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Article ; Online: Sensitivity and specificity of the INECO frontal screening (IFS) in the detection of patients with traumatic brain injury presenting executive deficits.

Pinasco, Clara / Oviedo, Mercedes / Goldfeder, María / Bruno, Diana / Lischinsky, Alicia / Torralva, Teresa / Roca, María

Applied neuropsychology. Adult

2021 Volume 30, Issue 3, Page(s) 289–296

Abstract: Executive dysfunction (EF) is a common feature of adult traumatic brain injury (TBI), especially in moderate to severe cases. Assessing EF usually requires the administration of an extensive neuropsychological battery, which is time consuming and ... ...

Abstract	Executive dysfunction (EF) is a common feature of adult traumatic brain injury (TBI), especially in moderate to severe cases. Assessing EF usually requires the administration of an extensive neuropsychological battery, which is time consuming and expensive. The INECO frontal screening (IFS) is a brief, easy-to-administer screening test which has previously shown to be useful in the detection of executive deficits in different psychiatric and neurological populations. The aim of the present study was to assess the usefulness of the IFS in the detection of executive dysfunction in TBI patients. Twenty-eight TBI patients and thirty-two healthy controls were assessed with a battery that included classical executive tests and the IFS. Our results indicated that with a cutoff score of 26.25 points, the IFS showed good sensitivity and specificity in the detection of executive impairments in TBI patients. It also showed good positive and negative predicted values. Our results suggest that the IFS can be considered a useful tool for identifying executive dysfunction in patients with TBI.
MeSH term(s)	Adult ; Humans ; Executive Function ; Neuropsychological Tests ; Sensitivity and Specificity ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnosis
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673736-X
ISSN	2327-9109 ; 2327-9095
ISSN (online)	2327-9109
ISSN	2327-9095
DOI	10.1080/23279095.2021.1937170
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Zs.A 4952: Show issues

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Article ; Online: Depressive symptoms and the role of affective temperament in adults with attention-deficit/hyperactivity disorder (ADHD): A comparison with bipolar disorder.

Torrente, Fernando / López, Pablo / Lischinsky, Alicia / Cetkovich-Bakmas, Marcelo / Manes, Facundo

Journal of affective disorders

2017 Volume 221, Page(s) 304–311

Abstract: Objectives: To investigate the characteristics of depressive symptoms and the influence of affective temperament in adults with attention-deficit/hyperactivity disorder (ADHD), in comparison with bipolar disorder (BD) patients and healthy controls (HCs). ...

Abstract	Objectives: To investigate the characteristics of depressive symptoms and the influence of affective temperament in adults with attention-deficit/hyperactivity disorder (ADHD), in comparison with bipolar disorder (BD) patients and healthy controls (HCs). Method: Sixty patients with ADHD, 50 patients with BD, and 30 HCs were assessed with instruments for measuring depressive symptoms (Beck Depression Inventory-II), and affective temperaments (Temperament Scale of Memphis, Pisa and San Diego, self-administered version; TEMPS-A). In addition, participants were evaluated with scales for measuring ADHD symptoms, impulsiveness, anxiety, executive dysfunction, and quality of life. Results: ADHD patients showed levels of depressive symptoms similar to BD patients and higher than HCs. Only neurovegetative symptoms of depression differentiated ADHD and BD groups (BD > ADHD). Depressive symptoms in ADHD patients correlated positively with core ADHD, impulsivity, anxiety, and dysexecutive symptoms and negatively with quality of life. Thirty-eight percent of patients with ADHD scored above the cutoff for at least one affective temperament. Cyclothymic was the more common affective temperament (25%). ADHD patients with affective temperamental traits were more depressed and impulsive than patients without those traits and showed a symptomatic profile analogous to BD patients. Limitations: The small size of resultant samples when ADHD group was stratified by the presence of affective temperament. In addition, results may not generalize to less severe ADHD patients from the community. Conclusions: Concomitant depressive symptoms constitute a common occurrence in adults with ADHD that carries significant psychopathological and functional consequences. The concept of affective temperaments may be an interesting link for explaining depressive symptomatology and emotional impulsivity in a subgroup of patients with ADHD, beyond the classic idea of comorbidity.
Language	English
Publishing date	2017-10-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2017.06.040
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Zs.A 1485: Show issues

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Article ; Online: "Ecological" and highly demanding executive tasks detect real-life deficits in high-functioning adult ADHD patients.

