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Article: Ameliorative effects of a Chinese herbal formula, fufang meidengmu on uterine leiomyoma in a mice model.

Liping Yang, - / Guangyun Zhang, - / Deqiang Feng, - / Maomao Zhang, - / Xiaohua Duan, -

Pakistan journal of pharmaceutical sciences

2023 Volume 36, Issue 3, Page(s) 863–871

Abstract: Fufang Meidengmu (FFMDM) is an ethnic herbal medicine form Yunnan province of China, which is often used for the treatment of uterine leiomyoma (UL). Combined Gancao (Glycyrrhiza uralensis Fisch.) and Haizao (Sargassum pallidum (Turn.) C.Ag) in FFMDM ... ...

Abstract	Fufang Meidengmu (FFMDM) is an ethnic herbal medicine form Yunnan province of China, which is often used for the treatment of uterine leiomyoma (UL). Combined Gancao (Glycyrrhiza uralensis Fisch.) and Haizao (Sargassum pallidum (Turn.) C.Ag) in FFMDM represent an herbal pair in the so-called "eighteen antagonistic medicaments" according to traditional Chinese medicine. In this study, we explored the prevention and treatment effects of FFMDM component compatibility on UL in mice. Female Kunming mice were injected for different periods of time with different concentrations of estradiol benzoate (EB) to investigate a feasible method to establish a mice model of UL. Treatment with 0.3mg/kg EB for 15 days was found to be the optimal condition for UL mice models. We then investigate the role of Gancao and Haizao in FFMDM, and explored the underlying mechanism of action of UL mice. Our findings suggested that Gancao and Haizao exerted the favorable effects. In addition, FFMDM is effective in the treatment of UL, and its mechanism was associated with the estrogen (ER) and progesterone receptors (PR).
MeSH term(s)	Mice ; Female ; Animals ; Humans ; China ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Leiomyoma/drug therapy ; Medicine, Chinese Traditional ; Receptors, Progesterone ; Uterine Neoplasms/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Receptors, Progesterone
Language	English
Publishing date	2023-08-15
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: Enhancing Land Cover Mapping and Monitoring

Haifei Chen / Liping Yang / Qiusheng Wu

Remote Sensing, Vol 15, Iss 4585, p

An Interactive and Explainable Machine Learning Approach Using Google Earth Engine

2023 Volume 4585

Abstract: Artificial intelligence (AI) and machine learning (ML) have been applied to solve various remote sensing problems. To fully leverage the power of AI and ML to tackle impactful remote sensing problems, it is essential to enable researchers and ... ...

Abstract	Artificial intelligence (AI) and machine learning (ML) have been applied to solve various remote sensing problems. To fully leverage the power of AI and ML to tackle impactful remote sensing problems, it is essential to enable researchers and practitioners to understand how AI and ML models actually work and thus to improve the model performance strategically. Accurate and timely land cover maps are essential components for informed land management decision making. To address the ever-increasing need for high spatial and temporal resolution maps, this paper developed an interactive and open-source online tool, in Python, to help interpret and improve the ML models used for land cover mapping with Google Earth Engine (GEE). The tool integrates the workflow of both land cover classification and land cover change dynamics, which requires the generation of a time series of land cover maps. Three feature importance metrics are reported, including impurity-based, permutation-based, and SHAP (Shapley additive explanations) value-based feature importance. Two case studies are presented to showcase the tool’s capability and ease of use, enabling a globally accessible and free convergent application of remote sensing technologies. This tool may inspire researchers to facilitate explainable AI (XAI)-empowered remote sensing applications with GEE.
Keywords	Google Earth Engine (GEE) ; explainable AI (XAI) ; land cover mapping ; feature importance ; SHAP ; Science ; Q
Subject code	910
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Palmatine treats urticaria by reducing inflammation and increasing autophagy

Tian Xiao / Xingzhi Yu / Liping Yang / Xiaohua Duan

Frontiers in Immunology, Vol

2023 Volume 14

Abstract: IntroductionChronic spontaneous urticaria (CSU) is mainly manifested as wheals and erythema on the skin accompanied by itching, which will cause emotional anxiety and seriously affect the quality of life in patients. Palmatine (PAL) is a main chemical ... ...

