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  1. Article ; Online: Does interstate trade of agricultural products in the U.S. alleviate land and water stress?

    Liu, Baobao / Feng, Kuishuang / Sun, Laixiang / Baiocchi, Giovanni

    Journal of environmental management

    2024  Volume 354, Page(s) 120427

    Abstract: Interregional free-trade of agricultural products is expected to transfer embodied (virtual) water from more to less water-productive regions. However, irrigation in semi-arid to arid regions may significantly push up agricultural productivity but cause ... ...

    Abstract Interregional free-trade of agricultural products is expected to transfer embodied (virtual) water from more to less water-productive regions. However, irrigation in semi-arid to arid regions may significantly push up agricultural productivity but cause local water scarcity. This may result in a puzzle: inter-regional trade may save overall water consumption but lead to more severe local water scarcity. An analogous puzzle may exist for farmland, for instance, trade may save farmland but not address farmland scarcity. To test the existence of these two important puzzles, we applied environmentally extended multi-regional input-output models to obtain the inter-regional virtual agricultural water and land transfer across 48 states of the conterminous U.S. and estimated their agricultural land and water footprints in 2017. Such a detailed analysis showed that while the land-abundant Midwestern states exported a sizable amount of virtual farmland to other densely populated areas and foreign nations, the water-stressed Western U.S. and Southwestern U.S. states, like California, Arizona, and New Mexico, exported considerable amounts of water-intensive crops such as fruits, vegetables and tree nuts to the Eastern U.S. and overseas, thus worsen the local water scarcity of those water scarce states. Our analysis highlights a critical dilemma inherent in an economic productivity-focused incentive regime: It frequently leads to increased withdrawal of scarce water. Therefore, resource scarcity rents need to be reflected in inter-regional trade with the support of local environmental policies.
    MeSH term(s) Humans ; Water Supply ; Water Resources ; Dehydration ; Agriculture ; Farms ; China
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120427
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  2. Article: Alfalfa xenomiR-162 targets G protein subunit gamma 11 to regulate milk protein synthesis in bovine mammary epithelial cells.

    Meng, Guizhi / Duan, Hongjuan / Jia, Jingying / Liu, Baobao / Ma, Yun / Cai, Xiaoyan

    Animal bioscience

    2024  Volume 37, Issue 3, Page(s) 509–521

    Abstract: Objective: It was shown that microRNAs (miRNAs) play an important role in milk protein synthesis. However, the post-transcriptional regulation of casein expression by exogenous miRNA (xeno-miRNAs) in ruminants remains unclear. This study explores the ... ...

    Abstract Objective: It was shown that microRNAs (miRNAs) play an important role in milk protein synthesis. However, the post-transcriptional regulation of casein expression by exogenous miRNA (xeno-miRNAs) in ruminants remains unclear. This study explores the regulatory roles of alfalfa xeno-miR162 on casein synthesis in bovine mammary epithelial cells (bMECs).
    Methods: The effects of alfalfa xenomiR-162 and G protein subunit gamma 11 (GNG11) on proliferation and milk protein metabolism of bMECs were detected by 5-Ethynyl-2'-Deoxyuridine (EdU) staining, flow cytometry, cell counting kit-8 (CCK-8), enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot. Dual-luciferase reporter assay was used to verify the targeting relationship between GNG11 and xenomiR-162.
    Results: Results showed that over-expression of xenomiR-162 inhibited cell proliferation but promoted apoptosis, which also up-regulated the expression of several casein coding genes, including CSN1S1, CSN1S2, and CSN3, while decreasing the expression of CSN2. Furthermore, the targeting relationship between GNG11 and xenomiR-162 was determined, and it was confirmed that GNG11 silencing also inhibited cell proliferation but promoted apoptosis and reduced the expression of casein coding genes and genes related to the mammalian target of rapamycin (mTOR) pathway.
    Conclusion: Alfalfa xenomiR-162 appears to regulate bMECs proliferation and milk protein synthesis via GNG11 in the mTOR pathway, suggesting that this xeno-miRNA could be harnessed to modulate CSN3 expression in dairy cows, and increase κ-casein contents in milk.
    Language English
    Publishing date 2024-01-20
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2765-0189
    ISSN 2765-0189
    DOI 10.5713/ab.23.0370
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  3. Article ; Online: A double association-based evolutionary algorithm for many-objective optimization.

    Liu, Junhua / Zhang, Wei / Tian, Mengnan / Ji, Hong / Liu, Baobao

    Mathematical biosciences and engineering : MBE

    2023  Volume 20, Issue 9, Page(s) 17324–17355

    Abstract: In this paper, a double association-based evolutionary algorithm (denoted as DAEA) is proposed to solve many-objective optimization problems. In the proposed DAEA, a double association strategy is designed to associate solutions with each subspace. ... ...

