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Article ; Online: Misdiagnosis features of ancient clinical records based on apriori algorithm

Ling Yu

Chinese Medicine and Culture, Vol 3, Iss 1, Pp 50-

2020 Volume 53

Abstract: Objective: To analyze misdiagnosis features in clinical cases of “Classified Medical Cases of Famous Physicians” and “Supplement to Classified Case Records of Celebrated Physicians.” Materials and Methods: Two hundred and five ancient misdiagnosed cases ... ...

Abstract	Objective: To analyze misdiagnosis features in clinical cases of “Classified Medical Cases of Famous Physicians” and “Supplement to Classified Case Records of Celebrated Physicians.” Materials and Methods: Two hundred and five ancient misdiagnosed cases were analyzed in aspects of locations (exterior-interior type, qi-blood type and Zang-Fu organs type) and patterns (heat-cold type and deficiency-excess type) by Apriori Algorithm Method. Results: The main types of misdiagnosis in those medical casesare as follows:: Zang-Fu location misjudgment, misjudging the interior as the exterior, misjudging deficiency pattern as excess pattern, and misjudging cold pattern as heat pattern. Among them, the most outstanding type is the misjudgment of deficiency–cold pattern as excess–heat pattern. Conclusions: (1) Accurate judgment of location and differentiation of deficiency and excess patterns are the key points in diagnosing the diseases correctly. The confusion of true deficiency–cold and pseudo-excess–heat pattern should be taken seriously. (2) Data mining on ancient clinical cases offers a new methodology for assisting clinical diagnosis of traditional Chinese medicine.
Keywords	ancient clinical cases ; apriori algorithm ; classified medical cases of famous physicians ; data mining ; misdiagnosis features ; supplement to classified case records of celebrated physicians ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Health/LWW
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Predicate Types on the Production of Copula "

Guo, Ling-Yu / Weiler, Brian

Journal of speech, language, and hearing research : JSLHR

2023 Volume 66, Issue 5, Page(s) 1792–1801

Abstract: Purpose: Prior work has shown that subject types affected the production of copula BE in young children who spoke General American English (GAE). However, the role of predicate types on the production of copula BE remains unclear. This study examined ... ...

Abstract	Purpose: Prior work has shown that subject types affected the production of copula BE in young children who spoke General American English (GAE). However, the role of predicate types on the production of copula BE remains unclear. This study examined how predicate types affected the production of copula " Method: Seventeen 2-year-old children with typical language development who spoke GAE were included in this study. Children's production rate of copula " Results: Two-year-old children who spoke GAE were more likely to repeat copula " Conclusions: Overall, locative predicates are the least facilitative for the production of copula " Supplemental material: https://doi.org/10.23641/asha.22630726.
MeSH term(s)	Humans ; Animals ; Dogs ; Language ; Language Development ; Language Tests
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1364086-0
ISSN	1558-9102 ; 1092-4388
ISSN (online)	1558-9102
ISSN	1092-4388
DOI	10.1044/2023_JSLHR-22-00479
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Article ; Online: Far-infrared stimulation of Neiguan acupoints improves heart rate variability and ameliorate fatigue in hemodialysis patients: A randomized trial.

Liao, Ling-Yu / Chien, Li-Wei / Liu, Chi-Feng

Journal of the Chinese Medical Association : JCMA

2024 Volume 87, Issue 3, Page(s) 340–345

Abstract: Background: In 2018, 84 615 patients in Taiwan received hemodialysis, of which about 62% to 97% suffered from fatigue. Fatigue caused by hemodialysis may be mental or physical. However, the detailed mechanism remains unclear. This study aimed to ... ...

