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Article ; Online: On the Global Dissipativity of a Class of Cellular Neural Networks with Multipantograph Delays

Liqun Zhou

Advances in Artificial Neural Systems, Vol

2011 Volume 2011

Keywords	Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cytoskeleton regulator RNA expression on cancer-associated fibroblasts is associated with prognosis and immunotherapy response in bladder cancer

Yucai Wu / Yangyang Xu / Shiming He / Yifan Li / Ninghan Feng / Jian Fan / Yanqing Gong / Xuesong Li / Liqun Zhou

Heliyon, Vol 9, Iss 3, Pp e13707- (2023)

2023

Abstract: Background: Dysregulation of long noncoding RNAs (lncRNAs) has been reported to be associated with multiple tumors where they act as tumor suppressors or accelerators. The lncRNA CYTOR was identified as an oncogene involved in many cancers, such as ... ...

Abstract	Background: Dysregulation of long noncoding RNAs (lncRNAs) has been reported to be associated with multiple tumors where they act as tumor suppressors or accelerators. The lncRNA CYTOR was identified as an oncogene involved in many cancers, such as gastric cancer, colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma. However, the role of CYTOR in bladder cancer (BCa) has rarely been reported. Methods: Using cancer datasets from The Cancer Genome Atlas (TCGA) program, we analyzed the association between CYTOR expression and prognostic value, oncogenic pathways, antitumor immunity and immunotherapy response in BCa. The influence of CYTOR on the immune infiltration pattern in the urothelial carcinoma microenvironment was further verified in our dataset. Single-cell analysis revealed the role of CYTOR in the tumor microenvironment (TME) of BCa. Finally, we evaluated the expression of CYTOR in BCa in the Peking University First Hospital (PKU–BCa) dataset and its correlation with the malignant phenotype of BCa in vitro and in vivo. Results: The results indicated that CYTOR was highly expressed in multiple cancer samples, including BCa, and increased CYTOR expression contributed to poor overall survival (OS). Additionally, elevated CYTOR expression was significantly correlated with clinicopathological features of BCa, such as female sex, advanced TNM stage, high histological grade and non-papillary subtype. Functional characterization revealed that CYTOR may be involved in immune-related pathways and the epithelial mesenchymal transformation (EMT) process. Moreover, CYTOR had a significant association with infiltrating immune cells, including M2 macrophages and regulatory T cells (Tregs). CYTOR facilitates the crosstalk between cancer-associated fibroblasts (CAFs) and macrophages, and mediates M2 polarization of macrophages. Correlation analysis revealed a positive correlation between CYTOR expression and programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1)/expression and other targets for ...
Keywords	Bladder cancer ; CYTOR ; Survival ; Immune infiltration ; Immunotherapy ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	616
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An accurate diagnostic approach for urothelial carcinomas based on novel dual methylated DNA markers in small-volume urine

Yucai Wu / Di Cai / Jian Fan / Chang Meng / Shiming He / Zhihua Li / Lianghao Zhang / Kunlin Yang / Aixiang Wang / Xinfei Li / Yicong Du / Shengwei Xiong / Mancheng Xia / Tingting Li / Lanlan Dong / Yanqing Gong / Liqun Zhou / Xuesong Li / Jinjiao Li

Chinese Medical Journal, Vol 137, Iss 2, Pp 232-

2024 Volume 234

Keywords	Medicine ; R
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: UCseek

Ping Wang / Yue Shi / Jianye Zhang / Jianzhong Shou / Mingxin Zhang / Daojia Zou / Yuan Liang / Juan Li / Yezhen Tan / Mei Zhang / Xingang Bi / Liqun Zhou / Weimin Ci / Xuesong Li

EBioMedicine, Vol 89, Iss , Pp 104437- (2023)

ultrasensitive early detection and recurrence monitoring of urothelial carcinoma by shallow-depth genome-wide bisulfite sequencing of urinary sediment DNAResearch in context

2023

Abstract: Summary: Background: Current methods for the detection and surveillance of urothelial carcinomas (UCs) are often invasive, costly, and not effective for low-grade, early-stage, and minimal residual disease (MRD) tumors. We aimed to develop and validate a ...

