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Article ; Online: Evaluation framework for multi-scale ecological infrastructure construction benefits based on nature-based solutions

Lingyu Liu / Longyu Shi / Meng Yang / Fengmei Yang / Ting Lan

Ecological Indicators, Vol 158, Iss , Pp 111609- (2024)

A case study of Guangdong-Hong Kong-Macao Greater Bay Area

2024

Abstract: Spatially, ecological infrastructure (EI) is a multi-scale and cross-level ecological network promoting sustainable urban development. Due to the distinct features of different scales, researchers have emphasized the importance of the multi-scale EI ... ...

Abstract	Spatially, ecological infrastructure (EI) is a multi-scale and cross-level ecological network promoting sustainable urban development. Due to the distinct features of different scales, researchers have emphasized the importance of the multi-scale EI construction, which calls for support from a framework for scientific evaluation. Thus, based on the nature-based solutions (NbS) criteria, this study proposes a multi-scale EI construction benefits (MECBs-NbS) evaluation framework with scale differences and chooses the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) as a case study. The results show that: (1) the MECBs-NbS evaluation framework is fairly applicable; (2) in 2020, the ecological benefits of EI construction for building ecological security patterns at the macro-scale (GBA urban agglomeration) by around 203.63 billion RMB; for improving human-nature harmony, the ecological, physical, and social benefits of EI construction at the meso-scale (Huizhou city) were about 358.50 billion RMB; while the EI construction benefit of completing engineering tasks at micro-scale (site) was about 34.85 million RMB; (3) overall, with the built-up area as the center, as scale decreased, the EI construction benefits gradually changed from being dominated by ecological benefits to being dominated by social benefits; (4) by supporting the status quo analysis before construction and the benefit assessment following construction, this evaluation framework may not only support the planning, design and management of EI, but also serve as a crucial tool to encourage public participation and evaluate the performance of government work. This study aims to provide a new perspective on the multi-scale evaluation of EI construction that will support and improve urban resilience.
Keywords	Ecological infrastructure ; Multi-scale benefits evaluation ; Guangdong-Hong Kong-Macao Greater Bay Area ; Ecosystem services ; Nature-based solutions ; Ecology ; QH540-549.5
Subject code	690
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Concomitant transverse myelitis and Guillain-Barré syndrome following varicella-zoster virus infection

Danmei Lan / Lingyu Liu / Yanjie Yin

Chinese Medical Journal, Vol 136, Iss 10, Pp 1256-

2023 Volume 1257

Keywords	Medicine ; R
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Altered glycosylation profiles of serum IgG in Takayasu arteritis

Lingyu Liu / Jing Li / Yunjiao Yang / Chaojun Hu / Xinping Tian

European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract Background Takayasu arteritis (TAK) is an autoimmune inflammatory disorder with an undefined etiology. This study aimed to characterize the glycosylation profiles of serum immunoglobulin G (IgG) in patients with TAK. Methods Lectin microarrays ... ...

Abstract	Abstract Background Takayasu arteritis (TAK) is an autoimmune inflammatory disorder with an undefined etiology. This study aimed to characterize the glycosylation profiles of serum immunoglobulin G (IgG) in patients with TAK. Methods Lectin microarrays containing 56 types of lectins were used to detect the glycan levels of serum IgG in 164 patients with TAK, 128 patients with atherosclerosis used as disease controls (DCs), and 100 healthy controls (HCs). Differentially altered glycosylation patterns between TAK and control groups as well as between TAK subgroups were identified and further validated by lectin blot. The classification performance of the TAK-specific glycosylation change was measured by receiver-operating characteristic (ROC) curve analysis. Results Lectin microarray analysis revealed significantly increased N-Acetylgalactosamine (GalNAc) levels in the TAK group compared to the DC and HC groups (all p < 0.01). For TAK subgroups, significantly decreased mannosylation was observed in patients with active TAK compared to patients with inactive disease (p < 0.01). These differences were validated by lectin blot. In addition, GalNAc levels exhibited a considerable potential for discriminating patients with TAK from patients with atherosclerosis, with an area under the curve of 0.749 (p < 0.001), a sensitivity of 71.7%, and a specificity of 73.8%. Conclusions Serum IgG in patients with TAK displayed disease-specific glycosylation alterations. Aberrant GalNAc glycosylation showed substantial value as a diagnostic biomarker. The potential proinflammatory properties of the abnormal glycans may provide new insights into the role of humoral immunity in the pathogenesis of TAK.
Keywords	Takayasu arteritis ; Immunoglobulin G ; Glycosylation ; Lectin microarray ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Continuous Hydrothermal Flow Synthesis and Characterization of ZrO 2 Nanoparticles Doped with CeO 2 in Supercritical Water

Qingyun Li / Lingyu Liu / Zihua Wang / Xuezhong Wang

Nanomaterials, Vol 12, Iss 668, p

2022 Volume 668

Abstract: A confined jet mixing reactor operated in continuous hydrothermal flow synthesis was investigated for the synthesis of CeO 2 -ZrO 2 (CZ) nanoparticles. The obtained ultrafine powders were characterized using scanning electron microscopy–energy dispersive ...

