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Article ; Online: Double-layered PLGA/HA microneedle systems as a long-acting formulation of polyphenols for effective and long-term management of atopic dermatitis.

Chen, Yi-Lun / Chang, Chih-Chi / Lin, Yi-Chin / Chen, Mei-Chin

2023 Volume 11, Issue 14, Page(s) 4995–5011

Abstract: Atopic dermatitis (AD) is a chronic, relapsing inflammatory disorder that requires long-term treatment to achieve optimal control. Topical corticosteroids or calcineurin inhibitors are the mainstay of treatment, but the safety and efficacy of their daily ...

Abstract	Atopic dermatitis (AD) is a chronic, relapsing inflammatory disorder that requires long-term treatment to achieve optimal control. Topical corticosteroids or calcineurin inhibitors are the mainstay of treatment, but the safety and efficacy of their daily use remain a concern. Here, we report a double-layered poly(lactic-
MeSH term(s)	Mice ; Animals ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/pathology ; Polyphenols/pharmacology ; Skin ; Drug Delivery Systems ; Curcumin/pharmacology
Chemical Substances	Polyphenols ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm00182b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unveiling the multifaceted nexus of subjective aging, biological aging, and chronological age: Findings from a nationally representative cohort study.

Lin, Yi-Chin / Lin, Hung-Yu / Chen, Liang-Kung / Hsiao, Fei-Yuan

Archives of gerontology and geriatrics

2023 Volume 117, Page(s) 105164

Abstract: Objectives: This study aims to investigate how subjective aging influences the psychological and behavioral responses of older individuals, specifically focusing on the associations between subjective aging and longitudinal changes in biological age.: ...

Abstract	Objectives: This study aims to investigate how subjective aging influences the psychological and behavioral responses of older individuals, specifically focusing on the associations between subjective aging and longitudinal changes in biological age. Methods: This is a retrospective cohort study retrieving data from the Taiwan Longitudinal Study on Aging (TLSA), over a 4-year follow-up period. Subjective aging is assessed by asking participants if they perceive themselves as old, while frailty is measured using a frailty index comprising 34 deficits from various domains. Participants are categorized into three groups based on their chronological age. The association between subjective aging and transition of biological age (as indicated by an increased frailty index) from 2011 to 2015 is examined using logistic regression models. Results: The study consisted of 2412 participants, who were categorized into middle-age (n = 1,082), young-old (n = 779), and old-old (n = 551) groups. Among them, individuals exhibiting subjective aging at baseline were more likely to be older in chronological age, female, illiterate, and unemployed, compared to those without subjective aging. The adjusted odds ratios (aORs) for the association between subjective aging and an increased biological age were 1.72 [95% CI: 0.88-3.34], 1.61 [0.77-3.37], and 1.08 [0.65-1.80], in the middle-age, young-old, and old-old groups, respectively. Discussions: No significant associations were found between changes in biological age and subjective aging across various chronological age groups. Notably, within the younger age group, a discernible trend towards an association was observed, indicating the potential age-related nuances in the complex interrelation between subjective age, biological aging, and chronological aging.
MeSH term(s)	Humans ; Female ; Cohort Studies ; Longitudinal Studies ; Frailty ; Retrospective Studies ; Aging/psychology
Language	English
Publishing date	2023-08-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2023.105164
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Zs.A 1729: Show issues

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Article ; Online: Privacy Concerns and Continued Use Intention of Telemedicine During COVID-19.

Kato-Lin, Yi-Chin / Thelen, Shawn T

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2022 Volume 28, Issue 10, Page(s) 1440–1448

Abstract: ... Introduction: ... Privacy concerns are a major barrier to online technology adoption. However, when consumers are facing personal risks (being ill) and environmental risks (pandemic), the effect of privacy concerns on continued use intention of ...

