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  1. Article ; Online: Estimating Psychiatric Outcomes in First Responders.

    Liston, Conor

    JAMA network open

    2020  Volume 3, Issue 9, Page(s) e2018678

    MeSH term(s) Earthquakes ; Emergency Responders ; Humans ; Japan ; Psychiatric Status Rating Scales ; Stress Disorders, Post-Traumatic
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2020.18678
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  2. Article: Divergent reward cue representations in the prefrontal cortex drive reward motivation in adolescence and adulthood.

    Nieves, Gabriela Manzano / Liston, Conor

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Alterations in motivation and reward-seeking are a transdiagnostic feature of numerous psychiatric disorders that commonly emerge in adolescence, including depression, obsessive- compulsive disorder, and attention deficit hyperactivity disorder. During ... ...

    Abstract Alterations in motivation and reward-seeking are a transdiagnostic feature of numerous psychiatric disorders that commonly emerge in adolescence, including depression, obsessive- compulsive disorder, and attention deficit hyperactivity disorder. During adolescence, reward motivation is naturally heightened, compared to adulthood, but the underlying mechanisms are not well understood. The medial prefrontal cortex (mPFC) is a late developing brain region that regulates reward learning and motivation and is still maturing in adolescence. The mPFC modulates reward-motivated behaviors in adults, and has been hypothesized to be responsible for adolescents' inability to suppress reward-seeking and impulsive behaviors. Using 2-photon imaging of the mPFC and an active reward task, we demonstrate that both the adult and adolescent mPFC encode reward-predictive cues, with distinct neuronal populations encoding rewarded and unrewarded cues. In adolescence the mPFC is hyper-responsive to reward cues and recruits a larger population of neurons to encode reward predictive cues. Furthermore, in the adolescent mPFC, representations of unrewarded cues are attenuated, compared to the adult mPFC, which may tip the balance of action toward reward-seeking. Differences in neuronal responses to rewarded and unrewarded cues were observed in both GABAergic and glutamatergic neurons, with GABAergic inhibition causing disparate effects in adolescents compared to adults. Together our findings identify differences in the functional properties of mPFC microcircuits in adolescents that may underlie differences in reward-seeking behavior and the ability to adaptively suppress reward seeking.
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.07.565069
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  3. Article ; Online: Gene-brain-behavior mechanisms underlying autism spectrum disorder: implications for precision psychiatry.

    Buch, Amanda M / Liston, Conor

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2023  Volume 49, Issue 1, Page(s) 343–344

    MeSH term(s) Humans ; Autism Spectrum Disorder/genetics ; Psychiatry ; Brain
    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type News
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-023-01722-0
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    Zs.A 2379: Show issues Location:
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  4. Article ; Online: Not immune to stress: LBP's link to depression.

    Rahn, Rachel / Liston, Conor

    Immunity

    2023  Volume 56, Issue 3, Page(s) 469–471

    Abstract: Investigators have long suspected a link between inflammation and depression, but the underlying mechanisms are not well understood. Fang et al. report that lipopolysaccharide-binding protein regulates monoamine biosynthesis and might be a missing link ... ...

    Abstract Investigators have long suspected a link between inflammation and depression, but the underlying mechanisms are not well understood. Fang et al. report that lipopolysaccharide-binding protein regulates monoamine biosynthesis and might be a missing link and potential therapeutic target for inflammation-associated depressive behaviors.
    MeSH term(s) Humans ; Depression ; Carrier Proteins ; Acute-Phase Proteins ; Inflammation
    Chemical Substances lipopolysaccharide-binding protein ; Carrier Proteins ; Acute-Phase Proteins
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.02.009
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  5. Article ; Online: MeCP2 for sustained antidepressant effects.

    Johnson, Shane / Liston, Conor

    Nature neuroscience

    2021  Volume 24, Issue 8, Page(s) 1047–1048

    MeSH term(s) Antidepressive Agents ; Methyl-CpG-Binding Protein 2
    Chemical Substances Antidepressive Agents ; Methyl-CpG-Binding Protein 2
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-021-00881-x
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  6. Article: An automated platform for Assessing Working Memory and prefrontal circuit function.

    Witztum, Jonathan / Singh, Ashna / Zhang, Rebecca / Johnson, Megan / Liston, Conor

    Neurobiology of stress

    2023  Volume 24, Page(s) 100518

    Abstract: Working memory is a process for actively maintaining and updating task-relevant information, despite interference from competing inputs, and is supported in part by sustained activity in prefrontal cortical pyramidal neurons and coordinated interactions ... ...

