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  1. Article: Evaluation of Extended Storage of Swine Complete Feed for Inactivation of Viral Contamination and Effect on Nutritional, Microbiological, and Toxicological Profiles.

    Gebhardt, Jordan T / Dee, Scott A / Little, Erin / Scales, Brittney N / Kern, Doug R

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 3

    Abstract: The extended storage of feed ingredients has been suggested as a method to mitigate the risk of pathogen transmission through contaminated ingredients. To validate the approach of extended storage of complete swine feed for the inactivation of swine ... ...

    Abstract The extended storage of feed ingredients has been suggested as a method to mitigate the risk of pathogen transmission through contaminated ingredients. To validate the approach of extended storage of complete swine feed for the inactivation of swine viruses, an experiment was conducted wherein swine feed was inoculated with 10 mL of 1 × 10
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14030393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Femoral Cartilage Ultrasound Echo Intensity Associates with Arthroscopic Cartilage Damage.

    Harkey, Matthew S / Little, Erin / Thompson, Mikaela / Zhang, Ming / Driban, Jeffrey B / Salzler, Matthew J

    Ultrasound in medicine & biology

    2020  Volume 47, Issue 1, Page(s) 43–50

    Abstract: This study compared quantitative cartilage ultrasound metrics between people with (n = 12) and without (n = 12) arthroscopic cartilage damage after anterior cruciate ligament injury (age, 24.9 ± 3.7 y; sex, 33% female, 67% male; days since injury = 50 ± ... ...

    Abstract This study compared quantitative cartilage ultrasound metrics between people with (n = 12) and without (n = 12) arthroscopic cartilage damage after anterior cruciate ligament injury (age, 24.9 ± 3.7 y; sex, 33% female, 67% male; days since injury = 50 ± 52). A transverse suprapatellar ultrasound assessment imaged the femoral cartilage in participants' injured knees before a clinical arthroscopy. A custom program automatically separated a manual cartilage segmentation into standardized medial and lateral femoral regions and calculated mean thickness (i.e., cross-sectional area/length of cartilage-bone interface), mean echo intensity and echo-intensity heterogeneity. An orthopedic surgeon assessed arthroscopic cartilage damage in the medial and lateral femoral condyles using the Outerbridge grading system (cartilage damage = Outerbridge ≥ 1). Separate logistic regressions for medial and lateral femoral cartilage were used to determine the association between each ultrasound metric and arthroscopic cartilage damage. In medial femoral cartilage, for every 1 standard deviation decrease in echo-intensity mean and heterogeneity, there is, respectively, a 91% (adjusted odds ratio, 0.09; 95% confidence interval, 0.01-0.69) and 97% (adjusted odds ratio, 0.03; 95% confidence interval, 0.002-0.50) increase in the odds of having arthroscopic cartilage damage. Lateral cartilage ultrasound metrics are not associated with lateral arthroscopic cartilage damage. This study provides preliminary evidence that femoral cartilage ultrasound echo intensity is a non-invasive measure associated with medial femoral cartilage health after anterior cruciate ligament injury.
    MeSH term(s) Adult ; Anterior Cruciate Ligament Injuries/complications ; Anterior Cruciate Ligament Injuries/diagnostic imaging ; Arthroscopy ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/injuries ; Female ; Humans ; Male ; Ultrasonography ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-10-17
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2020.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Review of efficacy and safety of laxatives use in geriatrics.

    Izzy, Manhal / Malieckal, Anju / Little, Erin / Anand, Sury

    World journal of gastrointestinal pharmacology and therapeutics

    2016  Volume 7, Issue 2, Page(s) 334–342

    Abstract: Aim: To study the efficacy and safety of pharmacological treatment of constipation in geriatrics.: Methods: PubMed, MEDLINE, google scholar, and Ovid were searched to identify human studies performed on the use of laxatives in elderly with ... ...

    Abstract Aim: To study the efficacy and safety of pharmacological treatment of constipation in geriatrics.
    Methods: PubMed, MEDLINE, google scholar, and Ovid were searched to identify human studies performed on the use of laxatives in elderly with constipation, which were conducted between January 1990 and January 2013 using the specified keywords. Controlled studies that enrolled geriatric patients with a diagnosis of constipation and addressed the efficacy and/or the safety of pharmacological treatments were included. Studies were excluded from this review if they were non-controlled trials, case series, or case reports.
    Results: Out of twenty three studies we initially retrieved in our search, only nine studies met the eligibility criteria of being controlled trials within geriatrics. The laxatives examined in the nine studies were senna, lactulose, sorbital, polyethylene glycol (PEG), lubiprostone, linaclotide, and prucalopride. In those studies, senna combinations had a higher efficacy than sorbitol or lactulose as well as, a very good adverse effect profile. PEG was also shown to be safe and effective in geriatric population. Furthermore, it has been shown that PEG is as safe in geriatrics as in general population. New agents like lubiprostone and prucalopride show promising results but the data about these agents in geriatrics are still limited which warrants further investigation.
    Conclusion: Senna combinations and PEG appear to have a more favorable profile over the other traditionally used laxatives in elderly patients with constipation.
    Language English
    Publishing date 2016-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583480-0
    ISSN 2150-5349
    ISSN 2150-5349
    DOI 10.4292/wjgpt.v7.i2.334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Quantifying Individual Response to PRRSV Using Dynamic Indicators of Resilience Based on Activity.

    van der Zande, Lisette E / Dunkelberger, Jenelle R / Rodenburg, T Bas / Bolhuis, J Elizabeth / Mathur, Pramod K / Cairns, W James / Keyes, Michael C / Eggert, John M / Little, Erin A / Dee, Scott A / Knol, Egbert F

    Frontiers in veterinary science

    2020  Volume 7, Page(s) 325

    Abstract: Pigs are faced with various perturbations throughout their lives, some of which are induced by management practices, others by natural causes. Resilience is described as the ability to recover from or cope with a perturbation. Using these data, activity ... ...

