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  1. Article ; Online: Providing take home naloxone needs to be improved to prevent opioid overdose deaths.

    Lintzeris, Nicholas

    The Medical journal of Australia

    2020  Volume 212, Issue 7, Page(s) 307–308

    MeSH term(s) Drug Overdose ; Humans ; Naloxone ; Narcotic Antagonists ; Nonprescription Drugs ; Pharmacies
    Chemical Substances Narcotic Antagonists ; Nonprescription Drugs ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2020-03-24
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The uptake of long-acting depot buprenorphine for treating opioid dependence in Australia, 2019-2022: longitudinal sales data analysis.

    Lintzeris, Nicholas / Hayes, Victoria / Dunlop, Adrian J

    The Medical journal of Australia

    2024  Volume 220, Issue 6, Page(s) 339–340

    MeSH term(s) Humans ; Buprenorphine/therapeutic use ; Opioid-Related Disorders/drug therapy ; Analgesics, Opioid/therapeutic use ; Australia/epidemiology ; Narcotic Antagonists/therapeutic use ; Opiate Substitution Treatment
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid ; Narcotic Antagonists
    Language English
    Publishing date 2024-03-04
    Publishing country Australia
    Document type Letter
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.52250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Feasibility and outcomes of a general practice and specialist alcohol and other drug collaborative care program in Sydney, Australia.

    Wilson, H H K / Schulz, M / Mills, L / Lintzeris, N

    Australian journal of primary health

    2022  Volume 28, Issue 2, Page(s) 158–163

    Abstract: Alcohol and other drug (AoD) use is an important health and community issue and may be positively affected by collaborative care programs between specialist AoD services and general practice. This paper describes the feasibility, model of care and ... ...

    Abstract Alcohol and other drug (AoD) use is an important health and community issue and may be positively affected by collaborative care programs between specialist AoD services and general practice. This paper describes the feasibility, model of care and patient outcomes of a pilot general practice and specialist AoD (GP-AoD) collaborative care program, in Sydney, Australia, based on usual care data, the minimum data set, service utilisation information and the Australian Treatment Outcome Profile (ATOP), a patient-reported outcome measure. There were 367 referrals to the collaborative care program. GPs referred 210 patients, whereas the AoD service referred 157 patients. Most GP referrals (91.9%) were for AoD problems, whereas nearly half the AoD service referrals were for other issues. The primary drugs of concern in the GP group were either opioids or non-opioids (mostly alcohol). The AoD service-referred patients were primarily using opioids. An ATOP was completed for 152 patients. At the time of referral, those in the GP-referred non-opioid group were significantly less likely to be abstinent, used their primary drug of concern more days and were more likely to be employed (all P  < 0.001). A second ATOP was completed for 93 patients. These data showed a significant improvement in the number of days the primary drug of concern was used (P  = 0.026) and trends towards abstinence, improved quality of life and physical and psychological well-being for patients in the program. There are few studies of GP-AoD collaborative care programs and nothing in the Australian context. This study suggests that GP-AoD collaborative care programs in Australia are feasible and improve drug use.
    MeSH term(s) Analgesics, Opioid ; Australia ; Feasibility Studies ; General Practice ; Humans ; Quality of Life ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2022-02-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2566332-X
    ISSN 1836-7399 ; 1448-7527
    ISSN (online) 1836-7399
    ISSN 1448-7527
    DOI 10.1071/PY20197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A systematic review on the effect of routine outcome monitoring and feedback on client outcomes in alcohol and other drug treatment.

    Cordony, India / Mills, Llewellyn / Mammen, Kristie / Lintzeris, Nicholas

    Drug and alcohol review

    2023  Volume 42, Issue 7, Page(s) 1701–1722

    Abstract: Issues: Routine outcome monitoring (ROM) involves regularly measuring clients' outcomes during treatment, which can then be fed back to clinicians and/or clients. In the mental health field, ROM and feedback have been shown to improve client outcomes; ... ...

