Article: Association of Baseline Frailty with Patient-Reported Outcomes in Systemic Lupus Erythematosus at 1 Year.
The Journal of frailty & aging
2023 Volume 12, Issue 3, Page(s) 247–251
Abstract: The relationship of baseline frailty with subsequent patient-reported outcomes in systemic lupus erythematosus (SLE) remains unclear. We assessed these associations in a pilot prospective cohort study. Frailty based on the FRAIL scale and the Fried ... ...
| Abstract | The relationship of baseline frailty with subsequent patient-reported outcomes in systemic lupus erythematosus (SLE) remains unclear. We assessed these associations in a pilot prospective cohort study. Frailty based on the FRAIL scale and the Fried phenotype and patient-reported outcomes, namely Patient Reported Outcomes Measurement Information System computerized adaptive tests and Valued Life Activities disability, were measured at baseline and 1 year among women aged 18-70 years with SLE enrolled at a single center. Differences in Patient Reported Outcomes Measurement Information System computerized adaptive tests between frail and non-frail participants were evaluated using Wilcoxon rank sum tests, and the association of baseline frailty with self-report disability at 1 year was estimated using linear regression. Of 51 participants, 24% (FRAIL scale) and 16% (Fried phenotype) met criteria for frailty at baseline despite median age of 55.0 and 56.0 years, respectively. Women with (versus without) baseline frailty using either measure had worse 1-year Patient Reported Outcomes Measurement Information System computerized adaptive test scores across multiple domains and greater self-report disability. Baseline frailty was significantly associated with self-report disability at 1 year (FRAIL scale: parameter estimate 0.55, 95% confidence interval (CI) 0.21-0.89, p<0.01; Fried phenotype: parameter estimate 0.61, 95% CI 0.22-1.00, p<0.01), including only slight attenuation after adjustment for SLE cumulative organ damage (FRAIL scale: parameter estimate 0.45, 95% CI 0.09-0.81, p=0.02; Fried phenotype: parameter estimate 0.49, 95% CI 0.09-0.90, p=0.02). These preliminary findings support frailty as an independent risk factor for clinically relevant patient-reported outcomes, including disability onset, among women with SLE. |
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| MeSH term(s) | Humans ; Female ; Aged ; Frailty/diagnosis ; Frailty/epidemiology ; Frailty/complications ; Frail Elderly ; Prospective Studies ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/complications ; Patient Reported Outcome Measures |
| Language | English |
| Publishing date | 2023-07-25 |
| Publishing country | France |
| Document type | Journal Article |
| ZDB-ID | 2856228-8 |
| ISSN | 2273-4309 ; 2260-1341 |
| ISSN (online) | 2273-4309 |
| ISSN | 2260-1341 |
| DOI | 10.14283/jfa.2023.24 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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