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  1. Article ; Online: Tailored mucosectomy and haemorrhoidopexy (TM & H): A new surgical option for selected Goligher grade III haemorrhoids - a video vignette.

    Elbetti, Claudio / Giani, Iacopo / Caminati, Filippo / Cioppa, Tommaso / Linari, Chiara / Zalla, Tiku

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  Volume 25, Issue 3, Page(s) 504–505

    MeSH term(s) Humans ; Hemorrhoids/surgery ; Hemorrhoidectomy ; Treatment Outcome ; Surgical Stapling
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Video-Audio Media ; Letter
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16338
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    Zs.A 5799: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Management of patients with bleeding disorders and educational needs regarding hemophilia a in 23 italian emergency departments - Results from a survey conducted in Piedmont.

    Pollio, Berardino / Ricca, Irene / Dainese, Cristina / Valeri, Federica / Valpreda, Alessandra / Linari, Claudia / Borchiellini, Alessandra

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 5, Page(s) e2022293

    Abstract: Background: Haemophilia and von Willebrand disease are the bleeding disorders most frequently encountered in the emergency department (ED), that are often the first point of contact for patients. Evidence suggests that management in the ED is currently ... ...

    Abstract Background: Haemophilia and von Willebrand disease are the bleeding disorders most frequently encountered in the emergency department (ED), that are often the first point of contact for patients. Evidence suggests that management in the ED is currently suboptimal, mainly because the physicians have few opportunities to deal with this kind of patients.
    Objectives: We carried out a survey to investigate the management of patients with haemophilia A in Emergency Departments (EDs), and to understand the training needs of the involved physicians.
    Methods: Overall, in Piedmont Region there are 32 EDs, and considering that our survey was conducted on 21 physicians working in 23 Emergency Departments (EDs), this number is representative of the Region's reality. The interviews were conducted through face-to-face meetings, including general aspects regarding the clinical characteristics and the management of patients, and self-evaluation of knowledge and interest in receiving information about the disease.
    Results: In 2019, 131 patients with haemophilia A were admitted (108 adults, 23 paediatric). The best-known and most widely available and used treatments were plasma derivatives, followed by first- and second-generation recombinant FVIII. More recent recombinant and bypassing agents were less known. Half of the interviewees considered their -knowledge of bleeding disorders in general and haemophilia in particular to be "basic", and only one third defined it as "good"; however, 86% expressed great interest in receiving information about the topic.
    Conclusions: The survey confirms the needs related to the clinical management of rare inherited clotting disorders in EDs. The physicians involved are keen to overcome this lack of knowledge, and proper initiatives should be implemented.
    MeSH term(s) Adult ; Humans ; Child ; Hemophilia A/therapy ; von Willebrand Diseases/complications ; von Willebrand Diseases/therapy ; Emergency Service, Hospital ; Surveys and Questionnaires ; Physicians
    Language English
    Publishing date 2022-10-26
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i5.13538
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  3. Article: Pro-inflammatory mediators in vaginal fluid and short cervical length in pregnancy.

    Sisti, G / Paccosi, S / Parenti, A / Seravalli, V / Linari, C / Di Tommaso, M / Witkin, S

    Bratislavske lekarske listy

    2020  Volume 121, Issue 4, Page(s) 278–281

    Abstract: Aim: We hypothesized that elevated vaginal levels of matrix metalloproteinase-8 (MMP-8), interleukin-8 (IL-8) and the 70kDa heat shock protein (hsp70), compounds involved in inflammatory responses, correlated with a short cervix in pregnant women.: ... ...

