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Article ; Online: Periventricular hemorrhagic infarction in preterm neonates: Etiology and time of development.

Ilves, N / Metsvaht, T / Laugesaar, R / Rull, K / Lintrop, M / Laan, M / Loorits, D / Kool, P / Ilves, P

2024 Volume 17, Issue 1, Page(s) 111–121

Abstract: Background: To find the obstetrical and delivery associated risk factors of antenatal and postnatal grade III intraventricular hemorrhage (IVH) or periventricular hemorrhagic infarction (PVHI) in preterm neonates.: Methods: A retrospective study of ... ...

Abstract	Background: To find the obstetrical and delivery associated risk factors of antenatal and postnatal grade III intraventricular hemorrhage (IVH) or periventricular hemorrhagic infarction (PVHI) in preterm neonates. Methods: A retrospective study of obstetric and delivery associated risk factors included neonates (<35 gestational weeks) with severe IVH/PVHI (n = 120) and a prospectively collected control group (n = 50). The children were divided into: (1) antenatal onset group (n = 27) with insult visible on cerebral ultrasonography within the first 12 hours of birth or periventricular cystic changes visible in PVHI within the first 3 days; (2) neonatal onset group (n = 70) with insult diagnosed after initial normal findings or I-II grade IVH, and (3) unknown time-onset group (n = 23) with insult visible at > 12 h of age. Results: The mothers of the antenatal onset group had significantly more bacterial infections before delivery compared to the neonatal onset group: 20/27 (74.1%) versus 23/69 (33.3%), (odds ratio (OR) 5.7 [95% confidence interval 2.1-16]; p = 0.0008) or compared to the control group (11/50 (22%); OR 11 [2.8-42]; p = 0.0005). Placental histology revealed chorioamnionitis more often in the antenatal compared to the neonatal onset group (14/21 (66.7%) versus 16/42 (38.1%), respectively; OR 3.7 [1.18-11]; p = 0.025). Neonates with neonatal development of severe IVH/PVHI had significantly more complications during delivery or intensive care. Conclusions: Bacterial infection during pregnancy is an important risk factor for development of antenatal onset severe IVH or PVHI. In neonates born to mothers with severe bacterial infection during pregnancy, cerebral ultrasonography is indicated for early detection of severe IVH or PVHI.
MeSH term(s)	Infant, Newborn ; Child ; Female ; Humans ; Pregnancy ; Retrospective Studies ; Gestational Age ; Placenta/pathology ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/epidemiology ; Cerebral Hemorrhage/etiology ; Infant, Newborn, Diseases ; Infarction/complications ; Infarction/pathology ; Bacterial Infections ; Infant, Premature, Diseases/diagnostic imaging ; Infant, Premature, Diseases/epidemiology ; Infant, Premature, Diseases/etiology
Language	English
Publishing date	2024-01-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2435387-5
ISSN	1878-4429 ; 1934-5798
ISSN (online)	1878-4429
ISSN	1934-5798
DOI	10.3233/NPM-230033
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sudan black poisoning resulted in methemoglobinemia in a baby with congenital chyloperitoneum.

Padari, Helgi / Kipper, Karin / Eelmäe, Imbi / Nerman, Jekaterina / Lintrop, Mare / Metsvaht, Tuuli

Clinical case reports

2024 Volume 12, Issue 4, Page(s) e8676

Abstract: Treatment of congenital chyloperitoneum is a challenge. Conservative methods may be ineffective. Preoperative visualization of the site of lymphatic leakage is crucial, but radiological imaging is technically complicated and may not provide sufficient ... ...

