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  1. Article ; Online: "Reverse life": A rare case report of situs inversus totalis combined with cardiac abnormalities in a young stroke.

    Chen, Xue-Qin / Lin, Song-Jun / Wang, Jian-Jun / Long, Sha / Kong, Fan-Xin / Guo, Zhou-Ke

    CNS neuroscience & therapeutics

    2022  Volume 28, Issue 9, Page(s) 1458–1460

    MeSH term(s) Humans ; Situs Inversus/complications ; Situs Inversus/diagnostic imaging ; Stroke/complications ; Stroke/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.13879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4537: Show issues Location:
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  2. Article ; Online: Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.

    Qin, Xiude / Hua, Jun / Lin, Song-Jun / Zheng, Hao-Tao / Wang, Jian-Jun / Li, Wei / Ke, Jin-Ju / Cai, Hao-Bin

    Biochemical and biophysical research communications

    2020  Volume 531, Issue 3, Page(s) 431–437

    Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder, and its etiology and pathogenesis are not fully understood. Astragalus polysaccharide (APS) has many pharmacological activities, but there are few reports about its role in AD. Using ...

    Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder, and its etiology and pathogenesis are not fully understood. Astragalus polysaccharide (APS) has many pharmacological activities, but there are few reports about its role in AD. Using the common AD model APP/PS1 mice, it was found that the expression of Keap1 (a negative regulatory factor of Nrf2), the protein level of cytoplasmic Nrf2 and the content of MDA were increased significantly, while the mRNA level of Nrf2, the expression of Nrf2 in nucleus and the contents of SOD and GSH-Px were decreased significantly. APS treatment significantly increased the expression of Nrf2 in the nucleus but decreased its expression in the cytoplasm, and restored the expression levels of Keap1, SOD, GSH-Px and MDA. When APP/PS1 mice were treated with APS and injected with Nrf2 siRNA, the down-regulation of Nrf2 expression significantly blocked the regulation of APS on oxidative stress. Continuing to test the physiological function of AD mice showed that the spatial learning and memory abilities of APP/PS1 mice were impaired, the apoptosis of brain cells and the content of β-amyloid (Aβ) were significantly increased. APS treatment significantly improved the cognitive ability of APP/PS1 mice, reduced apoptosis and the accumulation of Aβ, but the above effects of APS were blocked by Nrf2 siRNA injection. Therefore, APS can activate Nrf2 pathway to improve the physiological function of AD mice, which may have important clinical application value.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Apoptosis/drug effects ; Astragalus Plant/chemistry ; Cognition/drug effects ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/physiopathology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; NF-E2-Related Factor 2/metabolism ; Neurons/drug effects ; Neurons/pathology ; Oxidative Stress/drug effects ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Presenilin-1/metabolism ; Signal Transduction
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; NF-E2-Related Factor 2 ; Polysaccharides ; Presenilin-1
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.07.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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  3. Article: Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway

    Qin, Xiude / Hua, Jun / Lin, Song-jun / Zheng, Hao-tao / Wang, Jian-jun / Li, Wei / Ke, Jin-ju / Cai, Hao-bin

    Biochemical and biophysical research communications. 2020 Oct. 20, v. 531, no. 3

    2020  

    Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and its etiology and pathogenesis are not fully understood. Astragalus polysaccharide (APS) has many pharmacological activities, but there are few reports about its role in AD. Using ...

    Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and its etiology and pathogenesis are not fully understood. Astragalus polysaccharide (APS) has many pharmacological activities, but there are few reports about its role in AD. Using the common AD model APP/PS1 mice, it was found that the expression of Keap1 (a negative regulatory factor of Nrf2), the protein level of cytoplasmic Nrf2 and the content of MDA were increased significantly, while the mRNA level of Nrf2, the expression of Nrf2 in nucleus and the contents of SOD and GSH-Px were decreased significantly. APS treatment significantly increased the expression of Nrf2 in the nucleus but decreased its expression in the cytoplasm, and restored the expression levels of Keap1, SOD, GSH-Px and MDA. When APP/PS1 mice were treated with APS and injected with Nrf2 siRNA, the down-regulation of Nrf2 expression significantly blocked the regulation of APS on oxidative stress. Continuing to test the physiological function of AD mice showed that the spatial learning and memory abilities of APP/PS1 mice were impaired, the apoptosis of brain cells and the content of β-amyloid (Aβ) were significantly increased. APS treatment significantly improved the cognitive ability of APP/PS1 mice, reduced apoptosis and the accumulation of Aβ, but the above effects of APS were blocked by Nrf2 siRNA injection. Therefore, APS can activate Nrf2 pathway to improve the physiological function of AD mice, which may have important clinical application value.
    Keywords Astragalus ; apoptosis ; brain ; cognition ; cognitive disorders ; cytoplasm ; etiology ; gene expression ; memory ; models ; neurodegenerative diseases ; oxidative stress ; pathogenesis ; polysaccharides ; protein content ; research
    Language English
    Dates of publication 2020-1020
    Size p. 431-437.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.07.122
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  4. Article: [Effect of "Yinqi Guiyuan" needling on primary insomnia].

    Guan, Tian-Xiang / Xu, Ying-Fen / Lin, Song-Jun / Qin, Xiu-de / Li, Jin-Fang / Huang, Bin-Qing / Guo, Zhou-Ke

    Zhen ci yan jiu = Acupuncture research

    2019  Volume 44, Issue 11, Page(s) 840–842

    Abstract: Objective: To observe the clinical effect of "Yinqi Guiyuan" needling in the treatment of primary insomnia.: Methods: A total of 79 primary insomnia outpatients were randomly divided into treatment group (: Results: After treatment, the total ... ...

    Abstract Objective: To observe the clinical effect of "Yinqi Guiyuan" needling in the treatment of primary insomnia.
    Methods: A total of 79 primary insomnia outpatients were randomly divided into treatment group (
    Results: After treatment, the total score of PSQI, ISI and the score of each item were all significantly reduced in the two groups relevant to their own pre-treatment (
    Conclusion: "Yinqi Guiyuan" needling and Estazolam are comparable in treatment primary insomnia, and the former is superior to the latter in avoiding hypnotic drug use and in improving daytime function.
    MeSH term(s) Acupuncture Points ; Acupuncture Therapy ; Humans ; Sleep ; Sleep Initiation and Maintenance Disorders/therapy ; Treatment Outcome
    Language Chinese
    Publishing date 2019-11-27
    Publishing country China
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
    DOI 10.13702/j.1000-0607.180330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4364: Show issues Location:
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