    Abstract Pigs are faced with various perturbations throughout their lives, some of which are induced by management practices, others by natural causes. Resilience is described as the ability to recover from or cope with a perturbation. Using these data, activity patterns of an individual, as well as deviations from these patterns, can potentially be used to quantify resilience. Dynamic indicators of resilience (DIORs) may measure resilience on a different dimension by calculating variation, autocorrelation and skewness of activity from the absolute activity data. The aim of this study was to investigate the potential of using DIORs of activity, such as average, root mean square error (RMSE), autocorrelation or skewness as indicators of resilience to infection with the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). For this study, individual activity was obtained from 232 pigs equipped with ear tag accelerometers and inoculated with PRRSV between seven and 9 weeks of age. Clinical scores were assigned to each individual at 13 days post-challenge and used to distinguish between a resilient and non-resilient group. Mortality post-challenge was also recorded. Average, RMSE, autocorrelation and skewness of activity were calculated for the pre- and post-challenge phases, as well as the change in activity level pre- vs. post-challenge (i.e., delta). DIORs pre-challenge were expected to predict resilience to PRRSV in the absence of PRRSV infection, whereas DIORs post-challenge and delta were expected to reflect the effect of the PRRSV challenge. None of the pre-challenge DIORs predicted morbidity or mortality post-challenge. However, a higher RMSE in the 3 days post-challenge and larger change in level and RMSE of activity from pre- to post-challenge tended to increase the probability of clinical signs at day 13 post-infection (poor resilience). A higher skewness post-challenge (tendency) and a larger change in skewness from pre- to post-challenge increased the probability of mortality. A decrease in skewness post-challenge lowered the risk of mortality. The post-challenge DIOR autocorrelation was neither linked to morbidity nor to mortality. In conclusion, results from this study showed that post-challenge DIORs of activity can be used to quantify resilience to PRRSV challenge.
    Language English
    Publishing date 2020-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.00325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Quantifying Individual Response to PRRSV Using Dynamic Indicators of Resilience Based on Activity

    van der Zande, Lisette E. / Dunkelberger, Jenelle R. / Rodenburg, T.B. / Bolhuis, J.E. / Mathur, Pramod K. / Cairns, W.J. / Keyes, Michael C. / Eggert, John M. / Little, Erin A. / Dee, Scott A. / Knol, Egbert F.

    Frontiers in Veterinary Science

    2020  Volume 7

    Abstract: Pigs are faced with various perturbations throughout their lives, some of which are induced by management practices, others by natural causes. Resilience is described as the ability to recover from or cope with a perturbation. Using these data, activity ... ...

    Abstract Pigs are faced with various perturbations throughout their lives, some of which are induced by management practices, others by natural causes. Resilience is described as the ability to recover from or cope with a perturbation. Using these data, activity patterns of an individual, as well as deviations from these patterns, can potentially be used to quantify resilience. Dynamic indicators of resilience (DIORs) may measure resilience on a different dimension by calculating variation, autocorrelation and skewness of activity from the absolute activity data. The aim of this study was to investigate the potential of using DIORs of activity, such as average, root mean square error (RMSE), autocorrelation or skewness as indicators of resilience to infection with the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). For this study, individual activity was obtained from 232 pigs equipped with ear tag accelerometers and inoculated with PRRSV between seven and 9 weeks of age. Clinical scores were assigned to each individual at 13 days post-challenge and used to distinguish between a resilient and non-resilient group. Mortality post-challenge was also recorded. Average, RMSE, autocorrelation and skewness of activity were calculated for the pre- and post-challenge phases, as well as the change in activity level pre- vs. post-challenge (i.e., delta). DIORs pre-challenge were expected to predict resilience to PRRSV in the absence of PRRSV infection, whereas DIORs post-challenge and delta were expected to reflect the effect of the PRRSV challenge. None of the pre-challenge DIORs predicted morbidity or mortality post-challenge. However, a higher RMSE in the 3 days post-challenge and larger change in level and RMSE of activity from pre- to post-challenge tended to increase the probability of clinical signs at day 13 post-infection (poor resilience). A higher skewness post-challenge (tendency) and a larger change in skewness from pre- to post-challenge increased the probability of mortality. A decrease in skewness ...
    Keywords accelerometer ; activity ; dynamic indicator of resilience ; pig behavior ; resilience
    Subject code 630
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Conference proceedings ; Online: Defining resilient pigs after a PRRS challenge using activity and feeding data from accelerometers

    van der Zande, Lisette / Dunkelberger, Jenelle R. / Rodenburg, T.B. / Mathur, Pramod K. / Cairns, W.J. / Keyes, Michael C. / Knol, E.F. / Dee, Scott A. / Little, Erin A.

    Trade-offs in science – keeping the balance

    2019  

    Keywords Life Science
    Language English
    Publisher Wageningen University & Research
    Publishing country nl
    Document type Article ; Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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