Torralva, Teresa / Gleichgerrcht, Ezequiel / Lischinsky, Alicia / Roca, María / Manes, Facundo

Journal of attention disorders

2013 Volume 17, Issue 1, Page(s) 11–19

Abstract: Objective: Many adult ADHD patients with a convincing history of real-life executive deficits perform entirely within normal limits or with minimally impaired performance in classical executive tests. The authors assessed a group of high cognitive ... ...

Abstract	Objective: Many adult ADHD patients with a convincing history of real-life executive deficits perform entirely within normal limits or with minimally impaired performance in classical executive tests. The authors assessed a group of high cognitive functioning adult ADHD participants on "ecological" and "highly demanding" executive tasks. Method: A total of 117 adult ADHD participants were classified as showing either a high-functioning (Hi-ADHD) or a low-functioning (Lo-ADHD) neuropsychological profile based on standard assessment. Their performance was compared with healthy controls (n = 21) on an ecological task of executive function (the hotel task) and computerized tasks of high cognitive demand. Results: Lo-ADHD significantly differed from controls on multiple standard neuropsychological variables as well as on the experimental tasks. Hi-ADHD and healthy controls did not differ significantly on any of the standard neuropsychological variables, but a significant difference was found between the groups on measures of the experimental tasks. Conclusion: Real-life executive dysfunction of patients with ADHD who perform within normal range on standard assessment can be detected with the use of more ecological and highly demanding tasks.
MeSH term(s)	Adult ; Attention Deficit Disorder with Hyperactivity/psychology ; Case-Control Studies ; Cognition ; Executive Function ; Female ; Humans ; Male ; Neuropsychological Tests
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/1087054710389988
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Article: The phenomenology of depression after brain injury.

Starkstein, Sergio E / Lischinsky, Alicia

NeuroRehabilitation

2002 Volume 17, Issue 2, Page(s) 105–113

Abstract: One important challenge in neuropsychiatry is how to diagnose depression in patients with acute brain lesions, since there may be an overlap between symptoms of depression and signs associated with the neurologic disease. The best approach is to assess ... ...

Abstract	One important challenge in neuropsychiatry is how to diagnose depression in patients with acute brain lesions, since there may be an overlap between symptoms of depression and signs associated with the neurologic disease. The best approach is to assess the presence of depressive symptoms using semi-structured or structured psychiatric interviews such as the Present State Exam, the Structured Clinical Interview for DSM-IV, or the Schedules for Clinical Assessment in Neuropsychiatry. The diagnosis of a depressive syndrome should be made using standardized diagnostic criteria for mood disorders due to neurological disease such as in the DSM-IV or the ICD-10. Depression rating scales, such as the Hamilton Depression Scale and the Center for Epidemiologic Scales for Depression may be used to rate the severity of depression and monitor the progression of antidepressant treatment. Most studies in acute and chronic neurologic disorders demonstrated the specificity of both autonomic and psychological symptoms for the syndrome of depression. The present review article examines important considerations before a diagnosis of depression in neurologic disease, discusses a variety of psychiatric instruments that are used to examine the presence and severity of depression in neurologic disease, examines relevant phenomenological issues, and proposes different diagnostic strategies.
MeSH term(s)	Anxiety/diagnosis ; Anxiety/epidemiology ; Anxiety/etiology ; Brain Injuries/complications ; Brain Injuries/diagnosis ; Dementia/diagnosis ; Dementia/epidemiology ; Dementia/etiology ; Depressive Disorder/diagnosis ; Depressive Disorder/epidemiology ; Depressive Disorder/etiology ; Female ; Humans ; Injury Severity Score ; Male ; Neuropsychological Tests ; Prevalence ; Prognosis ; Psychiatric Status Rating Scales ; Risk Factors ; Severity of Illness Index ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology
Language	English
Publishing date	2002
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1087912-2
ISSN	1878-6448 ; 1053-8135
ISSN (online)	1878-6448
ISSN	1053-8135
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Zs.A 3328: Show issues

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Article: Propiedades psicométricas de la Escala de Impulsividad de Barratt en una muestra de Buenos Aires.

López, Pablo L / Cetkovich-Bakmas, Marcelo / Lischinsky, Alicia / Alvarez Prado, Dolores / Torrente, Fernando

Vertex (Buenos Aires, Argentina)

2012 Volume 23, Issue 102, Page(s) 85–91

Abstract: The Barratt Impulsiveness Scale was designed to assess the impulsivity construct in three dimensions: attentional, motor and unplanned. The scale has been applied to patients with different diagnoses in which the impulsivity symptoms are characteristic. ... ...