    Abstract Aim: We hypothesized that elevated vaginal levels of matrix metalloproteinase-8 (MMP-8), interleukin-8 (IL-8) and the 70kDa heat shock protein (hsp70), compounds involved in inflammatory responses, correlated with a short cervix in pregnant women.
    Methods: This prospective cohort study used a convenience sample of 64 women in their early third trimester with a singleton pregnancy. A short cervical length was present in 35 women (54.7 %). Vaginal fluid was tested for levels of MMP-8, IL-8 and hsp70 by enzyme-linked immunosorbent assay (ELISA). A receiver operating charasteristic (ROC) analysis was used to calculate the area under the curve (AUC) for each mediator in predicting short cervical length.
    Results: MMP-8 (109 vs 29.6 ng/ml, p=0.014), IL-8 (689 vs 330 pg/ml, p=0.007) and hsp70 (4.4 vs 2.9 ng/ml, p=0.036) were all elevated in vaginal samples from women with a short cervix. In addition, there was a negative association between the concentration of each compound in vaginal fluid and cervical length p≤0.026). The vaginal IL-8 concentration had the highest negative correlation with a short cervix (AUC=0.7, p=0.007).
    Conclusion: MMP-8, hsp70 and IL-8 contribute to a pro-inflammatory cervico-vaginal milieu that weakens cervical integrity and leads to a shortening in cervical length (Tab. 4, Fig. 1, Ref. 27).
    MeSH term(s) Cervix Uteri/anatomy & histology ; Female ; HSP70 Heat-Shock Proteins/analysis ; Humans ; Interleukin-8/analysis ; Matrix Metalloproteinase 8/analysis ; Pregnancy ; Pregnancy Trimester, Third ; Prospective Studies ; Vagina/chemistry
    Chemical Substances CXCL8 protein, human ; HSP70 Heat-Shock Proteins ; Interleukin-8 ; MMP8 protein, human (EC 3.4.24.34) ; Matrix Metalloproteinase 8 (EC 3.4.24.34)
    Language English
    Publishing date 2020-06-03
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 127421-1
    ISSN 0006-9248
    ISSN 0006-9248
    DOI 10.4149/BLL_2020_042
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    Zs.B 355: Show issues Location:
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  4. Article ; Online: The impact of COVID-19 pandemic on a tertiary referral proctology center: no one should be left behind.

    Giani, Iacopo / Gallo, Gaetano / Grossi, Ugo / Tanda, Cinzia / Linari, Chiara / Elbetti, Claudio

    Minerva surgery

    2021  Volume 77, Issue 1, Page(s) 30–34

    Abstract: Background: Coronavirus disease 2019 (COVID-19) has disrupted healthcare delivery. We aimed to describe a novel strategy to mitigate the impact of COVID-19 pandemic on a tertiary referral proctology center during the first wave of infection in Italy.: ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) has disrupted healthcare delivery. We aimed to describe a novel strategy to mitigate the impact of COVID-19 pandemic on a tertiary referral proctology center during the first wave of infection in Italy.
    Methods: All patients booked appointments at the Proctology Unit between March 9
    Results: On a total of 548 booked visits, 198 (36.1%) were cancelled before remote consultation. Of the remaining 350, 112 (32.0%) attended a follow-up visit. Among 238 (68.0%) patients undergoing remote consultation, 88 (25.1%) were deemed "deferrable" and 148 (42.3%) "non-deferrable." Two (0.6%) were hospitalized for COVID-19 while waiting for an outpatient visit. Twenty-five of 88 (28.4%) deferrable patients cancelled their appointment as felt no longer necessary. A total of 45 of 148 (30.4%) non deferrable patients (mean age, 46 years; 31% females) underwent in-office procedures, most often related to anal abscess and/or fistula (48.9%). Final diagnosis of malignancy occurred in four cases. A 55% increase in the number of in-office procedures was noted compared to the previous year. None of the attending patients nor staff members resulted COVID-19 positive during the study period.
    Conclusions: Despite the uncertainties accompanying the use of remote consultations in proctology, the results of this study may inform the development of strategies for restructuring activities in response to future emergencies of this magnitude.
    MeSH term(s) COVID-19/epidemiology ; Colorectal Surgery ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Remote Consultation ; SARS-CoV-2
    Language English
    Publishing date 2021-06-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.21.08897-3
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    Zs.A 25: Show issues Location:
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  5. Article ; Online: Robot-assisted gastrectomy for cancer.