Abstract	Summary: Background: Current methods for the detection and surveillance of urothelial carcinomas (UCs) are often invasive, costly, and not effective for low-grade, early-stage, and minimal residual disease (MRD) tumors. We aimed to develop and validate a model from urine sediments to predict different grade and stage UCs with low cost and high accuracy. Methods: We collected 167 samples, including 90 tumors and 77 individuals without tumors, as a discovery cohort. We assessed copy number variations and methylation values for them and constructed a diagnostic classifier to detect UC, UCseek, by using an individual read-based method and support vector machine. The performance of UCseek was validated in an independent cohort derived from three hospitals (n = 206) and a relapse cohort (n = 42) for monitoring recurrence. Findings: We constructed UCseek, which could predict UCs with high sensitivity (92.7%), high specificity (90.7%), and high accuracy (91.7%) in the independent validation set. The accuracy of UCseek in low-grade and early-stage patients reached 91.8% and 94.3%, respectively. Notably, UCseek retained great performance at ultralow sequencing depths (0.3X-0.5X). It also demonstrated a powerful ability to monitor recurrence in a surveillance cohort compared with cystoscopy (90.91% vs. 59.09%). Interpretation: We optimized an improved approach named UCseek for the noninvasive diagnosis and monitoring of UCs in both low- and high-grade tumors and in early- and advanced-stage tumors, even at ultralow sequencing depths, which may reduce the burden of cystoscopy and blind second surgery. Funding: A full list of funding bodies that contributed to this study can be found in the Acknowledgments section.
Keywords	Urothelial carcinoma ; Molecular diagnostics ; Tumor markers ; Diagnosis ; Relapse monitoring ; Machine learning ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of Targeted Biopsy and Combined Biopsy to Avoid Unnecessary Systematic Biopsy in Patients with PI-RADS 5 Lesions

Changwei Yuan / Derun Li / Jingyun Wu / Qi Shen / Xiaoying Wang / Jiangxi Xiao / Zhisong He / Liqun Zhou / Xuesong Li / Yi Liu / Zheng Zhao

Biomedicines, Vol 11, Iss 12, p

2023 Volume 3163

Abstract: Purpose: To evaluate the detection rates of prostate cancer (PCa) and clinically significant prostate cancer (CSPCa) detection via target biopsy (TB), systematic biopsy (SB), and combined biopsy (CB) in patients with PI-RADS 5 lesions. Methods: Patients ... ...

Abstract	Purpose: To evaluate the detection rates of prostate cancer (PCa) and clinically significant prostate cancer (CSPCa) detection via target biopsy (TB), systematic biopsy (SB), and combined biopsy (CB) in patients with PI-RADS 5 lesions. Methods: Patients with at least one PI-RADS 5 lesion were retrospectively enrolled in a prospectively collected database. The patients underwent multiparametric magnetic resonance imaging (mpMRI) followed by transrectal TB of PI-RADS 5 lesions and SB. The PCa and CSPCa detection rates and cores of TB and SB were compared with those of CB. Results: In 585 patients, prostate biopsy revealed PCa in 560 cases (95.73%) and CSPCa in 549 cases (93.85%). PCa was detected in T2 patients (93.13%, 217/233) and in T3/4 patients (97.44%, 343/352). CSPCa was detected in T2 patients (89.27%, 208/233) and in T3/4 patients (96.87%, 341/352). The positive rates of TB for T2/3/4, T3/4, and T2 were 94.02%, 96.21%, and 90.56%, respectively. SB added 1.71% (10/585) PCa and 1.37% (8/585) CSPCa detection to TB. There was no difference between TB and SB in detecting different stages of cancer ( p > 0.05). In the biopsy core analysis, TB had fewer biopsy cores and a higher detection rate than SB (all p < 0.05). Conclusions: In patients with PI-RADS score 5 lesions, TB can achieve the same detection rate as, with fewer biopsy cores than, CB. SB adds minimal clinical value and can be omitted for these patients.
Keywords	prostatic cancer ; PI-RADS ; combined biopsy ; targeted biopsy ; systematic biopsy ; Biology (General) ; QH301-705.5
Subject code	610 ; 616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Amine-functionalized MIL-53(Al) with embedded ruthenium nanoparticles as a highly efficient catalyst for the hydrolytic dehydrogenation of ammonia borane