Abstract	IntroductionChronic spontaneous urticaria (CSU) is mainly manifested as wheals and erythema on the skin accompanied by itching, which will cause emotional anxiety and seriously affect the quality of life in patients. Palmatine (PAL) is a main chemical component of Yajieshaba, which has been found to effectively alleviate the symptoms of food allergy. However, its role and mechanism in CSU remain unclear. The present study aimed to investigate the protective effect of PAL on CSU rats.MethodsWe replicated the CSU rat model by intraperitoneal injection of ovalbumin (OVA) in rats on days 0, 2, 4, and 14, with a double dose given on the last challenge. PAL, loratadine and saline were given by gavage from day 5 to day 14. We observed the skin pathologic changes, mast cell degranulation, immune factor levels, inflammatory response and autophagy-related protein expression in CSU rats.ResultsWe found PAL treatment to be effective in alleviating CSU-like skin lesions and reducing itching and mast cell degranulation in rats. Compared with the OVA group, the levels of immune and inflammatory factors were significantly reduced, neutrophil recruitment was alleviated, suggesting a reduced inflammatory response. The autophagy results showed that PAL further increased the expression of LC3, Beclin-1 and p-LKB1, p-AMPK, Atg5, Atg12 and Atg5-Atg12, while P62 and p-p70S6K1 expression decreased. They collectively suggested that autophagic flux was activated after PAL treatment. However, there was an increase in the expression of LC3I, probably due to the fact that PAL induced its accumulation in order to provide substrate for the generation of more LC3II.DiscussionOverall, PAL had a protective effect on CSU in normal rats, activated the expression of autophagy and improved the inflammatory response.
Keywords	chronic spontaneous urticaria ; palmatine ; inflammation ; autophagy ; ethnic medicine ; Immunologic diseases. Allergy ; RC581-607
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Research progress in the quality evaluation of Salvia miltiorrhiza based on the association of ‘morphological features — functional substances — pharmacological action — clinical efficacy’

Yiyang Chen / Juanjuan Liu / Jialing Zhang / Liping Yang / Ling Jin

Heliyon, Vol 9, Iss 10, Pp e20325- (2023)

2023

Abstract: Background: Salvia miltiorrhiza (Salvia miltiorrhiza Radix et Rhizoma) is the dried root and rhizome of Salvia miltiorrhiza Bge., a plant of the labiate family. It is a type of traditional Chinese medicine that can promote blood circulation for removing ... ...

Abstract	Background: Salvia miltiorrhiza (Salvia miltiorrhiza Radix et Rhizoma) is the dried root and rhizome of Salvia miltiorrhiza Bge., a plant of the labiate family. It is a type of traditional Chinese medicine that can promote blood circulation for removing blood stasis. It is often used to treat cardiovascular and cerebrovascular diseases in a clinic.Aim of the study: High-quality Chinese herbal medicines are the premise of the safe and effective use of Traditional Chinese Medicine (TCM) in clinics. We aim to prove the rationality of the traditional identification method, namely, ‘the redder the root colour and the thicker the root, the better is the quality’, to use the morphological features of Salvia miltiorrhiza as the main index to quickly and directly evaluate its quality. Materials and methods: By referring to relevant ancient books, domestic and foreign literature, and academic papers, we summarised the research progress regarding the morphological features, functional substances, pharmacological action, and clinical efficacy of Salvia miltiorrhiza. Results: The redder the colour, the thicker the root, and the denser the texture, the better is the quality of Salvia miltiorrhiza. In Salvia miltiorrhiza, tanshinone ⅡA and salvianolic acid B are the main functional substances that protect the cardiovascular and cerebrovascular functions. The higher the content of these two functional substances, the better is the clinical efficacy of Salvia miltiorrhiza. Conclusion: The research idea of the correlation between the ‘morphological features, functional substances, pharmacological action, and clinical efficacy’ can be applied to evaluate the quality of Salvia miltiorrhiza. This research idea and method can also be applied to more Chinese herbal medicines.
Keywords	Quality evaluation of Chinese herbal medicines ; Salvia miltiorrhiza ; Morphological features ; Functional substances ; Pharmacological action ; Clinical efficacy ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A method to characterize turquoise deposits in china using sedimentary environment sensitive elements

Yiheng Xian / Yun Liang / Chun Yu / Liping Yang / Yanwang Wu

Heritage Science, Vol 11, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract ‘Fingerprint’ identification is the key to turquoise provenance studies, but previous studies have met with limited success in China. Turquoises in China mainly occur in altered sedimentary rocks and are formed by weathering, leaching and ... ...

