic therapy (PDT) is aimed at causing oxidative damage and leading to bacterial death. Our findings provide an effective antibacterial strategy and offer new horizons for the application of CuS catalysts with VS in the NIR region.
Keywords	Bacillus subtilis ; Escherichia coli ; absorption ; antibacterial properties ; catalysts ; death ; irradiation ; lighting ; nanosheets ; photocatalysis ; photochemotherapy ; photothermotherapy ; reactive oxygen species ; sulfur ; synergism ; temperature
Language	English
Dates of publication	2022-0215
Size	p. 2896-2906.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2021.11.014
Database	NAL-Catalogue (AGRICOLA)

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Article: Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters

Bleasby, Kelly / Houle, Robert / Hafey, Michael / Lin, Meihong / Guo, Jingjing / Lu, Bing / Sanchez, Rosa I. / Fillgrove, Kerry L.

Viruses. 2021 Aug. 07, v. 13, no. 8

2021

Abstract: Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro. ... ...

Abstract	Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro. Elimination of islatravir is expected to be balanced between adenosine deaminase–mediated metabolism and renal excretion. Islatravir did not inhibit uridine diphosphate glucuronosyltransferase 1A1 or cytochrome p450 (CYP) enzymes CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, or 3A4, nor did it induce CYP1A2, 2B6, or 3A4. Islatravir did not inhibit hepatic transporters organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter (OCT) 1, bile salt export pump (BSEP), multidrug resistance-associated protein (MRP) 2, MRP3, or MRP4. Islatravir was neither a substrate nor a significant inhibitor of renal transporters organic anion transporter (OAT) 1, OAT3, OCT2, multidrug and toxin extrusion protein (MATE) 1, or MATE2K. Islatravir did not significantly inhibit P-glycoprotein and breast cancer resistance protein (BCRP); however, it was a substrate of BCRP, which is not expected to be of clinical significance. These findings suggest islatravir is unlikely to be the victim or perpetrator of drug-drug interactions with commonly co-prescribed medications, including statins, diuretics, anti-diabetic drugs, proton pump inhibitors, anticoagulants, benzodiazepines, and selective serotonin reuptake inhibitors.
Keywords	P-glycoproteins ; RNA-directed DNA polymerase ; adenosine ; benzodiazepines ; bile salts ; breast neoplasms ; cytochrome P-450 ; excretion ; extrusion ; metabolism ; organic cation transporters ; polypeptides ; proton pump ; serotonin ; toxins ; uridine diphosphate
Language	English
Dates of publication	2021-0807
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13081566
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters.

Bleasby, Kelly / Houle, Robert / Hafey, Michael / Lin, Meihong / Guo, Jingjing / Lu, Bing / Sanchez, Rosa I / Fillgrove, Kerry L

Viruses

2021 Volume 13, Issue 8

Abstract	Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro. Elimination of islatravir is expected to be balanced between adenosine deaminase-mediated metabolism and renal excretion. Islatravir did not inhibit uridine diphosphate glucuronosyltransferase 1A1 or cytochrome p450 (CYP) enzymes CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, or 3A4, nor did it induce CYP1A2, 2B6, or 3A4. Islatravir did not inhibit hepatic transporters organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter (OCT) 1, bile salt export pump (BSEP), multidrug resistance-associated protein (MRP) 2, MRP3, or MRP4. Islatravir was neither a substrate nor a significant inhibitor of renal transporters organic anion transporter (OAT) 1, OAT3, OCT2, multidrug and toxin extrusion protein (MATE) 1, or MATE2K. Islatravir did not significantly inhibit P-glycoprotein and breast cancer resistance protein (BCRP); however, it was a substrate of BCRP, which is not expected to be of clinical significance. These findings suggest islatravir is unlikely to be the victim or perpetrator of drug-drug interactions with commonly co-prescribed medications, including statins, diuretics, anti-diabetic drugs, proton pump inhibitors, anticoagulants, benzodiazepines, and selective serotonin reuptake inhibitors.
MeSH term(s)	Animals ; Biological Transport ; Cytochrome P-450 Enzyme System/metabolism ; Deoxyadenosines/blood ; Deoxyadenosines/metabolism ; Dogs ; Drug Interactions ; HIV Infections/drug therapy ; Humans ; In Vitro Techniques ; Madin Darby Canine Kidney Cells ; Membrane Transport Proteins/metabolism ; Mice ; Organic Anion Transporters/metabolism ; Pharmaceutical Preparations/metabolism ; Rabbits ; Reverse Transcriptase Inhibitors/metabolism
Chemical Substances	Deoxyadenosines ; Membrane Transport Proteins ; Organic Anion Transporters ; Pharmaceutical Preparations ; Reverse Transcriptase Inhibitors ; Cytochrome P-450 Enzyme System (9035-51-2) ; islatravir (QPQ082R25D)
Language	English
Publishing date	2021-08-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13081566
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