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Article ; Online: Tenapanor: A new treatment option for hyperphosphatemia in end stage kidney disease.

Lin, Tiffany / Al-Makki, Akram / Shepler, Brian

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2022 Volume 25, Page(s) 77–83

Abstract: Purpose: This narrative review explores the currently published studies that have evaluated tenapanor for the treatment of hyperphosphatemia in end-stage kidney disease (ESKD) patients on hemodialysis. This medication's new phosphate lowering mechanism ... ...

Abstract	Purpose: This narrative review explores the currently published studies that have evaluated tenapanor for the treatment of hyperphosphatemia in end-stage kidney disease (ESKD) patients on hemodialysis. This medication's new phosphate lowering mechanism of action reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux by inhibition of the sodium/hydrogen exporter isoform 3 (NHE3). Tenapanor additionally prevents active transcellular phosphate absorption compensation by decreasing the expression of sodium phosphorus 2b transport protein (NaPi2b). Methods: A comprehensive search of the literature was conducted using PubMed and ClinicalTrials.gov search engines. The search term "tenapanor hyperphosphatemia" was used for study retrieval. Results were limited to studies published in the English language and excluded review articles. Human, animal, and in vitro studies were included. No date range was specified. Results: A total of 11 primary studies were identified and included in this review, the largest human study of which enrolled 236 patients. Each study is presented in table format along with measured end points. Conclusions: Tenapanor is the first drug in its class that lowers hyperphosphatemia in ESKD patients through a novel mechanism of action involving paracellular inactive transport. Although more studies are needed, early results indicate that tenapanor may have a place in managing hyperphosphatemia in ESKD patients both as monotherapy and as an adjunct to existing phosphate binder therapy.
MeSH term(s)	Animals ; Biological Transport, Active/drug effects ; Cytochrome P-450 Enzyme Inhibitors ; Drug Interactions ; Humans ; Hyperphosphatemia/drug therapy ; Hyperphosphatemia/etiology ; Intestinal Absorption/drug effects ; Isoquinolines/pharmacokinetics ; Isoquinolines/therapeutic use ; Kidney Failure, Chronic/complications ; Phosphates/metabolism ; Rats ; Sodium-Hydrogen Exchanger 3/drug effects ; Sulfonamides/pharmacokinetics ; Sulfonamides/therapeutic use
Chemical Substances	Cytochrome P-450 Enzyme Inhibitors ; Isoquinolines ; Phosphates ; Sodium-Hydrogen Exchanger 3 ; Sulfonamides ; tenapanor (WYD79216A6)
Language	English
Publishing date	2022-01-18
Publishing country	Canada
Document type	Journal Article ; Systematic Review
ZDB-ID	1422972-9
ISSN	1482-1826 ; 1482-1826
ISSN (online)	1482-1826
ISSN	1482-1826
DOI	10.18433/jpps32284
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Comprehensive Review: Chronic Pain Sequelae in the Presence of Ehlers-Danlos Syndrome.

Basem, Jade I / Lin, Tiffany / Mehta, Neel D

Current pain and headache reports

2022

Abstract: Purpose of review: Patients diagnosed with Ehlers-Danlos syndromes (EDS), and especially those with the hypermobility subtype, often experience a diverse range of acute and chronic pain conditions throughout their lifetime. These can present in a ... ...