Title translation	Psychometric properties of the Barratt Impulsiveness Scale in a sample of the city of Buenos Aires.
Abstract	The Barratt Impulsiveness Scale was designed to assess the impulsivity construct in three dimensions: attentional, motor and unplanned. The scale has been applied to patients with different diagnoses in which the impulsivity symptoms are characteristic. In Argentina there aren't studies that evaluate the psychometrics properties of the scale in clinical population. The objective of the research was to evaluate the psychometrics properties in a sample of the city of Buenos Aires. 150 adult subjects were selected: 67 didn't have relevant psychiatric diagnoses, 56 met criteria for bipolar disorder and 27 had Attention Deficit Disorder. The internal consistency, the construct validity, discriminative validity and the factorial structure were assessed. The Cronbach alpha was 0.84 for the total scale. Also the instrument has demonstrated acceptable indicators of construct and discriminative validity. Significant differences were found when the results of the present study and the original factorial structure were compared. The results support the usefulness of the scale in the psychiatric, scientific and clinical context to evaluate the impulsivity construct. The total score of the scale obtained the strongest indicators of reliability and validity.
MeSH term(s)	Adolescent ; Adult ; Aged ; Argentina ; Female ; Humans ; Impulsive Behavior/diagnosis ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Psychometrics ; Urban Health ; Young Adult
Language	Spanish
Publishing date	2012-03
Publishing country	Argentina
Document type	English Abstract ; Journal Article
ISSN	0327-6139
ISSN	0327-6139
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Article ; Online: Not always hyperactive? Elevated apathy scores in adolescents and adults with ADHD.

Torrente, Fernando / Lischinsky, Alicia / Torralva, Teresa / López, Pablo / Roca, María / Manes, Facundo

Journal of attention disorders

2011 Volume 15, Issue 7, Page(s) 545–556

Abstract: Objectives: To investigate the presence of apathy symptoms in adolescents and adults with ADHD as a behavioral manifestation of underlying motivational deficits and to determine whether apathy symptoms were associated with a specific neuropsychological ... ...

Abstract	Objectives: To investigate the presence of apathy symptoms in adolescents and adults with ADHD as a behavioral manifestation of underlying motivational deficits and to determine whether apathy symptoms were associated with a specific neuropsychological profile. Method: A total of 38 ADHD participants (28 of the combined subtype [ADHD/C] and 10 of the inattentive subtype [ADHD/I]) and 30 healthy controls (Ctrl) were assessed on two measures of apathy administered to subjects and informants. As well, ADHD participants completed a comprehensive neuropsychological battery. Results: ADHD participants presented elevated scores on measures of apathy relative to controls (ADHD/I > ADHD/C > Ctrl). Informant-based ratings of apathy correlated significantly with behavioral measures of inattention. Apathy measures correlated significantly with executive tests, working memory, verbal fluency, and general intellectual abilities, only in the inattentive sample. Conclusions: This study stresses the relevance of motivational deficits in adult ADHD as a significant clinical dimension closely linked to inattention and executive difficulties.
MeSH term(s)	Adolescent ; Adult ; Apathy ; Attention Deficit Disorder with Hyperactivity/psychology ; Executive Function ; Female ; Humans ; Intelligence ; Male ; Memory, Short-Term ; Middle Aged ; Motivation ; Neuropsychological Tests ; Psychiatric Status Rating Scales ; Surveys and Questionnaires
Language	English
Publishing date	2011-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/1087054709359887
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Zs.A 5196: Show issues

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Article ; Online: Dysfunctional cognitions and their emotional, behavioral, and functional correlates in adults with attention deficit hyperactivity disorder (ADHD): is the cognitive-behavioral model valid?

Torrente, Fernando / López, Pablo / Alvarez Prado, Dolores / Kichic, Rafael / Cetkovich-Bakmas, Marcelo / Lischinsky, Alicia / Manes, Facundo

Journal of attention disorders

2014 Volume 18, Issue 5, Page(s) 412–424

Abstract: Objective: To investigate the presence of dysfunctional cognitions in adults with ADHD and to determine whether these cognitions are associated with emotional symptoms, maladaptive coping, and functional impairment, as predicted by the cognitive- ... ...