    Amore Bonapasta, S / Guerra, F / Linari, C / Annecchiarico, M / Boffi, B / Calistri, M / Coratti, A

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2017  Volume 88, Issue Suppl 1, Page(s) 12–18

    Abstract: Background: Laparoscopic gastrectomy for cancer is commonly considered a challenging procedure. The technical drawbacks of laparoscopy have been addressed by robotic technology, which can facilitate demanding reconstructions and fine dissection. These ... ...

    Title translation Roboterassistierte Magenresektion beim Karzinom.
    Abstract Background: Laparoscopic gastrectomy for cancer is commonly considered a challenging procedure. The technical drawbacks of laparoscopy have been addressed by robotic technology, which can facilitate demanding reconstructions and fine dissection. These features confer potential advantages in the execution of lymphadenectomy.
    Objectives: Here, we illustrate our technique of robotic gastrectomy and discuss advantages and drawbacks by reviewing the current literature.
    Materials and methods: We describe our technique for robot-assisted distal and total gastrectomy for cancer and assess the current literature dealing with short-term outcomes, immediate oncologic measures, and long-term oncologic outcomes of robot-assisted gastrectomy, in comparison with conventional laparoscopic and open surgery.
    Results: The robotic procedure seems to be as safe and effective as conventional gastrectomy for gastric cancer, with a longer operative time and decreased blood loss in comparison with laparoscopic gastrectomy.
    Conclusion: The technical advantages offered by robotics could help to standardize minimally invasive D2 lymphadenectomy and enable surgeons to perform this procedure routinely. Despite the scarcity of long-term data on survival, immediate oncological measures (lymph node yield and margin status) are encouraging. Further studies investigating the long-term oncological outcomes are required.
    Language English
    Publishing date 2017-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-016-0209-y
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  6. Article ; Online: Roboterassistierte Magenresektion beim Karzinom.

    Amore Bonapasta, S / Guerra, F / Linari, C / Annecchiarico, M / Boffi, B / Calistri, M / Coratti, A

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2016  Volume 87, Issue 8, Page(s) 643–650

    Abstract: Background: Laparoscopic gastrectomy for cancer is commonly considered a challenging procedure. The technical drawbacks of laparoscopy have been addressed by robotic technology, which can facilitate demanding reconstructions and fine dissection. These ... ...

    Title translation Robot-assisted gastrectomy for cancer. German version.
    Abstract Background: Laparoscopic gastrectomy for cancer is commonly considered a challenging procedure. The technical drawbacks of laparoscopy have been addressed by robotic technology, which can facilitate demanding reconstructions and fine dissection. These features confer potential advantages in the execution of lymphadenectomy.
    Objectives: Here, we illustrate our technique of robotic gastrectomy and discuss advantages and drawbacks by reviewing the current literature.
    Materials and methods: We describe our technique for robot-assisted distal and total gastrectomy for cancer and assess the current literature dealing with short-term outcomes, immediate oncologic measures, and long-term oncologic outcomes of robot-assisted gastrectomy, in comparison with conventional laparoscopic and open surgery.
    Results: The robotic procedure seems to be as safe and effective as conventional gastrectomy for gastric cancer, with a longer operative time and decreased blood loss in comparison with laparoscopic gastrectomy.
    Conclusion: The technical advantages offered by robotics could help to standardize minimally invasive D2 lymphadenectomy and enable surgeons to perform this procedure routinely. Despite the scarcity of long-termdata on survival, immediate oncological measures (lymph node yield and margin status) are encouraging. Further studies investigating the long-term oncological outcomes are required.
    Language German
    Publishing date 2016-08
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-016-0237-7
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  7. Article: Identification of Vaginal Microbial Communities Associated with Extreme Cervical Shortening in Pregnant Women.

    Di Paola, Monica / Seravalli, Viola / Paccosi, Sara / Linari, Carlotta / Parenti, Astrid / De Filippo, Carlotta / Tanturli, Michele / Vitali, Francesco / Torcia, Maria Gabriella / Di Tommaso, Mariarosaria

    Journal of clinical medicine

    2020  Volume 9, Issue 11

    Abstract: The vaginal microbiota plays a critical role in pregnancy. Bacteria ... ...