Abstract	*Introduction:* Privacy concerns are a major barrier to online technology adoption. However, when consumers are facing personal risks (being ill) and environmental risks (pandemic), the effect of privacy concerns on continued use intention of telemedicine is unknown. The large user pool of virtual visits during COVID-19 provides a great opportunity to understand consumers' privacy concerns when facing personal and environmental risks. *Objective:* This research investigates how patients weigh personal risks (e.g., illness) and environmental risks (e.g., pandemic) against privacy concerns when deciding whether to utilize telemedicine as an option for being treated for an acute illness. *Methods:* Respondents (1,059 qualified) meeting the following criteria: ≥18 years old, U.S. residents, virtual patient for acute conditions during COVID-19, and a Human Intelligence Task approval rate of >95%, were recruited utilizing Amazon Mechanical Turk during the middle of the pandemic. An online survey was conducted to collect data. *Results:* Analysis indicates that first-time telepatients (82% of respondents) have greater privacy concerns than repeat users. Findings also indicate that patients who are female and have some college education or less reported greater privacy concerns. Interestingly, privacy concerns are positively related to continued use intention. This result holds when satisfaction and user characteristics are controlled. *Conclusions:* When consumers are ill, privacy concerns still play an important role in telemedicine adoption. However, under environmental risks such as the COVID-19 pandemic, privacy concerns do not negatively impact their continued use intention, and satisfaction is positively associated with continued use intention.
MeSH term(s)	Adolescent ; COVID-19/epidemiology ; Female ; Humans ; Intention ; Male ; Pandemics ; Privacy ; Telemedicine
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2021.0603
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Article ; Online: Effects of declines in personal mastery on self-perceived mobility, physical function, cognitive function, and depressive symptoms: a 6-year follow-up study from the Social Environment and Biomarkers of Aging Study.

Shen, Chieh / Lin, Yi-Chin / Lin, Hung-Yu / Chen, Liang-Kung / Hsiao, Fei-Yuan

Aging clinical and experimental research

2023 Volume 35, Issue 12, Page(s) 3215–3226

Abstract: Objectives: As the psychosocial competence, personal mastery helps individuals to cope with stressful life events, and this study aims to examine impacts of declines in personal mastery on healthy aging among community-dwelling middle-aged and older ... ...

Abstract	Objectives: As the psychosocial competence, personal mastery helps individuals to cope with stressful life events, and this study aims to examine impacts of declines in personal mastery on healthy aging among community-dwelling middle-aged and older adults using a nationally representative cohort. Methods: Data from 648 study participants in the Social Environment and Biomarkers of Aging Study (SEBAS) were retrieved for analysis. All participants were divided into four groups based on their baseline and changes of personal mastery (measured by the Pearlin mastery score) during the 6-year follow-up. Multivariate logistic regression models were adopted to examine associations between declines in personal mastery and indicators for healthy aging (declines in self-perceived mobility, physical function (activities of daily living (ADLs) and instrumental activities of daily living (IADLs)), cognitive function and depressive symptoms). Results: After adjustments for demographics and comorbidities, those with declines in personal mastery were associated with greater risks of declines in self-perceived mobility (adjusted odds ratio (aOR) 1.50 [95% confidence interval 1.01-2.22], p < 0.05). Although the point estimate in the unadjusted models indicated similar associations between declines in personal mastery and declines in ADLs, IADLs, cognitive function or depressive symptoms, these outcomes did not reach statistical significance in the adjusted model. Conclusions: Declines in personal mastery were negatively associated with indicators related to healthy aging (particularly locomotion) in a 6-year follow-up. Further investigations are needed to explore the effects of preventing declines in personal mastery in promoting healthy aging over time.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Follow-Up Studies ; Activities of Daily Living/psychology ; Depression/psychology ; Cognition ; Social Environment ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-12-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-023-02613-6
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Zs.A 3343: Show issues

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Article: Quercetin supplementation attenuates cisplatin induced myelosuppression in mice through regulation of hematopoietic growth factors and hematopoietic inhibitory factors

Chuang, Cheng-Hung / Lin, Yi-Chin / Yang, Jung / Chan, Shu-Ting / Yeh, Shu-Lan

Journal of nutritional biochemistry. 2022 Aug. 09,

2022

Abstract: The present study investigated the effects of quercetin on cisplatin (CDDP)-induced common side effect, myelosuppression, and the possible mechanisms in Balb/c mice. The mice were randomly treated with CDDP alone or in combination with quercetin for 14 ... ...