Abstract	Objective: To investigate the presence of dysfunctional cognitions in adults with ADHD and to determine whether these cognitions are associated with emotional symptoms, maladaptive coping, and functional impairment, as predicted by the cognitive-behavioral model. Method: A total of 35 adult participants with ADHD, 20 nonclinical controls, and 20 non-ADHD clinical controls were assessed with measures of ADHD symptoms, dysfunctional cognitions, depression and anxiety symptoms, coping strategies, and quality of life. Results: ADHD group showed elevated scores of dysfunctional cognitions relative to nonclinical control group and comparable with clinical control group. Dysfunctional cognitions were strongly associated with emotional symptoms. ADHD group also showed elevated scores in maladaptive coping strategies of the escape-avoidance type. Life impairment was satisfactorily predicted in data analysis when ADHD symptoms, dysfunctional cognitions, and emotional symptoms were fitted into a regression model. Conclusion: Cognitive-behavioral therapy model appears to be a valid complementary model for understanding emotional and life impairment in adults with ADHD.
MeSH term(s)	Adult ; Anxiety/diagnosis ; Anxiety/psychology ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Case-Control Studies ; Cognition ; Cognition Disorders/diagnosis ; Cognition Disorders/psychology ; Cognition Disorders/therapy ; Cognitive Therapy ; Depression/diagnosis ; Depression/psychology ; Depressive Disorder/diagnosis ; Depressive Disorder/psychology ; Emotions ; Female ; Humans ; Male ; Middle Aged ; Quality of Life/psychology ; Reproducibility of Results ; Social Adjustment ; Social Behavior ; Surveys and Questionnaires
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/1087054712443153
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Article: Granulosa cell stimulation of thecal androgen synthesis.

Lischinsky, A / Armstrong, D T

Canadian journal of physiology and pharmacology

1983 Volume 61, Issue 5, Page(s) 472–477

Abstract: The role of granulosa cells on porcine follicular androgen synthesis was studied. Granulosa cells were cultured for 24 h either in Eagle's minimum essential medium (MEM) or in MEM plus follicle-stimulating hormone (FSH; 1 microgram/mL). Thecal ... ...

Abstract	The role of granulosa cells on porcine follicular androgen synthesis was studied. Granulosa cells were cultured for 24 h either in Eagle's minimum essential medium (MEM) or in MEM plus follicle-stimulating hormone (FSH; 1 microgram/mL). Thecal preparations were cultured with or without luteinizing hormone (LH), either in MEM, 50% "spent media" from granulosa cells control (MA) or 50% "spent media" from granulosa cells incubated with FSH (MB). In the absence of LH, MB stimulated accumulation of both delta 4-androstenedione (twofold) and testosterone (threefold). MB was found to contain high levels of C21-steroids, including progesterone and material which behaves chromatographically and immunologically like pregnenolone. These amounts of C21-steroids were able to stimulate thecal androgen production. The results suggest that granulosa cells contribute to thecal androgen production by providing steroid substrate. This would provide a means for granulosa cells to control the availability of aromatizable androgens.
MeSH term(s)	Androgens/biosynthesis ; Animals ; Cells, Cultured ; Culture Media ; Female ; Follicle Stimulating Hormone/pharmacology ; Granulosa Cells/physiology ; Luteinizing Hormone/pharmacology ; Pregnenolone/pharmacology ; Progesterone/pharmacology ; Swine ; Theca Cells/metabolism
Chemical Substances	Androgens ; Culture Media ; Progesterone (4G7DS2Q64Y) ; Pregnenolone (73R90F7MQ8) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	1983-05
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127527-6
ISSN	1205-7541 ; 0008-4212
ISSN (online)	1205-7541
ISSN	0008-4212
DOI	10.1139/y83-072
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Zs.A 589: Show issues

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Article: Neuropsychological functioning in adult bipolar disorder and ADHD patients: a comparative study.

Torralva, Teresa / Gleichgerrcht, Ezequiel / Torrente, Fernando / Roca, María / Strejilevich, Sergio A / Cetkovich, Marcelo / Lischinsky, Alicia / Manes, Facundo

Psychiatry research

2011 Volume 186, Issue 2-3, Page(s) 261–266

Abstract: Bipolar disorder (BD) and adult attention deficit hyperactivity disorder (ADHD) usually manifest with shared clinical symptoms, proving quite challenging to thoroughly differentiate one from another. Previous research has characterized these two ... ...

