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Article ; Online: Research Progress on the Medicinal and Edible Polygala fallax Hemsl. (Polygalaceae) Plant

Wu, Chao / Zhang, Xiujiao / Liu, Baoyu / Tang, Hui

Horticulturae. 2023 June 23, v. 9, no. 7

2023

Abstract: Polygala fallax Hemsl., a species belonging to the genus Polygala and the family Polygalaceae, is primarily distributed in southern China. Wild P. fallax Hemsl. (Polygalaceae) is currently endangered, but its utilization value has not yet been thoroughly ...

Abstract	Polygala fallax Hemsl., a species belonging to the genus Polygala and the family Polygalaceae, is primarily distributed in southern China. Wild P. fallax Hemsl. (Polygalaceae) is currently endangered, but its utilization value has not yet been thoroughly investigated. The present review summarizes the morphological and structural characteristics, wild resource distribution, chemical constituents and pharmacological efficacy, artificial breeding and cultivation techniques, and utilization value of P. fallax Hemsl. (Polygalaceae) to facilitate future studies on the conservation and use of P. fallax Hemsl plants. We conclude that (i) P. fallax Hemsl. (Polygalaceae) is a medicinal and edible plant, and also has eco-economic and ornamental value; (ii) roots are the primary medicinal parts, which contain pharmacologically active compounds such as saponins, flavones, oligosaccharide polyesters, polysaccharides, sterols, organic acids, etc.; and (iii) P. fallax Hemsl. (Polygalaceae) shows various pharmacological efficacies including anti-inflammatory effects, antivirus effects, antioxidative effects, an immunity-boosting function, hepatic-protective effects, hypolipidemic effect, blood-activating, stasis-eliminating effects, and antitumor, etc. More research on the applications of P. fallax Hemsl. (Polygalaceae) are needed, especially efforts to identify its effective constituents, pharmacological efficacy, quality control, and clinical applications. The use of P. fallax Hemsl. (Polygalaceae) resources should be enhanced, especially the use of the aboveground parts, and the pharmacological efficacy of other chemical constituents, such as flavones and polysaccharides, should be further explored.
Keywords	Polygala ; flavones ; food plants ; lipemic effect ; medicinal properties ; oligosaccharides ; ornamental value ; polysaccharides ; quality control ; saponins ; sterols ; China
Language	English
Dates of publication	2023-0623
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2813983-5
ISSN	2311-7524
ISSN	2311-7524
DOI	10.3390/horticulturae9070737
Database	NAL-Catalogue (AGRICOLA)

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Article: Transcriptomic and metabolomic profiling reveals the drought tolerance mechanism of

Zhang, Xiu-Jiao / Wu, Chao / Liu, Bao-Yu / Liang, Hui-Ling / Wang, Man-Lian / Li, Hong

Frontiers in plant science

2024 Volume 14, Page(s) 1284135

Abstract: ... Illicium ... ...

Abstract	Illicium difengpi
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1284135
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phytohormone Response of Drought-Acclimated

Wu, Chao / Liu, Baoyu / Zhang, Xiujiao / Wang, Manlian / Liang, Huiling

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: ... Illicium ... ...

Abstract	Illicium difengpi
MeSH term(s)	Plant Growth Regulators/pharmacology ; Illicium ; Schisandraceae ; Droughts ; Abscisic Acid ; Soil
Chemical Substances	Plant Growth Regulators ; Abscisic Acid (72S9A8J5GW) ; Soil
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216443
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanobiology of T Cell Activation: To Catch a Bond.

Liu, Baoyu / Kolawole, Elizabeth M / Evavold, Brian D

Annual review of cell and developmental biology

2021 Volume 37, Page(s) 65–87

Abstract: T cell activation is a critical event in the adaptive immune response, indispensable for cell-mediated and humoral immunity as well as for immune regulation. Recent years have witnessed an emerging trend emphasizing the essential role that physical force ...

Abstract	T cell activation is a critical event in the adaptive immune response, indispensable for cell-mediated and humoral immunity as well as for immune regulation. Recent years have witnessed an emerging trend emphasizing the essential role that physical force and mechanical properties play at the T cell interface. In this review, we integrate current knowledge of T cell antigen recognition and the different models of T cell activation from the perspective of mechanobiology, focusing on the interaction between the T cell receptor (TCR) and the peptide-major histocompatibility complex (pMHC) antigen. We address the shortcomings of TCR affinity alone in explaining T cell functional outcomes and the rising status of force-regulated TCR bond lifetimes, most notably the TCR catch bond. Ultimately, T cell activation and the ensuing physiological responses result from mechanical interaction between TCRs and the pMHC.
MeSH term(s)	Biophysics ; Histocompatibility Antigens ; Major Histocompatibility Complex/genetics ; Receptors, Antigen, T-Cell/genetics ; T-Lymphocytes
Chemical Substances	Histocompatibility Antigens ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1293750-2
ISSN	1530-8995 ; 1081-0706
ISSN (online)	1530-8995
ISSN	1081-0706
DOI	10.1146/annurev-cellbio-120219-055100
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multiview Clustering via Proximity Learning in Latent Representation Space.