Zhang, Shuren / Liqun Zhou / Menghuan Chen

RSC advances. 2018 Mar. 29, v. 8, no. 22

2018

Abstract: Well-dispersed ruthenium nanoparticles (Ru NPs) are immobilized within the pores of amine-functionalized MIL-53 via an in situ impregnation-reduction method. The resulting Ru/MIL-53(Al)-NH2 catalyst exhibits superior catalytic performance for the ... ...

Abstract	Well-dispersed ruthenium nanoparticles (Ru NPs) are immobilized within the pores of amine-functionalized MIL-53 via an in situ impregnation-reduction method. The resulting Ru/MIL-53(Al)-NH2 catalyst exhibits superior catalytic performance for the dehydrogenation of ammonia borane (AB) at ambient temperature relative to the Ru/MIL-53(Al) catalyst; it has a turnover frequency (TOF) of 287 mol H2 min−1 (mol Ru)−1 and an activation energy (Ea) of 30.5 kJ mol−1. The amine groups present in the MIL-53(Al)-NH2 framework facilitate the formation and stabilization of ultra-small Ru NPs by preventing their aggregation. Additionally, the Ru/MIL-53(Al)-NH2 catalyst exhibits satisfactory durability and reusability: 72.4% and 86.3% of the initial catalytic activity was maintained after the fifth successive cycle of the hydrolytic dehydrogenation of AB in the two respective tests.
Keywords	activation energy ; ambient temperature ; ammonia ; catalysts ; catalytic activity ; dehydrogenation ; durability ; hydrogen ; nanoparticles ; ruthenium
Language	English
Dates of publication	2018-0329
Size	p. 12282-12291.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c8ra01507d
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Metabolism-Related Signature Analysis Uncovers the Prognostic and Immunotherapeutic Characteristics of Renal Cell Carcinoma

Jianye Zhang / Qi Zhang / Yue Shi / Ping Wang / Yanqing Gong / Shiming He / Zhihua Li / Ninghan Feng / Yang Wang / Peng Jiang / Weimin Ci / Xuesong Li / Liqun Zhou

Frontiers in Molecular Biosciences, Vol

2022 Volume 9

Abstract: Renal cell carcinoma (RCC) is one of the most common urological cancers. RCC has a poor prognosis and is considered a metabolic disease. It has been reported that many metabolic pathways are associated with the development of RCC. However, the prognostic ...

Abstract	Renal cell carcinoma (RCC) is one of the most common urological cancers. RCC has a poor prognosis and is considered a metabolic disease. It has been reported that many metabolic pathways are associated with the development of RCC. However, the prognostic value of metabolism-related genes in RCC is unclear. We herein aimed to establish a scoring system based on the gene expression profile of metabolic genes to evaluate the response to immunotherapy and predict the prognosis of RCC. In this study, we collected multicentre RCC data and performed integrated analysis to characterize the role of tumour metabolism in RCC and explore the relationship between metabolism and prognosis and immune therapy. Based on transcriptomic data, metabolism-related genes were used for nonnegative matrix factorization clustering. We obtained three subclasses of RCC (M1, M2, and M3), and they are associated with different prognoses and immune infiltrate levels. Then, based on the pathway activity of 113 metabolism-related gene signatures, we classified patients into three distinct metabolism-related signatures. Finally, we provide a metabolism-related pathway score (MRPScore) that is significantly associated with RCC prognosis and the response to immunotherapy. Taken together, in this study, we established an RCC classification system based on metabolic gene expression profiles that could further the understanding of the diversity of RCC. We also present the MRPScore, which may be used as an indicator to predict the response to clinical immune therapy.
Keywords	renal cell carcinoma ; metabolism ; MRPScore ; prognosis ; immunotherapy ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of acetochlor on neurogenesis and behaviour in zebrafish at early developmental stages

