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  1. Article ; Online: Fundamental energy cost of finite-time parallelizable computing.

    Konopik, Michael / Korten, Till / Lutz, Eric / Linke, Heiner

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 447

    Abstract: The fundamental energy cost of irreversible computing is given by the Landauer bound of [Formula: see text]/bit, where k is the Boltzmann constant and T is the temperature in Kelvin. However, this limit is only achievable for infinite-time processes. We ... ...

    Abstract The fundamental energy cost of irreversible computing is given by the Landauer bound of [Formula: see text]/bit, where k is the Boltzmann constant and T is the temperature in Kelvin. However, this limit is only achievable for infinite-time processes. We here determine the fundamental energy cost of finite-time parallelizable computing within the framework of nonequilibrium thermodynamics. We apply these results to quantify the energetic advantage of parallel computing over serial computing. We find that the energy cost per operation of a parallel computer can be kept close to the Landauer limit even for large problem sizes, whereas that of a serial computer fundamentally diverges. We analyze, in particular, the effects of different degrees of parallelization and amounts of overhead, as well as the influence of non-ideal electronic hardware. We further discuss their implications in the context of current technology. Our findings provide a physical basis for the design of energy-efficient computers.
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36020-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tuning up Maxwell's demon.

    Linke, Heiner / Parrondo, Juan M R

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 26

    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2108218118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fluorescence excitation enhancement by waveguiding nanowires.

    Unksov, Ivan N / Anttu, Nicklas / Verardo, Damiano / Höök, Fredrik / Prinz, Christelle N / Linke, Heiner

    Nanoscale advances

    2023  Volume 5, Issue 6, Page(s) 1760–1766

    Abstract: The optical properties of vertical semiconductor nanowires can allow an enhancement of fluorescence from surface-bound fluorophores, a feature proven useful in biosensing. One of the contributing factors to the fluorescence enhancement is thought to be ... ...

    Abstract The optical properties of vertical semiconductor nanowires can allow an enhancement of fluorescence from surface-bound fluorophores, a feature proven useful in biosensing. One of the contributing factors to the fluorescence enhancement is thought to be the local increase of the incident excitation light intensity in the vicinity of the nanowire surface, where fluorophores are located. However, this effect has not been experimentally studied in detail to date. Here, we quantify the excitation enhancement of fluorophores bound to a semiconductor nanowire surface by combining modelling with measurements of fluorescence photobleaching rate, indicative of the excitation light intensity, using epitaxially grown GaP nanowires. We study the excitation enhancement for nanowires with a diameter of 50-250 nm and show that excitation enhancement reaches a maximum for certain diameters, depending on the excitation wavelength. Furthermore, we find that the excitation enhancement decreases rapidly within tens of nanometers from the nanowire sidewall. The results can be used to design nanowire-based optical systems with exceptional sensitivities for bioanalytical applications.
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d2na00749e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Information-to-work conversion in single-molecule experiments: From discrete to continuous feedback.

    Schmitt, Regina K / Potts, Patrick P / Linke, Heiner / Johansson, Jonas / Samuelsson, Peter / Rico-Pasto, Marc / Ritort, Felix

    Physical review. E

    2023  Volume 107, Issue 5, Page(s) L052104

    Abstract: We theoretically investigate the extractable work in single molecule unfolding-folding experiments with applied feedback. Using a simple two-state model, we obtain a description of the full work distribution from discrete to continuous feedback. The ... ...

    Abstract We theoretically investigate the extractable work in single molecule unfolding-folding experiments with applied feedback. Using a simple two-state model, we obtain a description of the full work distribution from discrete to continuous feedback. The effect of the feedback is captured by a detailed fluctuation theorem, accounting for the information aquired. We find analytical expressions for the average work extraction as well as an experimentally measurable bound thereof, which becomes tight in the continuous feedback limit. We further determine the parameters for maximal power or rate of work extraction. Although our two-state model only depends on a single effective transition rate, we find qualitative agreement with Monte Carlo simulations of DNA hairpin unfolding-folding dynamics.
    MeSH term(s) Feedback ; Biophysical Phenomena ; Protein Folding ; Thermodynamics
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.107.L052104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biosensing using arrays of vertical semiconductor nanowires: mechanosensing and biomarker detection.

