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  1. Article: Simultaneous multi-parametric acquisition and reconstruction techniques in cardiac magnetic resonance imaging: Basic concepts and status of clinical development.

    Eyre, Katerina / Lindsay, Katherine / Razzaq, Saad / Chetrit, Michael / Friedrich, Matthias

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 953823

    Abstract: Simultaneous multi-parametric acquisition and reconstruction techniques (SMART) are gaining attention for their potential to overcome some of cardiovascular magnetic resonance imaging's (CMR) clinical limitations. The major advantages of SMART lie within ...

    Abstract Simultaneous multi-parametric acquisition and reconstruction techniques (SMART) are gaining attention for their potential to overcome some of cardiovascular magnetic resonance imaging's (CMR) clinical limitations. The major advantages of SMART lie within their ability to simultaneously capture multiple "features" such as cardiac motion, respiratory motion, T1/T2 relaxation. This review aims to summarize the overarching theory of SMART, describing key concepts that many of these techniques share to produce co-registered, high quality CMR images in less time and with less requirements for specialized personnel. Further, this review provides an overview of the recent developments in the field of SMART by describing how they work, the parameters they can acquire, their status of clinical testing and validation, and by providing examples for how their use can improve the current state of clinical CMR workflows. Many of the SMART are in early phases of development and testing, thus larger scale, controlled trials are needed to evaluate their use in clinical setting and with different cardiac pathologies.
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.953823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development.

    Matsui, Yurika / Djekidel, Mohamed Nadhir / Lindsay, Katherine / Samir, Parimal / Connolly, Nina / Wu, Gang / Yang, Xiaoyang / Fan, Yiping / Xu, Beisi / Peng, Jamy C

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 4754

    Abstract: Stem cell survival versus death is a developmentally programmed process essential for morphogenesis, sizing, and quality control of genome integrity and cell fates. Cell death is pervasive during development, but its programming is little known. Here, we ...

    Abstract Stem cell survival versus death is a developmentally programmed process essential for morphogenesis, sizing, and quality control of genome integrity and cell fates. Cell death is pervasive during development, but its programming is little known. Here, we report that Smad nuclear interacting protein 1 (SNIP1) promotes neural progenitor cell survival and neurogenesis and is, therefore, integral to brain development. The SNIP1-depleted brain exhibits dysplasia with robust induction of caspase 9-dependent apoptosis. Mechanistically, SNIP1 regulates target genes that promote cell survival and neurogenesis, and its activities are influenced by TGFβ and NFκB signaling pathways. Further, SNIP1 facilitates the genomic occupancy of Polycomb complex PRC2 and instructs H3K27me3 turnover at target genes. Depletion of PRC2 is sufficient to reduce apoptosis and brain dysplasia and to partially restore genetic programs in the SNIP1-depleted brain in vivo. These findings suggest a loci-specific regulation of PRC2 and H3K27 marks to toggle cell survival and death in the developing brain.
    MeSH term(s) Humans ; Intracellular Signaling Peptides and Proteins ; RNA-Binding Proteins ; Signal Transduction/physiology ; NF-kappa B ; Hyperplasia ; Brain
    Chemical Substances Intracellular Signaling Peptides and Proteins ; RNA-Binding Proteins ; NF-kappa B ; SNIP1 protein, human
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-40487-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Blinatumomab for First-Line Treatment of Children and Young Persons With B-ALL.

    Hodder, Angus / Mishra, Avijeet K / Enshaei, Amir / Baird, Susan / Elbeshlawi, Ismail / Bonney, Denise / Clesham, Katherine / Cummins, Michelle / Vedi, Aditi / Gibson, Brenda / George, Lindsay / Ingham, Danielle / Jigoulina, Galina / Lancaster, Donna / Lindsay, Katherine / Madni, Majid / Malone, Andrea / Mitchell, Bethany / Moppett, John /
    Motwani, Jayashree / Moorman, Anthony V / Patrick, Katharine / Samrin, Lamia / Tewari, Sanjay / Thakur, Indu / O'Connor, David / Samarasinghe, Sujith / Vora, Ajay

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 42, Issue 8, Page(s) 907–914

    Abstract: Purpose: We tested whether blinatumomab (Blina) is effective as a toxicity-sparing alternative to first-line intensive chemotherapy in children and young persons (CYP) with B-ALL who were chemotherapy-intolerant or chemotherapy-resistant.: Methods: ... ...

