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  1. Article ; Online: Perverse Taiwan

    Lin Song

    Feminist Encounters: A Journal of Critical Studies in Culture and Politics, Vol 2, Iss 2, Pp - (2018)

    2018  

    Abstract: Review of the book "Perverse Taiwan" by Howard Chiang and Yin Wang (Eds.). ...

    Abstract Review of the book "Perverse Taiwan" by Howard Chiang and Yin Wang (Eds.).
    Keywords Social Sciences ; H ; Women. Feminism ; HQ1101-2030.7
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher Lectito Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Deuterodehalogenation Under Net Reductive or Redox-Neutral Conditions Enabled by Paired Electrolysis.

    Wood, Devin / Lin, Song

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 15, Page(s) e202218858

    Abstract: Interest in deuterated active pharmaceutical ingredients (APIs) is increasing as deuteration holds promise for kinetic isotope effect (KIE) regulated fine-tuning of API performance. Moreover, deuterium isotope labeling is frequently carried out to study ... ...

    Abstract Interest in deuterated active pharmaceutical ingredients (APIs) is increasing as deuteration holds promise for kinetic isotope effect (KIE) regulated fine-tuning of API performance. Moreover, deuterium isotope labeling is frequently carried out to study organic and bioorganic reaction mechanisms and to facilitate complex target synthesis. As such, methods for highly selective deuteration of organic molecules are highly desirable. Herein, we present an electrochemical method for the selective deuterodehalogenation of benzylic halides via a radical-polar crossover mechanism, using inexpensive deuterium oxide (D
    Language English
    Publishing date 2023-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202218858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reproductive factors and risk of cardiovascular diseases and all-cause and cardiovascular mortality in American women: NHANES 2003-2018.

    Yan, Yufeng / Lu, Hongjing / Lin, Song / Zheng, Yaguo

    BMC women's health

    2024  Volume 24, Issue 1, Page(s) 222

    Abstract: Background: The evidence regarding the association of reproductive factors with cardiovascular diseases (CVDs) is limited.: Aims: To investigate the relationship of reproductive factors with the risk of CVDs, as well as all-cause and cardiovascular ... ...

    Abstract Background: The evidence regarding the association of reproductive factors with cardiovascular diseases (CVDs) is limited.
    Aims: To investigate the relationship of reproductive factors with the risk of CVDs, as well as all-cause and cardiovascular mortality.
    Methods: This study included 16,404 adults with reproductive factors from the National Health and Nutrition Examination Survey (NHANES) and followed up until 31 December 2019. Logistic models and restricted cubic spline models were used to assess the association of reproductive factors with CVDs. COX proportional hazards models and restricted cubic spline models, with adjustment for potential confounding, were employed to analyze the relation between reproductive factors and cardiovascular and all-cause death.
    Results: There is a nonlinear relationship between age at menarche and CVDs. Age at menopause ≤ 11(OR 1.36, 95% CI 1.10-1.69) was associated with an increased risk of CVDs compared to ages 12-13 years. Age at Menopause ≤ 44 (OR 1.69, 95% CI 1.40-2.03) was associated with increased CVDs compared to age 35-49 years. Number of pregnancies ≥ 5(OR 1.26, 95% CI 1.02-1.55) was associated with an increased risk of CVDs compared to one pregnancy. In continuous variable COX regression models, a later age at menopause (HR 0.98, 95% CI 0.97-0.99) and a longer reproductive lifespan (HR 0.98, 95% CI 0.97-0.99) were associated with a decreased risk of all-cause death. A later age at menopause (HR 0.98, 95% CI 0.97-0.99) and a longer reproductive lifespan (HR 0.98, 95% CI 0.97-0.99) were associated with a decreased risk of cardiac death.
    Conclusions: Female reproductive factors are significant risk factors for CVDs American women.
    MeSH term(s) Pregnancy ; Adult ; Female ; United States/epidemiology ; Humans ; Child ; Adolescent ; Middle Aged ; Cardiovascular Diseases ; Nutrition Surveys ; Menopause ; Reproduction ; Risk Factors
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050444-5
    ISSN 1472-6874 ; 1472-6874
    ISSN (online) 1472-6874
    ISSN 1472-6874
    DOI 10.1186/s12905-024-03055-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evolutionary game theory and simulations based on doctor and patient medical malpractice under government regulation

    Lin Song / Zhenlei Yu / Juntao Fang / Qiang He

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 16

    Abstract: Abstract Physicians-patients are the two crucial participants in medical malpractice. The government, as the central authority responsible for addressing medical malpractices, plays a pivotal role in this matter. Guided by governmental agencies, its ... ...