Abstract	The present study investigated the effects of quercetin on cisplatin (CDDP)-induced common side effect, myelosuppression, and the possible mechanisms in Balb/c mice. The mice were randomly treated with CDDP alone or in combination with quercetin for 14 days. Quercetin was given by intraperitoneal injection (10 mg/kg, 3 times a week; IQ) or by a diet containing 0.1% or 1% quercetin (LQ and HQ, respectively). We found that quercetin supplementation especially HQ and IQ, significantly restored the decrease in number of bone marrow cells, total white blood cells, red blood cells and platelets, and the body weight in mice exposed to CDDP (p ≤ 0.05). Similar trends were observed in the number of neutrophils, lymphocytes and monocytes in the plasma. HQ and IQ also increased the levels of hematopoietic growth factors (HGFs), especially in granulocyte-macrophage-colony stimulating factor and IL-9 (p < 0.05), but decreased the levels of hematopoietic inhibitory factors (HIFs) and oxidative stress in the plasma and the bone marrow in CDDP-exposed mice. Furthermore, both quercetin and quercetin-3-O-glucuronide (Q3G) significantly increase cell viability and inhibited apoptosis at 48 or 72 h (p ≤ 0.05), accompanied by increasing HGF levels and decreasing HIF levels in the cultured medium in 32D cells exposed to CDDP. IL-9 siRNA transfection suppressed the effects of quercetin and Q3G on cell viability (p ≤ 0.05) in32D cells. In conclusion, our results indicate that quercetin attenuates CDDP-induced myelosuppression through the mechanisms associated with regulation of HGFs and HIFs.
Keywords	adverse effects ; apoptosis ; body weight ; bone marrow ; cell viability ; cisplatin ; diet ; interleukin-9 ; intraperitoneal injection ; monocytes ; neutrophils ; oxidative stress ; quercetin ; transfection
Language	English
Dates of publication	2022-0809
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2022.109149
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Telemedicine for Acute Conditions During COVID-19: A Nationwide Survey Using Crowdsourcing.

Kato-Lin, Yi-Chin / Thelen, Shawn T

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2020 Volume 27, Issue 7, Page(s) 714–723

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; COVID-19 ; Crowdsourcing ; Female ; Humans ; Pandemics ; SARS-CoV-2 ; Surveys and Questionnaires ; Telemedicine
Keywords	covid19
Language	English
Publishing date	2020-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2020.0351
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Article ; Online: Quercetin supplementation attenuates cisplatin induced myelosuppression in mice through regulation of hematopoietic growth factors and hematopoietic inhibitory factors.

Chuang, Cheng-Hung / Lin, Yi-Chin / Yang, Jung / Chan, Shu-Ting / Yeh, Shu-Lan

The Journal of nutritional biochemistry

2022 Volume 110, Page(s) 109149

Abstract	The present study investigated the effects of quercetin on cisplatin (CDDP)-induced common side effect, myelosuppression, and the possible mechanisms in Balb/c mice. The mice were randomly treated with CDDP alone or in combination with quercetin for 14 days. Quercetin was given by intraperitoneal injection (10 mg/kg, 3 times a week; IQ) or by a diet containing 0.1% or 1% quercetin (LQ and HQ, respectively). We found that quercetin supplementation especially HQ and IQ, significantly restored the decrease in number of bone marrow cells, total white blood cells, red blood cells and platelets, and the body weight in mice exposed to CDDP (P≤.05). Similar trends were observed in the number of neutrophils, lymphocytes and monocytes in the plasma. HQ and IQ also increased the levels of hematopoietic growth factors (HGFs), especially in granulocyte-macrophage-colony stimulating factor and IL-9 (P<.05), but decreased the levels of hematopoietic inhibitory factors (HIFs) and oxidative stress in the plasma and the bone marrow in CDDP-exposed mice. Furthermore, both quercetin and quercetin-3-O-glucuronide (Q3G) significantly increase cell viability and inhibited apoptosis at 48 or 72 h (P≤.05), accompanied by increasing HGF levels and decreasing HIF levels in the cultured medium in 32D cells exposed to CDDP. IL-9 siRNA transfection suppressed the effects of quercetin and Q3G on cell viability (P≤.05) in32D cells. In conclusion, our results indicate that quercetin attenuates CDDP-induced myelosuppression through the mechanisms associated with regulation of HGFs and HIFs.
MeSH term(s)	Animals ; Mice ; Cisplatin/toxicity ; Dietary Supplements ; Interleukin-9 ; Mice, Inbred BALB C ; Quercetin/pharmacology
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Interleukin-9 ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial, Veterinary
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2022.109149
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Article: Are you a protean talent?

