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Article: Viral Conjunctivitis Rates Unchanged Before and During the COVID-19 Pandemic in an Ophthalmology Clinic.

Piazza, Amber N / Downie, Peter A / Lee, Michael S / Lindgren, Bruce R / Olson, Joshua H

Clinical ophthalmology (Auckland, N.Z.)

2024 Volume 18, Page(s) 1289–1294

Abstract: Background: Millions of acute conjunctivitis cases occur in the United States annually. The impact of COVID-19 mitigation practices on viral conjunctivitis incidence within ophthalmology clinics has not been reported. We hypothesized that viral ... ...

Abstract	Background: Millions of acute conjunctivitis cases occur in the United States annually. The impact of COVID-19 mitigation practices on viral conjunctivitis incidence within ophthalmology clinics has not been reported. We hypothesized that viral conjunctivitis rates would decrease with implementation of such practices. Methods: A retrospective chart review was conducted at a single academic center's ophthalmology clinics. Electronic health record data was queried using ICD-10 diagnostic codes to include 649 patients aged 2-97 with viral, bacterial, or allergic conjunctivitis diagnosed either before (6/1/2018-5/1/2019) or during (6/1/2020-5/1/2021) COVID-19 precautions. Conjunctivitis rates per ophthalmology clinic visit were compared using rate-ratio analysis. Logistic regression evaluated the effects of age, sex, and race among those with conjunctivitis. Results: A total of 66,027 ophthalmology clinic visits occurred during the study period. Viral conjunctivitis rates per visit did not significantly change after enacting COVID-19 mitigation strategies, but allergic conjunctivitis rates significantly increased (viral: RR 0.82, 95% CI 0.51 to 1.31, p=0.408; allergic: RR 1.70, 95% CI 1.43 to 2.03, p<0.001). When controlling for time, younger age (≤ median age 55) (p=0.005) and Caucasian race (p=0.009) were associated with higher viral conjunctivitis frequency. Conclusion: Contrary to trends reported in emergency departments, viral conjunctivitis rates within an ophthalmology clinic did not significantly change after COVID-19 mitigation strategies, though allergic conjunctivitis rates increased. Patients' avoidance of emergency departments during the pandemic may have contributed. Further investigation is required to explore variation in ophthalmology patient populations and needs based on care setting.
Language	English
Publishing date	2024-05-10
Publishing country	New Zealand
Document type	Journal Article
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S445315
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Article ; Online: Knowledge, Attitudes and Perceptions of Dental Hygiene and Dental Therapy Students towards End-stage Renal Disease: A pilot study.

Bast, Kendall P / Arnett, Michelle C / Lindgren, Bruce R / Drake, Miranda A / Reibel, Yvette

Journal of dental hygiene : JDH

2023 Volume 97, Issue 1, Page(s) 56–65

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Humans ; Pilot Projects ; Health Knowledge, Attitudes, Practice ; Oral Hygiene ; Kidney Failure, Chronic/therapy ; Renal Insufficiency, Chronic
Language	English
Publishing date	2023-02-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1035719-1
ISSN	1553-0205 ; 1043-254X
ISSN (online)	1553-0205
ISSN	1043-254X
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Article ; Online: MRI Signal Intensity Varies Along the Course of the Normal Optic Nerve.

Prairie, Michael L / Gencturk, Mehmet / Lindgren, Bruce R / McClelland, Collin M / Lee, Michael S

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2023 Volume 43, Issue 4, Page(s) 509–513

Abstract: Background: MRI can help distinguish various causes of optic neuropathy including optic neuritis. Importantly, neuromyelitis optica spectrum disorder (NMOSD) has a propensity to cause enhancement of the prechiasmatic optic nerves. To determine whether ... ...