    Abstract Abstract Physicians-patients are the two crucial participants in medical malpractice. The government, as the central authority responsible for addressing medical malpractices, plays a pivotal role in this matter. Guided by governmental agencies, its regulations, administrative orders, and policies serve as the primary governance mechanisms to address medical malpractice, providing an effective means to balance the doctor-patient relationship and foster social harmony and stable development. A doctor-patient evolutionary game model developed based on the principles of information asymmetry and finite rationality. The study explores the strategic decision-making process of these two players within the context of medical malpractice. Through the manipulation of various parameters, the model's evolutionary equilibrium strategy is demonstrated using Vensim PLE Version 6.4 simulation. The findings reveal that government regulation, patient cognition, and the benefits associated with standardized medical practices are the pivotal factors influencing the doctor-patient evolutionary game system under government regulation. It is possible to mitigate medical malpractice through adjusting relative weights of differing strategic options, adding penalties for unlawful conduct, and normalizing malpractice charges on the basis of physicians' income from standardized practice. To effectively address medical malpractice, proposed measures include adjusting the regulatory framework, reasonably determining the strength of regulations regarding medical practitioners' illegal practices and patient medical malpractice behavior, diversifying regulatory approaches, establishing comprehensive physician–patient management systems for information to resolve medical malpractices.
    Keywords Medicine ; R ; Science ; Q
    Subject code 303
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Evolutionary game theory and simulations based on doctor and patient medical malpractice.

    Lin Song / Zhenlei Yu / Qiang He

    PLoS ONE, Vol 18, Iss 3, p e

    2023  Volume 0282434

    Abstract: Doctors and patients are the two critical players in medical malpractice. The evolutionary game model of doctors and patients is constructed based on information asymmetry and bounded rationality. The strategy selection problem of the two players in the ... ...

    Abstract Doctors and patients are the two critical players in medical malpractice. The evolutionary game model of doctors and patients is constructed based on information asymmetry and bounded rationality. The strategy selection problem of the two players in the medical malpractice process was studied. With change in different parameters, the evolutionary equilibrium strategy of the model was demonstrated using Vensim simulation. The results show that the weight, penalty amount, benefits of standardized practices, and patient medical alarm cost of strategies of different doctors are the key factors affecting doctor-patient evolutionary game system. Medical malpractice can be reduced by adjusting the weight of different strategy choices, increasing the penalties for illegal practices, and standardizing medical malpractice costs based on doctors' standardized practice income. Measures to effectively resolve medical malpractice are proposed by introducing a third-party normative system, establishing a doctor-patient information management system, and improving doctors' reward and punishment mechanisms.
    Keywords Medicine ; R ; Science ; Q
    Subject code 629 ; 303
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Correction: A tutorial on asymmetric electrocatalysis.

    Rein, Jonas / Zacate, Samson B / Mao, Kaining / Lin, Song

    Chemical Society reviews

    2024  Volume 53, Issue 1, Page(s) 545

    Abstract: Correction for 'A tutorial on asymmetric electrocatalysis' by Jonas ... ...

    Abstract Correction for 'A tutorial on asymmetric electrocatalysis' by Jonas Rein
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d3cs90096g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Identification of knowledge anxiety factors among researchers based on grounded theory.

    Zhenlei, Yu / Boyuan, Ma / Lin, Song / Chunxia, Guo / Qiang, He

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e25752

    Abstract: Based on a grounded theoretical analysis of interviews and open data, this study develops a model delineating the factors influencing Knowledge Anxiety, encompassing 5 primary categories and 20 subcategories. These categories encompass Academic ... ...

    Abstract Based on a grounded theoretical analysis of interviews and open data, this study develops a model delineating the factors influencing Knowledge Anxiety, encompassing 5 primary categories and 20 subcategories. These categories encompass Academic Characteristics (knowledge quantity, knowledge quality, and knowledge content), Outer Environment (paid marketing, negative feedback, intense competition, and evaluation mechanism), and Cognitive Environment (work stress, scientific research funding, interpersonal relationships, Time limitation, and Cause difficult) which have been identified as external drivers influencing researchers' Knowledge Anxiety. Conversely, Ability Characteristics (scientific literacy, personality traits, English proficiency, and self-expectations) and Emotional Cognition (inertia thinking, negative self-concept, perceived risks, self-efficacy, and knowledge demand) have been recognized as internal drivers impacting researchers' Knowledge Anxiety. Findings reveal that external factors such as Academic Characteristics, Outer Environment, and Cognitive Environment directly impact researchers' susceptibility to Knowledge Anxiety. Internal factors, represented by Individual Competencies and Emotional Perception, also wield significant influence. Furthermore, external forces can affect Knowledge Anxiety either directly or indirectly by interfacing with internal determinants. This study underscores that researchers' Knowledge Anxiety emerges from intricate interactions among diverse factors, rather than stemming from a solitary cause. These insights furnish valuable comprehension and prospective strategies for mitigating Knowledge Anxiety among researchers, ultimately contributing to the advancement of research in this domain.
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy.

