Article ; Online: Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis.
Molecular cancer research : MCR
2021 Volume 19, Issue 5, Page(s) 784–798
Abstract: Several master transcription factors (TF) can activate the epithelial-to-mesenchymal transition (EMT). However, their individual and combinatorial contributions to EMT in breast cancer are not defined. We show that overexpression of EMT-TFs individually ... ...
| Abstract | Several master transcription factors (TF) can activate the epithelial-to-mesenchymal transition (EMT). However, their individual and combinatorial contributions to EMT in breast cancer are not defined. We show that overexpression of EMT-TFs individually in epithelial cells upregulated endogenous SNAI2, ZEB1/2, TCF4, and TWIST1/2 as a result of positive feedback mediated in part by suppression of their negative regulator miRNAs miR200s/203/205. We identified TCF4 as a potential new target of miR200s. Expression of ZEB1/2 strongly correlated with the mesenchymal phenotype in breast cancer cells, with the CD24 |
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| MeSH term(s) | Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Culture Techniques ; Cell Line, Tumor ; Cell Proliferation/physiology ; Epithelial-Mesenchymal Transition ; Female ; Heterografts ; Humans ; Male ; Mice ; Mice, Inbred NOD ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Metastasis ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Zinc Finger E-box Binding Homeobox 2/genetics ; Zinc Finger E-box Binding Homeobox 2/metabolism ; Zinc Finger E-box-Binding Homeobox 1/genetics ; Zinc Finger E-box-Binding Homeobox 1/metabolism | |||||
| Chemical Substances | MicroRNAs ; Transcription Factors ; ZEB1 protein, human ; ZEB2 protein, human ; Zinc Finger E-box Binding Homeobox 2 ; Zinc Finger E-box-Binding Homeobox 1 | |||||
| Language | English | |||||
| Publishing date | 2021-01-26 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2098788-2 | |||||
| ISSN | 1557-3125 ; 1541-7786 | |||||
| ISSN (online) | 1557-3125 | |||||
| ISSN | 1541-7786 | |||||
| DOI | 10.1158/1541-7786.MCR-20-0532 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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