Abstract	Background: In 2018, 84 615 patients in Taiwan received hemodialysis, of which about 62% to 97% suffered from fatigue. Fatigue caused by hemodialysis may be mental or physical. However, the detailed mechanism remains unclear. This study aimed to evaluate whether far-infrared stimulation of the Neiguan acupoint (P6) could effectively reduce fatigue and improve heart rate variability (HRV) in hemodialysis patients. Methods: We conducted a two-arm, randomized trial in a hemodialysis center between March 2015 and March 2016. A total of 73 hemodialysis patients were included and were randomly assigned to an experimental group (n = 37) and a control group (n = 36). The experimental group received far-infrared radiation on Neiguan acupoint during hemodialysis for 12 weeks. The outcomes were fatigue level and HRV. Results: All patients showed moderate fatigue ( M = 26.00 ± 13.01, range = 0-78) at baseline. Far-infrared stimulation on Neiguan acupoint significantly reduced overall fatigue ( β = 24, p < 0.001) and improved HRV ( β = 74.36, p < 0.001). Compared to the control group, the experiment group had significantly reduced fatigue levels in all aspects such as reduced energy and motivation ( β = -2.97, p < 0.001), reduced physical strength ( β = -1.28, p < 0.01), reduced mental capability ( β = -2.38, p < 0.001), reduction in daily activities ( β = -1.48, p < 0.01), depressed mood and loss of control ( β = -1.21, p < 0.05) as well as increased autonomous nervous system activity ( β = 14.71, p < 0.01) in the third month of stimulation. Conclusion: Far-infrared stimulation of the Neiguan acupoints effectively reduces fatigue and increases autonomic nervous system activity in hemodialysis patients.
MeSH term(s)	Humans ; Heart Rate/physiology ; Acupuncture Points ; Renal Dialysis ; Fatigue/etiology ; Fatigue/therapy ; Taiwan
Language	English
Publishing date	2024-01-29
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000001060
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Article ; Online: Potential biomarkers of atopic dermatitis

Ling Yu / Linfeng Li

Frontiers in Medicine, Vol

2022 Volume 9

Abstract: Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease with a wide range of heterogeneity. Accurate biomarkers or predictors are the keys to instructing personalized tailored precise treatment. The development of technology such as ... ...

Abstract	Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease with a wide range of heterogeneity. Accurate biomarkers or predictors are the keys to instructing personalized tailored precise treatment. The development of technology such as transcriptomics, genomics, and proteomics provides novel insights into the possibility to find potential biomarkers. Meanwhile, emerging minimally invasive methods such as tape stripping were used to reveal different profiles of patients’ skin without biopsy. Several potential biomarkers or predictors have been found. In this review, we summarized the current development of potential biomarkers of AD. Nitric oxide synthase 2/inducible nitric oxide synthase (NOS2/iNOS), human beta-defensin-2 (hBD-2), and matrix metalloproteinases 8/9 (MMP8/9) may be the candidate biomarkers for AD diagnosis. Filaggrin (FLG) gene mutation increased the occurrence risk of AD. Fatty-acid-binding protein 5 (FABP5) may serve as an effective biomarker for the atopic march (AM). Squamous cell carcinoma antigen 2 (SCCA2), serum thymus and activation-regulated chemokine (TARC), cutaneous T-cell-attracting chemokine (CTACK), eosinophil-derived neurotoxin (EDN), macrophage-derived chemokine (MDC), lactate dehydrogenase (LDH), and interleukin (IL)-18 can be the candidate biomarkers for disease severity monitoring. IL-17, IL-23, IL-33, and indoleamine 2,3-dioxygenase (IDO1) can be used as predictive biomarkers for AD comorbidities. LDH, TARC, pulmonary and activation-regulated chemokine (PARC), periostin, IL-22, eotaxin-1/3, and IL-8 may be the candidate biomarkers for monitoring treatment effects. There are still unmet needs and a long way to go for more convenient, non-invasive, and effective predictors and biomarkers to better guide personalized precise treatment.
Keywords	atopic dermatitis ; biomarker ; predictor ; phenotype ; precise treatment ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism

Ling-Yu Tian / Daniel J. Smit / Manfred Jücker

International Journal of Molecular Sciences, Vol 24, Iss 2652, p

2023 Volume 2652

Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains unclearly described in HCC. The dysregulation of the PI3K/AKT/mTOR signaling ...