Abstract	Background: MRI can help distinguish various causes of optic neuropathy including optic neuritis. Importantly, neuromyelitis optica spectrum disorder (NMOSD) has a propensity to cause enhancement of the prechiasmatic optic nerves. To determine whether the prechiasmatic optic nerve (PC-ON) demonstrates a different intensity from the midorbital optic nerve (MO-ON) on MRI among patients without optic neuropathy. Methods: Data were retrospectively obtained from 75 patients who underwent brain MRI for an ocular motor nerve palsy between January 2005 and April 2021. Inclusion criteria were patients aged 18 years or older with visual acuities of at least 20/25 and no evidence of optic neuropathy on neuro-ophthalmic examination. A total of 67 right eyes and 68 left eyes were assessed. A neuroradiologist performed quantitative intensity measurements of the MO-ON and PC-ON on precontrast and postcontrast T1 axial images. Normal-appearing temporalis muscle intensity was also measured and used as a reference to calculate an intensity ratio to calibrate across images. Results: The mean PC-ON intensity ratio was significantly higher than the MO-ON intensity ratio on both precontrast (19.6%, P < 0.01) and postcontrast images (14.2%, P < 0.01). Age, gender, and laterality did not independently affect measurements. Conclusions: The prechiasmatic optic nerve shows brighter intensity ratios on both precontrast and postcontrast T1 images than the midorbital optic nerve among normal optic nerves. Clinicians should recognize this subtle signal discrepancy when assessing patients with presumed optic neuropathy.
MeSH term(s)	Humans ; Retrospective Studies ; Optic Nerve/diagnostic imaging ; Neuromyelitis Optica/diagnosis ; Optic Neuritis/diagnosis ; Optic Neuritis/complications ; Optic Nerve Diseases/diagnosis ; Optic Nerve Diseases/etiology ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/WNO.0000000000001823
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Article: Prospective Trial of Monocyte Count as a Biomarker of Hand-Foot Syndrome Among Patients With Soft Tissue Sarcomas Treated With Pegylated Liposomal Doxorubicin and Ifosfamide.

Skubitz, Keith M / Lindgren, Bruce R / Domingo-Musibay, Evidio / Cheng, Edward Y

Cureus

2022 Volume 14, Issue 4, Page(s) e24498

Abstract: Pegylated liposomal doxorubicin (PLD) is widely used and can be used for prolonged periods, with the limiting toxicity usually being hand-foot syndrome (HFS). The pharmacokinetics of PLD is variable between patients, leading to variability in the risk of ...

Abstract	Pegylated liposomal doxorubicin (PLD) is widely used and can be used for prolonged periods, with the limiting toxicity usually being hand-foot syndrome (HFS). The pharmacokinetics of PLD is variable between patients, leading to variability in the risk of developing HFS. Dosing based on body surface area does not decrease variability in PLD clearance; thus, other predictive markers could be useful. The peripheral blood absolute monocyte count (AMC) has been suggested as a possible marker of both reticuloendothelial system function and PLD pharmacokinetics. The present study examined the AMC as a potential predictive biomarker in a prospective trial of pre-operative PLD combined with ifosfamide in soft tissue sarcomas (STSs). While our results suggest a relationship between pre-treatment AMC and PLD-induced HFS, the association did not reach statistical significance. The clinical utility of the AMC as a predictor of PLD-induced HFS appears limited, at least when given with ifosfamide.
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.24498
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Article: Peer Group Support Intervention to Reduce Cardiovascular Disease Risk for African American Men According to Life's Simple 7 in Faith-Based Communities.

Lee, Sohye / Niakosari Hadidi, Niloufar / Lindgren, Bruce R / Kelley, Robin / Lindquist, Ruth

Research and theory for nursing practice

2022

Abstract: Background and purpose: Adverse cardiovascular health disparities persist for African American men. Although changing health behaviors is perhaps one of the most effective methods to prevent cardiovascular disease (CVD)-related deaths, previous behavior ...

Abstract	Background and purpose: Adverse cardiovascular health disparities persist for African American men. Although changing health behaviors is perhaps one of the most effective methods to prevent cardiovascular disease (CVD)-related deaths, previous behavior change programs targeting single or multiple CVD risk factors in target groups have had mixed success. The purpose of this pilot study was to determine whether a multi-faceted peer group intervention model based on American Heart Association's Life's Simple 7 was feasible, safe, acceptable, and efficacious in producing meaningful risk reduction for African American men. Methods: A convenience sample of 24 African American men with at least one CVD risk factor participated quasi-experimental study having peer intervention vs Results: All twenty-four men completed the study with no study-related adverse symptoms and medical events. The peer groups had moderate to high attendance, and the peer program evaluation was highly positive among participants. Between baseline and 6-months, there were significant differences between the intervention and the comparison group in cholesterol levels and weights ( Implication for practice: The multi-faceted peer support intervention was feasible, acceptable, and shown to have potential efficacy to reduce CVD risk for highly motivated African American men. Future studies with a larger sample size are needed to test the effectiveness of this intervention model to reduce CVD risk among African American men.
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2083159-6
ISSN	1945-7286 ; 1541-6577 ; 0889-7182
ISSN (online)	1945-7286
ISSN	1541-6577 ; 0889-7182
DOI	10.1891/RTNP-2021-0111
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Article: Prospective Trial of Neutrophil/Lymphocyte Ratio and Other Blood Counts as Biomarkers of Survival among Patients with High-Grade Soft Tissue Sarcomas Treated with Pegylated Liposomal Doxorubicin and Ifosfamide.

