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Article ; Online: Effects of temperature, rainfall, and El Niño Southern Oscillations on dengue-like-illness incidence in Solomon Islands.

Andhikaputra, Gerry / Lin, Yu-Han / Wang, Yu-Chun

2023 Volume 23, Issue 1, Page(s) 206

Abstract: Background: This study investigated associations between climate variables (average temperature and cumulative rainfall), and El Niño Southern Oscillation (ENSO) and dengue-like-illness (DLI) incidence in two provinces (Western and Guadalcanal Provinces) ...

Abstract	Background: This study investigated associations between climate variables (average temperature and cumulative rainfall), and El Niño Southern Oscillation (ENSO) and dengue-like-illness (DLI) incidence in two provinces (Western and Guadalcanal Provinces) in Solomon Islands (SI). Methods: Weekly DLI and meteorological data were obtained from the Ministry of Health and Medical Services SI and the Ministry of Environment, Climate Change, Disaster Management and Meteorology from 2015 to 2018, respectively. We used negative binomial generalized estimating equations to assess the effects of climate variables up to a lag of 2 months and ENSO on DLI incidence in SI. Results: We captured an upsurge in DLI trend between August 2016 and April 2017. We found the effects of average temperature on DLI in Guadalcanal Province at lag of one month (IRR: 2.186, 95% CI: 1.094-4.368). Rainfall had minor but consistent effect in all provinces. La Niña associated with increased DLI risks in Guadalcanal Province (IRR: 4.537, 95% CI: 2.042-10.083), whereas El Niño associated with risk reduction ranging from 72.8% to 76.7% in both provinces. Conclusions: Owing to the effects of climate variability and ENSO on DLI, defining suitable and sustainable measures to control dengue transmission and enhancing community resilience against climate change in low- and middle-developed countries are important.
MeSH term(s)	Humans ; Temperature ; El Nino-Southern Oscillation ; Incidence ; Melanesia/epidemiology ; Dengue/epidemiology
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08188-x
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Article ; Online: MicroRNA-29a Mitigates Laminectomy-Induced Spinal Epidural Fibrosis and Gait Dysregulation by Repressing TGF-β1 and IL-6.

Lin, I-Ting / Lin, Yu-Han / Lian, Wei-Shiung / Wang, Feng-Sheng / Wu, Re-Wen

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Spinal epidural fibrosis is one of the typical features attributable to failed back surgery syndrome, with excessive scar development in the dura and nerve roots. The microRNA-29 family (miR-29s) has been found to act as a fibrogenesis-inhibitory factor ... ...

Abstract	Spinal epidural fibrosis is one of the typical features attributable to failed back surgery syndrome, with excessive scar development in the dura and nerve roots. The microRNA-29 family (miR-29s) has been found to act as a fibrogenesis-inhibitory factor that reduces fibrotic matrix overproduction in various tissues. However, the mechanistic basis of miRNA-29a underlying the overabundant fibrotic matrix synthesis in spinal epidural scars post-laminectomy remained elusive. This study revealed that miR-29a attenuated lumbar laminectomy-induced fibrogenic activity, and epidural fibrotic matrix formation was significantly lessened in the transgenic mice (miR-29aTg) as compared with wild-type mice (WT). Moreover, miR-29aTg limits laminectomy-induced damage and has also been demonstrated to detect walking patterns, footprint distribution, and moving activity. Immunohistochemistry staining of epidural tissue showed that miR-29aTg was a remarkably weak signal of IL-6, TGF-β1, and DNA methyltransferase marker, Dnmt3b, compared to the wild-type mice. Taken together, these results have further strengthened the evidence that miR-29a epigenetic regulation reduces fibrotic matrix formation and spinal epidural fibrotic activity in surgery scars to preserve the integrity of the spinal cord core. This study elucidates and highlights the molecular mechanisms that reduce the incidence of spinal epidural fibrosis, eliminating the risk of gait abnormalities and pain associated with laminectomy.
MeSH term(s)	Mice ; Animals ; Interleukin-6/genetics ; Transforming Growth Factor beta1/genetics ; Laminectomy/adverse effects ; Cicatrix/genetics ; Epigenesis, Genetic ; MicroRNAs/genetics ; Fibrosis ; Mice, Transgenic ; Gait
Chemical Substances	Interleukin-6 ; Transforming Growth Factor beta1 ; MicroRNAs ; MIRN29 microRNA, mouse
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119158
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Article ; Online: A novel approach with concomitant laparoscopic uterine artery ligation and D&C as initial treatment for complicated gestational trophoblast disease in cesarean scar and cervical ectopic pregnancies.