    Abstract In this paper, a double association-based evolutionary algorithm (denoted as DAEA) is proposed to solve many-objective optimization problems. In the proposed DAEA, a double association strategy is designed to associate solutions with each subspace. Different from the existing association methods, the double association strategy takes the empty subspace into account and associates it with a promising solution, which can facilitate the exploration of unknown areas. Besides, a new quality evaluation scheme is developed to evaluate the quality of each solution in subspace, where the convergence and diversity of each solution is first measured, and in order to evaluate the diversity of solutions more finely, the global diversity and local diversity is designed to measure the diversity of each solution. Then, a dynamic penalty coefficient is designed to balance the convergence and diversity by penalizing the global diversity distribution of solutions. The performance of DAEA is validated by comparing with five state-of-the-art many-objective evolutionary algorithms on a number of well-known benchmark problems with up to 20 objectives. Experimental results show that our DAEA has high competitiveness in solving many-objective optimizatiopn problems compared with the other compared algorithms.
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023771
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  4. Article ; Online: A novel antibacterial strategy for targeting the bacterial methionine biosynthesis pathway.

    Bin, Peng / Liu, Wanyang / Zhang, Xiaojie / Liu, Baobao / Zhu, Guoqiang

    International journal of antimicrobial agents

    2023  Volume 63, Issue 2, Page(s) 107057

    Abstract: Bacterial pathogens reprogramme their metabolic networks to support growth and establish infection at specific sites. Bacterial central metabolism has been considered attractive for developing antimicrobial drugs; however, most metabolic enzymes are ... ...

    Abstract Bacterial pathogens reprogramme their metabolic networks to support growth and establish infection at specific sites. Bacterial central metabolism has been considered attractive for developing antimicrobial drugs; however, most metabolic enzymes are conserved between humans and bacteria. This study found that blockade of methionine biosynthesis in Citrobacter rodentium and Salmonella enteritidis inhibited bacterial growth and activity of the type III secretion system, resulting in severe defects in colonization and pathogenicity. In addition, α-methyl-methionine was found to inhibit the activity of methionine biosynthetic enzyme MetA, and consequently reduce the virulence and pathogenicity of enteric pathogens. These findings highlight the crucial role of methionine in bacterial virulence, and describe a potential new drug target.
    MeSH term(s) Humans ; Virulence ; Virulence Factors ; Anti-Bacterial Agents/pharmacology ; Bacteria ; Methionine ; Bacterial Proteins
    Chemical Substances Virulence Factors ; Anti-Bacterial Agents ; Methionine (AE28F7PNPL) ; Bacterial Proteins
    Language English
    Publishing date 2023-12-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2023.107057
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  5. Article: The vertical transmission of

    Liu, Baobao / Zhang, Xiaojie / Ding, Xueyan / Bin, Peng / Zhu, Guoqiang

    One health (Amsterdam, Netherlands)

    2022  Volume 16, Page(s) 100469

    Abstract: Salmonella ... ...

    Abstract Salmonella enterica
    Language English
    Publishing date 2022-12-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2022.100469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Alfalfa Xeno-miR168b Target

    Jia, Jingying / Duan, Hongjuan / Liu, Baobao / Ma, Yanfen / Ma, Yun / Cai, Xiaoyan

    Metabolites

    2023  Volume 13, Issue 1

    Abstract: It was shown that microRNAs (miRNAs) play an important role in the synthesis of milk fat; thus, this manuscript evaluated whether exogenous miRNA (xeno-miRNAs) from alfalfa could influence the milk fat content in dairy cows. At first, mtr-miR168b was ... ...

    Abstract It was shown that microRNAs (miRNAs) play an important role in the synthesis of milk fat; thus, this manuscript evaluated whether exogenous miRNA (xeno-miRNAs) from alfalfa could influence the milk fat content in dairy cows. At first, mtr-miR168b was screened from dairy cow milk and blood. Then, EdU staining, flow cytometry, Oil Red O staining, qRT-PCR, and WB were applied to explore the effect of xeno-miR168b on the proliferation, apoptosis, and lipid metabolism of bovine mammary epithelial cells (BMECs). Finally, in order to clarify the pathway that regulated the lipid metabolism of BMECs using xeno-miR168b, a double-luciferase reporter assay was used to verify the target gene related to milk fat. These results showed that overexpression of xeno-miR168b inhibited cell proliferation but promoted apoptosis, which also decreased the expression of several lipid metabolism genes, including
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13010076
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  7. Article ; Online: Metabolomics Analysis of the Effect of GAT-2 Deficiency on Th1 Cells in Mice.

    Ding, Xueyan / Yan, Dong / Zhang, Xiaojie / Liu, Baobao / Zhu, Guoqiang

    Journal of proteome research

    2021  Volume 20, Issue 11, Page(s) 5054–5063

    Abstract: The classic neurotransmitter γ-aminobutyric acid (GABA) has been shown to shape the activation and function of immune cells. There are four high-affinity GABA transporters (GATs, including GAT-1, GAT-2, GAT-3, and GAT-4) responsible for the transmembrane ...