Abstract	Abstract ‘Fingerprint’ identification is the key to turquoise provenance studies, but previous studies have met with limited success in China. Turquoises in China mainly occur in altered sedimentary rocks and are formed by weathering, leaching and sedimentation. This paper evaluates the potential for sedimentary environment sensitive elements to be used to distinguish between turquoise deposits in China. In this paper, the ratios of V/Mo, Ce/Ce*, Ni/Co, Sr/Ba, Tl/Ga, Li/Ba and V/Cr were calculated for turquoise of different origins. Our results show that these parameters when used alongside Ga concentration permit effective discrimination between turquoise sources in China. This approach brings to light a new means of analyzing trace element databases and an untapped wealth of information that can be used for future turquoise provenance studies.
Keywords	Turquoise ; Sedimentary environment sensitive elements ; Provenance studies ; Fine Arts ; N ; Analytical chemistry ; QD71-142
Subject code	950
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Artificial Intelligence Technology-Based Medical Information Processing and Emergency First Aid Nursing Management

Qing Liu / Liping Yang / Qingrong Peng

Computational and Mathematical Methods in Medicine, Vol

2022 Volume 2022

Abstract: This study was aimed at exploring the new management mode of medical information processing and emergency first aid nursing management under the new artificial intelligence technology. This study will use the artificial intelligence algorithm to optimize ...

Abstract	This study was aimed at exploring the new management mode of medical information processing and emergency first aid nursing management under the new artificial intelligence technology. This study will use the artificial intelligence algorithm to optimize medical information processing and emergency first aid nursing management process, in order to improve the efficiency of emergency department and first aid efficiency. The successful rescue rates of hemorrhagic shock, coma, dyspnea, and more than three organs injury were 96.7%, 92.5%, 93.7%, and 87.2%, respectively, after the emergency first aid nursing mode was used in the hospital emergency center. The success rates of first aid within three years were compared, which were 91.8%, 93.4%, and 94.2%, respectively, showing an increasing trend year by year. 255 emergency patients in five batches in June and five batches in July were selected as the research objects by convenience sampling method. Among them, 116 cases in June were taken as the experimental group, and 139 cases in July were taken as the control group, which was used to verify the efficiency of the design model in this study. The results showed that the triage time of the two groups was 8.16±2.07 min and 19.21±6.36 min, respectively, and the difference was statistically significant (P<0.01). The triage coincidence rates were 96.35% and 90.04%, respectively, and the difference was statistically significant (P<0.05). The research proved that the design of intelligent medical information processing and emergency first aid nursing management research model can effectively improve the triage efficiency of the wounded, assist the efficiency of emergency nursing of medical staff, and improve the survival rate of emergency patients, which is worthy of clinical promotion.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Behaviors of 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB) in wheat seedlings

Huanting Zhao / Liping Yang / Xiaojing Yang / Shuyan Zhao

Ecotoxicology and Environmental Safety, Vol 238, Iss , Pp 113585- (2022)

Bioaccumulation, biotransformation and ecotoxicity

2022

Abstract: As a new alternative to perfluorooctane sulfonate (PFOS), 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB) has been currently used in industrial and consumer applications, which has been frequently detected in environment media. However, the ... ...

Abstract	As a new alternative to perfluorooctane sulfonate (PFOS), 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB) has been currently used in industrial and consumer applications, which has been frequently detected in environment media. However, the behaviors of 6:2 FTAB in plants are still unclear. This study investigated the bioaccumulation, biotransformation and ecotoxicity of 6:2 FTAB in wheat (Triticum aestivum L.) by hydroponic exposure. 6:2 FTAB was easily taken up by roots with the root concentration factor (RCF) as high as 94.8, but difficult to be acropetally translocated in the shoots with the translocation factor (TF) as low as 0.058. Two intermediates and six terminal perfluorocarboxylic acid (PFCA) metabolites were detected in roots and shoots. The detected metabolites included 6:2 fluorotelomer sulfonic acid (6:2 FTSA), 6:2 fluorotelomer carboxylic acid (6:2 FTCA), perfluoroheptanoic acid (PFHpA), perfluorohexanoic acid (PFHxA), perfluoropentanoic acid (PFPeA), perfluorobutyric acid (PFBA), pentafluoropropionic acid (PFPrA) and trifluoroacetic acid (TFA), and 6:2 FTSA was the main metabolite. 6:2 FTAB significantly reduced the biomass of plant and prevented chlorophyll (Chl) accumulation, while caused no significant change in malondialdehyde (MDA) content. Significant reduction in glutathione (GSH) contents, excess production of reactive oxygen species (ROS), and obvious inhibition of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) and glutathione-s-transferase (GST) activities were observed, suggesting damage of antioxidant defense systems and failure to detoxication of 6:2 FTAB in wheat. These findings provide important knowledge for the fate of 6:2 FTAB in plants.
Keywords	6:2 FTAB ; Wheat ; Bioaccumulation ; Biotransformation ; Ecotoxicity ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Impact of Application of the Humanistic Nursing Model on Quality of Life and Satisfaction with Nursing among Breast Cancer Patients

Qiujuan Mao / Hui Zhang / Jing Huang / Juan Liu / Liping Yang

Iranian Journal of Public Health, Vol 51, Iss

2022 Volume 5

Abstract: ... No ... ...