    Abstract Issues: Routine outcome monitoring (ROM) involves regularly measuring clients' outcomes during treatment, which can then be fed back to clinicians and/or clients. In the mental health field, ROM and feedback have been shown to improve client outcomes; however, no systematic reviews have examined whether improvement is also seen in alcohol and other drug (AOD) treatment outcomes. This review examines whether feedback to clients and/or clinicians of ROM data in AOD treatment improves future client outcomes.
    Approach: This systematic review of papers identified in Medline, PsycInfo and Scopus examines the effect on client outcomes of feeding back ROM data to clinicians and/or clients in AOD treatment settings. Key client outcomes included substance use, treatment attendance and wellbeing measures.
    Key findings: Ten studies were included-five randomised controlled trials and five pre-post within-subjects designs. Six studies were deemed good- or fair-quality. Of these six, three provided feedback to clinicians only, one to clients only, and two to both clients and clinicians. Only one of the six found feedback was associated with significant reductions in substance use and only among off-track clients. Four of the six found feedback improved other outcomes, including treatment retention, global functioning, therapeutic alliance and mood symptoms.
    Conclusions: There may be some positive effects for clients of providing feedback to clients and/or clinicians; however, the small number of randomised trials and the heterogeneity of methods, outcome measures and findings, mean that firm conclusions cannot be drawn about the efficacy of feedback until larger randomised studies are conducted.
    MeSH term(s) Humans ; Feedback ; Mental Health ; Treatment Outcome ; Substance-Related Disorders/therapy ; Outcome Assessment, Health Care
    Language English
    Publishing date 2023-08-31
    Publishing country Australia
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1080442-0
    ISSN 1465-3362 ; 0959-5236
    ISSN (online) 1465-3362
    ISSN 0959-5236
    DOI 10.1111/dar.13742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The impact of changes in opioid dependency treatment upon COVID-19 transmission in Sydney, Australia: a retrospective longitudinal observational study.

    Trevitt, Benjamin T / Hayes, Victoria / Deacon, Rachel / Mills, Llewellyn / Demirkol, Apo / Lintzeris, Nicholas

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 349

    Abstract: Background: In April 2020, in response to the COVID-19 public health emergency, South Eastern Sydney Local Health District (SESLHD) Drug and Alcohol services modified their delivery of opioid dependency treatment (ODT) to reduce spread of COVID-19 and ... ...

    Abstract Background: In April 2020, in response to the COVID-19 public health emergency, South Eastern Sydney Local Health District (SESLHD) Drug and Alcohol services modified their delivery of opioid dependency treatment (ODT) to reduce spread of COVID-19 and maintain continuity of care by increasing use of takeaway doses (TADs), transferring clients to local community pharmacies for dosing and encouraging the use of long-acting depot buprenorphine (LADB) which enabled once a month dosing.
    Methods: This study was a retrospective longitudinal case-control study conducted from August 1st, to November 30th, 2021. Eligible clients were those admitted for treatment with SESLHD ODT Services prior to August 1st,2021 and who remained in treatment beyond November 30th, 2021. COVID-19 diagnoses were determined by a COVID-19 PCR and extracted from the electronic Medical Records (eMR) Discern Reporting Portal. Demographic, clinical and dosing related data were collected from eMR and the Australian Immunisation Register (AIR).
    Results: Clients attending SESLHD ODT services had significantly greater odds of acquiring COVID-19 than the NSW adult population at large (OR: 13.63, 95%CI: 9.64,18.88). Additionally, amongst SESLHD ODT clients, being of Aboriginal and Torres Strait Islander origin was associated with greater odds of acquiring COVID-19 (OR = 2.18, CI: 1.05,4.53); whilst being employed (OR = 0.06, CI:0.01,0.46), receiving doses at pharmacy (OR = 0.43, CI: 0.21,0.89), and being vaccinated (OR = 0.12, CI: 0.06,0.26) were associated with lower odds. Every additional day of attendance required for dosing was associated with a 5% increase in odds of acquiring COVID-19 (OR = 1.05, CI: 1.02,1.08).
    Conclusions: Clients attending SESLHD ODT services are significantly more likely to acquire COVID-19 than the NSW population at large. Promoting vaccination uptake, transferring clients to pharmacy, and reducing the frequency of dosing (by use of takeaway doses or long-acting depot buprenorphine) are all potential methods to reduce this risk.
    MeSH term(s) Adult ; Humans ; Australia/epidemiology ; Analgesics, Opioid/therapeutic use ; Retrospective Studies ; Case-Control Studies ; COVID-19/epidemiology ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Buprenorphine/therapeutic use
    Chemical Substances Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-17827-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Response to Steele and Acheson.

    Lintzeris, Nicholas / Jansen, Louisa / Hayes, Victoria

    Drug and alcohol review

    2022  Volume 41, Issue 5, Page(s) 1023–1024

    MeSH term(s) Humans ; Public Health
    Language English
    Publishing date 2022-05-10
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1080442-0
    ISSN 1465-3362 ; 0959-5236
    ISSN (online) 1465-3362
    ISSN 0959-5236
    DOI 10.1111/dar.13478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Effects of ascending buprenorphine doses on measures of experimental pain: A pilot study.

