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  1. Article ; Online: HSV1716 Prevents Myeloma Cell Regrowth When Combined with Bortezomib

    Tazzyman, Simon / Stewart, Georgia R / Yeomans, James / Linford, Adam / Lath, Darren / Conner, Joe / Muthana, Munitta / Chantry, Andrew D / Lawson, Michelle A

    Viruses

    2023  Volume 15, Issue 3

    Abstract: Multiple myeloma remains largely incurable due to refractory disease; therefore, novel treatment strategies that are safe and well-tolerated are required. Here, we studied the modified herpes simplex virus HSV1716 ( ... ...

    Abstract Multiple myeloma remains largely incurable due to refractory disease; therefore, novel treatment strategies that are safe and well-tolerated are required. Here, we studied the modified herpes simplex virus HSV1716 (SEPREHVIR
    MeSH term(s) Humans ; Animals ; Mice ; Bortezomib/pharmacology ; Bortezomib/therapeutic use ; Multiple Myeloma/drug therapy ; Mice, Inbred C57BL ; Simplexvirus/genetics ; Annexins ; Cell Line, Tumor ; Apoptosis
    Chemical Substances Bortezomib (69G8BD63PP) ; Annexins
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15030603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.

    Georgiadi, Anastasia / Lopez-Salazar, Valeria / Merahbi, Rabih El- / Karikari, Rhoda Anane / Ma, Xiaochuan / Mourão, André / Klepac, Katarina / Bühler, Lea / Alfaro, Ana Jimena / Kaczmarek, Isabell / Linford, Adam / Bosma, Madeleen / Shilkova, Olga / Ritvos, Olli / Nakamura, Nobuhiro / Hirose, Shigehisa / Lassi, Maximilian / Teperino, Raffaele / Machado, Juliano /
    Scheideler, Marcel / Dietrich, Arne / Geerlof, Arie / Feuchtinger, Annette / Blutke, Andreas / Fischer, Katrin / Müller, Timo Dirk / Kessler, Katharina / Schöneberg, Torsten / Thor, Doreen / Hornemann, Silke / Kruse, Michael / Nawroth, Peter / Pivovarova-Ramich, Olga / Pfeiffer, Andreas Friedrich Hermann / Sattler, Michael / Blüher, Matthias / Herzig, Stephan

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 2999

    Abstract: The proper functional interaction between different tissues represents a key component in systemic metabolic control. Indeed, disruption of endocrine inter-tissue communication is a hallmark of severe metabolic dysfunction in obesity and diabetes. Here, ... ...

    Abstract The proper functional interaction between different tissues represents a key component in systemic metabolic control. Indeed, disruption of endocrine inter-tissue communication is a hallmark of severe metabolic dysfunction in obesity and diabetes. Here, we show that the FNDC4-GPR116, liver-white adipose tissue endocrine axis controls glucose homeostasis. We found that the liver primarily controlled the circulating levels of soluble FNDC4 (sFNDC4) and lowering of the hepatokine FNDC4 led to prediabetes in mice. Further, we identified the orphan adhesion GPCR GPR116 as a receptor of sFNDC4 in the white adipose tissue. Upon direct and high affinity binding of sFNDC4 to GPR116, sFNDC4 promoted insulin signaling and insulin-mediated glucose uptake in white adipocytes. Indeed, supplementation with FcsFNDC4 in prediabetic mice improved glucose tolerance and inflammatory markers in a white-adipocyte selective and GPR116-dependent manner. Of note, the sFNDC4-GPR116, liver-adipose tissue axis was dampened in (pre) diabetic human patients. Thus our findings will now allow for harnessing this endocrine circuit for alternative therapeutic strategies in obesity-related pre-diabetes.
    MeSH term(s) 3T3-L1 Cells ; Adipocytes/metabolism ; Adipose Tissue, White/cytology ; Adipose Tissue, White/metabolism ; Adolescent ; Adult ; Aged ; Animals ; CHO Cells ; Cohort Studies ; Cricetulus ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/prevention & control ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Female ; Gene Knockdown Techniques ; Glucose/metabolism ; HEK293 Cells ; Hep G2 Cells ; Humans ; Insulin/metabolism ; Insulin Resistance ; Islets of Langerhans/metabolism ; Liver/metabolism ; Male ; Membrane Proteins/administration & dosage ; Membrane Proteins/blood ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; Middle Aged ; NIH 3T3 Cells ; Prediabetic State/blood ; Prediabetic State/drug therapy ; Prediabetic State/etiology ; Prediabetic State/metabolism ; Primary Cell Culture ; Proteins/analysis ; Proteins/metabolism ; Receptors, G-Protein-Coupled/blood ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/isolation & purification ; Young Adult
    Chemical Substances ADGRF5 protein, human ; FNDC4 protein, human ; Frcp1 protein, mouse ; Gpr116 protein, mouse ; Insulin ; Membrane Proteins ; Proteins ; Receptors, G-Protein-Coupled ; Recombinant Fusion Proteins ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-22579-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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