Lin, Yu-Han / Ou, Yu-Che / Kung, Fu-Tsai

Taiwanese journal of obstetrics & gynecology

2021 Volume 60, Issue 6, Page(s) 1090–1093

Abstract: Objective: Gestational trophoblast disease (GTD) in low-lying implantation ectopic pregnancy (LLIEP) is extremely rare. Surgical removal of GTD lesions which is the initial treatment of choice carries a high risk of intraoperative massive bleeding. ... ...

Abstract	Objective: Gestational trophoblast disease (GTD) in low-lying implantation ectopic pregnancy (LLIEP) is extremely rare. Surgical removal of GTD lesions which is the initial treatment of choice carries a high risk of intraoperative massive bleeding. Adequate management is challenging and inconclusive. Case report: We present two unusual cases with a diagnosis of GTD in advanced LLIEP. The first case had choriocarcinoma in cesarean scar and the second case had mole pregnancy in cervix. Both cases were managed with laparoscopy uterine artery ligations followed by transvaginal intrauterine curettage and vacuum aspiration with a small amount of surgical blood loss and then resumed regular menstruation. To understand the different surgical approaches and their potential advantages in managing such rare diseases, relevant cases in the literature were reviewed. Conclusion: Much attention should be paid to avoid massive bleeding at initial surgical intervention in patients with GTD in advanced LLIEP. This novel approach with combination of laparoscopic uterine artery ligations and evacuating curettage in selected patients is highly recommended to minimize surgical blood loss. The obvious advantages include technical feasibility, less surgery-related bleeding and potential fertility preservation.
MeSH term(s)	Adult ; Blood Loss, Surgical/prevention & control ; Cervix Uteri/pathology ; Cesarean Section/adverse effects ; Cicatrix/complications ; Cicatrix/surgery ; Female ; Gestational Trophoblastic Disease/pathology ; Gestational Trophoblastic Disease/surgery ; Humans ; Laparoscopy ; Pregnancy ; Pregnancy, Ectopic/etiology ; Pregnancy, Ectopic/surgery ; Treatment Outcome ; Uterine Artery/pathology ; Uterine Artery/surgery
Language	English
Publishing date	2021-07-09
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	2202946-1
ISSN	1875-6263 ; 1028-4559
ISSN (online)	1875-6263
ISSN	1028-4559
DOI	10.1016/j.tjog.2021.09.022
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Article ; Online: Variability in Leaf Color Induced by Chlorophyll Deficiency: Transcriptional Changes in Bamboo Leaves.

Zhu, Peng-Kai / Zeng, Mei-Yin / Lin, Yu-Han / Tang, Yu / He, Tian-You / Zheng, Yu-Shan / Chen, Ling-Yan

Current issues in molecular biology

2024 Volume 46, Issue 2, Page(s) 1503–1515

Abstract: The diversity of leaf characteristics, particularly leaf color, underscores a pivotal area of inquiry within plant science. The synthesis and functionality of chlorophyll, crucial for photosynthesis, largely dictate leaf coloration, with varying ... ...

Abstract	The diversity of leaf characteristics, particularly leaf color, underscores a pivotal area of inquiry within plant science. The synthesis and functionality of chlorophyll, crucial for photosynthesis, largely dictate leaf coloration, with varying concentrations imparting different shades of green. Complex gene interactions regulate the synthesis and degradation of chlorophyll, and disruptions in these pathways can result in abnormal chlorophyll production, thereby affecting leaf pigmentation. This study focuses on
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46020097
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Article: Tricarboxylic Acid Cycle Regulation of Metabolic Program, Redox System, and Epigenetic Remodeling for Bone Health and Disease.

Lian, Wei-Shiung / Wu, Re-Wen / Lin, Yu-Han / Chen, Yu-Shan / Jahr, Holger / Wang, Feng-Sheng

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates the development of osteoporosis, which is the leading risk factor of disability in the elderly. Harmonizing the metabolic actions of bone-making cells and bone ... ...

Abstract	Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates the development of osteoporosis, which is the leading risk factor of disability in the elderly. Harmonizing the metabolic actions of bone-making cells and bone resorbing cells to the mineralized matrix network is required to maintain bone mass homeostasis. The tricarboxylic acid (TCA) cycle in mitochondria is a crucial process for cellular energy production and redox homeostasis. The canonical actions of TCA cycle enzymes and intermediates are indispensable in oxidative phosphorylation and adenosine triphosphate (ATP) biosynthesis for osteogenic differentiation and osteoclast formation. Knockout mouse models identify these enzymes' roles in bone mass and microarchitecture. In the noncanonical processes, the metabolites as a co-factor or a substrate involve epigenetic modification, including histone acetyltransferases, DNA demethylases, RNA m6A demethylases, and histone demethylases, which affect genomic stability or chromatin accessibility for cell metabolism and bone formation and resorption. The genetic manipulation of these epigenetic regulators or TCA cycle intermediate supplementation compromises age, estrogen deficiency, or inflammation-induced bone mass loss and microstructure deterioration. This review sheds light on the metabolic functions of the TCA cycle in terms of bone integrity and highlights the crosstalk of the TCA cycle and redox and epigenetic pathways in skeletal tissue metabolism and the intermediates as treatment options for delaying osteoporosis.
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13040470
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Article ; Online: Unraveling the Pathogenetic Mechanisms Underlying the Association between Specific Mitochondrial DNA Haplogroups and Parkinson's Disease.