    Abstract Working memory is a process for actively maintaining and updating task-relevant information, despite interference from competing inputs, and is supported in part by sustained activity in prefrontal cortical pyramidal neurons and coordinated interactions with inhibitory interneurons, which may serve to regulate interference. Chronic stress has potent effects on working memory performance, possibly by interfering with these interactions or by disrupting long-range inputs from key upstream brain regions. Still, the mechanisms by which chronic stress disrupts working memory are not well understood, due in part to a need for scalable, easy-to-implement behavioral assays that are compatible with two-photon calcium imaging and other tools for recording from large populations of neurons. Here, we describe the development and validation of a platform that was designed specifically for automated, high-throughput assessments of working memory and simultaneous two-photon imaging in chronic stress studies. This platform is relatively inexpensive and easy to build; fully automated and scalable such that one investigator can test relatively large cohorts of animals concurrently; fully compatible with two-photon imaging, yet also designed to mitigate head-fixation stress; and can be easily adapted for other behavioral paradigms. Our validation data confirm that mice could be trained to perform a delayed response working memory task with relatively high-fidelity over the course of ∼15 days. Two-photon imaging data validate the feasibility of recording from large populations of cells during working memory tasks performance and characterizing their functional properties. Activity patterns in >70% of medial prefrontal cortical neurons were modulated by at least one task feature, and a majority of cells were engaged by multiple task features. We conclude with a brief literature review of the circuit mechanisms supporting working memory and their disruption in chronic stress states-highlighting directions for future research enabled by this platform.
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2816500-7
    ISSN 2352-2895
    ISSN 2352-2895
    DOI 10.1016/j.ynstr.2023.100518
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  7. Article ; Online: Synaptic Mechanisms Regulating Mood State Transitions in Depression.

    Parekh, Puja K / Johnson, Shane B / Liston, Conor

    Annual review of neuroscience

    2022  Volume 45, Page(s) 581–601

    Abstract: Depression is an episodic form of mental illness characterized by mood state transitions with poorly understood neurobiological mechanisms. Antidepressants reverse the effects of stress and depression on synapse function, enhancing neurotransmission, ... ...

    Abstract Depression is an episodic form of mental illness characterized by mood state transitions with poorly understood neurobiological mechanisms. Antidepressants reverse the effects of stress and depression on synapse function, enhancing neurotransmission, increasing plasticity, and generating new synapses in stress-sensitive brain regions. These properties are shared to varying degrees by all known antidepressants, suggesting that synaptic remodeling could play a key role in depression pathophysiology and antidepressant function. Still, it is unclear whether and precisely how synaptogenesis contributes to mood state transitions. Here, we review evidence supporting an emerging model in which depression is defined by a distinct brain state distributed across multiple stress-sensitive circuits, with neurons assuming altered functional properties, synapse configurations, and, importantly, a reduced capacity for plasticity and adaptation. Antidepressants act initially by facilitating plasticity and enabling a functional reconfiguration of this brain state. Subsequently, synaptogenesis plays a specific role in sustaining these changes over time.
    MeSH term(s) Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Depression ; Neuronal Plasticity/physiology ; Neurons ; Synapses/physiology ; Synaptic Transmission/physiology
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282459-0
    ISSN 1545-4126 ; 0147-006X
    ISSN (online) 1545-4126
    ISSN 0147-006X
    DOI 10.1146/annurev-neuro-110920-040422
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    Zs.A 1433: Show issues Location:
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  8. Article ; Online: Toward Circuit Mechanisms of Pathophysiology in Depression.

    Spellman, Timothy / Liston, Conor

    The American journal of psychiatry

    2020  Volume 177, Issue 5, Page(s) 381–390

    Abstract: The search for more effective treatments for depression is a long-standing primary objective in both psychiatry and translational neuroscience. From initial models centered on neurochemical deficits, such as the monoamine hypothesis, research toward this ...

    Abstract The search for more effective treatments for depression is a long-standing primary objective in both psychiatry and translational neuroscience. From initial models centered on neurochemical deficits, such as the monoamine hypothesis, research toward this goal has shifted toward a focus on network and circuit models to explain how key nodes in the limbic system and beyond interact to produce persistent shifts in affective states. To build these models, researchers have turned to two complementary approaches: neuroimaging studies in human patients (and their healthy counterparts) and neurophysiology studies in animal models, facilitated in large part by optogenetic and chemogenetic techniques. As the authors discuss, functional neuroimaging studies in humans have included largely task-oriented experiments, which have identified brain regions differentially activated during processing of affective stimuli, and resting-state functional MRI experiments, which have identified brain-wide networks altered in depressive states. Future work in this area will build on a multisite approach, assembling large data sets across diverse populations, and will also leverage the statistical power afforded by longitudinal imaging studies in patient samples. Translational studies in rodents have used optogenetic and chemogenetic tools to identify not just nodes but also connections within the networks of the limbic system that are both critical and permissive for the expression of motivated behavior and affective phenotypes. Future studies in this area will exploit mesoscale imaging and multisite electrophysiology recordings to construct network models with cell-type specificity and high statistical power, identifying candidate circuit and molecular pathways for therapeutic intervention.
    MeSH term(s) Animals ; Depressive Disorder/physiopathology ; Disease Models, Animal ; Forecasting ; Humans ; Limbic System ; Longitudinal Studies ; Magnetic Resonance Imaging ; Nerve Net ; Neural Pathways
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2020.20030280
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  9. Article ; Online: Psychedelics re-engineered for potential use in the clinic.

    Manzano-Nieves, Gabriela / Liston, Conor

    Nature

    2020  Volume 589, Issue 7842, Page(s) 358–359

    MeSH term(s) Hallucinogens
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2020-12-10
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-03404-z
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  10. Article ; Online: Reply to: A Closer Look at Depression Biotypes: Correspondence Relating to Grosenick et al. (2019).

    Grosenick, Logan / Liston, Conor

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2020  Volume 5, Issue 5, Page(s) 556

    MeSH term(s) Depression ; Humans ; Optogenetics
    Language English
    Publishing date 2020-01-08
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2019.11.002
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