    Abstract The vaginal microbiota plays a critical role in pregnancy. Bacteria from
    Language English
    Publishing date 2020-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9113621
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  8. Article ; Online: SARS-COV-2-associated coagulopathy and thromboembolism prophylaxis in children: A single-center observational study.

    Del Borrello, Giovanni / Giraudo, Isaac / Bondone, Claudia / Denina, Marco / Garazzino, Silvia / Linari, Claudia / Mignone, Federica / Pruccoli, Giulia / Scolfaro, Carlo / Spadea, Manuela / Pollio, Berardino / Saracco, Paola

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 19, Issue 2, Page(s) 522–530

    Abstract: Background: Multiple investigators have described an increased incidence of thromboembolic events in SARS-CoV-2-infected individuals. Data concerning hemostatic complications in children hospitalized for COVID-19/multisystem inflammatory syndrome in ... ...

    Abstract Background: Multiple investigators have described an increased incidence of thromboembolic events in SARS-CoV-2-infected individuals. Data concerning hemostatic complications in children hospitalized for COVID-19/multisystem inflammatory syndrome in children (MIS-C) are scant.
    Objectives: To share our experience in managing SARS-CoV-2-associated pro-coagulant state in hospitalized children.
    Methods: D-dimer values were recorded at diagnosis in children hospitalized for SARS-CoV-2-related manifestations. In moderately to critically ill patients and MIS-C cases, coagulation and inflammatory markers were checked at multiple time points and median results were compared. Pro-thrombotic risk factors were appraised for each child and thromboprophylaxis was started in selected cases.
    Results: Thirty-five patients were prospectively enrolled. D-dimer values did not discriminate COVID-19 of differing severity, whereas were markedly different between the COVID-19 and the MIS-C cohorts. In both cohorts, D-dimer and C-reactive protein levels increased upon clinical worsening but were not accompanied by decreased fibrinogen or platelet values, with all parameters returning to normal upon disease resolution. Six patients had multiple thrombotic risk factors and were started on pharmacological thromboprophylaxis. No deaths or thrombotic or bleeding complications occurred.
    Conclusions: COVID-19 pediatric patients show mildly altered coagulation and inflammatory parameters; on the other hand, MIS-C cases showed laboratory signs of an inflammatory driven pro-coagulant status. Universal anticoagulant prophylaxis in hospitalized children with SARS-CoV-2-related manifestations is not warranted, but may be offered to patients with other pro-thrombotic risk factors in the context of a multi-modal therapeutic approach.
    MeSH term(s) Adolescent ; Age Factors ; Anticoagulants/therapeutic use ; Biomarkers/blood ; Blood Coagulation/drug effects ; Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/etiology ; COVID-19/blood ; COVID-19/complications ; Child ; Child, Preschool ; Clinical Decision-Making ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Italy ; Male ; Prospective Studies ; Risk Factors ; Thromboembolism/blood ; Thromboembolism/etiology ; Thromboembolism/prevention & control ; Time Factors ; Treatment Outcome ; Young Adult ; COVID-19 Drug Treatment
    Chemical Substances Anticoagulants ; Biomarkers
    Language English
    Publishing date 2020-12-23
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15216
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  9. Article ; Online: Primary omental torsion: A case report.

    Scabini, Stefano / Rimini, Edoardo / Massobrio, Andrea / Romairone, Emanuele / Linari, Chiara / Scordamaglia, Renato / Marini, Luisito De / Ferrando, Valter

    World journal of gastrointestinal surgery

    2011  Volume 3, Issue 10, Page(s) 153–155

    Abstract: A patient presented with an acute abdomen at the Emergency Department. The patient, a 69-year-old man, was admitted and underwent surgery with a provisional diagnosis of acute appendicitis. During surgery, omental torsion was diagnosed and the involved ... ...

