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  1. Article ; Online: Pleiotropic role of NOTUM in colorectal cancer.

    van Driel, Milou S / Linssen, Jasmijn D G / van Neerven, Sanne M / Vermeulen, Louis

    Gut

    2023  Volume 72, Issue 12, Page(s) 2222–2223

    MeSH term(s) Humans ; Colorectal Neoplasms ; Adenocarcinoma
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-330807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Incidence, clinical management and prognosis of patients with small intestinal adenocarcinomas from 1999 through 2019: A nationwide Dutch cohort study.

    de Back, Tim R / Linssen, Jasmijn D G / van Erning, Felice N / Verbakel, Caitlin S E / Schafrat, Pascale J M / Vermeulen, Louis / de Hingh, Ignace / Sommeijer, Dirkje W

    European journal of cancer (Oxford, England : 1990)

    2024  Volume 199, Page(s) 113529

    Abstract: Background: Small intestinal adenocarcinomas (SIAs) are rare. Hence, randomized controlled trials are lacking and understanding of the disease features is limited. This nationwide cohort investigates incidence, treatment and prognosis of SIA patients, ... ...

    Abstract Background: Small intestinal adenocarcinomas (SIAs) are rare. Hence, randomized controlled trials are lacking and understanding of the disease features is limited. This nationwide cohort investigates incidence, treatment and prognosis of SIA patients, to improve disease outcome.
    Patients and methods: Data of 2697 SIA patients diagnosed from January 1999 through December 2019 were retrieved from the Netherlands Cancer Registry and Pathology Archive. Incidence was calculated using the revised European Standardized Rate. The influence of patient and tumor characteristics on overall survival (OS) was studied using survival analyses.
    Results: The age-standardized incidence rate almost doubled from 0.58 to 1.06 per 100,000 person-years, exclusively caused by an increase in duodenal adenocarcinomas. OS did not improve over time. Independent factors for a better OS were a younger age, jejunal tumors, Lynch syndrome and systemic therapy. Only 13.8% of resected patients was treated with adjuvant chemotherapy, which improved OS compared to surgery alone in stage III disease (HR 0.47 (0.35-0.61)), but not in the limited group of deficient mismatch repair (MMR) patients (n = 53, HR 0.93 (0.25-3.47)). In the first-line setting, CAPOX was associated with improved OS compared to FOLFOX (HR 0.51 (0.36-0.72)). For oligometastatic patients, a metastasectomy significantly improved OS (HR 0.54 (0.36-0.80)).
    Conclusions: The incidence of SIAs almost doubled in the past 20 years, with no improvement in OS. This retrospective non-randomized study suggests the use of adjuvant chemotherapy for stage III disease and first-line CAPOX for metastatic patients. For selected oligometastatic patients, a metastasectomy may be considered. MMR-status testing could aid in clinical decision-making.
    MeSH term(s) Humans ; Adenocarcinoma/therapy ; Adenocarcinoma/drug therapy ; Cohort Studies ; Incidence ; Jejunal Neoplasms/therapy ; Jejunal Neoplasms/drug therapy ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.113529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 583: Show issues

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  3. Article ; Online: The CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial.

    Linssen, Jasmijn D G / van Neerven, Sanne M / Aelvoet, Arthur S / Elbers, Clara C / Vermeulen, Louis / Dekker, Evelien

    BMC gastroenterology

    2022  Volume 22, Issue 1, Page(s) 383

    Abstract: Background: Familial adenomatous polyposis (FAP) is a rare autosomal dominant disease characterized by germline mutations in the Adenomatous Polyposis Coli (APC) gene, resulting in the development of numerous colorectal adenomas. As these patients have ... ...

    Abstract Background: Familial adenomatous polyposis (FAP) is a rare autosomal dominant disease characterized by germline mutations in the Adenomatous Polyposis Coli (APC) gene, resulting in the development of numerous colorectal adenomas. As these patients have a high risk of developing colorectal cancer (CRC), guidelines suggest prophylactic colectomy during early adulthood, however, adenoma development is still observed in the remaining intestinal tract. Therefore, FAP patients would benefit from chemoprevention strategies reducing the development of adenomas. Recent work in mice reveals a chemopreventive effect of lithium on the development of adenomas by inhibiting the expansion of Apc mutated intestinal stem cells (ISCs) within the crypts of normal intestinal mucosa. Here, we aim to investigate the effect of lithium on the spread of APC mutant cells within the human intestinal epithelium.
    Methods: This prospective phase II single arm trial has a duration of 18 months. FAP patients (18-35 years) with a genetically confirmed APC mutation who did not undergo colectomy will be treated with lithium carbonate orally achieving a serum level of 0.2-0.4 mmol/l between month 6 and 12. Colonoscopy with biopsies of normal intestinal mucosa will be performed at baseline and every six months. The primary endpoint is the effect of lithium on the spread of APC mutant cells within intestinal crypts over time by using APC specific marker NOTUM in situ hybridization. Secondary endpoints include change in adenoma burden, patient reported side effects and safety-outcomes. Total sample size is 12 patients and recruitment will take place in the Amsterdam UMC, location AMC in the Netherlands.
    Discussion: The outcome of this study will function as a proof-of-concept for the development of novel chemoprevention approaches that interfere with the competition between normal and mutant ISCs.
    Trial registration: ClinicalTrials.gov ( https://clinicaltrials.gov/ ): NCT05402891 (June 1, 2022) and the EU Clinical Trials Register: EuraCT 2022-000240-30 (January 1, 2022).
    MeSH term(s) Adenomatous Polyposis Coli/drug therapy ; Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/prevention & control ; Adenomatous Polyposis Coli Protein/genetics ; Adolescent ; Adult ; Clinical Trials, Phase II as Topic ; Genes, APC ; Humans ; Lithium/therapeutic use ; Prospective Studies ; Young Adult
    Chemical Substances Adenomatous Polyposis Coli Protein ; Lithium (9FN79X2M3F)
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-022-02442-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition.

    van Driel, Milou S / Linssen, Jasmijn D G / Flanagan, Dustin J / Vlahov, Nikola / Nijman, Lisanne E / de Groot, Nina E / Elbers, Clara C / Koster, Jan / Sansom, Owen J / Vermeulen, Louis / van Neerven, Sanne M

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 16, Issue 4, Page(s) 652–655

    MeSH term(s) Caffeine/pharmacology ; Clone Cells ; Intestines
    Chemical Substances Caffeine (3G6A5W338E)
    Language English
    Publishing date 2023-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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