Abstract	No Abstract
Keywords	Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Precolumn Derivatization High-Performance Liquid Chromatography for Determination of Perfluorocarboxylic Acids in Catalytic Degradation Solutions

Liping Yang / Binbin Sun / Haochen Cui / Lingyan Zhu / Guoqiang Shan

International Journal of Analytical Chemistry, Vol

2022 Volume 2022

Abstract: Perfluoroalkyl carboxylic acids (PFCAs), a series of ubiquitous contaminants in the global environment, attracted much attention due to their potential for high bioaccumulation and toxicity to various organisms. There are a lot of measurement requests in ...

Abstract	Perfluoroalkyl carboxylic acids (PFCAs), a series of ubiquitous contaminants in the global environment, attracted much attention due to their potential for high bioaccumulation and toxicity to various organisms. There are a lot of measurement requests in currently increasing degradation studies of PFCAs, which usually rely on expensive liquid chromatography-mass spectrometry (LC-MS). The degradation solutions containing high-concentration PFCAs can easily cause the pipeline pollution of the LC/MS instrument, which is usually used for trace analysis of environmental samples. In this study, a simple and reliable precolumn derivatization LC method coupled with an ultraviolet detector (UV) was developed for the determination of the main PFCAs (C4-9) of environmental concern. These PFCAs in degradation solutions were crosslinked to UV-responsive 3, 4-diphenylamine (DCA) by a carbodiimidization method, followed by a simple solid-phase extraction (SPE) cleanup, and quantitatively measured using a conventional LC-UV instrument. Compared to previously reported precolumn derivatization methods, this new derivatization approach has the advantages such as mild reaction conditions, easy operation, enhanced stability of derivatives, and low cost. The instrumental limits of detection (ILDs) for the targeted PFCAs in organic and aqueous mediums were 0.2–0.5 and 0.6–1.5 mg/L, respectively. The method has been successfully applied to the determination of PFCAs in catalytic degradation solutions and recommended for use in other assays involving relatively high-concentration PFCAs.
Keywords	Analytical chemistry ; QD71-142
Subject code	540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishes

Yuru Zhang / Junmei Zhang / Kedi Gao / Ronghua Lu / Xianglin Cao / Liping Yang / Guoxing Nie

FEBS Open Bio, Vol 13, Iss 6, Pp 1067-

2023 Volume 1085

Abstract: Membrane fatty acid desaturase (FADS)‐like superfamily proteins (FADSs) are essential for the synthesis of unsaturated fatty acids (UFAs). Recently, studies on FADS in fishes have mostly focused on marine species, and a comprehensive analysis of the FADS ...

Abstract	Membrane fatty acid desaturase (FADS)‐like superfamily proteins (FADSs) are essential for the synthesis of unsaturated fatty acids (UFAs). Recently, studies on FADS in fishes have mostly focused on marine species, and a comprehensive analysis of the FADS superfamily, including the FADS, stearoyl‐CoA desaturase (SCD), and sphingolipid delta 4‐desaturase (DEGS) families, in freshwater economic fishes is urgently required. To this end, we conducted a thorough analysis of the number, gene/protein structure, chromosomal location, gene linkage map, phylogeny, and expression of the FADS superfamily. We identified 156 FADSs genes in the genome of 27 representative species. Notably, FADS1 and SCD5 were lost in most freshwater fish and other teleosts. All FADSs proteins contain 4 transmembrane helices and 2–3 amphipathic α‐helices. FADSs in the same family are often linked on the same chromosome; moreover, FADS and SCD or DEGS are frequently collocated on the same chromosome. In addition, FADS, SCD, and DEGS family proteins share similar evolutionary patterns. Interestingly, FADS6, as a member of the FADS family, exhibits a similar gene structure and chromosome location to that of SCD family members, which may be the transitional form of FADS and SCD. This study shed light on the type, structure, and phylogenetic relationship of FADSs in freshwater fishes, offering a new perspective into the functional mechanism analysis of FADSs.
Keywords	FADS ; freshwater economic fishes ; gene structure ; phylogenetic analysis ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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