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  1. Book: Neck Rejuvenation

    Lin, Samuel / Slavin, Sumner

    Surgical and Nonsurgical Techniques

    2024  

    Keywords aging neck ; deep plane neck lift ; jawline contouring ; platysmaplasty ; skin rejuvenation
    Language English
    Size 208 p.
    Edition 1
    Publisher Thieme Medical Publishers
    Document type Book
    Note PDA Manuell_25
    Format 178 x 254
    ISBN 9781626239630 ; 1626239630
    Database PDA

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  2. Book ; Online ; E-Book: Bioinformatics methods

    Lin, Shili / Scholtens, Denise / Batta, Sujay

    from omics to next generation sequencing

    (Chapman and Hall/CRC mathematical & computational biology series)

    2023  

    Abstract: The past three decades have witnessed an explosion of what is now referred to as high-dimensional 'omics' data. Bioinformatics Methods: From Omics to Next Generation Sequencing describes the statistical methods and analytic frameworks that are best ... ...

    Author's details Shili Lin, Denise Scholtens and Sujay Datta
    Series title Chapman and Hall/CRC mathematical & computational biology series
    Abstract "The past three decades have witnessed an explosion of what is now referred to as high-dimensional 'omics' data. Bioinformatics Methods: From Omics to Next Generation Sequencing describes the statistical methods and analytic frameworks that are best equipped to interpret these complex data and how they apply to health-related research. Covering the technologies that generate data, subtleties of various data types, and statistical underpinnings of methods, this book identifies a suite of potential analytic tools, and highlights commonalities among statistical methods that have been developed. An ideal reference for biostatisticians and data analysts that work in collaboration with scientists and clinical investigators looking to ensure rigorous application of available methodologies"--
    Keywords Bioinformatics ; Genetics Technique ; High-throughput nucleotide sequencing
    Subject code 570.285
    Language English
    Dates of publication 2023-2023
    Size 1 online resource (351 pages)
    Publisher CRC Press
    Publishing place Boca Raton, Florida ; London ; New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-315-15372-6 ; 978-1-315-15372-8 ; 1-351-64976-0 ; 9781498765152 ; 9781032341835 ; 978-1-351-64976-6 ; 1498765157 ; 1032341831
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice

    LIN, Shaoling

    Food Science & Nutrition, 7(2):579-588

    2019  

    Abstract: To evaluate the anti‐obesity effects of chlorogenic acid (CGA), the mice were fed a high‐fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body ... ...

    Abstract To evaluate the anti‐obesity effects of chlorogenic acid (CGA), the mice were fed a high‐fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD‐induced gut microbiota dysbiosis, including significantly inhibiting the growth of Desulfovibrionaceae, Ruminococcaceae, Lachnospiraceae, Erysipelotrichaceae, and raising the growth of Bacteroidaceae, Lactobacillaceae. Overall, the amelioration of HFD‐induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD‐induced obesity.
    Keywords chlorogenic acid ; body weight ; gut microbiota ; obesity
    Language English
    Document type Article
    Database Repository for Life Sciences

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  4. Article: Tenderization effect of whelk meat using ultrasonic treatment

    LIN, Shaoling

    Food Science & Nutrition, 6(7):1848-1857

    2018  

    Abstract: This study was conducted to assess the potential application of ultrasonic treatment to enhance the tenderness of whelk (Buccinum undatum ) meat. The optimum ultrasonic conditions for the maximum tenderization effect were determined using response ... ...

    Abstract This study was conducted to assess the potential application of ultrasonic treatment to enhance the tenderness of whelk (Buccinum undatum ) meat. The optimum ultrasonic conditions for the maximum tenderization effect were determined using response surface methodology by a three‐level factorial Box–Behnken design for the optimization of three variables. The optimum conditions for the three variables found were as follows: ultrasound power at 200 W, treatment time for 9.6 min, and temperature at 45°C. The resulted tenderization effect was comparable to traditional enzymatic methods. Furthermore, disruption of muscle microstructure was observed in the ultrasonic‐treated whelk meat by scanning electron microscopy, while evaluations on physicochemical properties indicated the ultrasonic treatment has no significant undesirable effects on the quality of whelk meat including pH, water‐holding capacity, and lipid oxidation. In conclusion, this study showed the feasibility of ultrasonic treatment as a promising tenderization method for whelk meat without detrimental effects on its quality.
    Keywords Buccinum undatum ; surface methodology ; tenderization, ultrasound
    Language English
    Document type Article
    Database Repository for Life Sciences

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  5. Article ; Online: Internal-state-dependent modulation of olfactory responses: a tale of dopamine neurons in the adult Drosophila mushroom body.