Skubitz, Keith M / Domingo-Musibay, Evidio / Lindgren, Bruce R / Cheng, Edward Y

Cancers

2022 Volume 14, Issue 14

Abstract: Several studies have reported an association between levels of circulating blood cells, in particular the neutrophil to lymphocyte ratio (absolute neutrophil count (ANC)/absolute lymphocyte count (ALC)) and outcomes in patients with cancer. In the ... ...

Abstract	Several studies have reported an association between levels of circulating blood cells, in particular the neutrophil to lymphocyte ratio (absolute neutrophil count (ANC)/absolute lymphocyte count (ALC)) and outcomes in patients with cancer. In the current study, the association between lymphocyte, neutrophil, monocyte, and platelet counts and survival was examined in a prospective trial of preoperative pegylated-liposomal doxorubicin and ifosfamide for high-grade soft-tissue sarcomas. A statistically significant association between overall survival, but not progression free-survival, was observed with the ANC/ALC ratio at a cutoff value of ≥2 and a statistically significant trend using a cutoff of ≥5. Our results suggest that a balance between the lymphocyte count and the number of circulating myeloid cells that can suppress lymphocyte function may be predictive of survival in patients with soft-tissue sarcomas. Future research should therefore examine the role of lymphocyte-myeloid cell balance in sarcoma biology.
Language	English
Publishing date	2022-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14143419
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Article ; Online: Randomized Electronic Promotion of Lung Cancer Screening: A Pilot.

Begnaud, Abbie L / Joseph, Anne M / Lindgren, Bruce R

JCO clinical cancer informatics

2019 Volume 1, Page(s) 1–6

Abstract: Purpose: Screening for lung cancer with low-dose computed tomography is endorsed by the US Preventive Services Task Force, but many eligible patients have yet to be offered screening. Major barriers to the implementation of screening are physician and ... ...

Abstract	Purpose: Screening for lung cancer with low-dose computed tomography is endorsed by the US Preventive Services Task Force, but many eligible patients have yet to be offered screening. Major barriers to the implementation of screening are physician and system related-the requirement for a detailed smoking history, including pack-years, to determine eligibility. We conducted this pilot to determine the feasibility of lung cancer screening (LCS) promotion that would offer screening to eligible persons and patient completion of smoking history to estimate the size of the population of former smokers who may be eligible for LCS in a single health care system. Patients and methods: Two hundred participants were randomly selected from former smokers who were seen at the University of Minnesota Health in the past 2 years and assigned to control (usual care) and electronic promotion, stratified by age. Electronic messages to promote LCS were sent to an intervention group, including a link to complete a detailed smoking history in the electronic health record. Results: Of 99 participants, 66 (67%) in the intervention group read the message, 24 (36%) of 66 responded, and 19 (79%) of 24 respondents completed the smoking history. Ten intervention participants and 13 usual care participants were eligible for screening on the basis of pack-year history. Four eligible participants underwent screening in the intervention group compared with one participant in the usual care group. Conclusion: Electronic promotion may help identify patients who are eligible for LCS but will not reliably reach all patients because of low response rates. In this sample of former smokers, the majority are ineligible for LCS on the basis of pack-year history. Electronic methods can improve documentation of smoking history.
MeSH term(s)	Aged ; Early Detection of Cancer/methods ; Electronic Health Records/statistics & numerical data ; Female ; Health Promotion/methods ; Health Promotion/statistics & numerical data ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Male ; Mass Screening ; Middle Aged ; Pilot Projects ; Preventive Health Services/methods ; Preventive Health Services/statistics & numerical data ; Risk Factors ; Tomography, X-Ray Computed ; User-Computer Interface
Keywords	covid19
Language	English
Publishing date	2019-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2473-4276
ISSN (online)	2473-4276
DOI	10.1200/CCI.17.00033
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Article ; Online: Prevalence of frontal fibrosing alopecia among Brazilian dermatologists: A cross-sectional survey.

Donati, Aline / Lindgren, Bruce R / Abreu, Gilmayara / Hordinsky, Maria

JAAD international

2020 Volume 1, Issue 2, Page(s) 148–150

Language	English
Publishing date	2020-08-31
Publishing country	United States
Document type	Journal Article
ISSN	2666-3287
ISSN (online)	2666-3287
DOI	10.1016/j.jdin.2020.07.008
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Article ; Online: Characterization of Baseline Temperature Characteristics Using Thermography in The Clinical Setting.