Abstract	A confined jet mixing reactor operated in continuous hydrothermal flow synthesis was investigated for the synthesis of CeO 2 -ZrO 2 (CZ) nanoparticles. The obtained ultrafine powders were characterized using scanning electron microscopy–energy dispersive spectrometry (SEM-EDS), inductively coupled plasma–atomic emission spectroscopy (ICP-AES), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffraction analysis (XRD), transmission electron microscopy (TEM) coupled with selected area electron diffraction (SAED), a BET (Brunauer-Emmett-Teller)-specific surface area test and pore analysis, oxygen storage capacity (OSC) test, and a H 2 temperature programmed reduction (H 2 -TPR) test. The XRD results show that all samples were composed of high-purity cubic CZ nanoparticles. High resolution transmission electron microscope (HR-TEM) analysis showed that CZ nanoparticles with uniform size and shape distributions were obtained in this investigation. The d-spacing values, determined based on the TEM-selected area electron diffraction (SAED) patterns, were in good agreements with the reference data. BET results showed that the prepared CZ samples had large specific surface areas. Pore volume and size distribution were obtained by pore analysis. Oxygen pulse adsorption technology was used to test the oxygen storage capacity of the sample. The redox capacity of the CZ material was determined by a H 2 temperature-programmed reduction test.
Keywords	continuous hydrothermal flow synthesis ; confined jet mixing reactor ; CeO 2 -ZrO 2 nanoparticles ; XRD ; BET ; Chemistry ; QD1-999
Subject code	669
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phosphorylated signal transducer and activator of transcription proteins 1 in salivary glandular tissue

Bin Wang / Qing Zheng / Guixiu Shi / Yan He / Lingyu Liu / Mengqin Zhang

RMD Open, Vol 9, Iss

an important histological marker for diagnosis of primary Sjögren’s syndrome

2023 Volume 1

Abstract: Objectives The pathological diagnostic criteria for primary Sjögren’s syndrome (SjS) have certain limitations. We first explored the key pathogenic pathways of SjS through a bioinformatics approach, and then evaluated the diagnostic value of the ... ...

Abstract	Objectives The pathological diagnostic criteria for primary Sjögren’s syndrome (SjS) have certain limitations. We first explored the key pathogenic pathways of SjS through a bioinformatics approach, and then evaluated the diagnostic value of the important biomarker in SjS.Methods Transcriptome data from non-SjS controls and patients with SjS were analysed using integrated bioinformatics methods. In a case–control study, phosphorylated signal transducer and activator of transcription proteins 1 (p-STAT1), a key biomarker for the activation of interferon (IFN) pathway, was selected to evaluate its diagnostic value by immunohistochemical analyses in salivary gland (SG) tissues.Results The IFN-related pathways were aberrantly activated in patients with SjS. Positive staining of p-STAT1 was detected in the SjS group, but not in non-SjS control group. There was a significant difference in the integrated optical density values of p-STAT1 expressions between the controls and the SjS groups, as well as between the controls and the SjS lymphatic foci-negative groups (p<0.05). The area under the curve of the receiver operating characteristic curve for p-STAT1 was 0.990 (95% CI 0.969 to 1.000). There was a significant difference in both accuracy and sensitivity of p-STAT1 compared with the Focus Score (p<0.05). The Jorden index for p-STAT1 was 0.968 (95% CI 0.586 to 0.999).Conclusions The IFN pathway is the key pathogenic pathway in SjS. p-STAT1 may serve as an important biomarker, in addition to lymphocytic infiltration, to diagnose SjS. Particularly in SG samples with negative lymphatic foci, p-STAT1 confers pathological diagnostic value.
Keywords	Medicine ; R
Subject code	616
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Network Pharmacology, Molecular Docking and Molecular Dynamics to Explore the Potential Immunomodulatory Mechanisms of Deer Antler

Lingyu Liu / Yu Jiao / Mei Yang / Lei Wu / Guohui Long / Wei Hu

International Journal of Molecular Sciences, Vol 24, Iss 10370, p

2023 Volume 10370

Abstract: The use of deer antlers dates back thousands of years in Chinese history. Deer antlers have antitumor, anti-inflammatory, and immunomodulatory properties and can be used in treating neurological diseases. However, only a few studies have reported the ... ...