Abstract	Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains unclearly described in HCC. The dysregulation of the PI3K/AKT/mTOR signaling pathway is common in HCC and is, therefore, a topic of further research and the concern of developing a novel target for liver cancer therapy. In this review, we illustrate mechanisms by which this signaling network is accountable for regulating HCC cellular metabolism, including glucose metabolism, lipid metabolism, amino acid metabolism, pyrimidine metabolism, and oxidative metabolism, and summarize the ongoing clinical trials based on the inhibition of the PI3K/AKT/mTOR pathway in HCC.
Keywords	cancer therapy ; HCC treatment ; glucose metabolism ; lipid metabolism ; amino acid metabolism ; pyrimidine metabolism ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: An Improved Chinese Pause Fillers Prediction Module Based on RoBERTa

Ling Yu / Xiaoqun Zhou / Fanglin Niu

Applied Sciences, Vol 13, Iss 10652, p

2023 Volume 10652

Abstract: The prediction of pause fillers plays a crucial role in enhancing the naturalness of synthesized speech. In recent years, neural networks, including LSTM, BERT, and XLNet, have been employed for pause fillers prediction modules. However, these methods ... ...

Abstract	The prediction of pause fillers plays a crucial role in enhancing the naturalness of synthesized speech. In recent years, neural networks, including LSTM, BERT, and XLNet, have been employed for pause fillers prediction modules. However, these methods have exhibited relatively lower accuracy in predicting pause fillers. This paper introduces the utilization of the RoBERTa model for predicting Chinese pause fillers and presents a novel approach to training the RoBERTa model, effectively enhancing the accuracy of Chinese pause fillers prediction. Our proposed approach involves categorizing text from different speakers into four distinct style groups based on the frequency and position of Chinese pause fillers. The RoBERTa model is trained on these four groups of data, which incorporate different styles of fillers, thereby ensuring a more natural synthesis of speech. The Chinese pause fillers prediction module is evaluated on systems such as Parallel Tacotron2, FastPitch, and Deep Voice3, achieving a notable 26.7% improvement in word-level prediction accuracy compared to the BERT model, along with a 14% enhancement in position-level prediction accuracy. This substantial improvement results in a significant enhancement of the naturalness of the generated speech.
Keywords	RoBERTa ; naturalness of speech ; speech synthesis ; Chinese pause fillers ; prediction module ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	006
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [The Effect of Dry Care on the Time of Umbilical Cord Separation in Newborns: A Systematic Review and Meta-Analysis].

Hsieh, Ling-Yu / Chen, Pi-Hui

Hu li za zhi The journal of nursing

2022 Volume 69, Issue 4, Page(s) 64–75

Abstract: Background: There are many different approaches to umbilical cord care in clinical practice. Dry care is recommended by the WHO based on its ease of implementation and relatively low cost. However, the effect of dry care on the time of umbilical cord ... ...