    Lin, Suewei

    Current opinion in insect science

    2023  Volume 59, Page(s) 101104

    Abstract: Olfaction is a vital sense that insects use to forage and interact with each other. When an insect smells an odor, its nervous system processes the odor information and transforms it into an appropriate behavioral decision. Olfactory processing and ... ...

    Abstract Olfaction is a vital sense that insects use to forage and interact with each other. When an insect smells an odor, its nervous system processes the odor information and transforms it into an appropriate behavioral decision. Olfactory processing and transformation are not label-lined, but instead are modulated by internal states. The vinegar fly, Drosophila melanogaster, has become a primary model organism for studying this modulation. It has been observed that internal state modulates olfactory behaviors in multiple sites of the fly brain. In this review article, I focus on the mushroom body, a computational center in the fly brain, and discuss how the dopamine system in this brain region mediates internal-state signals and shapes olfactory responses in adult flies.
    Language English
    Publishing date 2023-08-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2772833-X
    ISSN 2214-5753 ; 2214-5745
    ISSN (online) 2214-5753
    ISSN 2214-5745
    DOI 10.1016/j.cois.2023.101104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The making of the Drosophila mushroom body.

    Lin, Suewei

    Frontiers in physiology

    2023  Volume 14, Page(s) 1091248

    Abstract: The mushroom body (MB) is a computational center in ... ...

    Abstract The mushroom body (MB) is a computational center in the
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1091248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phosphate limitation and ocean acidification co-shape phytoplankton physiology and community structure.

    Lin, Senjie

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2699

    MeSH term(s) Phytoplankton/physiology ; Seawater/chemistry ; Phosphates ; Hydrogen-Ion Concentration ; Ocean Acidification ; Oceans and Seas ; Carbon Dioxide/chemistry
    Chemical Substances Phosphates ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38381-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer.

    Lin, Shan

    Biochemical and biophysical research communications

    2023  Volume 681, Page(s) 106–110

    Abstract: The global incidence of pancreatic cancer is associated with a high mortality rate and one of the lowest survival rates among all types of cancer. The clinical management modalities for pancreatic cancer encompass surgical intervention, chemotherapy, ... ...

    Abstract The global incidence of pancreatic cancer is associated with a high mortality rate and one of the lowest survival rates among all types of cancer. The clinical management modalities for pancreatic cancer encompass surgical intervention, chemotherapy, radiation therapy, targeted therapy, immunotherapy, or a combination thereof. Nevertheless, the diagnosis of pancreatic cancer often occurs at an advanced stage, thereby restricting treatment options and diminishing the prospects of achieving a cure. The cGAS-STING pathway has emerged as a potential target for antitumor therapy due to its role in promoting immune responses against cancer cells. Activation of the cGAS-STING pathway in tumor cells can lead to the production of pro-inflammatory cytokines and type I interferons, which can enhance the recruitment and activation of immune cells to the tumor microenvironment. The cGAS protein was detected in only a half of tumor tissues in pancreatic cancer patients and the underlying mechanism is still elusive. In this study, we have identified the E3 ligase DTX3L as a key regulator of cGAS-STING signaling in pancreatic cancer cells by mediating the ubiquitination and degradation of cGAS. The expression levels of DTX3L were found to be upregulated in pancreatic tumor tissues and correlated with a poor prognosis for patients with pancreatic cancer. Silencing of DTX3L resulted in enhanced activation of the cGAS-STING signaling pathway and improved antitumor immunity for pancreatic cancer, suggesting that targeting the DTX3L-cGAS axis could hold promise for the treatment of this disease.
    MeSH term(s) Humans ; Nucleotidyltransferases/genetics ; Pancreas ; Pancreatic Neoplasms/therapy ; Tumor Microenvironment ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination ; Pancreatic Neoplasms
    Chemical Substances DTX3L protein, human (EC 2.3.2.27) ; Nucleotidyltransferases (EC 2.7.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; cGAS protein, human (EC 2.7.7.-)
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.09.073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: COVID-19 Pandemic and Im/migrants' Elevated Health Concerns in Canada: Vaccine Hesitancy, Anticipated Stigma, and Risk Perception of Accessing Care.