Abstract	Treatment of congenital chyloperitoneum is a challenge. Conservative methods may be ineffective. Preoperative visualization of the site of lymphatic leakage is crucial, but radiological imaging is technically complicated and may not provide sufficient information, especially in small patients. To ease the detection of lymphatic leakage during surgery, preoperative feeding with fat-rich formula with Sudan Black has been recommended. However, administration of Sudan Black may result in life-threatening methemoglobinemia and liver damage without any advantage of revealing leakage during surgery. We recommend preoperative feeding with pure fat-rich formula.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8676
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Article ; Online: New insights into the natural course of knee osteoarthritis: early regulation of cytokines and growth factors, with emphasis on sex-dependent angiogenesis and tissue remodeling. A pilot study.

Kisand, K / Tamm, A E / Lintrop, M / Tamm, A O

Osteoarthritis and cartilage

2018 Volume 26, Issue 8, Page(s) 1045–1054

Abstract: Objective: This study was conducted to identify cytokine profiles associated with radiographic phenotypes of knee osteoarthritis (rKOA) with a focus on early stage of the disease.: Methods: The pilot population study involved 60 middle-aged patients ( ...

Abstract	Objective: This study was conducted to identify cytokine profiles associated with radiographic phenotypes of knee osteoarthritis (rKOA) with a focus on early stage of the disease. Methods: The pilot population study involved 60 middle-aged patients (mean age 50 ± 7.3y.). Standardized weight-bearing anteroposterior and axial radiographs were used to assess rKOA severity in tibiofemoral (TFJ) of patellofemoral joint (PFJ) by grading system (grades 0-3). Luminex (xMAP Results: Several pathways of angiogenic (CXCL10/IP-10, FGF1/2, PDGF-AA/BB, ANG1, RANTES), tissue remodeling/fibrosis (MMP1/3, TIMP2/3/4, TGFβ), and fat tissue (leptin) BMs associated with rKOA severity already in very early phase (grade 1). We identified several sets of cytokines as key markers of early knee osteoarthritis (KOA) predicting radiographic features in logistic-regression models (AUC = 0.80-0.97). Marked sex-specificity of rKOA course was detected: upregulation of angiogenesis dominated in females, whereas the activation of tissue remodeling was dominant in males. Several of these shifts, e.g., decrease of CXCL10/IP-10, took place only in grade 1 KOA and disappeared or reversed in later stages. OA of different knee-joint compartments has distinct profiles of cytokines. A broad list of BMs (TIMP2/3/4, MMP1/3, TGFβ1/2, vWF-A2, sE-selectin and leptin) associated with OA in the PFJ. Conclusion: Our results demonstrate that substantial and time-limited shifts in the angiogenic and TIMP/MMP systems occur in the early stage of KOA. Our study findings highlight the sex-, grade- and compartment-dependent shifts in above processes. The data may contribute to the individualized prevention of KOA in the future.
MeSH term(s)	Biomarkers/metabolism ; Chemokine CXCL10/metabolism ; Chemokine CXCL10/physiology ; Cytokines/metabolism ; Cytokines/physiology ; Disease Progression ; Fibroblast Growth Factor 1/metabolism ; Fibroblast Growth Factor 1/physiology ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Intercellular Signaling Peptides and Proteins/physiology ; Matrix Metalloproteinase 1/metabolism ; Matrix Metalloproteinase 1/physiology ; Middle Aged ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Osteoarthritis, Knee/metabolism ; Osteoarthritis, Knee/pathology ; Pilot Projects ; Platelet-Derived Growth Factor/metabolism ; Platelet-Derived Growth Factor/physiology ; Sex Factors ; Tissue Inhibitor of Metalloproteinase-2/metabolism ; Tissue Inhibitor of Metalloproteinase-2/physiology ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta/physiology
Chemical Substances	Biomarkers ; CXCL10 protein, human ; Chemokine CXCL10 ; Cytokines ; Intercellular Signaling Peptides and Proteins ; Platelet-Derived Growth Factor ; TIMP2 protein, human ; Transforming Growth Factor beta ; platelet-derived growth factor A ; Fibroblast Growth Factor 1 (104781-85-3) ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; MMP1 protein, human (EC 3.4.24.7) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
Language	English
Publishing date	2018-05-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2018.05.009
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Article ; Online: Maternal Pyelonephritis as a Potential Cause of Perinatal Periventricular Venous Infarction in Term-Born Children.