    Lard, Mercy / Linke, Heiner / Prinz, Christelle N

    Nanotechnology

    2019  Volume 30, Issue 21, Page(s) 214003

    Abstract: Due to their high aspect ratio and increased surface-to-foot-print area, arrays of vertical semiconductor nanowires are used in numerous biological applications, such as cell transfection and biosensing. Here we focus on two specific valuable biosensing ... ...

    Abstract Due to their high aspect ratio and increased surface-to-foot-print area, arrays of vertical semiconductor nanowires are used in numerous biological applications, such as cell transfection and biosensing. Here we focus on two specific valuable biosensing approaches that, so far, have received relatively limited attention in terms of their potential capabilities: cellular mechanosensing and lightguiding-induced enhanced fluorescence detection. Although proposed a decade ago, these two applications for using vertical nanowire arrays have only very recently achieved significant breakthroughs, both in terms of understanding their fundamental phenomena, and in the ease of their implementation. We review the status of the field in these areas and describe significant findings and potential future directions.
    MeSH term(s) Biomarkers/urine ; Biosensing Techniques ; Cell Line ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Humans ; Interleukin-8/urine ; Light ; MCF-7 Cells ; Mechanotransduction, Cellular/physiology ; Myosin Subfragments/chemistry ; Myosin Subfragments/metabolism ; Nanowires/chemistry ; Nanowires/ultrastructure ; Semiconductors ; Spectrometry, Fluorescence/methods ; Tumor Necrosis Factor-alpha/urine ; Xylella/cytology ; Xylella/physiology ; Zinc Oxide/chemistry
    Chemical Substances Biomarkers ; Interleukin-8 ; Myosin Subfragments ; Tumor Necrosis Factor-alpha ; Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2019-01-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ab0326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle.

    Korosec, Chapin S / Unksov, Ivan N / Surendiran, Pradheebha / Lyttleton, Roman / Curmi, Paul M G / Angstmann, Christopher N / Eichhorn, Ralf / Linke, Heiner / Forde, Nancy R

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1511

    Abstract: Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins - the building blocks selected by nature - to design autonomous motors has so far remained elusive. Here we report the ... ...

    Abstract Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins - the building blocks selected by nature - to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with proteases. Its "burnt-bridge" motion is directed by cleavage of a peptide lawn, promoting motion towards unvisited substrate. We find that Lawnmowers exhibit directional motion with average speeds of up to 80 nm/s, comparable to biological motors. By selectively patterning the peptide lawn on microfabricated tracks, we furthermore show that the Lawnmower is capable of track-guided motion. Our work opens an avenue towards nanotechnology applications of artificial protein motors.
    MeSH term(s) Nanotechnology ; Motion ; Molecular Motor Proteins/chemistry ; Peptides
    Chemical Substances Molecular Motor Proteins ; Peptides
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45570-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sub-Nanomolar Detection of Oligonucleotides Using Molecular Beacons Immobilized on Lightguiding Nanowires.

    Johansson, Therese B / Davtyan, Rubina / Valderas-Gutiérrez, Julia / Gonzalez Rodriguez, Adrian / Agnarsson, Björn / Munita, Roberto / Fioretos, Thoas / Lilljebjörn, Henrik / Linke, Heiner / Höök, Fredrik / Prinz, Christelle N

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 5

    Abstract: The detection of oligonucleotides is a central step in many biomedical investigations. The most commonly used methods for detecting oligonucleotides often require concentration and amplification before detection. Therefore, developing detection methods ... ...

