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  1. Article ; Online: Rationale for targeting complement in COVID‐19

    Anastasia Polycarpou / Mark Howard / Conrad A Farrar / Roseanna Greenlaw / Giorgia Fanelli / Russell Wallis / Linda S Klavinskis / Steven Sacks

    EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)

    2020  

    Abstract: Abstract A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread internationally, posing a health emergency to the global community. COVID‐19 caused by SARS‐CoV‐2 is associated with an acute respiratory illness that varies from mild to ... ...

    Abstract Abstract A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread internationally, posing a health emergency to the global community. COVID‐19 caused by SARS‐CoV‐2 is associated with an acute respiratory illness that varies from mild to the life‐threatening acute respiratory distress syndrome (ARDS). The complement system is part of the innate immune arsenal against pathogens, in which many viruses can evade or employ to mediate cell entry. The immunopathology and acute lung injury orchestrated through the influx of pro‐inflammatory macrophages and neutrophils can be directly activated by complement components to prime an overzealous cytokine storm. The manifestations of severe COVID‐19 such as the ARDS, sepsis and multiorgan failure have an established relationship with activation of the complement cascade. We have collected evidence from all the current studies we are aware of on SARS‐CoV‐2 immunopathogenesis and the preceding literature on SARS‐CoV‐1 and MERS‐CoV infection linking severe COVID‐19 disease directly with dysfunction of the complement pathways. This information lends support for a therapeutic anti‐inflammatory strategy against complement, where a number of clinically ready potential therapeutic agents are available.
    Keywords complement proteins ; COVID‐19 ; lectin pathway ; SARS‐CoV‐2 ; therapeutics ; Medicine (General) ; R5-920 ; Genetics ; QH426-470 ; covid19
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Skin vaccination with live virus vectored microneedle arrays induce long lived CD8+ T cell memory

    Becker, Pablo D / Catherine Hervouet / Gavin M. Mason / Linda S. Klavinskis / Sung-Yun Kwon

    Vaccine. 2015 Sept. 08, v. 33, no. 37

    2015  

    Abstract: A simple dissolvable microneedle array (MA) platform has emerged as a promising technology for vaccine delivery, due to needle-free injection with a formulation that preserves the immunogenicity of live viral vectored vaccines dried in the MA matrix. ... ...

    Abstract A simple dissolvable microneedle array (MA) platform has emerged as a promising technology for vaccine delivery, due to needle-free injection with a formulation that preserves the immunogenicity of live viral vectored vaccines dried in the MA matrix. While recent studies have focused largely on design parameters optimized to induce primary CD8+ T cell responses, the hallmark of a vaccine is synonymous with engendering long-lasting memory. Here, we address the capacity of dried MA vaccination to programme phenotypic markers indicative of effector/memory CD8+ T cell subsets and also responsiveness to recall antigen benchmarked against conventional intradermal (ID) injection. We show that despite a slightly lower frequency of dividing T cell receptor transgenic CD8+ T cells in secondary lymphoid tissue at an early time point, the absolute number of CD8+ T cells expressing an effector memory (CD62L−CD127+) and central memory (CD62L+CD127+) phenotype during peak expansion were comparable after MA and ID vaccination with a recombinant human adenovirus type 5 vector (AdHu5) encoding HIV-1 gag. Similarly, both vaccination routes generated CD8+ memory T cell subsets detected in draining LNs for at least two years post-vaccination capable of responding to secondary antigen. These data suggest that CD8+ T cell effector/memory generation and long-term memory is largely unaffected by physical differences in vaccine delivery to the skin via dried MA or ID suspension.
    Keywords antigens ; CD8-positive T-lymphocytes ; Human adenovirus C ; Human immunodeficiency virus 1 ; immune response ; phenotype ; vaccination ; vaccines ; viruses
    Language English
    Dates of publication 2015-0908
    Size p. 4691-4698.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2015.04.046
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

    Marija Zaric / Pablo D. Becker / Catherine Hervouet / Petya Kalcheva / Andor Doszpoly / Negin Blattman / Lauren A. O’ Neill / Barbara Ibarzo Yus / Clement Cocita / Sung-Yun Kwon / Andrew H. Baker / Graham M. Lord / Linda S. Klavinskis

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 14

    Abstract: Mucosal immunisation is important for initiating mucosal CD8+ T­cell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 ...

    Abstract Mucosal immunisation is important for initiating mucosal CD8+ T­cell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 recruiting CD8+ T cells to the mucosa after skin immunisation.
    Keywords Science ; Q
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

    Marija Zaric / Pablo D. Becker / Catherine Hervouet / Petya Kalcheva / Andor Doszpoly / Negin Blattman / Lauren A. O’ Neill / Barbara Ibarzo Yus / Clement Cocita / Sung-Yun Kwon / Andrew H. Baker / Graham M. Lord / Linda S. Klavinskis

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 14

    Abstract: Mucosal immunisation is important for initiating mucosal CD8+ T­cell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 ...

    Abstract Mucosal immunisation is important for initiating mucosal CD8+ T­cell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 recruiting CD8+ T cells to the mucosa after skin immunisation.
    Keywords Science ; Q
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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