Ilves, Norman / Laugesaar, Rael / Rull, Kristiina / Metsvaht, Tuuli / Lintrop, Mare / Laan, Maris / Loorits, Dagmar / Kool, Pille / Ilves, Pilvi

Journal of child neurology

2022 Volume 37, Issue 8-9, Page(s) 677–688

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Child ; Female ; Humans ; Infant, Newborn ; Infarction/epidemiology ; Infarction/etiology ; Pregnancy ; Prospective Studies ; Pyelonephritis/complications ; Pyelonephritis/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639288-x
ISSN	1708-8283 ; 0883-0738
ISSN (online)	1708-8283
ISSN	0883-0738
DOI	10.1177/08830738221109340
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Article ; Online: Diagnostic and prognostic value of bone biomarkers in progressive knee osteoarthritis: a 6-year follow-up study in middle-aged subjects.

Kumm, J / Tamm, A / Lintrop, M

Osteoarthritis and cartilage

2013 Volume 21, Issue 6, Page(s) 815–822

Abstract: Objective: To determine the value of bone markers in early-stage progressive knee osteoarthritis (OA), a population-based cohort of middle-aged subjects with chronic knee complaints was followed over 6 years (two consecutive two 3-year periods).: ... ...

Abstract	Objective: To determine the value of bone markers in early-stage progressive knee osteoarthritis (OA), a population-based cohort of middle-aged subjects with chronic knee complaints was followed over 6 years (two consecutive two 3-year periods). Methods: Tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects (mean age at baseline 45 ± 6.2 years) in 2002, 2005 and 2008. Bone formation was assessed by the serum concentration of procollagen type I amino-terminal propeptide (sPINP); bone resorption by the level of the C-terminal cross-linked telopeptides of type I collagen (sCTx-I); and bone mineralization by the values of osteocalcin (sOC) by electrochemiluminescence immunoassay. A novel marker of bone resorption, urinary osteocalcin midfragments (uMidOC), was assayed using enzyme linked immunosorbent assay (ELISA). Results: Several diagnostic associations were found between the bone markers (PINP, OC, MidOC) and progressive OA expressed by TF osteophytosis. The increasing output of MidOC demonstrated several-fold higher risk for progressive TF osteophytosis [odds ratio (OR) 5.32; 95% confidence interval (CI) 1.41-20.06, P = 0.014] than other bone markers. The values of PINP had prognostic value for subsequent more severely expressed knee OA progression [r(s) = 0.460, P = 0.005]. Conclusions: Bone metabolism is activated in early-stage knee OA. OA progression was preceded by the enhanced bone formation (by PINP) and accompanied by the activation of bone formation (by PINP), non-collagenous bone resorption (by MidOC), as well as by changes in mineralization (by OC). All three bone markers had diagnostic value, and one of them, PINP, had also a predictive value for knee OA progression, especially for progressive osteophytosis.
MeSH term(s)	Adult ; Biomarkers/metabolism ; Bone Resorption/metabolism ; Collagen Type I/blood ; Disease Progression ; Enzyme-Linked Immunosorbent Assay ; Follow-Up Studies ; Humans ; Middle Aged ; Osteoarthritis, Knee/metabolism ; Osteocalcin/metabolism ; Osteogenesis/physiology ; Peptide Fragments/blood ; Peptides/blood ; Procollagen/blood
Chemical Substances	Biomarkers ; Collagen Type I ; Peptide Fragments ; Peptides ; Procollagen ; collagen type I trimeric cross-linked peptide ; procollagen Type I N-terminal peptide ; Osteocalcin (104982-03-8)
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2013.03.008
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Article ; Online: The value of cartilage biomarkers in progressive knee osteoarthritis: cross-sectional and 6-year follow-up study in middle-aged subjects.

