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  1. AU="Ling, Xiaocui"
  2. AU="Chiu, I"
  3. AU="Bergsma, Tessa"
  4. AU="Nicitra, Emanuele"
  5. AU=Strauss Eric J AU=Strauss Eric J
  6. AU="Andy C. Y. Tse"
  7. AU=Diel J
  8. AU="Teper, Alejandro"
  9. AU="Daniel Cisterna"
  10. AU="Barré-Sinoussi, Françoise"
  11. AU="Siracusa, Massimiliano"
  12. AU="Mishra, Vipin Kumar"
  13. AU=Martinez Victor D.
  14. AU="Seol, Myung Do"
  15. AU="Sato, Keiyu"
  16. AU="Go, Ji Young"
  17. AU="Zhao, Bingjian"
  18. AU="Ringeisen, Bradley R"
  19. AU=Sciascia Savino
  20. AU="Capito, Carmen"
  21. AU=Osman Mahasin

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  1. Artikel ; Online: D-Xylose Blocks the Broad Negative Regulation of XylR on Lipid Metabolism and Affects Multiple Physiological Characteristics in Mycobacteria.

    Wang, Kun / Cui, Xujie / Ling, Xiaocui / Chen, Jiarui / Zheng, Jiachen / Xiang, Yuling / Li, Weihui

    International journal of molecular sciences

    2023  Band 24, Heft 8

    Abstract: D-xylose is the most abundant fermentable pentose, which usually represents an architectural component of the bacterial cell wall. However, its regulatory function and the involved signaling pathway in bacteria remain largely unclear. Here, we show that ... ...

    Abstract D-xylose is the most abundant fermentable pentose, which usually represents an architectural component of the bacterial cell wall. However, its regulatory function and the involved signaling pathway in bacteria remain largely unclear. Here, we show that D-xylose can act as a signaling molecule to regulate the lipid metabolism and affect multiple physiological characteristics in mycobacteria. D-xylose directly interacts with XylR and inhibits its DNA-binding ability, thus blocking XylR-mediated repression. The xylose inhibitor, XylR, plays a global regulatory role and affects the expression of 166 mycobacterial genes that are involved in lipid synthesis and metabolism. Furthermore, we show that the xylose-dependent gene regulation of XylR affects the multiple physiological characteristics of
    Mesh-Begriff(e) Xylose/metabolism ; Transcription Factors/metabolism ; Lipid Metabolism ; Pentoses ; Mycobacterium smegmatis/genetics ; Mycobacterium smegmatis/metabolism ; Gene Expression Regulation, Bacterial ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemische Substanzen Xylose (A1TA934AKO) ; Transcription Factors ; Pentoses ; Bacterial Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-04-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087086
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria.

    Ling, Xiaocui / Liu, Xiao / Wang, Kun / Guo, Minhao / Ou, Yanzhe / Li, Danting / Xiang, Yulin / Zheng, Jiachen / Hu, Lihua / Zhang, Hongyun / Li, Weihui

    Nature communications

    2024  Band 15, Heft 1, Seite(n) 695

    Abstract: Cyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation in mycobacteria in a manner dependent on the ... ...

    Abstract Cyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation in mycobacteria in a manner dependent on the nucleoid-associated protein Lsr2. We show that c-di-GMP specifically binds to Lsr2 at a ratio of 1:1. Lsr2 upregulates the expression of HadD, a (3R)-hydroxyacyl-ACP dehydratase, thus promoting the synthesis of keto-mycolic acid and biofilm formation. Thus, Lsr2 acts as a c-di-GMP receptor that links the second messenger's function to lipid synthesis and biofilm formation in mycobacteria.
    Mesh-Begriff(e) Mycolic Acids ; Adipogenesis ; Mycobacterium ; Keto Acids ; Biofilms ; Cyclic GMP/analogs & derivatives
    Chemische Substanzen bis(3',5')-cyclic diguanylic acid (61093-23-0) ; Mycolic Acids ; Keto Acids ; Cyclic GMP (H2D2X058MU)
    Sprache Englisch
    Erscheinungsdatum 2024-01-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44774-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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