Wang, Honglei / Huiqiang Lu / Liqun Zhou / Rongfang Ye / Xinjun Liao / Zhen Meng / Zigang Cao

Chemosphere. 2019 Apr., v. 220

2019

Abstract: The herbicide acetochlor is used in most parts of the world and is frequently detected in agricultural land and surface water; however, knowledge on the neurotoxicity of acetochlor is limited. Here, to test the effects of acetochlor on zebrafish ... ...

Abstract	The herbicide acetochlor is used in most parts of the world and is frequently detected in agricultural land and surface water; however, knowledge on the neurotoxicity of acetochlor is limited. Here, to test the effects of acetochlor on zebrafish development and behaviour, zebrafish embryos were exposed to acetochlor from 6 h post-fertilization (hpf) to 24 hpf, and larvae at 6 days post-fertilization (dpf) were exposed to acetochlor for 24 h. Both were exposed to 5, 10, or 20 mg/L acetochlor. We found that acetochlor induced developmental abnormalities, locomotion variations and changes in the physiology and gene expression in the embryos and larvae. The abnormalities included spinal curvature, brain abnormalities, and the decreased formation of newborn neurons. Larval locomotion was decreased with increases in the absolute turn angle and sinuosity. Acetylcholinesterase activity reduced in both embryos and larvae, and the expression of genes that are involved in neurodevelopment and the neurotransmitter system altered. Acetochlor increased the production of ROS and the accumulation of MDA but decreased CAT activity in the embryonic brain. Additionally, acetochlor induced cell death in the brain and tail spinal cord, and the expression of the apoptosis-related genes Bcl2 and caspase 3 were significantly upregulated. Collectively, this is the first study to examine the molecular and physiological effects of acetochlor on neuronal development, and the potential mechanisms appear to be associated with oxidative stress and decreased AChE activity, which disrupt the expression of nervous system genes and apoptosis-related genes and finally lead to apoptosis and morphological malformations.
Keywords	abnormal development ; acetochlor ; acetylcholinesterase ; agricultural land ; apoptosis ; brain ; caspase-3 ; Danio rerio ; embryo (animal) ; enzyme activity ; gene expression ; gene expression regulation ; genes ; larvae ; locomotion ; neonates ; neurodevelopment ; neurogenesis ; neurons ; neurotoxicity ; neurotransmitters ; oxidative stress ; spinal cord ; surface water ; tail
Language	English
Dates of publication	2019-04
Size	p. 954-964.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2018.12.199
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Single‐Cell RNA‐seq Reveals a Developmental Hierarchy Super‐Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer

Guangzhe Ge / Yang Han / Jianye Zhang / Xinxin Li / Xiaodan Liu / Yanqing Gong / Zhentao Lei / Jie Wang / Weijie Zhu / Yangyang Xu / Yiji Peng / Jianhua Deng / Bao Zhang / Xuesong Li / Liqun Zhou / Huiying He / Weimin Ci

Advanced Science, Vol 9, Iss 15, Pp n/a-n/a (2022)

2022

Abstract: Abstract Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non‐genetic intra‐tumoral heterogeneity, the cellular differentiation ... ...