Kumm, Jaanika / Tamm, Ann / Lintrop, Mare / Tamm, Agu

Rheumatology international

2012 Volume 33, Issue 4, Page(s) 903–911

Abstract: To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) ...

Abstract	To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects (mean age at baseline, 45 ± 6.2 years) in 2002, 2005, and 2008. Cartilage degradation was assessed by urinary C-telopeptide fragments of type II collagen (uCTx-II), synthesis by serum type II A procollagen N-terminal propeptide (sPIIANP), and articular tissue turnover in general by cartilage oligomeric matrix protein (sCOMP). Several diagnostic associations were found between all studied biomarkers and progressive osteophytosis. COMP and CTx-II had a predictive value for subsequent progressive osteophytosis in multiple knee compartments and in case of CTx-II-also for progressive JSN. Over the first 3 years (2002-2005), significant associations were observed between COMP and progressive osteophytosis, whereas 3 years later (2005-2008) between CTx-II and progressive JSN. Thus, the associations between cartilage markers (COMP, CTx-II) and progression of radiographic OA features--osteophytes and JSN--were different between 2002-2005 and 2005-2008. Logistic regression revealed that for every unit increase in COMP level, there was 33 % higher risk for TF osteophyte progression. During early-stage OA, the presence and progression of osteophytosis is accompanied by increased level of cartilage biomarkers. This is the first study to demonstrate biochemical differences over the course of knee OA, illustrating a phasic nonpersistent character of OA with periods of progression and stabilization.
MeSH term(s)	Adult ; Biomarkers/urine ; Cartilage Oligomeric Matrix Protein ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/metabolism ; Collagen Type II/urine ; Cross-Sectional Studies ; Disease Progression ; Extracellular Matrix Proteins/urine ; Female ; Follow-Up Studies ; Glycoproteins/urine ; Humans ; Knee Joint/diagnostic imaging ; Knee Joint/metabolism ; Longitudinal Studies ; Male ; Matrilin Proteins ; Middle Aged ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/metabolism ; Osteoarthritis, Knee/urine ; Peptide Fragments/urine ; Procollagen/urine ; Prognosis ; Radiography
Chemical Substances	Biomarkers ; Cartilage Oligomeric Matrix Protein ; Collagen Type II ; Extracellular Matrix Proteins ; Glycoproteins ; Matrilin Proteins ; Peptide Fragments ; Procollagen ; TSP5 protein, human ; procollagen Type I N-terminal peptide
Language	English
Publishing date	2012-07-21
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-012-2463-8
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Article ; Online: The prevalence and progression of radiographic knee osteoarthritis over 6 years in a population-based cohort of middle-aged subjects.

Kumm, Jaanika / Tamm, Ann / Lintrop, Mare / Tamm, Agu

Rheumatology international

2011 Volume 32, Issue 11, Page(s) 3545–3550

Abstract: Details of the development of early knee osteoarthritis (OA) are largely unknown. The prevalence and progression of radiographic knee OA over 6 years in middle-aged subjects with chronic knee pain is investigated. In a prospective population-based study, ...