    Nielsen, S / Rivas, C / Demirkol, A / Lintzeris, N

    Journal of substance abuse treatment

    2019  Volume 104, Page(s) 128–134

    Abstract: Background: Buprenorphine is widely used in the treatment of opioid use disorder and pain management. Little is known about the analgesic effects of high-dose sublingual buprenorphine, particularly in doses of >8 mg. The aim of this study was to examine ...

    Abstract Background: Buprenorphine is widely used in the treatment of opioid use disorder and pain management. Little is known about the analgesic effects of high-dose sublingual buprenorphine, particularly in doses of >8 mg. The aim of this study was to examine the effect of ascending doses of buprenorphine upon acute pain measures in patients stabilized on buprenorphine as treatment for opioid dependence.
    Methods: The pilot study (n = 7) was a randomised, controlled, double-blind, double-dummy, within-subject crossover study examining cold-pressor threshold and tolerance testing under different buprenorphine dose conditions. Each participant attended three sessions to test the analgesic effect of buprenorphine in their usual dose (100%), 150% and 200% of their usual daily dose.
    Results: No significant effects of increased dose were seen on experimental pain measures. Expected physiological effects on pupil size and pulse were observed with increasing dose. No effect of buprenorphine condition was seen on subjective ratings of drug strength, or self-reported sedation, though lower ratings drug liking were seen with 150% and 200% conditions, and lower ratings of 'bad effects' and intoxication were reported with the 200% buprenorphine dose condition. No safety concerns with the 150 and 200% buprenorphine dose condition were observed.
    Discussion: This pilot study suggests that a ceiling effect on analgesia may be observed in people maintained on buprenorphine, though larger studies may confirm this finding. Clinical Trial Number: ACTRN12614001038684.
    MeSH term(s) Acute Pain/drug therapy ; Administration, Sublingual ; Adult ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/pharmacology ; Buprenorphine/administration & dosage ; Buprenorphine/pharmacology ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Opiate Substitution Treatment/adverse effects ; Opioid-Related Disorders/drug therapy ; Pain Measurement ; Pilot Projects
    Chemical Substances Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2019-07-13
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 605923-5
    ISSN 1873-6483 ; 0740-5472
    ISSN (online) 1873-6483
    ISSN 0740-5472
    DOI 10.1016/j.jsat.2019.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Depot buprenorphine during COVID-19 in Australia: Opportunities and challenges.

    Arunogiri, Shalini / Lintzeris, Nicholas

    Journal of substance abuse treatment

    2020  Volume 124, Page(s) 108221

    Abstract: The COVID-19 pandemic has presented challenges for traditional models of opioid use disorder treatment worldwide. Depot buprenorphine became available in Australia shortly before the height of the COVID-19 pandemic. This timing provided us an opportunity ...

    Abstract The COVID-19 pandemic has presented challenges for traditional models of opioid use disorder treatment worldwide. Depot buprenorphine became available in Australia shortly before the height of the COVID-19 pandemic. This timing provided us an opportunity to examine the utilization and uptake of depot buprenorphine, and to understand the particular benefits and implementation challenges associated with this new formulation of opioid agonist treatment.
    MeSH term(s) Australia ; Buprenorphine/supply & distribution ; Buprenorphine/therapeutic use ; COVID-19/prevention & control ; Delayed-Action Preparations/therapeutic use ; Humans ; Injections, Subcutaneous ; Narcotic Antagonists/therapeutic use ; Opiate Substitution Treatment ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/rehabilitation ; Quarantine
    Chemical Substances Delayed-Action Preparations ; Narcotic Antagonists ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605923-5
    ISSN 1873-6483 ; 0740-5472
    ISSN (online) 1873-6483
    ISSN 0740-5472
    DOI 10.1016/j.jsat.2020.108221
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  9. Article ; Online: Clinical Case Conference: Strategies for Transferring From Methadone to Buprenorphine.

    Hill, Duncan / Hayes, Victoria / Demirkol, Apo / Lintzeris, Nicholas

    Journal of addiction medicine

    2021  Volume 16, Issue 2, Page(s) 152–156

    Abstract: The mainstay of treatment for opioid use disorder are medications, methadone (a full opioid agonist), or buprenorphine (a partial opioid agonist), in conjunction with psychosocial interventions. Both treatments are effective but safety, efficacy, and ... ...