    Lin, Shen

    Journal of immigrant and minority health

    2022  Volume 24, Issue 4, Page(s) 896–908

    Abstract: Vaccine hesitancy has taken a toll on COVID-19 immunization globally. This study aims to characterize three COVID-19-related health concerns (i.e., vaccine hesitancy, anticipated stigma, and risk perception) in Canada and how they differ based on im/ ... ...

    Abstract Vaccine hesitancy has taken a toll on COVID-19 immunization globally. This study aims to characterize three COVID-19-related health concerns (i.e., vaccine hesitancy, anticipated stigma, and risk perception) in Canada and how they differ based on im/migration status and other social determinants. Data were obtained from a nationwide probability sample of the Canadian Perspective Survey Series 3 (June 15 to 21, 2020). Multivariable binary logistic regression analysis was performed to investigate the association between each COVID-19 concern and nativity status, while controlling for socio-demographics. Of 3522 participants aged ≥ 25 years, the estimated overall prevalence of vaccine hesitancy was 16.9%, with im/migrants being greater than non-immigrants (21.5% vs. 15.5%, p < 0.001). After controlling for all covariates, im/migrants had around two-fold greater odds of all three health concerns, including risk perception of accessing care (aOR 2.44, 95% CI 1.89-3.15), anticipated stigma of being targeted (aOR 2.24, 95% CI 1.81, 2.78) and COVID-19 vaccine hesitancy (aOR 1.99, 95% CI 1.57-2.52), compared to their Canadian-born peers. Among vaccine-hesitant individuals (n = 596), im/migrants reported higher concerns, than non-immigrants, on vaccine safety (71.3% vs. 49.5%), side effects (66.4% vs 47.3%) and mistrust in vaccinations (12.5% vs 6.6%) as possible reasons of vaccine refusal. For migrant justice, health authorities should ensure equitable access to COVID-19 vaccines and other health-enhancing resources for im/migrants to mitigate their heightened fear, stigma, and mistrust of new vaccines amidst turbulent times.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Canada/epidemiology ; Humans ; Pandemics ; Perception ; Transients and Migrants ; Vaccination Hesitancy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2220162-2
    ISSN 1557-1920 ; 1557-1912
    ISSN (online) 1557-1920
    ISSN 1557-1912
    DOI 10.1007/s10903-022-01337-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Dietary fiber in bakery products: Source, processing, and function.

    Lin, Suyun

    Advances in food and nutrition research

    2022  Volume 99, Page(s) 37–100

    Abstract: Bakery products are prevalently consumed foods in the world, and they have been regarded as convenient dietary vehicles for delivering nutritive ingredients into people's diet, of which, dietary fiber (DF) is one of the most popular items. The food ... ...

    Abstract Bakery products are prevalently consumed foods in the world, and they have been regarded as convenient dietary vehicles for delivering nutritive ingredients into people's diet, of which, dietary fiber (DF) is one of the most popular items. The food industry attempts to produce fiber-enriched bakery products with both increasing nutritional value and appealing palatability. As many new sources of DFs become available, and consumers are moving towards healthier diets, studies of using these DFs as functional ingredients in baked goods are becoming vast. Besides, the nutrition value of DF is commonly accepted, and many investigations have also revealed the health benefits of fiber-enriched bakery products. Thus, this chapter presents an overview of (1) trends in supplementation of DF from various sources, (2) impact of DF on dough processing, quality and physiological functionality of bakery products, and (3) technologies used to improve the compatibility of DF in bakery products.
    MeSH term(s) Diet ; Dietary Fiber ; Humans ; Nutritive Value
    Chemical Substances Dietary Fiber
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1011108-6
    ISSN 1043-4526
    ISSN 1043-4526
    DOI 10.1016/bs.afnr.2021.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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