Article ; Online: Busulfan target exposure attainment in children undergoing allogeneic hematopoietic cell transplantation: a single day versus a multiday therapeutic drug monitoring regimen.
2023 Volume 58, Issue 7, Page(s) 762–768
Abstract: Busulfan exposure has previously been linked to clinical outcomes, hence the need for therapeutic drug monitoring (TDM). Study objective was to evaluate the effect of day 1 TDM-guided dosing (regimen d1) versus days 1 + 2 TDM-guided dosing (regimen d1 + ... ...
| Abstract | Busulfan exposure has previously been linked to clinical outcomes, hence the need for therapeutic drug monitoring (TDM). Study objective was to evaluate the effect of day 1 TDM-guided dosing (regimen d1) versus days 1 + 2 TDM-guided dosing (regimen d1 + 2) on attaining adequate busulfan exposure. In this observational study, we included all children receiving busulfan-based allogeneic hematopoietic cell transplantation. Primary outcome was the percentage of patients achieving busulfan target attainment in both TDM regimens. Secondary outcomes were the variance in busulfan exposure and day-4 clearance (Cl |
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| MeSH term(s) | Child ; Humans ; Busulfan ; Drug Monitoring ; Hematopoietic Stem Cell Transplantation ; Transplantation Conditioning | |||||
| Chemical Substances | Busulfan (G1LN9045DK) | |||||
| Language | English | |||||
| Publishing date | 2023-03-31 | |||||
| Publishing country | England | |||||
| Document type | Observational Study ; Journal Article | |||||
| ZDB-ID | 632854-4 | |||||
| ISSN | 1476-5365 ; 0268-3369 ; 0951-3078 | |||||
| ISSN (online) | 1476-5365 | |||||
| ISSN | 0268-3369 ; 0951-3078 | |||||
| DOI | 10.1038/s41409-023-01971-z | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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