    Abstract Purpose: We tested whether blinatumomab (Blina) is effective as a toxicity-sparing alternative to first-line intensive chemotherapy in children and young persons (CYP) with B-ALL who were chemotherapy-intolerant or chemotherapy-resistant.
    Methods: Data were collected for consecutive CYP (age 1-24 years) with Philadelphia chromosome-positive or Philadelphia chromosome-negative B-ALL who received Blina as first-line therapy. Blina was given as replacement for postremission intensive chemotherapy to patients with chemotherapy intolerance or resistance. Blina responders received further chemotherapy (Blin-CT) or first remission hematopoietic stem-cell transplant (Blin-HSCT) if indicated. Event-free survival (EFS) and overall survival (OS) of the Blin-CT group were compared with those of matched controls treated with standard chemotherapy in the UKALL 2003 trial. Events were defined as death, relapse, or secondary cancer.
    Results: From February 2018 to February 2023, 105 patients were treated, of whom 85 were in the Blin-CT group and 20 were in the Blin-HSCT group. A majority of Blin-CT patients received Blina for chemotherapy intolerance (70 of 85, 82%), and the group had a higher-risk profile than unselected patients with B-ALL. Blina was well tolerated with only one patient having a grade 3/4-related toxicity event, and of the 60 patients who were minimal residual disease-positive pre-Blina, 58 of 60 (97%) responded. At a median follow-up of 22 months, the 2-year outcomes of the 80 matched Blin-CT group patients were similar to those of 192 controls (EFS, 95% [95% CI, 85 to 98]
    Conclusion: Blina is safe and effective in first-line treatment of chemotherapy-intolerant CYP with ALL.
    MeSH term(s) Child ; Humans ; Infant ; Child, Preschool ; Adolescent ; Young Adult ; Adult ; Philadelphia Chromosome ; Neoplasm Recurrence, Local/drug therapy ; Antibodies, Bispecific/adverse effects ; Leukemia, Myeloid, Acute/drug therapy ; Hematopoietic Stem Cell Transplantation
    Chemical Substances blinatumomab (4FR53SIF3A) ; Antibodies, Bispecific
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.01392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 650: Show issues

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  4. Article: Enhanced Mobilization of Field Contaminated Soil-bound PAHs to the Aqueous Phase under Anaerobic Conditions

    Kim, Han S / Lindsay, Katherine S / Pfaender, Frederic K

    Water, air, and soil pollution. 2008 Mar., v. 189, no. 1-4

    2008  

    Abstract: Although microbially-mediated redox environments can alter the characteristics of soil/sediment organic matter (SOM) and its interactions with persistent hydrophobic organic contaminants (HOCs) bound to soils and sediments, the nature of their effects ... ...

    Abstract Although microbially-mediated redox environments can alter the characteristics of soil/sediment organic matter (SOM) and its interactions with persistent hydrophobic organic contaminants (HOCs) bound to soils and sediments, the nature of their effects has not been adequately addressed. In this study, a field soil collected from a manufacturer gas plant site and contaminated historically with creosotes was incubated under aerobic and anoxic/anaerobic conditions along with various amendments (extra carbon and enrichment minerals) for stimulating microbial activities. Anaerobic conditions stimulated significant fractions of bound polycyclic aromatic hydrocarbons (PAHs) encompassing naphthalene through benzo[g,h,i]perylene to be mobilized to the aqueous phase, leaving their aqueous phase concentrations far in excess of solubility (increases in their apparent aqueous phase concentrations by factors as high as 62.8 relative to their initial aqueous phase concentrations). Such effects became more evident for high molecular weight PAHs. Dissolved organic matter exhibiting a high affinity for PAHs was liberated from soils during the anaerobic soil incubations. Feasibility of this concept for field applications was evaluated with a lab-scale continuous flow system composed of an anaerobic soil column followed by an aerobic bioreactor inoculated with PAH-degrading microbes. High quantities of PAHs exceeding their aqueous solubilities were eluted from the anaerobic soil column and those mobilized PAHs were readily bioavailable in the secondary aerobic bioreactor. This study may offer a potential method for cost-effective and performance-efficient ex situ remediation technologies (or in situ if appropriate hydrological control available in the contaminated field site) and risk assessment for the HOC-contaminated soils/sediments.
    Keywords soil pollution ; polluted soils ; sediment contamination ; polycyclic aromatic hydrocarbons ; creosote ; soil organic matter ; anaerobic conditions ; dissolved organic matter ; binding capacity ; water solubility ; subsurface flow ; bioreactors ; bioremediation ; biodegradation ; bioavailability ; microbial activity ; Kentucky
    Language English
    Dates of publication 2008-03
    Size p. 135-147.
    Publisher Springer Netherlands
    Publishing place Dordrecht
    Document type Article
    ZDB-ID 120499-3
    ISSN 1573-2932 ; 0049-6979 ; 0043-1168
    ISSN (online) 1573-2932
    ISSN 0049-6979 ; 0043-1168
    DOI 10.1007/s11270-007-9562-2
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2719: Show issues

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