Lan, Min-Yu / Lin, Tsu-Kung / Lace, Baiba / Utkus, Algirdas / Burnyte, Birute / Grigalioniene, Kristina / Lin, Yu-Han / Inashkina, Inna / Liou, Chia-Wei

Cells

2024 Volume 13, Issue 8

Abstract: Variants of mitochondrial DNA (mtDNA) have been identified as risk factors for the development of Parkinson's disease (PD). However, the underlying pathogenetic mechanisms remain unclear. Cybrid models carrying various genotypes of mtDNA variants were ... ...

Abstract	Variants of mitochondrial DNA (mtDNA) have been identified as risk factors for the development of Parkinson's disease (PD). However, the underlying pathogenetic mechanisms remain unclear. Cybrid models carrying various genotypes of mtDNA variants were tested for resistance to PD-simulating MPP
MeSH term(s)	Parkinson Disease/genetics ; Humans ; DNA, Mitochondrial/genetics ; Haplotypes/genetics ; Protein Phosphatase 1/genetics ; Protein Phosphatase 1/metabolism ; Mitochondria/metabolism ; Mitochondria/genetics ; Unfolded Protein Response/genetics
Chemical Substances	DNA, Mitochondrial ; Protein Phosphatase 1 (EC 3.1.3.16)
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13080694
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Article ; Online: Atypical Renal Clearance of Nanoparticles Larger Than the Kidney Filtration Threshold.

Adhipandito, Christophorus F / Cheung, Siu-Hung / Lin, Yu-Han / Wu, Si-Han

International journal of molecular sciences

2021 Volume 22, Issue 20

Abstract: In recent years, several publications reported that nanoparticles larger than the kidney filtration threshold were found intact in the urine after being injected into laboratory mice. This theoretically should not be possible, as it is widely known that ... ...

Abstract	In recent years, several publications reported that nanoparticles larger than the kidney filtration threshold were found intact in the urine after being injected into laboratory mice. This theoretically should not be possible, as it is widely known that the kidneys prevent molecules larger than 6-8 nm from escaping into the urine. This is interesting because it implies that some nanoparticles can overcome the size limit for renal clearance. What kinds of nanoparticles can "bypass" the glomerular filtration barrier and cross into the urine? What physical and chemical characteristics are essential for nanoparticles to have this ability? And what are the biomolecular and cellular mechanisms that are involved? This review attempts to answer those questions and summarize known reports of renal-clearable large nanoparticles.
MeSH term(s)	Animals ; Glomerular Filtration Barrier ; Kidney/physiology ; Mice ; Nanoparticles
Language	English
Publishing date	2021-10-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222011182
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Article ; Online: Early-onset dietary restriction maintains mitochondrial health, autophagy and ER function in the left ventricle during aging.

Li, Sin-Jin / Lin, Yu-Han / Chiang, Chun-Hsien / Wang, Pei-Yu / Chen, Ching-Yi

The Journal of nutritional biochemistry

2022 Volume 101, Page(s) 108944

Abstract: Dietary restriction (DR) exerts healthy benefits, including heart functions. However, the cardioprotective role of DR is till controversial among researchers due to the variation of DR conditions. The present study focuses on the protective effect of ... ...

Abstract	Dietary restriction (DR) exerts healthy benefits, including heart functions. However, the cardioprotective role of DR is till controversial among researchers due to the variation of DR conditions. The present study focuses on the protective effect of early-onset DR on cardiac injury using mitochondrial structure and expression of protein associated with mitochondrial homeostasis, autophagy and endoplasmic reticulum (ER) function as measures. 2-month-old mice were fed with a breeding diet ad libitum (AL) or DR (60% of AL) for 3 (Young) or 20 (Aged) months. Body weight increased with aging, whereas DR treatment kept body weight consistent. DR mice exhibited a higher relative heart weight than AL mice. DR mice displayed lower plasma glucose levels, compared with AL groups. Furthermore, Aged-AL, but not Aged-DR mice, had increased collagen content and morphological distortions in the left ventricle (LV). Aged-DR mice had a higher ATP and lower TBARS in the LV than Aged-AL mice. Mitochondrial morphology was detected by electron microscopy; Aged-AL mice had increased abnormal morphology of mitochondria. Treatment with DR reduced abnormal mitochondrial accumulation. Aging elevated the protein expressions of mitochondrial functions and ER-induced apoptosis. Aging downregulated autophagy related proteins and chaperones in the heart. Dietary restriction reversed those protein expressions. The present study demonstrated a beneficial effect of early onset DR on cardiac aging. The age-dependent mitochondrial dysfunction and protein quality control dysregulation was significantly reversed by long-term DR, demonstrating a concordance with the beneficial effect in the heart.
MeSH term(s)	Aging ; Animals ; Autophagy ; Caloric Restriction ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/ultrastructure ; Endoplasmic Reticulum Stress ; Heart Ventricles/metabolism ; Heart Ventricles/ultrastructure ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/ultrastructure ; Mitochondrial Proteins/metabolism ; Myocardium/metabolism ; Oxidative Phosphorylation ; Ventricular Function
Chemical Substances	Mitochondrial Proteins
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2022.108944
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Article ; Online: Maize Antifungal Protein AFP1 Elevates Fungal Chitin Levels by Targeting Chitin Deacetylases and Other Glycoproteins.