Abstract	Purpose of review: Patients diagnosed with Ehlers-Danlos syndromes (EDS), and especially those with the hypermobility subtype, often experience a diverse range of acute and chronic pain conditions throughout their lifetime. These can present in a variety of different phenotypes and comorbidities, making it difficult to develop structured treatment protocols. This review seeks to summarize the current literature to address old and novel treatments for EDS. Recent findings: Historically, medications and surgery have been used to treat patients with EDS but with low efficacy. Newer therapies that have shown promising effects for both decreasing pain and increasing quality of life include physical/occupational therapy, transcutaneous electrical nerve stimulation units, trigger point injections, low-dose naltrexone, and laser therapy. In addition, addressing the psychosocial aspects of pain with EDS through methods like cognitive behavioral therapy and patient education has shown to be vital in minimizing pain. Most research also emphasizes that pain management should not only focus on pain reduction, but on helping reduce symptoms of hypermobility, central sensitization, and fatigue to make an impactful difference. Research on pain in EDS is still limited with good clinical practice guidelines often limited by poor sample size and lack of clinical studies. Treatment options should be structured based on the specific type of pain pathology and presenting symptoms of each patient and their comorbidities. Future research should attempt to prioritize larger sample sizes, clear definitions of EDS subtypes, randomized trials for treatment efficacy, and more studies dedicated to non-musculoskeletal forms of pain.
Language	English
Publishing date	2022-11-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055062-5
ISSN	1534-3081 ; 1531-3433
ISSN (online)	1534-3081
ISSN	1531-3433
DOI	10.1007/s11916-022-01093-z
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Zs.A 5477: Show issues

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Article ; Online: The arc of fellowship.

Lin, Tiffany F

Pediatric blood & cancer

2016 Volume 64, Issue 3

MeSH term(s)	Adolescent ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Fatal Outcome ; Fellowships and Scholarships ; Female ; Glioblastoma/mortality ; Glioblastoma/pathology ; Hematology ; Humans ; Medical Oncology ; Pediatrics ; Physician-Patient Relations ; Physicians/psychology
Language	English
Publishing date	2016-11-22
Publishing country	United States
Document type	Case Reports ; Journal Article ; Personal Narratives
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.26355
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Zs.A 1131: Show issues

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Article ; Online: Lung nodule malignancy classification with associated pulmonary fibrosis using 3D attention-gated convolutional network with CT scans.

Liu, Yucheng / Hsu, Hao Yun / Lin, Tiffany / Peng, Boyu / Saqi, Anjali / Salvatore, Mary M / Jambawalikar, Sachin

Journal of translational medicine

2024 Volume 22, Issue 1, Page(s) 51

Abstract: Background: Chest Computed tomography (CT) scans detect lung nodules and assess pulmonary fibrosis. While pulmonary fibrosis indicates increased lung cancer risk, current clinical practice characterizes nodule risk of malignancy based on nodule size and ...

Abstract	Background: Chest Computed tomography (CT) scans detect lung nodules and assess pulmonary fibrosis. While pulmonary fibrosis indicates increased lung cancer risk, current clinical practice characterizes nodule risk of malignancy based on nodule size and smoking history; little consideration is given to the fibrotic microenvironment. Purpose: To evaluate the effect of incorporating fibrotic microenvironment into classifying malignancy of lung nodules in chest CT images using deep learning techniques. Materials and methods: We developed a visualizable 3D classification model trained with in-house CT dataset for the nodule malignancy classification task. Three slightly-modified datasets were created: (1) nodule alone (microenvironment removed); (2) nodule with surrounding lung microenvironment; and (3) nodule in microenvironment with semantic fibrosis metadata. For each of the models, tenfold cross-validation was performed. Results were evaluated using quantitative measures, such as accuracy, sensitivity, specificity, and area-under-curve (AUC), as well as qualitative assessments, such as attention maps and class activation maps (CAM). Results: The classification model trained with nodule alone achieved 75.61% accuracy, 50.00% sensitivity, 88.46% specificity, and 0.78 AUC; the model trained with nodule and microenvironment achieved 79.03% accuracy, 65.46% sensitivity, 85.86% specificity, and 0.84 AUC. The model trained with additional semantic fibrosis metadata achieved 80.84% accuracy, 74.67% sensitivity, 84.95% specificity, and 0.89 AUC. Our visual evaluation of attention maps and CAM suggested that both the nodules and the microenvironment contributed to the task. Conclusion: The nodule malignancy classification performance was found to be improving with microenvironment data. Further improvement was found when incorporating semantic fibrosis information.
MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/diagnostic imaging ; Pulmonary Fibrosis/pathology ; Solitary Pulmonary Nodule/diagnostic imaging ; Solitary Pulmonary Nodule/pathology ; Tomography, X-Ray Computed/methods ; Lung/pathology ; Tumor Microenvironment
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04798-w
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Article: Psychiatric Symptoms in Cushing's Syndrome: A Systematic Review.

