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  1. Article: Editorial: Smart nanomaterials for biosensing and therapy applications.

    Lin, Xiaofeng / Huang, Qitong

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1137508

    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1137508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Circular RNA circMTO1 suppressed the progression of renal cell carcinoma progression by sponging miR-211 and miR-204.

    Wang, Ke / Lin, Xiaofeng

    publication RETRACTED

    Mammalian genome : official journal of the International Mammalian Genome Society

    2022  Volume 33, Issue 3, Page(s) 517–524

    Abstract: Despite considerable improvements in renal cell carcinoma (RCC) diagnostic and therapeutic strategy, the clinical prognosis of patients is far from satisfactory due to its recurrence and metastasis. Here, we attempted to explore the role of circMTO1 in ... ...

    Abstract Despite considerable improvements in renal cell carcinoma (RCC) diagnostic and therapeutic strategy, the clinical prognosis of patients is far from satisfactory due to its recurrence and metastasis. Here, we attempted to explore the role of circMTO1 in RCC progression, and the underlying mechanism was further elucidated. We first detected the expression of circMTO1 in 90 pairs of RCC tissues and adjacent normal tissues using qRT-PCR. Besides, circMTO1, miR-211, miR-204 and KLF6 expression levels in RCC cells were also measured using qRT-PCR. MTT assay, cell migration, flow cytometry analysis, qRT-PCR and western blotting analysis were applied to evaluating the effect of circMTO1 in RCC cells. The bioinformatics analysis and the rescue experiment were devoted to the underlying mechanism. The results demonstrated CircMTO1 expression was significantly down-regulated in RCC tissues and cell lines. Besides, CircMTO1 inhibited cell proliferation, migration and invasion, induced apoptosis in RCC cells. In addition, CircMTO1 serves as a sponge for miR-211 and miR-204, KLF6 is a direct target of miR-211 and miR-204. Furthermore, circMTO1 and KLF6 overexpression rescued the suppression of miR-211/204 in RCC cell proliferation. In short, circMTO1 repressed RCC progression by regulating KLF6 via sponging miR-211 and miR-204, which may provide new idea of diagnosis and treatment in renal cell carcinoma.
    MeSH term(s) Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Cell Movement ; Gene Expression Regulation, Neoplastic ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/genetics
    Chemical Substances MIRN204 microRNA, human ; MIRN211 microRNA, human ; MicroRNAs ; RNA, Circular
    Language English
    Publishing date 2022-01-29
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s00335-022-09944-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3489: Show issues Location:
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  3. Article: Different Microeukaryotic Trophic Groups Show Different Latitudinal Spatial Scale Dependences in Assembly Processes across the Continental Shelves of China.

    Zhang, Yong / Qu, Zhishuai / Zhang, Kexin / Li, Jiqiu / Lin, Xiaofeng

    Microorganisms

    2024  Volume 12, Issue 1

    Abstract: The relative role of stochasticity versus determinism is critically dependent on the spatial scale over which communities are studied. However, only a few studies have attempted to reveal how spatial scales influence the balance of different assembly ... ...

    Abstract The relative role of stochasticity versus determinism is critically dependent on the spatial scale over which communities are studied. However, only a few studies have attempted to reveal how spatial scales influence the balance of different assembly processes. In this study, we investigated the latitudinal spatial scale dependences in assembly processes of microeukaryotic communities in surface water and sediment along the continental shelves of China. It was hypothesized that different microeukaryotic trophic groups (i.e., autotroph, heterotroph, mixotroph, and parasite) showed different latitudinal scale dependences in their assembly processes. Our results disclosed that the relative importance of different assembly processes depended on a latitudinal space scale for planktonic microeukaryotes. In surface water, as latitudinal difference increased, the relative contributions of homogenous selection and homogenizing dispersal decreased for the entire community, while those of heterogeneous selection and drift increased. The planktonic autotrophic and heterotrophic groups shifted from stochasticity-dominated processes to heterogeneous selection as latitudinal differences surpassed thresholds of 8° and 16°, respectively. For mixotrophic and parasitic groups, however, the assembly processes were always dominated by drift across different spatial scales. The balance of different assembly processes for the autotrophic group was mainly driven by temperature, whereas that of the heterotrophic group was driven by salinity and geographical distance. In sediment, neither the entire microeukaryotic community nor the four trophic groups showed remarkable spatial scale dependences in assembly processes; they were always overwhelmingly dominated by the drift. This work provides a deeper understanding of the distribution mechanisms of microeukaryotes along the continental shelves of China from the perspective of trophic groups.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12010124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Circular RNA circMTO1 suppressed the progression of renal cell carcinoma progression by sponging miR-211 and miR-204

    Wang, Ke / Lin, Xiaofeng

    Mammalian genome. 2022 Sept., v. 33, no. 3

    2022  

    Abstract: Despite considerable improvements in renal cell carcinoma (RCC) diagnostic and therapeutic strategy, the clinical prognosis of patients is far from satisfactory due to its recurrence and metastasis. Here, we attempted to explore the role of circMTO1 in ... ...

