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  1. Article: Treatment of cancer cells with chemotherapeutic drugs results in profound changes in expression of genes encoding aldehyde-metabolizing enzymes.

    Zinovieva, Olga L / Grineva, Evgeniya N / Krasnov, George S / Karpov, Dmitry S / Zheltukhin, Andrei O / Snezhkina, Anastasiya V / Kudryavtseva, Anna V / Mashkova, Tamara D / Lisitsyn, Nikolai A

    Journal of Cancer

    2019  Volume 10, Issue 18, Page(s) 4256–4263

    Abstract: Using RNA-seq, RT-qPCR, and bioinformatics we have studied the influence of a wide spectrum of chemotherapeutic drugs on transcription ... ...

    Abstract Using RNA-seq, RT-qPCR, and bioinformatics we have studied the influence of a wide spectrum of chemotherapeutic drugs on transcription of
    Language English
    Publishing date 2019-07-10
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.32608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation.

    Karpov, Dmitry S / Spirin, Pavel V / Zheltukhin, Andrey O / Tutyaeva, Vera V / Zinovieva, Olga L / Grineva, Evgenia N / Matrosova, Vera A / Krasnov, George S / Snezhkina, Anastasiya V / Kudryavtseva, Anna V / Prassolov, Vladimir S / Mashkova, Tamara D / Lisitsyn, Nikolai A

    International journal of molecular sciences

    2020  Volume 21, Issue 21

    Abstract: Overcoming drug resistance of cancer cells is the major challenge in molecular oncology. Here, we demonstrate that long non-coding RNA LINC00973 is up-regulated in normal and cancer cells of different origins upon treatment with different ... ...

    Abstract Overcoming drug resistance of cancer cells is the major challenge in molecular oncology. Here, we demonstrate that long non-coding RNA LINC00973 is up-regulated in normal and cancer cells of different origins upon treatment with different chemotherapeutics. Bioinformatics analysis shows that this is a consequence of DNA damage response pathway activation or mitotic arrest. Knockdown of
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Drug Resistance, Neoplasm/genetics ; HCT116 Cells ; Humans ; Neoplasms/genetics ; RNA, Long Noncoding/genetics ; Signal Transduction/drug effects ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Antineoplastic Agents ; Cyclin-Dependent Kinase Inhibitor p21 ; RNA, Long Noncoding ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2020-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21218322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs.

    Zinovieva, Olga L / Grineva, Evgenia N / Prokofjeva, Maria M / Karpov, Dmitry S / Zheltukhin, Andrei O / Krasnov, George S / Snezhkina, Anastasiya V / Kudryavtseva, Anna V / Chumakov, Peter M / Mashkova, Tamara D / Prassolov, Vladimir S / Lisitsyn, Nikolai A

    Biochimie

    2018  Volume 151, Page(s) 67–72

    Abstract: Early prediction of tumor relapse depends on the identification of new prognostic cancer biomarkers, which are suitable for monitoring tumor response to different chemotherapeutic drugs. Using RNA-Seq, RT-qPCR, bioinformatics, and studies utilizing the ... ...

    Abstract Early prediction of tumor relapse depends on the identification of new prognostic cancer biomarkers, which are suitable for monitoring tumor response to different chemotherapeutic drugs. Using RNA-Seq, RT-qPCR, bioinformatics, and studies utilizing the murine tumor xenograft model, we have found significant and consistent changes in the abundance of five lincRNAs (LINC00973, LINC00941, CASC19, CCAT1, and BCAR4) upon treatment of both HT-29 and HCT-116 cells with 5-fluorouracil, oxaliplatin, and irinotecan at different doses and durations; both in vitro and in vivo. The most frequent changes were detected for LINC00973, whose content is most strongly and consistently increased upon treatment of both colon cancer cell lines with all three chemotherapeutic drugs. Additional studies are required in order to determine the molecular mechanisms by which anticancer drugs affect LINC00973 expression and to define the consequences of its upregulation on drug resistance of cancer cells.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor ; Colonic Neoplasms/drug therapy ; HCT116 Cells ; HT29 Cells ; Humans ; Mice ; RNA, Long Noncoding/genetics ; Transcription, Genetic/drug effects ; Xenograft Model Antitumor Assays
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor ; RNA, Long Noncoding
    Language English
    Publishing date 2018-06-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 120345-9
    ISSN 1638-6183 ; 0300-9084
    ISSN (online) 1638-6183
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2018.05.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.135: Show issues Location:
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  4. Article ; Online: Enteric alpha defensins in norm and pathology

    Lisitsyn Nikolai A / Bukurova Yulia A / Nikitina Inna G / Krasnov George S / Sykulev Yuri / Beresten Sergey F

    Annals of Clinical Microbiology and Antimicrobials, Vol 11, Iss 1, p

    2012  Volume 1

    Abstract: Abstract Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as ... ...