Abstract	Details of the development of early knee osteoarthritis (OA) are largely unknown. The prevalence and progression of radiographic knee OA over 6 years in middle-aged subjects with chronic knee pain is investigated. In a prospective population-based study, tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects (mean age 45 ± 6.2 years) for the presence of osteophytes and joint space narrowing (JSN). Radiographic progression was defined as: (i) the presence of osteophytes and/or JSN in subjects with no previous OA or (ii) an increase in the grade and/or number of already existing osteophytes and/or JSN. Altogether 56% (72/128) of subjects had knee OA, the majority of them was diagnosed with OA grade 1. In 57% of cases, radiographic OA was based on the presence of osteophytes alone versus 13% on JSN. More than 1/3 of subjects had isolated PF joint involvement. Knee OA progression rate over 6 years was 56% (71/128). During 6 years, a non-linear course of radiographic OA progression with intermittent periods of progression and stabilization was observed. Individual course of OA revealed distinct subsets of radiographic progression. Osteophytosis is an important early radiographic sign of OA and its progression. Isolated PF joint involvement is a frequent expression of knee OA. In middle-aged subjects, the progression rate of knee OA over 6 years was 56%. A non-linear course of radiographic OA progression was observed. Several radiographic subsets refer to the heterogeneity of the OA process.
MeSH term(s)	Adult ; Disease Progression ; Female ; Humans ; Knee Joint/diagnostic imaging ; Longitudinal Studies ; Male ; Middle Aged ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/epidemiology ; Osteophyte/diagnostic imaging ; Prevalence ; Prospective Studies ; Radiography
Language	English
Publishing date	2011-11-16
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-011-2221-3
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Article: Associations between cartilage oligomeric matrix protein and several articular tissues in early knee joint osteoarthritis.

Kumm, J / Tamm, A / Veske, K / Lintrop, M

Rheumatology (Oxford, England)

2006 Volume 45, Issue 10, Page(s) 1308–1309

MeSH term(s)	Adult ; Biomarkers/blood ; Cartilage Oligomeric Matrix Protein ; Cartilage, Articular/diagnostic imaging ; Cohort Studies ; Extracellular Matrix Proteins/blood ; Female ; Glycoproteins/blood ; Humans ; Knee Joint/diagnostic imaging ; Male ; Matrilin Proteins ; Middle Aged ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/diagnostic imaging ; Sex Factors ; Statistics, Nonparametric ; Synovial Membrane/diagnostic imaging ; Ultrasonography
Chemical Substances	Biomarkers ; Cartilage Oligomeric Matrix Protein ; Extracellular Matrix Proteins ; Glycoproteins ; Matrilin Proteins ; TSP5 protein, human
Language	English
Publishing date	2006-10
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kel271
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Article ; Online: Evaluation of correlation of articular cartilage staining for DDR2 and proteoglycans with histological tissue damage and the results of radiographic assessment in patients with early stages of knee osteoarthritis.

Suutre, Siim / Kerna, Irina / Lintrop, Mare / Tamm, Hannes / Aunapuu, Marina / Arend, Andres / Tamm, Agu

International journal of clinical and experimental pathology

2015 Volume 8, Issue 5, Page(s) 5658–5665

Abstract: Objective: To determine, if staining of articular cartilage for proteoglycans (natural element of healthy and functioning cartilage) and discoidin domain receptor 2 (DDR2) (a protein associated with articular cartilage degradation) is correlated with ... ...