Abstract	The use of deer antlers dates back thousands of years in Chinese history. Deer antlers have antitumor, anti-inflammatory, and immunomodulatory properties and can be used in treating neurological diseases. However, only a few studies have reported the immunomodulatory mechanism of deer antler active compounds. Using network pharmacology, molecular docking, and molecular dynamics simulation techniques, we analyzed the underlying mechanism by which deer antlers regulate the immune response. We identified 4 substances and 130 core targets that may play immunomodulatory roles, and the beneficial and non-beneficial effects in the process of immune regulation were analyzed. The targets were enriched in pathways related to cancer, human cytomegalovirus infection, the PI3K-Akt signaling pathway, human T cell leukemia virus 1 infection, and lipids and atherosclerosis. Molecular docking showed that AKT1, MAPK3, and SRC have good binding activity with 17 beta estradiol and estrone. Additionally, the molecular dynamics simulation of the molecular docking result using GROMACS software (version: 2021.2) was performed and we found that the AKT1–estrone complex, 17 beta estradiol–AKT1 complex, estrone–MAPK3 complex, and 17 beta estradiol–MAPK3 complex had relatively good binding stability. Our research sheds light on the immunomodulatory mechanism of deer antlers and provides a theoretical foundation for further exploration of their active compounds.
Keywords	deer antler ; network pharmacology ; molecular docking ; molecular dynamics simulation ; immunomodulatory mechanisms ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571 ; 540
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pretreatment to terahertz absorption curves by narrow undulation constraint and Its quick implementation suggested by convex hull

Yizhang Li / Lingyu Liu / Ke Li / Zhongmin Wang / Tianying Chang / Wenqing Xu

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract In this work, a method of pretreating THz absorption curve is proposed, which leads to minimal range in absorption, reserving necessary undulation of curve for identification by convolutional neural network. The kernel thought of proposed method ...

Abstract	Abstract In this work, a method of pretreating THz absorption curve is proposed, which leads to minimal range in absorption, reserving necessary undulation of curve for identification by convolutional neural network. The kernel thought of proposed method is about confining the undulation of curve with a pair of narrow parallel lines and solving their optimal position by consecutively rotation of normalized curve at two fixed points. A fast algorithm is further proposed based on features of convex hull, whose procedure is described in detail. The algorithm involves definition of some important point sets, calculating and comparing slopes and determining best choice out of 4 potential rotations. The rationality of searching critical point is illustrated in a geometric way. Additionally, the adaption of the method is discussed and real examples are given to show the capacity of method to extract nonlinear information of a curve. The study suggests that methods regarding computer graphics also contributes to feature extraction with respect to THz curve and pattern recognition.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: How do construct a sponge city that can improve residents' satisfaction? Evidence from a suburb of Huizhou City, China

Meng Yang / Dingkai Chen / Longyu Shi / Ju He / Lingyu Liu / Xiaoqi Shang

Ecological Indicators, Vol 142, Iss , Pp 109238- (2022)

2022

Abstract: The construction of the sponge city can effectively alleviate the problems of urban waterlogging and pollution and promote the city's sustainable development. However, few studies on sponge city construction take into account both natural background ... ...

Abstract	The construction of the sponge city can effectively alleviate the problems of urban waterlogging and pollution and promote the city's sustainable development. However, few studies on sponge city construction take into account both natural background conditions and resident satisfaction. This study considers both physical and psychological benefits and presents a new integrated theoretical framework to improve urban runoff quality and the well-being of residents. The developed framework consists of two parts: sponge city control space identification and optimization design. The control space suitable for sponge city construction was identified, using the Eco-Importance-Resident Satisfaction Analysis (EIRSA) methodology, and the relationship between the basic needs of suburban residents and the current ecosystem service capacity was explored. The Multi-Criteria Decision Making (MCDM) method was used to optimize the design of the identified control space. The resident subjective visions and sponge city construction goals were used to determine the construction area and type of LID using GIS and the Storm Water Management Model (SWMM). The proposed framework was then applied to a suburb of Huizhou City, China, as a case study. This study analyzed the physical and psychological benefits of sponge city design schemes with different rainfall scenarios (S1, S2, S3, and S4) for the LID construction project. The results identified this scheme had met 90% or more of the region's volume capture ratio of annual rainfall constraints. Furthermore, >60% of the respondents were content with our planning scheme, with 21% being extremely satisfied, compared to only 2.1% satisfied, and 0.7% very satisfied. Considering the trade-off between ecological importance and resident satisfaction, it is a feasible strategy to build a sponge city that can improve residents' well-being in the future. The findings of this paper provide a detailed decision-making basis for the construction of sponge city in suburban areas.
Keywords	Sponge City ; Eco-Importance-Resident Satisfaction Analysis (EIRSA) ; Resident Satisfaction ; Multi-Criteria Decision Making (MCDM) Method ; Suburb ; Ecology ; QH540-549.5
Subject code	690
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of Industrial Urea Energy Consumption (EC) Based on Life Cycle Assessment (LCA)

Longyu Shi / Lingyu Liu / Bin Yang / Gonghan Sheng / Tong Xu

Sustainability, Vol 12, Iss 3793, p

2020 Volume 3793

Abstract: With the increasingly prominent environmental problems and the decline of fossil fuel reserves, the reduction of energy consumption (EC) has become a common goal in the world. Urea industry is a typical energy-intensive chemical industry. However, ... ...