Abstract	Bipolar disorder (BD) and adult attention deficit hyperactivity disorder (ADHD) usually manifest with shared clinical symptoms, proving quite challenging to thoroughly differentiate one from another. Previous research has characterized these two disorders independently, but no study compared both pathologies from a neuropsychological perspective. The aim of this study was to compare the neuropsychological profile of adult ADHD and BD with each other and against a control group, in order to understand the way in which comprehensive cognitive assessment can contribute to their discrimination as distinct clinical entities as well as their differential diagnosis. All groups were successfully matched for age, sex, years of education, and premorbid IQ. Participants were assessed with an extensive neuropsychological battery evaluating multiple domains. Compared to controls, BD patients had a poorer performance on immediate verbal memory tasks. Both clinical groups exhibited significantly lower scores than controls on the recognition phase of verbal and non-verbal memory tasks, as well as on a task of executive functioning with high working memory demand. Noticeably, however, ADHD had significantly better performance than BD on the recognition phase of both the Rey list memory task and the Rey Figure. The better performance of ADHD patients over BD may reflect the crucial role of the executive component on their memory deficits and gives empirical support to further differentiate the neuropsychological profile of BD and adult ADHD patients in clinical practice.
MeSH term(s)	Adult ; Analysis of Variance ; Attention/physiology ; Attention Deficit Disorder with Hyperactivity/complications ; Bipolar Disorder/complications ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Executive Function ; Female ; Humans ; Male ; Memory ; Middle Aged ; Neuropsychological Tests ; Statistics, Nonparametric ; Young Adult
Language	English
Publishing date	2011-04-30
Publishing country	Ireland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0165-1781 ; 0925-4927
DOI	10.1016/j.psychres.2010.08.007
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Article ; Online: Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder.

Barttfeld, Pablo / Petroni, Agustín / Báez, Sandra / Urquina, Hugo / Sigman, Mariano / Cetkovich, Marcelo / Torralva, Teresa / Torrente, Fernando / Lischinsky, Alicia / Castellanos, Xavier / Manes, Facundo / Ibañez, Agustín

Neuropsychobiology

2014 Volume 69, Issue 2, Page(s) 65–75

Abstract: Objectives: To assess brain functional connectivity and variability in adults with attention deficit/hyperactivity disorder (ADHD) or euthymic bipolar disorder (BD) relative to a control (CT) group.: Methods: Electroencephalography (EEG) was measured ...

Abstract	Objectives: To assess brain functional connectivity and variability in adults with attention deficit/hyperactivity disorder (ADHD) or euthymic bipolar disorder (BD) relative to a control (CT) group. Methods: Electroencephalography (EEG) was measured in 35 participants (BD = 11; ADHD = 9; CT = 15) during an eyes-closed 10-min rest period, and connectivity and graph theory metrics were computed. A coefficient of variation (CV) computed also the connectivity's temporal variability of EEG. Multivariate associations between functional connectivity and clinical and neuropsychological profiles were evaluated. Results: An enhancement of functional connectivity was observed in the ADHD (fronto-occipital connections) and BD (diffuse connections) groups. However, compared with CTs, intrinsic variability (CV) was enhanced in the ADHD group and reduced in the BD group. Graph theory metrics confirmed the existence of several abnormal network features in both affected groups. Significant associations of connectivity with symptoms were also observed. In the ADHD group, temporal variability of functional connections was associated with executive function and memory deficits. Depression, hyperactivity and impulsivity levels in the ADHD group were associated with abnormal intrinsic connectivity. In the BD group, levels of anxiety and depression were related to abnormal frontotemporal connectivity. Conclusions: In the ADHD group, we found that intrinsic variability was associated with deficits in cognitive performance and that connectivity abnormalities were related to ADHD symptomatology. The BD group exhibited less intrinsic variability and more diffuse long-range brain connections, and those abnormalities were related to interindividual differences in depression and anxiety. These preliminary results are relevant for neurocognitive models of abnormal brain connectivity in both disorders.
MeSH term(s)	Adult ; Anxiety/physiopathology ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Attention Deficit Disorder with Hyperactivity/psychology ; Bipolar Disorder/physiopathology ; Bipolar Disorder/psychology ; Brain/physiopathology ; Cognition Disorders/physiopathology ; Depression/physiopathology ; Electroencephalography ; Humans ; Impulsive Behavior/physiology ; Male ; Middle Aged ; Multivariate Analysis ; Neural Pathways/physiopathology ; Neuropsychological Tests ; Rest ; Time Factors
Language	English
Publishing date	2014
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	442239-9
ISSN	1423-0224 ; 0302-282X
ISSN (online)	1423-0224
ISSN	0302-282X
DOI	10.1159/000356964
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