Abstract	Objective: To determine, if staining of articular cartilage for proteoglycans (natural element of healthy and functioning cartilage) and discoidin domain receptor 2 (DDR2) (a protein associated with articular cartilage degradation) is correlated with histological tissue damage or radiographic assessment score in patients with early stages of knee osteoarthritis (OA). Method: 40 patients, with early stage OA were enrolled, from whom the biopsies for histological and immunohistochemical studies were obtained from edge of the femoral condyle during the arthroscopy. Semi-quantitative computer based analysis was used to evaluate the proportion of staining in histological sections. Results: No correlation was shown between the proportion of tissue stained for DDR2 and histological score or the results of radiographic assessment of tibiofemoral (TF) joint. There was a negative correlation between the proportion of tissue stained for DDR2 and radiographic grade of patellofemoral (PF) OA (Spearman r=-0.34; 95% CI -0.60 to -0.02; P=0.03). No correlation was shown between the proportion of tissue stained for proteoglycans and histological score or the results of radiographic assessment of TF and PF joints. A negative correlation was found between proportion of tissue stained for DDR2 and proteoglycans. Spearman r=-0.43; 95% CI=-0.66 to -0.12; P=0.006. Conclusion: Production of DDR2 in articular cartilage could be related to early stages of OA, as it is significantly correlated to decrease of staining for cartilage proteoglycans. The role of production of DDR2 in cartilage may be decreased in stages, where higher grades of OA are detected on the radiographs.
MeSH term(s)	Adult ; Arthroscopy ; Biomarkers/analysis ; Biopsy ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/enzymology ; Discoidin Domain Receptors ; Female ; Humans ; Immunohistochemistry ; Knee Joint/diagnostic imaging ; Knee Joint/enzymology ; Male ; Middle Aged ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/enzymology ; Predictive Value of Tests ; Prognosis ; Proteoglycans/analysis ; Radiography ; Receptor Protein-Tyrosine Kinases/analysis ; Receptors, Mitogen/analysis ; Severity of Illness Index ; Staining and Labeling
Chemical Substances	Biomarkers ; Proteoglycans ; Receptors, Mitogen ; Discoidin Domain Receptors (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2418306-4
ISSN	1936-2625 ; 1936-2625
ISSN (online)	1936-2625
ISSN	1936-2625
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Article ; Online: Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort.

Kerna, I / Kisand, K / Tamm, A E / Lintrop, M / Veske, K / Tamm, A O

Osteoarthritis and cartilage

2009 Volume 17, Issue 8, Page(s) 1093–1098

Abstract: Objective: One of the recognized candidate genes of osteoarthritis (OA) is the ADAM metallopeptidase domain 12 (meltrin alpha) gene. We investigated the potential role of two single nucleotide polymorphisms (SNP) of the ADAM12 gene in susceptibility to ... ...

Abstract	Objective: One of the recognized candidate genes of osteoarthritis (OA) is the ADAM metallopeptidase domain 12 (meltrin alpha) gene. We investigated the potential role of two single nucleotide polymorphisms (SNP) of the ADAM12 gene in susceptibility to radiographic knee OA and its progression in an Estonian cohort. Methods: The rs3740199 and rs1871054 polymorphisms were genotyped according to restriction fragment polymorphism in a population-based cohort consisting of 189 subjects selected from the age group 32-55 years. The radiological features of OA were measured in the tibio- and patellofemoral joints (PFJ). The X-ray investigation was repeated 3 years later for estimation of OA progression. Results: We found statistically significant association between rs3740199 polymorphism and patellofemoral OA in male patients (P=0.014), genetic risk was mostly related to CC homozygosity. The same SNP also affected the presence of advanced grade (II+III) osteophytes in the whole group (P=0.042) and the occurrence of osteophytes on the patellar margins in the PFJ (P=0.046). In OA progression the most significant association was found between joint space narrowing of the tibiofemoral joint and rs3740199 SNP in women (P=0.018). The rs1871054 polymorphism was not related to OA susceptibility or to progression traits. In our study the haplotype GC (rs3740199/rs1871054) was associated with reduced risk for development of osteophytes in the PFJ (P=0.041). Conclusions: We conclude that rs3740199 polymorphism may affect occurrence of knee OA and its progression. We also hypothesize that the genetic contribution of ADAM12 to OA is remarkably gender-dependent and anatomical site-specific.
MeSH term(s)	ADAM Proteins/genetics ; ADAM12 Protein ; Adult ; Disease Progression ; Estonia ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Knee Joint/diagnostic imaging ; Male ; Membrane Proteins/genetics ; Middle Aged ; Mutation, Missense/genetics ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/genetics ; Pilot Projects ; Polymorphism, Single Nucleotide ; Radiography
Chemical Substances	Membrane Proteins ; ADAM Proteins (EC 3.4.24.-) ; ADAM12 Protein (EC 3.4.24.-) ; ADAM12 protein, human (EC 3.4.24.-)
Language	English
Publishing date	2009-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2009.02.006
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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito