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Article ; Online: Validation of a size exclusion method for concomitant purification and formulation of peptide radiopharmaceuticals.

Martin, Sebastian / Wendlinger, Lennard / Litvinenko, Alexandra / Faizova, Radmila / Schottelius, Margret

EJNMMI radiopharmacy and chemistry

2024 Volume 9, Issue 1, Page(s) 23

Abstract: Background: Both in clinical routine and in preclinical research, the established standard procedure for the final purification of radiometal-labeled peptide radiopharmaceuticals is cartridge-based reversed-phase (RP) solid phase extraction (SPE). It ... ...

Abstract	Background: Both in clinical routine and in preclinical research, the established standard procedure for the final purification of radiometal-labeled peptide radiopharmaceuticals is cartridge-based reversed-phase (RP) solid phase extraction (SPE). It allows the rapid and quantitative separation of the radiolabeled peptide from hydrophilic impurities and easy integration into automated synthesis procedures. However, product elution from RP cartridges necessitates the use of organic solvents and product recovery is sometimes limited. Thus, an alternative purification method based on commercially available size exclusion cartridges was investigated. Results: Since most peptide radiopharmaceuticals have a molecular weight > 1 kDa, Sephadex G10 cartridges with a molecular size cut-off of 700 Da were used for the final purification of a broad palette of Conclusions: Overall, size exclusion purification yielded all peptide radiopharmaceuticals in excellent radiochemical purities (> 99%) in saline within 10-12 min. Although product recovery is marginally inferior to classical SPE purifications, this method has the advantage of completely avoiding organic solvents and representing a cost-effective, easy-to-implement purification approach for automated radiotracer synthesis.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ISSN	2365-421X
ISSN (online)	2365-421X
DOI	10.1186/s41181-024-00254-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 3D polarization-interference holographic histology for wavelet-based differentiation of the polycrystalline component of biological tissues with different necrotic states. Forensic applications.

Ushenko, Alexander / Dubolazov, Alexander / Zheng, Jun / Litvinenko, Alexandra / Gorsky, Mykhaylo / Ushenko, Yuriy / Soltys, Iryna / Salega, Olexander / Chen, Zhebo / Wanchuliak, Oleh

Journal of biomedical optics

2024 Volume 29, Issue 5, Page(s) 52920

Abstract: Significance: The interference-holographic method of phase scanning of fields of scattered laser radiation is proposed. The effectiveness of this method for the selection of variously dispersed components is demonstrated. This method made it possible to ...

Abstract	Significance: The interference-holographic method of phase scanning of fields of scattered laser radiation is proposed. The effectiveness of this method for the selection of variously dispersed components is demonstrated. This method made it possible to obtain polarization maps of biological tissues at a high level of depolarized background. The scale-selective analysis of such maps was used to determine necrotic changes in the optically anisotropic architectonics of biological tissues. Objective: Development and experimental approbation of layered phase polarimetry of repeatedly scattered fields in diffuse layers of biological tissues. Application of scale-selective processing of the found coordinate distributions of polarization states in various phase sections of object fields. Determination of criteria (markers) for histological differential diagnosis of the causes of necrotic changes in optical anisotropy of biological tissues. Approach: We used a synthesis of three instrumental and analytical methods. Polarization-interference registration of laser radiation scattered by a sample of biological tissue. Digital holographic reconstruction and layered phase scanning of distributions of complex amplitudes of the object field. Analytical determination of polarization maps of various phase cross-sections of repeatedly scattered radiation. Application of wavelet analysis of the distributions of polarization states in the phase plane of a single scattered component of an object field. Determination of criteria (markers) for differential diagnosis of necrotic changes in biological tissues with different morphological structure. Two cases are considered. The first case is the myocardium of those who died as a result of coronary heart disease and acute coronary insufficiency. The second case is lung tissue samples of deceased with bronchial asthma and fibrosis. Results: A method of polarization-interference mapping of diffuse object fields of biological tissues has been developed and experimentally implemented. With the help of digital holographic reconstruction of the distributions of complex amplitudes, polarization maps in various phase sections of a diffuse object field are found. The wavelet analysis of azimuth and ellipticity distributions of polarization in the phase plane of a single scattered component of laser radiation is used. Scenarios for changing the amplitude of the wavelet coefficients for different scales of the scanning salt-like MHAT function are determined. Statistical moments of the first to fourth orders are determined for the distributions of the amplitudes of the wavelet coefficients of the azimuth maps and the ellipticity of polarization. As a result, diagnostic markers of necrotic changes in the myocardium and lung tissue were determined. The statistical criteria found are the basis for determining the accuracy of their differential diagnosis of various necrotic states of biological tissues. Conclusions: Necrotic changes caused by "coronary artery disease-acute coronary insufficiency" and "asthma-pulmonary fibrosis" were demonstrated by the method of wavelet differentiation with polarization interference with excellent accuracy.
MeSH term(s)	Holography ; Lasers ; Spectrum Analysis ; Histological Techniques ; Myocardium
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1309154-2
ISSN	1560-2281 ; 1083-3668
ISSN (online)	1560-2281
ISSN	1083-3668
DOI	10.1117/1.JBO.29.5.052920
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Article ; Online: 3D digital polarization-holographic wavelet histology in determining the duration of mechanical damage to the myocardium.

Ushenko, Alexander / Zheng, Jun / Litvinenko, Alexandra / Gorsky, Mykhaylo / Wanchuliak, Oleh / Dubolazov, Alexander / Ushenko, Yuriy / Soltys, Iryna / Salega, Olexander / Chen, Zhebo

Journal of biophotonics

2024 Volume 17, Issue 3, Page(s) e202300372

Abstract: We aimed developing and experimentally validating methods for 3D scale-selective polarimetry of multiply scattered fields in diffuse myocardium layers for mechanical myocardial injury prescription histological differential diagnostics. We used the ... ...

Abstract	We aimed developing and experimentally validating methods for 3D scale-selective polarimetry of multiply scattered fields in diffuse myocardium layers for mechanical myocardial injury prescription histological differential diagnostics. We used the synthesis of diffuse object field polarization-interference registration and polarization-inhomogeneous field digital holographic reconstruction and layer-by-layer complex amplitudes distributions The method for selection single and diffuse object field multiply scattered components polarization maps is proposed. The conditions for eliminating the distorting influence of a depolarized background high level are found. On the basis of еру object field single scattered component polarization maps a large-scale selective wavelet analysis the criteria (markers) for mechanical myocardial injury different prescription diagnosis was determinate. Excellent accuracy mechanical injury myocardium necrotic changes with different duration using polarization-interference wavelet differentiation were achieved.
MeSH term(s)	Myocardium/pathology ; Heart/diagnostic imaging
Language	English
Publishing date	2024-01-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2390063-5
ISSN	1864-0648 ; 1864-063X
ISSN (online)	1864-0648
ISSN	1864-063X
DOI	10.1002/jbio.202300372
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Article ; Online: Efficient Multi-Hop Wireless Power Transfer for the Indoor Environment.

Eidaks, Janis / Kusnins, Romans / Babajans, Ruslans / Cirjulina, Darja / Semenjako, Janis / Litvinenko, Anna

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 17

Abstract: With the rapid development of the Internet of Things (IoT) and wireless sensor networks (WSN), the modern world requires advanced solutions for the wireless powering of low-power autonomous devices. The present study addresses the wireless power transfer ...

Abstract	With the rapid development of the Internet of Things (IoT) and wireless sensor networks (WSN), the modern world requires advanced solutions for the wireless powering of low-power autonomous devices. The present study addresses the wireless power transfer (WPT) efficiency problem by exploiting a multi-hop concept-based technique to increase the received power at the end sensor node (ESN). The current work adopts efficient multi-hop technology from the communications field to examine its impact on WPT performance. The investigation involves power transfer modeling and experimental measurements in a sub-GHz frequency range, chosen for being capable of providing a greater distance to transmit power. The paper proposes a multi-hop (MH) WPT concept based on signal amplification and demonstrates the fabricated multi-hop node (MHN) prototype. The experimental verification of the MHN is performed in the laboratory environment. The present paper examines two WPT scenarios: line-of-sight (LoS) and non-line-of-sight (NLoS). The turn-on angle of 90 degrees on MHN is used for the NLoS case. The received power and RF-DC converted voltage on the ESN are measured for all investigated scenarios. Moreover, the paper proposes an efficient simulation approach for the performance evaluation of MH WPT technology, providing an opportunity to analyze and optimize wireless sensor nodes' spatial distribution to increase the received power.
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23177367
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Book ; Online: Solving weakly supervised regression problem using low-rank manifold regularization

Berikov, Vladimir / Litvinenko, Alexander

2021

Abstract: We solve a weakly supervised regression problem. Under "weakly" we understand that for some training points the labels are known, for some unknown, and for others uncertain due to the presence of random noise or other reasons such as lack of resources. ... ...

Abstract	We solve a weakly supervised regression problem. Under "weakly" we understand that for some training points the labels are known, for some unknown, and for others uncertain due to the presence of random noise or other reasons such as lack of resources. The solution process requires to optimize a certain objective function (the loss function), which combines manifold regularization and low-rank matrix decomposition techniques. These low-rank approximations allow us to speed up all matrix calculations and reduce storage requirements. This is especially crucial for large datasets. Ensemble clustering is used for obtaining the co-association matrix, which we consider as the similarity matrix. The utilization of these techniques allows us to increase the quality and stability of the solution. In the numerical section, we applied the suggested method to artificial and real datasets using Monte-Carlo modeling. Comment: 14 pages, 5 Tables
Keywords	Computer Science - Machine Learning ; Mathematics - Numerical Analysis ; Statistics - Machine Learning ; 62H30 ; 68T20 ; 68T37 ; I.2.6
Subject code	518
Publishing date	2021-04-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fast and Accurate Approach to RF-DC Conversion Efficiency Estimation for Multi-Tone Signals.

Eidaks, Janis / Kusnins, Romans / Babajans, Ruslans / Cirjulina, Darja / Semenjako, Janis / Litvinenko, Anna

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 3

Abstract: The paper presents a computationally efficient and accurate numerical approach to evaluating RF-DC power conversion efficiency (PCE) for energy harvesting circuits in the case of multi-tone power-carrying signal with periodic envelopes. This type of ... ...

Abstract	The paper presents a computationally efficient and accurate numerical approach to evaluating RF-DC power conversion efficiency (PCE) for energy harvesting circuits in the case of multi-tone power-carrying signal with periodic envelopes. This type of signal has recently received considerable attention in the literature. It has been shown that their use may result in a higher PCE than the conventional sine wave signal for low to medium input power levels. This reason motivated the authors to develop a fast and accurate two-frequency harmonic balance method (2F-HB), as fast PCE calculation might appreciably expedite the converter circuit optimization process. In order to demonstrate the computational efficiency of the 2F-HB, a comparative study is performed. The results of this study show that the 2F-HB significantly outperforms such extensively used methods as the transient analysis (TA), the harmonic balance method (HB), and the multidimensional harmonic balance method (MHB). The method also outperforms the commercially available non-linear circuit simulator Keysight ADS employing both HB and MHB. Furthermore, the proposed method can be readily integrated into commonly used commercially available non-linear circuit simulation software, including the Keysight ADS, Ansys HFSS, just to name a few-minor modifications are required. In addition, to increase the correctness and reliability of the proposed method, the influence of PCB is considered by calculating Y parameters of its 3D model. The widely employed voltage doubler-based RF-DC converter for energy harvesting and wireless power transfer (WPT) in sub-GHz diapason is chosen to validate the proposed method experimentally. This RF-DC converter is chosen for its simplicity and capability to provide sufficiently high PCE. The measurements of the PCE for a voltage doubler prototype employing different multi-tone waveform signals were performed in laboratory conditions. Various combinations of the matching circuit element values were considered to find the optimal one in both-theoretical model and experimental prototype. The measured PCE is in very good agreement with the PCE calculated numerically, which attests to the validity of the proposed approach. The proposed PCE estimation method is not limited to one selected RF-DC conversion circuit and can also be applied to other circuits and frequency bands. The comparison of the PCE obtained by means of the proposed approach and the measured one shows very good agreement between them. The PCE estimation error reaches as low as 0.37%, and the maximal estimation error is 32.65%.
Language	English
Publishing date	2022-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22030787
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Article ; Online: Efficiency of application of means of sports preparation of combat sportsmen in physical training of students of technical high school

Litvinenko A.M.

Physical Education of Students, Vol 2, Pp 49-

2013 Volume 53

Abstract: The problem of efficiency of application of different volumes of trainings facilities of sporting single combats (on the example of kickboxing) is considered in physical education of students. The complexity of influence of facilities of east single ... ...

Abstract	The problem of efficiency of application of different volumes of trainings facilities of sporting single combats (on the example of kickboxing) is considered in physical education of students. The complexity of influence of facilities of east single combats is shown on sportsmen. In an experiment took part 50 students of first-year of teaching in age 17-18 years. Tests were used: undercutting on a cross-bar, broad jumps from a place, at shuttle run of 4х9 m. Positive intercommunication of increase of volume of the training loading is shown by effectiveness of pedagogical process. It is set that increase of number of employments by students in kickboxing to three one time per a week allows for certain to improve the indexes of physical preparedness on the chosen tests. The higher level of technical preparedness of students is statistically confirmed applying the greater amount of physical exercises, sent to forming of skills of kickboxing. Distribution of students is educed on the tactical types of conduct of competition fight: 36 % is a playing manner, 44 % is a rate manner, 8 % is a manner of slog, 12 % is an universal manner. Offered to recommendation on the correction of volume of loading for the increase of didactic potential of employments on physical education.
Keywords	single combats ; skills ; readiness ; efficiency ; loading ; Sports ; GV557-1198.995 ; Recreation. Leisure ; GV1-1860 ; Geography. Anthropology. Recreation ; G ; DOAJ:Sports Science ; DOAJ:Social Sciences
Subject code	796
Language	Russian
Publishing date	2013-02-01T00:00:00Z
Publisher	Kharkov Regional Branch of the National Olympic Committee of Ukraine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Semi-Supervised Regression using Cluster Ensemble and Low-Rank Co-Association Matrix Decomposition under Uncertainties