    Abstract Despite considerable improvements in renal cell carcinoma (RCC) diagnostic and therapeutic strategy, the clinical prognosis of patients is far from satisfactory due to its recurrence and metastasis. Here, we attempted to explore the role of circMTO1 in RCC progression, and the underlying mechanism was further elucidated. We first detected the expression of circMTO1 in 90 pairs of RCC tissues and adjacent normal tissues using qRT-PCR. Besides, circMTO1, miR-211, miR-204 and KLF6 expression levels in RCC cells were also measured using qRT-PCR. MTT assay, cell migration, flow cytometry analysis, qRT-PCR and western blotting analysis were applied to evaluating the effect of circMTO1 in RCC cells. The bioinformatics analysis and the rescue experiment were devoted to the underlying mechanism. The results demonstrated CircMTO1 expression was significantly down-regulated in RCC tissues and cell lines. Besides, CircMTO1 inhibited cell proliferation, migration and invasion, induced apoptosis in RCC cells. In addition, CircMTO1 serves as a sponge for miR-211 and miR-204, KLF6 is a direct target of miR-211 and miR-204. Furthermore, circMTO1 and KLF6 overexpression rescued the suppression of miR-211/204 in RCC cell proliferation. In short, circMTO1 repressed RCC progression by regulating KLF6 via sponging miR-211 and miR-204, which may provide new idea of diagnosis and treatment in renal cell carcinoma.
    Keywords apoptosis ; bioinformatics ; cell movement ; cell proliferation ; circular RNA ; flow cytometry ; genome ; mammals ; metastasis ; prognosis ; renal cell carcinoma ; therapeutics ; toxicity testing
    Language English
    Dates of publication 2022-09
    Size p. 517-524.
    Publishing place Springer US
    Document type Article
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s00335-022-09944-1
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 3489: Show issues Location:
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  5. Article ; Online: Predation risk affects the ecotoxicity evaluation of antibiotics: Population growth and antioxidase activity in the ciliate Paramecium jenningsi.

    Li, Jiqiu / Yu, Ziyue / Warren, Alan / Lin, Xiaofeng

    Ecotoxicology and environmental safety

    2023  Volume 251, Page(s) 114536

    Abstract: Although predation risk exists under natural conditions, its role is usually ignored when evaluating the ecotoxicity of environmental contaminants, and the interaction between predation risk and antibiotic ecotoxicity is not yet clear. To investigate the ...

    Abstract Although predation risk exists under natural conditions, its role is usually ignored when evaluating the ecotoxicity of environmental contaminants, and the interaction between predation risk and antibiotic ecotoxicity is not yet clear. To investigate the nonconsumptive effects (NCEs) of predation on the ecotoxicity evaluation of antibiotics, the median lethal concentration (LC
    MeSH term(s) Animals ; Paramecium ; Population Growth ; Anti-Bacterial Agents/toxicity ; Predatory Behavior/physiology ; Ciliophora ; Nitrofurazone/toxicity
    Chemical Substances Anti-Bacterial Agents ; Nitrofurazone (X8XI70B5Z6)
    Language English
    Publishing date 2023-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2023.114536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1418: Show issues Location:
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  6. Article: Assessment of the implementation of accelerated drug marketing registration procedures for antineoplastic and immunomodulating agents in China: based on 2016-2022 review data.

    Lan, Yipeng / Lin, Xiaofeng / Yu, Jialin / Wang, Li / Sun, Lihua / Huang, Zhe

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1345672

    Abstract: Objective: Since 2016, China has successively implemented Accelerated Drug Marketing Registration Procedures (ADMRPs) for drugs, including Breakthrough Therapy Drug (BTD), Conditional Approval (CA), and Priority Review and Approval (PRA), which have ... ...