Lin, Tiffany Y / Hanna, Jasmine / Ishak, Waguih William

Innovations in clinical neuroscience

2020 Volume 17, Issue 1-3, Page(s) 30–35

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2020-06-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2675366-2
ISSN	2158-8341 ; 2158-8333
ISSN (online)	2158-8341
ISSN	2158-8333
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Article ; Online: Sciatic, Femoral, and Lateral Femoral Cutaneous Nerve Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation.

Singh, Harmandeep / Gargya, Akshat / Lin, Tiffany / Gulati, Amitabh

Pain medicine (Malden, Mass.)

2020 Volume 21, Issue Suppl 1, Page(s) S47–S50

Abstract: Objective: With advances in peripheral nerve stimulation technology, there has been an emergence of new minimally invasive techniques to provide neurostimulation therapies for chronic pain. This technical note describes the utilization of ... ...

Abstract	Objective: With advances in peripheral nerve stimulation technology, there has been an emergence of new minimally invasive techniques to provide neurostimulation therapies for chronic pain. This technical note describes the utilization of ultrasonography for percutaneous placement of peripheral nerve stimulation leads at the sciatic, femoral, and lateral femoral cutaneous nerves. Methods: Ultrasound can be utilized to localize a specific nerve, view neighboring soft tissue anatomy, and plan a needle trajectory. Various ultrasound techniques and transducer orientations allow for multiple options for lead placement relative to the targeted nerve. Conclusions: The option of ultrasound-guided percutaneous technique for neurostimulation lead placement allows this treatment modality to be made available to more patients with chronic pain in specific nerve distributions.
MeSH term(s)	Femur ; Humans ; Lumbosacral Plexus ; Sciatic Nerve/diagnostic imaging ; Transcutaneous Electric Nerve Stimulation ; Ultrasonography ; Ultrasonography, Interventional
Language	English
Publishing date	2020-09-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2015903-1
ISSN	1526-4637 ; 1526-2375
ISSN (online)	1526-4637
ISSN	1526-2375
DOI	10.1093/pm/pnaa040
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Article ; Online: Extraforaminal Thoracic and Lumbar Spinal Nerve Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation.

Gargya, Akshat / Singh, Harmandeep / Lin, Tiffany / Gulati, Amitabh

Pain medicine (Malden, Mass.)

2020 Volume 21, Issue Suppl 1, Page(s) S38–S40

Abstract: Objective: Peripheral nerve stimulation provides targeted stimulation and pain relief within a specific nerve distribution. This technical case report provides a method to perform selective nerve root stimulation of thoracic and lumbar spinal nerves ... ...

Abstract	Objective: Peripheral nerve stimulation provides targeted stimulation and pain relief within a specific nerve distribution. This technical case report provides a method to perform selective nerve root stimulation of thoracic and lumbar spinal nerves using ultrasonography. Methods: Ultrasound-guided peripheral nerve stimulation of thoracic and lumbar spinal nerves allows better visualization of soft tissue anatomy and planning of needle trajectory. Conclusions: Ultrasound-guided peripheral nerve stimulation procedures may provide a safer method for neurostimulation lead placement when compared with fluoroscopic-guided techniques.
MeSH term(s)	Humans ; Peripheral Nerves ; Spinal Nerves/diagnostic imaging ; Transcutaneous Electric Nerve Stimulation ; Ultrasonography ; Ultrasonography, Interventional
Language	English
Publishing date	2020-09-16
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2015903-1
ISSN	1526-4637 ; 1526-2375
ISSN (online)	1526-4637
ISSN	1526-2375
DOI	10.1093/pm/pnaa166
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Book ; Online: Applying the Model of Human Occupation During the Pandemic Stay-at-Home Order

Lin, Tiffany T / Fisher, Gail

The Open Journal of Occupational Therapy

2020

Keywords	model of human occupation ; COVID-19 pandemic ; quarantine ; stay-at-home order ; Medicine and Health Sciences ; Occupational Therapy ; covid19
Publishing date	2020-10-15T13:25:39Z
Publisher	ScholarWorks at WMU
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Survey of stigma across healthcare workers in an urban, academic medical center regarding perinatal patients using opioids.