Lin, Yi-chin

Career development international : the journal for executive, consultants, academics and individuals Vol. 20, No. 7 , p. 753-772

the influence of protean career attitude, learning-goal orientation and perceived internal and external employability

2015 Volume 20, Issue 7, Page(s) 753–772

Author's details	Yi-chun Lin (Graduate Institute of International Human Resource Development, National Taiwan Normal University, Taipei, Taiwan)
Keywords	Learning-goal orientation ; Perceived external employability ; Perceived internal employabilit ; Protean career attitude ; Protean talent
Language	English
Publisher	Emerald
Publishing place	Bradford
Document type	Article
ZDB-ID	1317068-5
ISSN	1362-0436
ISSN	1362-0436
Database	ECONomics Information System

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Article: Telemedicine for Acute Conditions During COVID-19: A Nationwide Survey Using Crowdsourcing

Kato-Lin, Yi-Chin / Thelen, Shawn T

Telemed. j. e. health

Abstract: Background: COVID-19 has resulted in a rapid and significant adoption of telemedicine for acute conditions. Understanding whether patient demand will last after the pandemic helps providers and payers make informed decisions about whether to continue ... ...

Abstract	Background: COVID-19 has resulted in a rapid and significant adoption of telemedicine for acute conditions. Understanding whether patient demand will last after the pandemic helps providers and payers make informed decisions about whether to continue adopting telemedicine. Objective: We examine user experience as well as process and patient outcomes of using telemedicine for acute conditions during COVID-19 and assess how patient outcomes are affected by waiting times and demographics. Materials and Methods: A survey was conducted via Amazon Mechanical Turk during June 17-29, 2020. Inclusion criteria were: (1) ≥18 years old, (2) residing in the United States, (3) used telemedicine for acute conditions after January, and 4) a human intelligence task approval rate of >95%. Process outcomes included patient waiting time with patient outcomes being satisfaction and future use intention. Bivariate analysis and regressions of the data were performed. Results: On average, respondents reported appointment wait time of 2.76 days and virtual office wait time of 19.44 min. Overall, respondents reported moderate satisfaction (mean 5.08-5.35 of 7) and future use intention (mean 5.10-5.32 of 7). Over 72% of the respondents were satisfied and had future use intention. Females, heavier internet users, and those on the higher/lower ends of the education spectrum reported better patient outcomes. Patients "visiting" a doctor experiencing eye problems, vis-à-vis other ailments, reported lower satisfaction and intention. Waiting time negatively associates with satisfaction. Conclusions: Given the satisfactory outcomes, the high demand for telemedicine may continue after the COVID-19 pandemic. However, whether providers will continue to offer telemedicine visits may require more evidence.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #926319
Database	COVID19

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Article ; Online: Tension pneumothorax caused by iatrogenic intra-abdominal explosion during laparoscopic procedure.

Lai, Meng-Fu / Lin, Yi-Chin / Wu, Zhi-Fu

Journal of clinical anesthesia

2018 Volume 55, Page(s) 72–73

MeSH term(s)	Abdominal Cavity/surgery ; Aged ; Explosions ; Female ; Head-Down Tilt ; Humans ; Hysterectomy/adverse effects ; Hysterectomy/methods ; Iatrogenic Disease ; Intraoperative Complications/diagnostic imaging ; Intraoperative Complications/etiology ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Monitoring, Intraoperative/instrumentation ; Monitoring, Intraoperative/methods ; Pneumoperitoneum, Artificial/adverse effects ; Pneumothorax/diagnostic imaging ; Pneumothorax/etiology ; Point-of-Care Systems ; Ultrasonography/instrumentation ; Ultrasonography/methods
Language	English
Publishing date	2018-12-28
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2018.12.039
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