Ma, Lay-Sun / Tsai, Wei-Lun / Damei, Florensia Ariani / Kalunke, Raviraj M / Xu, Meng-Yun / Lin, Yu-Han / Lee, Hui-Chun

mBio

2023 Volume 14, Issue 2, Page(s) e0009323

Abstract: Pathogenic fungi convert chitin to chitosan to evade plant perception and disarm chitin-triggered immune responses. Whether plants have evolved factors to counteract this evasion mechanism remains obscure. Here, we decipher the mechanism underlying the ... ...

Abstract	Pathogenic fungi convert chitin to chitosan to evade plant perception and disarm chitin-triggered immune responses. Whether plants have evolved factors to counteract this evasion mechanism remains obscure. Here, we decipher the mechanism underlying the antifungal activity of maize secretory mannose-binding
MeSH term(s)	Chitin/metabolism ; Chitosan ; Antifungal Agents/metabolism ; Zea mays/microbiology ; Mannose ; Glycoproteins ; Membrane Glycoproteins ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Cell Wall/metabolism
Chemical Substances	Chitin (1398-61-4) ; Chitosan (9012-76-4) ; Antifungal Agents ; Mannose (PHA4727WTP) ; Glycoproteins ; Membrane Glycoproteins ; Fungal Proteins
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00093-23
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Article ; Online: Early-onset caloric restriction alleviates ageing-associated steatohepatitis in male mice via restoring mitochondrial homeostasis.

Chiang, Chun-Hsien / Li, Sin-Jin / Lin, Yu-Han / Wang, Pei-Yu / Hsu, Pu-Sheng / Lin, Shau-Ping / Chiang, Ting-Chia / Chen, Ching-Yi

Biogerontology

2023 Volume 24, Issue 3, Page(s) 391–401

Abstract: Non-alcoholic fatty liver disease is associated with ageing, and impaired mitochondrial homeostasis is the main cause for hepatic ageing. Caloric restriction (CR) is a promising therapeutic approach for fatty liver. The purpose of the present study was ... ...

Abstract	Non-alcoholic fatty liver disease is associated with ageing, and impaired mitochondrial homeostasis is the main cause for hepatic ageing. Caloric restriction (CR) is a promising therapeutic approach for fatty liver. The purpose of the present study was to investigate the possibility of early-onset CR in decelerating the progression of ageing-related steatohepatitis. The putative mechanism associated with mitochondria was further determined. C57BL/6 male mice at 8 weeks of age were randomly assigned to one of three treatments: Young-AL (AL, ad libitum), Aged-AL, or Aged-CR (60% intake of AL). Mice were sacrificed when they were 7 months old (Young) or 20 months old (Aged). Aged-AL mice displayed the greatest body weight, liver weight, and liver relative weight among treatments. Steatosis, lipid peroxidation, inflammation, and fibrosis coexisted in the aged liver. Mega mitochondria with short, randomly organized crista were noticed in the aged liver. The CR ameliorated these unfavourable outcomes. The level of hepatic ATP decreased with ageing, but this was reversed by CR. Ageing caused a decrease in mitochondrial-related protein expressions of respiratory chain complexes (NDUFB8 and SDHB) and fission (DRP1), but an increase in proteins related to mitochondrial biogenesis (TFAM), and fusion (MFN2). CR reversed the expression of these proteins in the aged liver. Both Aged-CR and Young-AL revealed a comparable pattern of protein expression. To summarize, this study demonstrated the potential of early-onset CR in preventing ageing-associated steatohepatitis, and maintaining mitochondrial functions may contribute to CR's protection during hepatic ageing.
MeSH term(s)	Mice ; Male ; Animals ; Caloric Restriction ; Mice, Inbred C57BL ; Mitochondria ; Fatty Liver/prevention & control ; Aging/metabolism ; Homeostasis
Language	English
Publishing date	2023-02-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-023-10023-4
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