Abstract	With the increasingly prominent environmental problems and the decline of fossil fuel reserves, the reduction of energy consumption (EC) has become a common goal in the world. Urea industry is a typical energy-intensive chemical industry. However, studies just focus on the breakthrough of specific production technology or only consider the EC in the production stage. This results in a lack of evaluations of the life cycle of energy consumption (LcEC). In order to provide a systematic, scientific, and practical theoretical basis for the industrial upgrading and the energy transformation, LcEC of urea production and the greenhouse gas (GHG) emissions generated in the process of EC are studied in this paper. The results show that the average LcEC is about 30.1 GJ/t urea. The EC of the materials preparation stage, synthesis stage, and waste-treatment stage (EC RMP , EC PP , EC WD ) is about 0.388 GJ/t urea, 24.8 GJ/t urea, and 4.92 GJ/t urea, accounting for 1.3%, 82.4%, and 16.3% of LcEC, respectively. Thus, the synthesis stage is a dominant energy-consumer, in which 15.4 GJ/t urea of energy, accounting for 62.0% of EC pp , supports steam consumption. According to the energy distribution analysis, it can be concluded that coal presents the primary energy in the process of urea production, which supports 94.4% of LcEC. The proportion of coal consumption is significantly higher than that of the average of 59% in China. Besides, the GHG emissions in the synthesis stage are obviously larger than that in the other stage, with an average of 2.18 t eq.CO 2 /t urea, accounting for 81.3% of the life cycle of GHG (LcGHG) emissions. In detail, CO 2 is the dominant factor accounting for 90.0% of LcGHG emissions, followed by CH 4 , while N 2 O is negligible. Coal is the primary source of CO 2 emissions. The severe high proportion of coal consumption in the life cycle of urea production is responsible for this high CO 2 content of GHG emissions. Therefore, for industrial urea upgrading and energy transformation, reducing coal ...
Keywords	energy consumption (EC) ; evaluation ; urea industry ; life cycle assessment (LCA) ; greenhouse gas (GHG) emissions ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	670
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells

Bing Huang / Weihao Zhao / Xue Cai / Yumin Zhu / Yingxian Lu / Junli Zhao / Nan Xiang / Xiaofei Wang / Hu Deng / Xiaping Tang / Lingyu Liu / Yanyu Zhao / Yigong Shi

International Journal of Molecular Sciences, Vol 24, Iss 11131, p

2023 Volume 11131

Abstract: The rapid growth of wireless electronic devices has raised concerns about the harmful effects of leaked electromagnetic radiation (EMR) on human health. Even though numerous studies have been carried out to explore the biological effects of EMR, no clear ...

Abstract	The rapid growth of wireless electronic devices has raised concerns about the harmful effects of leaked electromagnetic radiation (EMR) on human health. Even though numerous studies have been carried out to explore the biological effects of EMR, no clear conclusions have been drawn about the effect of radio frequency (RF) EMR on oligodendrocytes. To this end, we exposed oligodendroglia and three other types of brain cells to 2.4 GHz EMR for 6 or 48 h at an average input power of 1 W in either a continuous wave (CW-RF) or a pulse-modulated wave (PW-RF, 50 Hz pulse frequency, 1/3 duty cycle) pattern. RNA sequencing, RT-qPCR, and Western blot were used to examine the expression of C/EBPβ and its related genes. Multiple reaction monitoring (MRM) was used to examine the levels of expression of C/EBPβ-interacting proteins. Our results showed that PW-RF EMR significantly increased the mRNA level of C/EBPβ in oligodendroglia but not in other types of cells. In addition, the expression of three isoforms and several interacting proteins and targeted genes of C/EBPβ were markedly changed after 6-h PW-RF but not CW-RF. Our results indicated that RF EMR regulated the expression and functions of C/EBPβ in a waveform- and cell-type-dependent manner.
Keywords	radio frequency (RF) ; 2.4 GHz ; pulse modulated ; oligodendrocyte ; CCAAT/enhancer-binding protein β (C/EBPβ) ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	612
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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