Abstract	Background: There are many different approaches to umbilical cord care in clinical practice. Dry care is recommended by the WHO based on its ease of implementation and relatively low cost. However, the effect of dry care on the time of umbilical cord separation and related complications require further study. Purpose: The aim of this study was to conduct a systematic review and meta-analysis of randomized controlled trials to evaluate the effect of dry care on the time of umbilical cord separation and related adverse events in newborns. Methods: A literature search was conducted of articles published before December 2021 in the Cochrane Library, PubMed, Medline, CINAHL, Embase, Airiti Library, and National Digital Library of Theses in Taiwan databases. The research quality of the identified articles was assessed using the Modified Jadad Scale. Statistical analyses were performed using Review Manager, version 5.3, with statistics reported as mean differences with 95% confidence intervals. Results: Seven randomized controlled trials covering a total of 27,037 newborns were identified for analysis. Umbilical cord care in these studies included the following approaches: dry care, alcohol, chlorhexidine (CHX), mother's milk, and salicylic sugar powder (SSP). The results of the meta-analysis showed that umbilical cord separation time was significantly lower for the dry care approach compared to the alcohol approach (MD: -1.78 days, 95% CI: -2.4 to -1.16, three studies, n = 2,102) but not significantly different than the CHX approach (MD: -0.15 days, 95% CI [-1.99, 1.69], two studies, n = 10,519). Notably, the umbilical cord separation time for both mother's milk (MD: 1.19 days, 95% CI [0.82, 1.56], three studies, n = 730) and SSP (MD: 4.9 days, 95% CI [3.71, 6.09], one study, n = 92) approaches were reported as significantly less than the dry care approach. In addition, the CHX approach was associated with significantly fewer cord-related adverse events, while the alcohol, mother's milk, and SSP approaches were associated with rates of cord-related adverse advents similar to dry care. Conclusions / implications for practice: Because using dry care for umbilical cord care shortens the cord separation time compared to the alcohol approach and does not increase the incidence of omphalitis, this approach should be the first choice for cord care. Both mother's milk and SSP approaches are also associated with shorter umbilical cord separation times without adverse effects, and may be used as alternatives to dry care in umbilical cord care.
MeSH term(s)	Anti-Infective Agents, Local/pharmacology ; Chlorhexidine ; Humans ; Incidence ; Infant, Newborn ; Taiwan ; Umbilical Cord
Chemical Substances	Anti-Infective Agents, Local ; Chlorhexidine (R4KO0DY52L)
Language	Chinese
Publishing date	2022-07-25
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	0047-262X
ISSN	0047-262X
DOI	10.6224/JN.202208_69(4).09
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Article ; Online: Validating the Use of Percent Grammatical Utterances for Assessing Mandarin-Speaking Children's Grammatical Skill: Evidence From 3-Year-Olds.

Guo, Ling-Yu / Lee, Ping / Hsu, Hsin-Jen / Spencer, Linda

Journal of speech, language, and hearing research : JSLHR

2024 Volume 67, Issue 4, Page(s) 1173–1185

Abstract: Purpose: The study examined the use of percent grammatical utterances (PGUs) for assessing grammatical skills in Mandarin-speaking 3-year-old children.: Method: Participants were 30 Mandarin-speaking 3-year-olds with typical development. Language ... ...

Abstract	Purpose: The study examined the use of percent grammatical utterances (PGUs) for assessing grammatical skills in Mandarin-speaking 3-year-old children. Method: Participants were 30 Mandarin-speaking 3-year-olds with typical development. Language samples were collected in two visits for each child using a picture description task. Children were asked to talk about 16 pictures in response to questions and prompts at each visit. Pictures for the language sample collection were identical across the visits. PGUs were computed, and the grammatical errors that children produced in the task were coded and tallied for error types at each visit. Test-retest reliability, split-half reliability, and concurrent criterion validity of PGUs were evaluated. Results: The mean PGU level was approximately 78% at Visit 1 and 81% at Visit 2, both of which were significantly below the mastery level (i.e., 90%). The correlation coefficient for test-retest reliability of PGU was large ( Conclusion: The initial evidence from psychometric properties suggests that PGU computed from the picture description task is a reliable and valid measure for evaluating grammatical skills in Mandarin-speaking 3-year-old children. Supplemental material: https://doi.org/10.23641/asha.25395499.
MeSH term(s)	Humans ; Child, Preschool ; Child ; Reproducibility of Results ; Language Tests ; Language ; Child Language ; Language Development Disorders
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1364086-0
ISSN	1558-9102 ; 1092-4388
ISSN (online)	1558-9102
ISSN	1092-4388
DOI	10.1044/2024_JSLHR-23-00557
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Article ; Online: Study on the Exercise and Nutrition Intervention on Body Composition and Fitness of Female College Students with Invisible Obesity

Wei-wei Zhang / Ling Yu

E3S Web of Conferences, Vol 233, p

2021 Volume 02038

Abstract: To observe the effect of exercise intervention and nutrition health education on body composition and fitness of female college students with invisible obesity. 60 female college students with invisible obesity were randomly divided into three groups: ... ...