    Abstract The classic neurotransmitter γ-aminobutyric acid (GABA) has been shown to shape the activation and function of immune cells. There are four high-affinity GABA transporters (GATs, including GAT-1, GAT-2, GAT-3, and GAT-4) responsible for the transmembrane transport of GABA in mice. To explore the effect of GAT-2 on type 1 helper T (Th1) cells, naïve CD4
    MeSH term(s) Animals ; GABA Plasma Membrane Transport Proteins/genetics ; GABA Plasma Membrane Transport Proteins/metabolism ; Gas Chromatography-Mass Spectrometry ; Metabolomics ; Mice ; Polymers ; Th1 Cells/metabolism
    Chemical Substances GABA Plasma Membrane Transport Proteins ; Polymers ; GAT (31325-29-8)
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.1c00601
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  8. Article ; Online: Regulatory mechanisms of sub-inhibitory levels antibiotics agent in bacterial virulence.

    Liu, Baobao / Zhang, Xiaojie / Ding, Xueyan / Wang, Yang / Zhu, Guoqiang

    Applied microbiology and biotechnology

    2021  Volume 105, Issue 9, Page(s) 3495–3505

    Abstract: Antibiotics play a key role in the prevention and treatment of bacterial diseases for human and animals. The widespread use of antibiotics results in bacterial exposure to the concentrations that are lower than the MIC (that is, sub-inhibitory ... ...

    Abstract Antibiotics play a key role in the prevention and treatment of bacterial diseases for human and animals. The widespread use of antibiotics results in bacterial exposure to the concentrations that are lower than the MIC (that is, sub-inhibitory concentration (sub-MIC)) in the environment, humans, and livestock, which can lead to antibiotic resistance. In this review, we focus on the impact of sub-MIC antibiotics in bacterial virulence. This paper summarized the known relationships between sub-MIC antibiotics in the environment and bacterial virulence. Together, considering the impact of sub-MIC antibiotics and their alternative products in the virulence of bacteria, it is helpful to the rational use of antibiotics and the development of antibiotic alternative products to provide new insights.Key points• Sub-MIC level antibiotics exist in the environment, humans, and livestock.• The review includes mechanisms of sub-MIC antibiotics in bacterial virulence.• New antibacterial strategies and agents are being a new way to weaken virulence. Graphical Abstract.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Microbial ; Humans ; Microbial Sensitivity Tests ; Virulence
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-04-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-021-11291-1
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  9. Article: Regulatory Mechanisms between Quorum Sensing and Virulence in

    Zhang, Xiaojie / Liu, Baobao / Ding, Xueyan / Bin, Peng / Yang, Yang / Zhu, Guoqiang

    Microorganisms

    2022  Volume 10, Issue 11

    Abstract: ... ...

    Abstract Salmonella
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10112211
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  10. Article: Metabolomics Analysis of the Effect of GAT-2 Deficiency on Th1 Cells in Mice

    Ding, Xueyan / Yan, Dong / Zhang, Xiaojie / Liu, Baobao / Zhu, Guoqiang

    Journal of proteome research. 2021 Oct. 14, v. 20, no. 11

    2021  

    Abstract: The classic neurotransmitter γ-aminobutyric acid (GABA) has been shown to shape the activation and function of immune cells. There are four high-affinity GABA transporters (GATs, including GAT-1, GAT-2, GAT-3, and GAT-4) responsible for the transmembrane ...

    Abstract The classic neurotransmitter γ-aminobutyric acid (GABA) has been shown to shape the activation and function of immune cells. There are four high-affinity GABA transporters (GATs, including GAT-1, GAT-2, GAT-3, and GAT-4) responsible for the transmembrane transport of GABA in mice. To explore the effect of GAT-2 on type 1 helper T (Th1) cells, naïve CD4⁺ T cells were isolated from splenocytes of GAT-2 knockout (KO) and wild-type (WT) mice and cultured for Th1 cell differentiation, and then, metabolomics analysis of Th1 cells was performed via gas chromatography coupled to time-of-flight mass spectrometry added with multivariate analyses. Based on the variable importance projection value > 1 and P < 0.05, a total of nine differentially expressed metabolites (DEMs) were identified between WT and KO. Then, DEMs were mapped to the KEGG database, and five metabolic pathways were significantly enriched, including the cysteine and methionine metabolism, the riboflavin metabolism, the purine metabolism, the glycerolipid metabolism, and the glycerophospholipid metabolism. Collectively, our metabolomics analysis revealed that deficiency of GAT-2 influenced the metabolomics profile of Th1 cells, which will provide insights into T cell response to GAT-2 deficiency in mice. Data are available via MetaboLights with identifier MTBLS3358.
    Keywords cell differentiation ; cysteine ; databases ; gas chromatography ; glycerophospholipids ; mass spectrometry ; metabolism ; metabolites ; metabolomics ; methionine ; neurotransmitters ; proteome ; research ; riboflavin ; splenocytes
    Language English
    Dates of publication 2021-1014
    Size p. 5054-5063.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.1c00601
    Database NAL-Catalogue (AGRICOLA)

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