    Abstract Objective: Since 2016, China has successively implemented Accelerated Drug Marketing Registration Procedures (ADMRPs) for drugs, including Breakthrough Therapy Drug (BTD), Conditional Approval (CA), and Priority Review and Approval (PRA), which have played an important role in promoting the development and review of clinically urgently needed drugs. In this study, we focused on the antineoplastic and immunomodulating agents approved for marketing through ADMRPs, to provide a reference for promoting the formation of a stable and mature regulatory system for the review and approval of antineoplastic drugs and immunomodulating agents in China.
    Methods: Reviewed the National Medical Products Administration (NMPA) drug review reports for the years 2016-2022 and screened the antineoplastic and immunomodulating agents approved through ADMRPs. Then, with the help of the NMPA website and the Yaozhi Database, two researchers independently queried and entered the detailed information of the selected drugs, and checked with each other. The attribute classification and main characteristics of the drugs were then analyzed with descriptive statistics to obtain the trend of drug types, drug review and approval status, and timeliness.
    Results: A total of 206 antineoplastic and immunomodulating agents were approved for marketing through five accelerated marketing registration procedures (or procedure combinations), with the average review time shortened by about 81 days. Among them, imported drugs accounted for a larger proportion, the most drugs for treating non-small cell lung cancer and lymphoma, and the largest number of PD-1/PDL-1 inhibitors, but pediatric drugs and rare disease drugs accounted for a smaller proportion.
    Conclusion: ADMRPs can promote the accessibility of antineoplastic and immunomodulating agents in China and safeguard the life and health rights of more patients. Nevertheless, it is necessary to pay attention to the expansion of the types of indications for medicines and to increase the development of drugs that are urgently needed by a small number of patients.
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1345672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unraveling the conumdrum: innovative technique to remove the stent from the displaced pancreatic duct in stenosis.

    Chen, Junqian / Wen, Shuting / Lin, Xiaofeng / Zhong, Zhuodan / Guo, Yan / Zhou, Dongjing / Liu, Tianwen

    Endoscopy

    2024  Volume 56, Issue S 01, Page(s) E177–E178

    MeSH term(s) Humans ; Constriction, Pathologic/etiology ; Constriction, Pathologic/surgery ; Pancreatic Ducts/diagnostic imaging ; Pancreatic Ducts/surgery ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Stents
    Language English
    Publishing date 2024-02-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2255-9168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  8. Article ; Online: Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery.

    Chen, Jiyun / Chen, Hong / Li, Shanshan / Lin, Xiaofeng / Hu, Rong / Zhang, Kaiming / Liu, Liang

    eLife

    2024  Volume 12

    Abstract: Precursor ribosomal RNA (pre-rRNA) processing is a key step in ribosome biosynthesis and involves numerous RNases. A HEPN (higher eukaryote and prokaryote nucleotide binding) nuclease Las1 and a polynucleotide kinase Grc3 assemble into a tetramerase ... ...

    Abstract Precursor ribosomal RNA (pre-rRNA) processing is a key step in ribosome biosynthesis and involves numerous RNases. A HEPN (higher eukaryote and prokaryote nucleotide binding) nuclease Las1 and a polynucleotide kinase Grc3 assemble into a tetramerase responsible for rRNA maturation. Here, we report the structures of full-length
    MeSH term(s) RNA, Ribosomal ; RNA Precursors ; Ribosomes ; RNA Processing, Post-Transcriptional ; Endonucleases
    Chemical Substances RNA, Ribosomal ; RNA Precursors ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: How antibiotic exposure affect predator-prey interactions by population dynamics in ciliates?

    Li, Jiqiu / Yu, Ziyue / Zheng, Qinyun / Chen, Weihuang / Lin, Xiaofeng

    Aquatic toxicology (Amsterdam, Netherlands)

    2023  Volume 267, Page(s) 106814

    Abstract: Biodiversity loss resulting from environmental pollution is a global concern. While interspecific interactions are central to ecology, the impact of environmental pollution on predator-prey interactions and its ecological consequences, such as extinction ...

    Abstract Biodiversity loss resulting from environmental pollution is a global concern. While interspecific interactions are central to ecology, the impact of environmental pollution on predator-prey interactions and its ecological consequences, such as extinction and biodiversity loss, remain unclear. To investigate the effects of antibiotic exposure on predation strength and the resulting ecological consequence, the Didinium-Paramecium was utilized as a predator-prey model and exposed to nitrofurazone or erythromycin, two common pollutants, respectively. Initially, we determined prey population growth dynamics, body size, and predator numerical-functional responses. Subsequently, these above parameters were integrated into a mathematical model of predator-prey predation. Then both the long time-series data and phase portraits obtained through model simulation were used to estimate interaction strength and to predict the outcome of predator-prey coexistence. Our results revealed that exposure to either antibiotic significantly reduced prey population growth parameters (e.g., μ
    MeSH term(s) Animals ; Anti-Bacterial Agents/toxicity ; Water Pollutants, Chemical/toxicity ; Population Dynamics ; Population Growth ; Biodiversity ; Predatory Behavior ; Food Chain
    Chemical Substances Anti-Bacterial Agents ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-12-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2023.106814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: DIAGNOSTIC AND THERAPEUTIC CHALLENGES.

    Ding, Xiaohu / Zhang, Xiongze / Lin, Xiaofeng / Doan, Thuy / Moussa, Kareem

    Retina (Philadelphia, Pa.)

    2023  Volume 44, Issue 4, Page(s) 741–743

    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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