    Abstract Abstract Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.
    Keywords Enteric alpha defensins ; Paneth cells ; innate immunity ; IBD ; colon cancer ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Enteric alpha defensins in norm and pathology.

    Lisitsyn, Nikolai A / Bukurova, Yulia A / Nikitina, Inna G / Krasnov, George S / Sykulev, Yuri / Beresten, Sergey F

    Annals of clinical microbiology and antimicrobials

    2012  Volume 11, Page(s) 1

    Abstract: Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in ... ...

    Abstract Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.
    MeSH term(s) Animals ; Enteritis/immunology ; Enteritis/physiopathology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/physiology ; Humans ; Mammals ; alpha-Defensins/immunology ; alpha-Defensins/metabolism
    Chemical Substances alpha-Defensins
    Language English
    Publishing date 2012-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2097873-X
    ISSN 1476-0711 ; 1476-0711
    ISSN (online) 1476-0711
    ISSN 1476-0711
    DOI 10.1186/1476-0711-11-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Expression of cyclophilin A in gastric adenocarcinoma patients and its inverse association with local relapses and distant metastasis.

    Grigoryeva, Evgeniya S / Cherdyntseva, Nadezhda V / Karbyshev, Mikhail S / Volkomorov, Viktor V / Stepanov, Ivan V / Zavyalova, Marina V / Perelmuter, Vladimir M / Buldakov, Mikhail A / Afanasjev, Sergey G / Tuzikov, Sergey A / Bukurova, Yulia A / Lisitsyn, Nikolai A / Beresten, Sergey F

    Pathology oncology research : POR

    2013  Volume 20, Issue 2, Page(s) 467–473

    Abstract: The aim of this study was to identify new protein markers of the intestinal and diffuse type gastric adenocarcinoma and to determine their relation to local relapses and distant metastasis. Using two-dimensional gel electrophoresis, we searched for ... ...

    Abstract The aim of this study was to identify new protein markers of the intestinal and diffuse type gastric adenocarcinoma and to determine their relation to local relapses and distant metastasis. Using two-dimensional gel electrophoresis, we searched for proteins that are overexpressed in the intestinal and/or diffuse type gastric adenocarcinoma, as compared to matched normal mucosa samples with further change confirmation by Western blot. Expression of the selected proteins was further assessed by immunohistocemistry in a large panel of gastric adenocarcinoma with various clinicopathological features. Expression level of cyclophilin A measured with western blot appeared to be increased on average ten times in 63 % of gastric adenocarcinoma vs. paired samples of normal mucosa. The frequency of immunihistochemistry detected cyclophilin A protein expression was found to be equal in tumor of both histotypes, but staining intensity was higher in intestinal versus diffuse types of gastric adenocarcinoma. cyclophilin A protein expression appeared to be lower in deeply invading glandular and cribriform structures of intestinal tumors, as well as in discretely placed groups of the intestinal tumor cells. Local relapses as well as distant metastases registered within 3 year follow up were observed to occur much less frequently in patients with positive cyclophilin A immunostaining in gastric tumors. Analysis of cyclophilin A expression has a potential value for prognosis of gastric adenocarcinoma recurrence and distant metastasis.
    MeSH term(s) Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Biomarkers, Tumor/metabolism ; Cyclophilin A/metabolism ; Female ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Humans ; Immunohistochemistry/methods ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Metastasis/pathology ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging/methods ; Prognosis ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology
    Chemical Substances Biomarkers, Tumor ; Cyclophilin A (EC 5.2.1.-)
    Language English
    Publishing date 2013-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1375979-6
    ISSN 1532-2807 ; 1219-4956
    ISSN (online) 1532-2807
    ISSN 1219-4956
    DOI 10.1007/s12253-013-9718-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4936: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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