Berikov, Vladimir / Litvinenko, Alexander

2019

Abstract: In this paper, we solve a semi-supervised regression problem. Due to the lack of knowledge about the data structure and the presence of random noise, the considered data model is uncertain. We propose a method which combines graph Laplacian ... ...

Abstract	In this paper, we solve a semi-supervised regression problem. Due to the lack of knowledge about the data structure and the presence of random noise, the considered data model is uncertain. We propose a method which combines graph Laplacian regularization and cluster ensemble methodologies. The co-association matrix of the ensemble is calculated on both labeled and unlabeled data; this matrix is used as a similarity matrix in the regularization framework to derive the predicted outputs. We use the low-rank decomposition of the co-association matrix to significantly speedup calculations and reduce memory. Numerical experiments using the Monte Carlo approach demonstrate robustness, efficiency, and scalability of the proposed method. Comment: 12 pages, 1 figure, 3 tables, submitted to the proceedings of the 14th Computer Science Symposium in Russia (CSR 2019)
Keywords	Statistics - Machine Learning ; Computer Science - Machine Learning
Publishing date	2019-01-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Phase noise analysis of mutually synchronized spin Hall nano-oscillators

Litvinenko, Artem / Kumar, Akash / Rajabali, Mona / Awad, Ahmad A. / Khymyn, Roman / Akerman, Johan

2023

Abstract: The reduction of phase noise in electronic systems is of utmost importance in modern communication and signal processing applications and requires an understanding of the underlying physical processes. Here, we systematically study the phase noise in ... ...

Abstract	The reduction of phase noise in electronic systems is of utmost importance in modern communication and signal processing applications and requires an understanding of the underlying physical processes. Here, we systematically study the phase noise in mutually synchronized chains of nano-constriction spin Hall nano-oscillators (SHNOs). We find that longer chains have improved phase noise figures at low offset frequencies (1/f noise), where chains of two and ten mutually synchronized SHNOs have 2.8 and 6.2 dB lower phase noise than single SHNOs. This is close to the theoretical values of 3 and 10 dB, and the deviation is ascribed to process variations between nano-constrictions. However, at higher offset frequencies (thermal noise), the phase noise unexpectedly increases with chain length, which we ascribe to process variations, a higher operating temperature in the long chains at the same drive current and phase delays in the coupling between nano-constrictions.
Keywords	Condensed Matter - Mesoscale and Nanoscale Physics ; Physics - Applied Physics
Subject code	612
Publishing date	2023-03-31
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Mutual synchronization in spin torque and spin Hall nano-oscillators

Kumar, Akash / Litvinenko, Artem / Behera, Nilamani / Awad, Ahmad A. / Khymyn, Roman / Åkerman, Johan

2023

Abstract: This chapter reviews the state of the art in mutually synchronized spin-torque and spin Hall nano-oscillator (STNO and SHNO) arrays. After briefly introducing the underlying physics, we discuss different nano-oscillator implementations and their ... ...

Abstract	This chapter reviews the state of the art in mutually synchronized spin-torque and spin Hall nano-oscillator (STNO and SHNO) arrays. After briefly introducing the underlying physics, we discuss different nano-oscillator implementations and their functional properties with respect to frequency range, output power, phase noise, and modulation rates. We then introduce the concepts and the theory of mutual synchronization and discuss the possible coupling mechanisms in spintronic nano-oscillators, such as dipolar, electrical, and spin-wave coupling. We review the experimental literature on mutually synchronized STNOs and SHNOs in one- and two-dimensional arrays and discuss ways to increase the number of mutually synchronized nano-oscillators. Finally, the potential for applications ranging from microwave signal sources/detectors and ultrafast spectrum analyzers to neuromorphic computing elements and Ising machines is discussed together with the specific electronic circuitry that has been designed so far to harness this potential. Comment: Book Chapter (Dynamical Phenomena in Spintronics/nano-magnetism)
Keywords	Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
Subject code	535
Publishing date	2023-12-15
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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