Abstract	To observe the effect of exercise intervention and nutrition health education on body composition and fitness of female college students with invisible obesity. 60 female college students with invisible obesity were randomly divided into three groups: control group, exercise intervention group and exercise + nutrition health education group. The control group had normal study and life; the exercise intervention group used aerobic exercise and resistance exercise to carry out collective exercise prescription exercise and individual contract exercise; the exercise intervention + nutrition health education group carried out nutrition health education on the basis of exercise intervention. Before the experiment, the three groups of female college students were homogenous (P > 0.05); after 16 weeks of the experiment, the body composition and fitness of the exercise intervention group and the exercise intervention + nutrition and health education group were significantly higher than that before the experiment, among which there were significant differences in BMI, BF%, VFI, vital capacity, 800m, sit forward flexion and sit up indexes (P < 0.05); after 8 weeks of training, the exercise intervention group was significantly higher than that before the experiment (P < 0.05) The BMI, BF% and VFI of the exercise intervention + nutrition health education group continued to decrease (P < 0.05). The combination of aerobic exercise and resistance exercise can reduce the body composition and improve the fitness level of female college students with recessive obesity. The effect of combined intervention of nutrition and health education on the basis of exercise intervention is better than that of single exercise intervention, and it can promote students to form the concept of reasonable nutrition and exercise actively. It is suggested that the correct nutrition concept and active exercise of the recessive obese college students can reduce the body composition and improve the fitness level of the recessive obese female ...
Keywords	Environmental sciences ; GE1-350
Subject code	796
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Prescription of Traditional Sports Regimen on Depression of College Students

Ling Yu / Jun-mei Xia

E3S Web of Conferences, Vol 233, p

2021 Volume 02011

Abstract: To explore the effect of prescription of traditional sports regimen with different amounts of exercise on improving depression and sleep quality of college students. Depression Screening Scale (PHQ-9) and Zung’s Self-rating Depression Scale (SDS) were ... ...

Abstract	To explore the effect of prescription of traditional sports regimen with different amounts of exercise on improving depression and sleep quality of college students. Depression Screening Scale (PHQ-9) and Zung’s Self-rating Depression Scale (SDS) were used to screen students with mild depression, who were randomly divided into control group, experimental group 1 (moderate exercise intensity, 30min each time, 5 times a week,) and experimental group 2 (moderate exercise intensity, 60min each time, 5 times a week). The exercise prescription intervention with different exercise amount was performed for 16 weeks. Compared with before exercise, the total scores of SDS and PSQI of the two experimental groups decreased significantly after 8 weeks of intervention; after 16 weeks of intervention, the total scores of SDS and PSQI of the experimental groups were obviously different (P < 0.05) compared with 8 weeks of intervention; after 8 weeks of training cessation, the total scores of SDS and PSQI of the experimental groups were increased, but however, significant decrease in the total scores still can be seen compared with those before the experiment(P<0.05). Compared with the control group, after 8 weeks of intervention, 16 weeks of intervention and 8 weeks of training cessation, the total scores of SDS and PSQI of the two experimental groups were significantly reduced and the effect of experimental group 2 on improving PSQI score of college students was significantly better than that of experimental group 1.Traditional sports regimen intervention can improve college students’ depression and improve their sleep quality, and it can still maintain the effect after stopping training for 8 weeks; exercise intervention of 60 minutes each time, 5 times a week, has better effect on improving college students’ sleep quality than that of 30 minutes each time, 5 times a week.
Keywords	Environmental sciences ; GE1-350
Subject code	796
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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