    Abstract A patient presented with an acute abdomen at the Emergency Department. The patient, a 69-year-old man, was admitted and underwent surgery with a provisional diagnosis of acute appendicitis. During surgery, omental torsion was diagnosed and the involved omentum was removed. The patient had no previous surgical history. Omental torsion is a rare cause of acute abdomen in children and adults who may present with various signs and symptoms; a preoperative diagnosis may therefore be difficult and can usually only be established during surgery.
    Language English
    Publishing date 2011-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366 ; 1948-9366
    ISSN (online) 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v3.i10.153
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  10. Article: c-kit is expressed in soft tissue sarcoma of neuroectodermic origin and its ligand prevents apoptosis of neoplastic cells.

    Ricotti, E / Fagioli, F / Garelli, E / Linari, C / Crescenzio, N / Horenstein, A L / Pistamiglio, P / Vai, S / Berger, M / di Montezemolo, L C / Madon, E / Basso, G

    Blood

    1998  Volume 91, Issue 7, Page(s) 2397–2405

    Abstract: During development, mice with mutations of stem cell factor (SCF) or its receptor c-kit exhibit defects in melanogenesis, as well as hematopoiesis and gonadogenesis. Consequently, accumulating evidence suggests that the c-kit/SCF system plays a crucial ... ...

    Abstract During development, mice with mutations of stem cell factor (SCF) or its receptor c-kit exhibit defects in melanogenesis, as well as hematopoiesis and gonadogenesis. Consequently, accumulating evidence suggests that the c-kit/SCF system plays a crucial role in all of these processes and in tumors which derive from them. Especially in neuroblastoma (infant tumors of neuroectoderm crest derivation such as melanocytes) it would appear that an autocrine loop exists between c-kit and SCF, and that the functional block of the c-kit receptors with monoclonal antibodies (MoAbs) results in a significant decrease in cellular proliferation. We studied the expression and role of c-kit and SCF in cell lines of soft tissue sarcoma of neuroectodermic origin, such as Ewing's sarcoma (ES) and peripheral neuro-ectodermal tumors (PNET). Using flow cytometry with MoAb CD117 PE, c-kit expression was highlighted in all six of the cell lines examined. This receptor was specifically and functionally activated by SCF, as shown by the binding experiments and the intracellular phosphotyrosine and immunoprecipitation studies that were performed. Using reverse transcriptase polymerase chain reaction analysis, five of the six cellular lines expressed the mRNA of SCF. In the medium measured by using an enzyme- linked immunosorbent assay, low concentrations of SCF were found: only the TC32 cellular line produced significantly higher levels (32 pg) than control. In serum-free culture the addition of SCF reduced the percentage of apoptotic cells from 25% to 90% in five out of the six cellular lines. This observation was confirmed by (1) the functional block of c-kit with MoAb: after 7 days of culture more than 30% of the cells were apoptotic (range 31.5% to 100%) in five out of six cell lines and there was also a decrease in the percentage of cells in phase S, and (2) c-kit antisense oligonucleotides: in the cellular lines treated with oligonucleotides (in relation to the untreated lines) there was a notable reduction (P < .001) both in the absolute number of cells and the 3H-thymidine uptake. These results indicate that ES and PNET express c-kit and its ligand SCF and that SCF is capable of protecting the tumor cells against apoptosis. Furthermore, the reverse transcriptase-polymerase chain reaction performed on the biopsies revealed the presence of mRNA both of SCF and c-kit in practically all of the samples studied. Our in vitro data lead us to assume that SCF may also inhibit tumor cell apoptosis in vivo.
    MeSH term(s) Animals ; Apoptosis ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Neuroectodermal Tumors, Primitive, Peripheral/metabolism ; Neuroectodermal Tumors, Primitive, Peripheral/pathology ; Oligonucleotides, Antisense ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Sarcoma/metabolism ; Sarcoma/pathology ; Sarcoma, Ewing/metabolism ; Sarcoma, Ewing/pathology ; Stem Cell Factor/genetics ; Stem Cell Factor/metabolism ; Tumor Cells, Cultured
    Chemical Substances Oligonucleotides, Antisense ; Stem Cell Factor ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 1998-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
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