    Abstract The mainstay of treatment for opioid use disorder are medications, methadone (a full opioid agonist), or buprenorphine (a partial opioid agonist), in conjunction with psychosocial interventions. Both treatments are effective but safety, efficacy, and patient preference can lead to a decision to change from one treatment to the other. Transfer from buprenorphine to methadone is not clinically challenging; however, changing from methadone to buprenorphine is more complex. Published reports describe varied approaches to manage this transfer to both minimize patient symptoms associated with withdrawal from methadone and reduce risk of precipitating withdrawal symptoms with introduction of the partial agonist buprenorphine [Lintzeris et al. J Addict Med. 2020; in press]. There is no single approach for methadone to buprenorphine that is superior to others and no approach that is suitable for all case presentations. This case conference describes three different approaches to achieve a successful methadone to buprenorphine transfer and provides commentary on how the case may be managed based on published transfer "strategies."
    MeSH term(s) Buprenorphine/therapeutic use ; Humans ; Methadone/therapeutic use ; Opioid-Related Disorders/complications ; Opioid-Related Disorders/drug therapy ; Patient Preference ; Substance Withdrawal Syndrome/complications ; Substance Withdrawal Syndrome/drug therapy
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2021-02-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1935-3227
    ISSN (online) 1935-3227
    DOI 10.1097/ADM.0000000000000854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Differences in prescribed medicinal cannabis use by cannabinoid product composition: Findings from the cannabis as medicine survey 2020 (CAMS-20) Australia-wide study.

    Trevitt, Benjamin T / Bailey, Sasha / Mills, Llewellyn / Arkell, Thomas R / Suraev, Anastasia / McGregor, Iain S / Lintzeris, Nicholas

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297092

    Abstract: Introduction: Prescribed medicinal cannabis (MC) is an increasingly common prescription in Australia for treating pain, anxiety, and sleep disorders. Prescribed MC products generally contain tetrahydrocannabinol (THC) and/or cannabidiol (CBD) in a ... ...

    Abstract Introduction: Prescribed medicinal cannabis (MC) is an increasingly common prescription in Australia for treating pain, anxiety, and sleep disorders. Prescribed MC products generally contain tetrahydrocannabinol (THC) and/or cannabidiol (CBD) in a variety of dose levels and forms. It is unclear whether THC and CBD products are used by patients with different characteristics and for different conditions.
    Objectives: To examine consumer experiences of using THC- and CBD-containing prescribed MC products to better understand how they are being used within the Australian context.
    Methods: We utilised data collected from an online anonymous cross-sectional survey of individuals (CAMS-20 survey), consisting of Australian residents using cannabis for therapeutic reasons. We focused on a subgroup of participants (N = 546) receiving prescribed MC products. We utilised linear, logistic, and multinomial regression modelling to analyse responses to survey questions based on the cannabinoid profile of the prescribed product.
    Results: Participants prescribed THC-dominant MC products were statistically more likely to be younger, male, and to prefer inhaled routes of administration than participants using CBD-dominant products who were older, female, and preferred oral routes of administration. Pain and mental health were the most common reasons for all types of prescribed MC, but were more likely to be treated with THC than CBD despite the significantly higher risk of mild to severe drowsiness, dry mouth and eye irritation. Consumer reported effectiveness of prescribed MC was very positive, particularly for THC-containing products. Consumers on opioids and antipsychotics were statistically more likely to be prescribed THC-containing products than products containing CBD only, despite the greater risk of impairment.
    Conclusions: This Australia-wide study found clear differences in consumer-reported experiences of prescribed THC- and CBD-containing products. Current prescriptions of these products do not always align with relevant clinical guidance. Educating prescribers around cannabinoid products is essential to ensure optimal prescribing practices and to prevent avoidable drug side effects and interactions.
    MeSH term(s) Humans ; Male ; Female ; Cannabinoids/adverse effects ; Cannabinoids/analysis ; Cannabis ; Medical Marijuana/adverse effects ; Cross-Sectional Studies ; Australia ; Hallucinogens ; Cannabidiol ; Pain/chemically induced ; Cannabinoid Receptor Agonists ; Dronabinol/adverse effects
    Chemical Substances Cannabinoids ; Medical Marijuana ; Hallucinogens ; Cannabidiol (19GBJ60SN5) ; Cannabinoid Receptor Agonists ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297092
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