Wilson, Anna C / Jungbauer, Walter N / Hussain, Fareeda T / Lindgren, Bruce R / Lassig, Amy Anne D

The Journal of surgical research

2021 Volume 272, Page(s) 26–36

Abstract: Background: Thermography is a diagnostic method based on the ability to record infrared radiation emitted by the skin and is unique in its ability to accurately show physiological and/or pathological cutaneous temperature changes in a non-invasive way. ... ...

Abstract	Background: Thermography is a diagnostic method based on the ability to record infrared radiation emitted by the skin and is unique in its ability to accurately show physiological and/or pathological cutaneous temperature changes in a non-invasive way. This method can be used to indirectly assess changes or impairments in cutaneous perfusion. Significant technological advancements have allowed thermography to be more commonly utilized by clinicians, yet a basic consensus of patient characteristics that may affect temperature recordings is not established. Materials and methods: We evaluated cutaneous temperature in a cohort of outpatients to understand what factors, including tobacco use and other high-risk characteristics, contribute to cutaneous tissue perfusion as measured by thermography. Participants were prospectively enrolled if they were a combustible cigarette smoker, an electronic cigarette (e-cigarette) user, or a never smoker. Standardized thermographic images of the subject's facial profiles, forearms, and calves were taken and demographic characteristics, medical comorbidities, and tobacco product use were assessed. These variables were statistically tested for associations with temperature at each anatomic site. Results: We found that gender had a significant effect on thermographic temperature that differed by anatomic site, and we found a lack of significant difference in thermographic temperature by race. Our regression analysis did not support significant differences in thermographic temperatures across smoking groups, while there was a trend for decreased perfusion in smokers relative to non-smokers and e-cigarette users relative to non-smokers. Conclusion: Thermographic imaging is a useful tool for clinical and research use with consideration of sex and other perfusion-affecting characteristics.
MeSH term(s)	Animals ; Body Temperature ; Cattle ; Electronic Nicotine Delivery Systems ; Humans ; Smoking ; Temperature ; Thermography/methods
Language	English
Publishing date	2021-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2021.11.006
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Article ; Online: InCISE: Instrument for Comprehensive Incisional and Surgical Evaluation.

Lassig, Amy Anne D / Lindgren, Bruce R / Wilson, Anna C / Joseph, Anne M / Davison, Mark / Yueh, Bevan

The Laryngoscope

2022 Volume 133, Issue 9, Page(s) 2166–2173

Abstract: Objective: The evaluation of healing after head and neck surgery is currently qualitative and non-standardized, limiting the quality of surgical healing assessments in clinical and research settings. We sought to develop an objective, standardized wound ...

Abstract	Objective: The evaluation of healing after head and neck surgery is currently qualitative and non-standardized, limiting the quality of surgical healing assessments in clinical and research settings. We sought to develop an objective, standardized wound assessment score, and hypothesize that a reliable instrument can be developed to evaluate head and neck surgical wounds. Methods: A prospective cohort study was conducted in a tertiary-care, academic head and neck surgery practice. Patients undergoing head and neck surgery were enrolled. A digital photograph protocol was developed for evaluating healing surgical wounds. A panel of experts developed and refined a wound healing score and established reliability, reproducibility, internal consistency, and validity of the score. Results: InCISE: Instrument for comprehensive incisional and surgical evaluation was created. The utility of our wound healing score was assessed using classical test theory. We performed the major steps of establishing reliability in head and neck surgeons: (1) internal consistency (Cronbach's α = 0.81), (2) inter-observer reliability (intra-class correlation = 0.76), and (3) intra-rater reliability (intra-class correlation = 0.87), and content validity (through focus groups). Our composite measure was found to have strong internal consistency, inter-rater reliability, and intra-rater reliability. Preliminary work suggests criterion validity via associations with physical health related quality of life (SF-12). Conclusion: A wound healing score for head and neck surgery, InCISE, has been developed and is reliable, reproducible, and consistent. Although content validity is present and criterion validity is suggested, work continues to establish validity in this instrument to allow for expanded clinical and research use. Level of evidence: NA Laryngoscope, 133:2166-2173, 2023.
MeSH term(s)	Humans ; Physical Examination/methods ; Physical Examination/standards ; Prospective Studies ; Quality of Life ; Reproducibility of Results ; Surgical Wound/classification ; Surgical Wound/complications ; Surgical Wound/diagnosis ; Cohort Studies ; Wound Healing ; Male ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Photography ; Surgeons/statistics & numerical data ; Physician Assistants/statistics & numerical data ; General Surgery/instrumentation ; Postoperative Complications/classification ; Postoperative Complications/diagnosis
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30439
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