Abstract	Abstract Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non‐genetic intra‐tumoral heterogeneity, the cellular differentiation state and the interplay between subclonal evolution and transcriptional heterogeneity are poorly understood. Here, the authors perform single‐cell RNA sequencing from 14 untreated PCa patients. They create an extensive cell atlas of the PCa patients and mapped developmental states onto tumor subclonal evolution. They identify distinct subclones across PCa patients and then stratify tumor cells into four transcriptional subtypes, EMT‐like (subtype 0), luminal A‐like (subtype 1), luminal B/C‐like (subtype 2), and basal‐like (subtype 3). These subtypes are hierarchically organized into stem cell‐like and differentiated status. Strikingly, multiple subclones within a single primary tumor present with distinct combinations of preferential subtypes. In addition, subclones show different communication strengths with other cell types within the tumor ecosystem, which may modulate the distinct transcriptional subtypes of the subclones. Notably, by integrating TCGA data, they discover that both tumor cell transcriptional heterogeneity and cellular ecosystem diversity correlate with features of a poor prognosis. Collectively, their study provides the analysis of subclonal and transcriptional heterogeneity and its implication for patient prognosis.
Keywords	cellular ecosystem ; epithelial‐to‐mesenchymal transition ; prostate cancer ; subtype ; transcriptional heterogeneity ; tumor subclone ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical characteristics and surgical treatment of ureteral endometriosis

Kunlin Yang / Sida Cheng / Yukun Cai / Jiankun Qiao / Yangyang Xu / Xinfei Li / Shengwei Xiong / Ye Lu / Aobing Mei / Xuesong Li / Liqun Zhou

BMC Women's Health, Vol 21, Iss 1, Pp 1-

our experience with 40 cases

2021 Volume 7

Abstract: Abstract Background To present the experience with the surgical management of ureteral endometriosis (UE) in our single center. Methods To present the experience with the surgical management of ureteral endometriosis (UE) in our single center. A ... ...

Abstract	Abstract Background To present the experience with the surgical management of ureteral endometriosis (UE) in our single center. Methods To present the experience with the surgical management of ureteral endometriosis (UE) in our single center. A retrospective analysis of 40 patients with UE who presented with intraoperative surgical findings of endometriosis involving the ureter and pathology-proven UE was performed. Results Forty patients (median age, 42.5 years) with histological evidence of UE were included. Six (15%) patients had a history of endometriosis. Twenty-one (52%) patients had urological symptoms, and 19 (48%) patients were asymptomatic. All patients had hydronephrosis. The mean glomerular filtration rate (GFR) of the ipsilateral kidney was significantly worse than that of the contralateral kidney (23.4 vs 54.9 ml/min; P < 0.001). Twelve (30%) patients were treated with ureteroureterostomy (11 open approaches and 1 robotic approach). Twenty-two (55%) patients underwent ureteroneocystostomy (17 open approaches, 4 laparoscopic approaches and 1 robotic approach). Five patients underwent nephroureterectomy. One patient refused aggressive surgery and received ureteroscopic biopsy and ureteral stent placement. Thirteen (33%) patients required gynecological operations. Three (8%) patients in the open group suffered from major surgical complications. Nine (24%) patients received postoperative endocrine therapy. Twenty-eight (70%) patients were followed up (median follow-up time, 71 months). Twenty-four patients received kidney-sparing surgeries. The success rate for these 24 patients was 21/24 (87.5%). The success rates of ureteroneocystostomy and ureteroureterostomy were 15/16 (93.8%) and 5/7 (71.4%), respectively. Conclusions Although UE is rare, we should remain vigilant for the disease among female patients with silent hydronephrosis. Typically, a multidisciplinary surgical team is necessary. For patients with severe UE, segmental ureteral resection with ureteroureterostomy (UU) or ...
Keywords	Ureteralendometriosis ; Ureteroureterostomy ; Ureteroneocystostomy ; Nephroureterectomy ; Case report ; Gynecology and obstetrics ; RG1-991 ; Public aspects of medicine ; RA1-1270
Subject code	616 ; 610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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