    Abstract The detection of oligonucleotides is a central step in many biomedical investigations. The most commonly used methods for detecting oligonucleotides often require concentration and amplification before detection. Therefore, developing detection methods with a direct read-out would be beneficial. Although commonly used for the detection of amplified oligonucleotides, fluorescent molecular beacons have been proposed for such direct detection. However, the reported limits of detection using molecular beacons are relatively high, ranging from 100 nM to a few µM, primarily limited by the beacon fluorescence background. In this study, we enhanced the relative signal contrast between hybridized and non-hybridized states of the beacons by immobilizing them on lightguiding nanowires. Upon hybridization to a complementary oligonucleotide, the fluorescence from the surface-bound beacon becomes coupled in the lightguiding nanowire core and is re-emitted at the nanowire tip in a narrower cone of light compared with the standard 4π emission. Prior knowledge of the nanowire positions allows for the continuous monitoring of fluorescence signals from each nanowire, which effectively facilitates the discrimination of signals arising from hybridization events against background signals. This resulted in improved signal-to-background and signal-to-noise ratios, which allowed for the direct detection of oligonucleotides at a concentration as low as 0.1 nM.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14050453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Solving the subset sum problem with a nonideal biological computer

    Konopik, Michael / Korten, Till / Linke, Heiner / Lutz, Eric

    2021  

    Abstract: We consider the solution of the subset sum problem based on a parallel computer consisting of self-propelled biological agents moving in a nanostructured network that encodes the NP-complete task in its geometry. We develop an approximate analytical ... ...

    Abstract We consider the solution of the subset sum problem based on a parallel computer consisting of self-propelled biological agents moving in a nanostructured network that encodes the NP-complete task in its geometry. We develop an approximate analytical method to analyze the effects of small errors in the nonideal junctions composing the computing network by using a Gaussian confidence interval approximation of the multinomial distribution. We concretely evaluate the probability distribution for error-induced paths and determine the minimal number of agents required to obtain a proper solution. We finally validate our theoretical results with exact numerical simulations of the subset sum problem for different set sizes and error probabilities.
    Keywords Computer Science - Emerging Technologies ; Physics - Biological Physics
    Publishing date 2021-07-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Geometric symmetry breaking and nonlinearity can increase thermoelectric power

    Fast, Jonatan / Lundström, Hanna / Dorsch, Sven / Samuelson, Lars / Burke, Adam / Samuelsson, Peter / Linke, Heiner

    2023  

    Abstract: Direct thermal-to-electric energy converters typically operate in the linear regime, where the ratio of actual maximum power relative to the ideal maximum power, the so-called fill factor (FF), is 0.25. By increasing the FF one can potentially increase ... ...

    Abstract Direct thermal-to-electric energy converters typically operate in the linear regime, where the ratio of actual maximum power relative to the ideal maximum power, the so-called fill factor (FF), is 0.25. By increasing the FF one can potentially increase maximum power by up to four times, but this is only possible in the nonlinear regime of transport and has previously rarely been considered. Here we show, based on fundamental symmetry considerations, that the leading order non-linear terms that can increase the FF require devices with broken spatial symmetry. To experimentally demonstrate such a system, we study nonlinear, thermoelectric transport across an asymmetric energy barrier epitaxially defined in a single semiconductor nanowire. We find in both experiment and theory that we can increase the FF above the linear-response limit of 0.25, accompanied by a drastic increase in short circuit current, open-circuit voltage and maximum power. Our results show that geometric symmetry breaking combined with the design of nonlinear behaviour represent a design strategy for increasing the performance of thermal-to-electric energy converters such as in hot-carrier photovoltaics, thermophotovoltaics or in anisotropic thermoelectric materials.

    Comment: 11 pages, 3 figures. Submitted to Nature Physics
    Keywords Condensed Matter - Mesoscale and Nanoscale Physics
    Subject code 621
    Publishing date 2023-04-04
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Conference proceedings: Controlled nanoscale motion

    Linke, Heiner

    Nobel Symposium 131

    (Lecture notes in physics ; 711)

    2007  

    Institution Nobel Symposium
    Event/congress Nobel Symposium (131, 2005.06.13-17, BäckaskogSlott)
    Author's details Heiner Linke ... (eds.)
    Series title Lecture notes in physics ; 711
    Keywords Biological transport, Active ; Biological transport, Active/Regulation ; Nanotechnology ; Ultrastructure (Biology) ; Bewegung ; Nanometerbereich ; Molekularer Motor
    Language English
    Size XX, 409 S, Ill., graph. Darst, 24 cm
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 3540495215 ; 9783540495215
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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