    Lin, Song / Jing, Houjin / Du, Xiaojiao / Yang, Xianzhu / Wang, Jun

    Biomaterials science

    2024  Volume 12, Issue 8, Page(s) 2057–2066

    Abstract: To date, five siRNA-based medications have received clinical approval and have demonstrated remarkable therapeutic efficacy in treating various diseases. However, their application has been predominantly limited to liver-specific diseases due to ... ...

    Abstract To date, five siRNA-based medications have received clinical approval and have demonstrated remarkable therapeutic efficacy in treating various diseases. However, their application has been predominantly limited to liver-specific diseases due to constraints in siRNA delivery capabilities. In this study, we have developed a siRNA delivery system utilizing clinically approved mPEG-
    MeSH term(s) Humans ; RNA, Small Interfering ; Polymers ; Melanoma/drug therapy ; Nanoparticles ; Immunotherapy ; Lipids ; Polyesters ; Polyethylene Glycols
    Chemical Substances RNA, Small Interfering ; Polymers ; methoxypolyethyleneglycol-poly(lactic-co-glycolic acid) ; Lipids ; Polyesters ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm02071a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association between alcohol consumption and latent fasting blood glucose trajectories among midlife women.

    Wang, Xingzhou / Lin, Song / Wang, Xiwei / Gao, Pengxia / Chen, Juan

    Frontiers in public health

    2024  Volume 12, Page(s) 1331954

    Abstract: Background: This investigation sought to elucidate the correlations between alcohol intake and trajectories of fasting blood glucose (FBG) among American women in midlife.: Methods: Our analysis was rooted in the foundational data from the Study of ... ...

    Abstract Background: This investigation sought to elucidate the correlations between alcohol intake and trajectories of fasting blood glucose (FBG) among American women in midlife.
    Methods: Our analysis was rooted in the foundational data from the Study of Women's Health Across the Nation (SWAN), a comprehensive longitudinal study centered on US women during their midlife transition. We employed group-based trajectory modeling to chart the FBG trajectories spanning from 1996 to 2005. Employing logistic regression, we gauged the odds ratios (ORs) and 95% confidence intervals (CIs) to draw connections between initial alcohol consumption and FBG trajectory patterns, whilst controlling for predominant potential confounders.
    Results: Our cohort comprised 2,578 women in midlife, ranging in age from 42 to 52, each having a minimum of three subsequent FPG assessments. We discerned two distinct FBG trajectories: a low-stable pattern (
    Conclusion: Moderate alcohol consumption may protect against high FPG trajectories in middle-aged women in a dose-response manner. Further researches are needed to investigate this causality in midlife women.
    MeSH term(s) Humans ; Middle Aged ; Female ; United States/epidemiology ; Longitudinal Studies ; Blood Glucose ; Risk Factors ; Alcohol Drinking/epidemiology ; Fasting
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1331954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Extracellular ATP is a homeostatic messenger that mediates cell‒cell communication in physiological processes and psychiatric diseases.

    Chen, Yi-Hua / Lin, Song / Jin, Shi-Yang / Gao, Tian-Ming

    Biological psychiatry

    2024  

    Abstract: Neuronal activity is the basis of information encoding and processing in the brain. During neuronal activation, intracellular ATP is generated to meet the high-energy demands. Meantime, ATP is secreted, increasing the extracellular ATP concentration and ... ...

    Abstract Neuronal activity is the basis of information encoding and processing in the brain. During neuronal activation, intracellular ATP is generated to meet the high-energy demands. Meantime, ATP is secreted, increasing the extracellular ATP concentration and acting as a homeostatic messenger that mediates cell‒cell communication to prevent aberrant hyperexcitability of the nervous system. In addition to the confined release and fast synaptic signaling of classic neurotransmitters within synaptic clefts, ATP can be released by all brain cells, diffuses widely and targets different types of purinergic receptors on neurons and glial cells, making it possible to orchestrate brain neuronal activity and participate in various physiological aspects, such as sleep and wakefulness, learning and memory, and feeding. Dysregulation of extracellular ATP leads to a "destabilizing" effect on the neural network, as found in the etiopathology of many psychiatric diseases, including depression, anxiety, schizophrenia, and autism spectrum disorder. This review summarizes advances in the understanding of the mechanisms by which extracellular ATP serves as an intercellular signaling molecule to regulate neural activity, with a focus on how it maintains the homeostasis of neural networks. In particular, we also focus on neural activity issues resulting from dysregulation of extracellular ATP and propose that aberrant levels of extracellular ATP may play a role in the etiopathology of some psychiatric diseases, highlighting the potential therapeutic targets of ATP signaling in the treatment of these psychiatric diseases. Finally, we suggest potential avenues to further elucidate the role of extracellular ATP in intercellular communication and psychiatric diseases.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2024.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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