Braverman, Alexis / Lin, Tiffany / Messmer, Sarah / Wollner, Kathy / Taylor, Renee / Williams, Adrienne A / Class, Quetzal A

The American journal on addictions

2023 Volume 32, Issue 5, Page(s) 510–514

Abstract: Background and objectives: To examine healthcare workers' attitudes towards pregnant woman using opioids across provider type, specialty, and years of service.: Methods: Cross-sectional, anonymous survey of healthcare workers at an urban, academic ... ...

Abstract	Background and objectives: To examine healthcare workers' attitudes towards pregnant woman using opioids across provider type, specialty, and years of service. Methods: Cross-sectional, anonymous survey of healthcare workers at an urban, academic medical center regarding attitudes towards pregnant women using opioids. Results: One hundred and nineteen surveys were completed. Nurses were less likely to feel sympathetic towards pregnant women that use opioids (p = .016). Discussion and conclusions: Differences in attitudes towards pregnant women using opioids were found between clinicians and nurses. Scientific significance: Training and experience may contribute to attitude differences towards pregnant women using opioids.
MeSH term(s)	Humans ; Female ; Pregnancy ; Analgesics, Opioid ; Cross-Sectional Studies ; Health Personnel ; Surveys and Questionnaires ; Attitude of Health Personnel ; Academic Medical Centers ; Health Knowledge, Attitudes, Practice
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1141440-6
ISSN	1521-0391 ; 1055-0496
ISSN (online)	1521-0391
ISSN	1055-0496
DOI	10.1111/ajad.13446
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Zs.A 3594: Show issues

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Article ; Online: Investigation of Pediatric Anemia in the Commonwealth of the Northern Mariana Islands.

Lin, Tiffany F / Huang, James N / Cash, Haley L

Maternal and child health journal

2019 Volume 23, Issue 3, Page(s) 416–421

Abstract: Objective To report on the prevalence and etiology of pediatric anemia in the Commonwealth of the Northern Mariana Islands (CNMI). Method A retrospective chart review was conducted that included patients up to 19 years of age who presented for well child ...

Abstract	Objective To report on the prevalence and etiology of pediatric anemia in the Commonwealth of the Northern Mariana Islands (CNMI). Method A retrospective chart review was conducted that included patients up to 19 years of age who presented for well child care and whose hemoglobin or hematocrit was checked in the CNMI from 2014 to 2015. Lab values, diagnoses and treatment plans, patient reported ethnicity, and follow-up results were collected from eligible patients. Results The records for 1483 pediatric patients who had 1584 well child visits were reviewed. The prevalence of anemia amongst all eligible patients was 8.0% (5.4-10.7). This included 292 9 to 18 months old patients, which is estimated to be 40% of the total pediatric population of CNMI in that age group. Among the 9 to 18 months old patients, the prevalence of anemia is 5.5% (2.6-8.4). Etiology of anemia was investigated and of the patients treated with iron, 55.2% had a documented response. The majority of those without documentation of improvement with iron were patients who were lost to follow-up. In addition, a total of 10 patients were found to have an alpha or beta thalassemia variant discovered initially by anemia screening or sibling tracing. Discussion In this United States Commonwealth, prevalence of anemia appears lower than prevalence reported for other independent Pacific Island nations and closer to that of the US. Thalassemia is documented within this population. Limitations to this data were use of a convenient sample that may be hampered by lack of presentation to well-child care. This study will guide future public health studies on anemia prevalence and can guide public health intervention decisions to improve pediatric care in the CNMI.
MeSH term(s)	Anemia/diagnosis ; Anemia/epidemiology ; Female ; Humans ; Infant ; Male ; Micronesia/epidemiology ; Prevalence ; Retrospective Studies
Language	English
Publishing date	2019-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339905-6
ISSN	1573-6628 ; 1092-7875
ISSN (online)	1573-6628
ISSN	1092-7875
DOI	10.1007/s10995-018-02713-0
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