Liu, Bao-Yu / Huang, Ling / Wang, Chang-Dong / Lai, Jian-Huang / Yu, Philip S

IEEE transactions on neural networks and learning systems

2023 Volume 34, Issue 2, Page(s) 973–986

Abstract: Most existing multiview clustering methods are based on the original feature space. However, the feature redundancy and noise in the original feature space limit their clustering performance. Aiming at addressing this problem, some multiview clustering ... ...

Abstract	Most existing multiview clustering methods are based on the original feature space. However, the feature redundancy and noise in the original feature space limit their clustering performance. Aiming at addressing this problem, some multiview clustering methods learn the latent data representation linearly, while performance may decline if the relation between the latent data representation and the original data is nonlinear. The other methods which nonlinearly learn the latent data representation usually conduct the latent representation learning and clustering separately, resulting in that the latent data representation might be not well adapted to clustering. Furthermore, none of them model the intercluster relation and intracluster correlation of data points, which limits the quality of the learned latent data representation and therefore influences the clustering performance. To solve these problems, this article proposes a novel multiview clustering method via proximity learning in latent representation space, named multiview latent proximity learning (MLPL). For one thing, MLPL learns the latent data representation in a nonlinear manner which takes the intercluster relation and intracluster correlation into consideration simultaneously. For another, through conducting the latent representation learning and consensus proximity learning simultaneously, MLPL learns a consensus proximity matrix with k connected components to output the clustering result directly. Extensive experiments are conducted on seven real-world datasets to demonstrate the effectiveness and superiority of the MLPL method compared with the state-of-the-art multiview clustering methods.
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2021.3104846
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mechanical Properties Variation in Wood-Plastic Composites with a Mixed Wood Fiber Size.

Xu, Hailong / Yang, Yang / Li, Lifen / Liu, Baoyu / Fu, Xiubo / Yang, Xiaohui / Cao, Yan

Materials (Basel, Switzerland)

2023 Volume 16, Issue 17

Abstract: In this study, the influence of fiber particle size on the mechanical properties of a wood--plastic composite (WPC) was investigated using a combination of experimental measurements and numerical modeling. Four different sizes of wood fibers (10-20 mesh, ...

Abstract	In this study, the influence of fiber particle size on the mechanical properties of a wood--plastic composite (WPC) was investigated using a combination of experimental measurements and numerical modeling. Four different sizes of wood fibers (10-20 mesh, 20-40 mesh, 40-80 mesh, and 80-120 mesh) were used to reinforce high-density polyethylene (HDPE), either separately or in combination. The different sizes of fibers produced varying properties in the resulting composites. The smallest fiber size (80-120 mesh) resulted in the lowest flexural and tensile properties, but the highest impact strength (15.79 kJ/m
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16175801
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of exogenous AHLs on the spoilage characteristics of Pseudomonas koreensis PS1

Dai, Jinyue / Fang, Limin / Wu, Yan / Liu, Baoyu / Cheng, Xin / Yao, Mingyin / Huang, Lin

Journal of food science. 2022 Feb., v. 87, no. 2

2022

Abstract: Some specific spoilage organisms (SSO) respond to the presence of exogenous N‐acyl‐homoserine lactones (AHLs) through the quorum sensing (QS) system to modulate their spoilage characteristics. To explore the effect of exogenous AHLs on the spoilage ... ...

Abstract	Some specific spoilage organisms (SSO) respond to the presence of exogenous N‐acyl‐homoserine lactones (AHLs) through the quorum sensing (QS) system to modulate their spoilage characteristics. To explore the effect of exogenous AHLs on the spoilage characteristics of Pseudomonas koreensis PS1 from spoiled chilled pork, four kinds of AHLs were added to the liquid medium to analyze their effect on the cell growth and spoilage characteristics of P. koreensis PS1, and N‐hexanoyl‐l‐homoserine lactone (C6‐HSL) was added to evaluate its effect on spoilage characteristics of P. koreensis PS1 inoculated in fresh chilled pork. The results showed that the addition of low concentrations of C6‐HSL (10 µmol/L) to the liquid medium could remarkably promote the protease activity, lipase activity, and biofilm formation of P. koreensis PS1 (p < 0.05), and more than 30 µmol/L C6‐HSL could significantly increase the cell density (p < 0.05). Furthermore, the addition of 10 µmol/L C6‐HSL into fresh chilled pork could increase the lipase and protease activities of P. koreensis PS1. The enzyme activity accelerated the decomposition of total protein, total fat, and total sugar, and led to an increase in putrescine, tyramine, cadaverine, and total volatile basic nitrogen (TVB‐N) content in chilled pork during the storage at 4°C. PRACTICAL APPLICATION: The infestation of chilled pork with SSO may be a challenge for the meat industry. In this study, exogenous AHLs were found to have a positive effect on the spoilage of chilled pork. The elimination of the QS phenomenon of bacteria should be considered when looking for ways to prolong the preservation of chilled pork.
Keywords	Pseudomonas koreensis ; biofilm ; cadaverine ; carboxylic ester hydrolases ; cell growth ; enzyme activity ; food science ; lactones ; liquids ; livestock and meat industry ; pork ; protein content ; proteinases ; putrescine ; spoilage ; sugars ; total volatile basic nitrogen ; tyramine
Language	English
Dates of publication	2022-02
Size	p. 819-832.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	241615-3
ISSN	1750-3841 ; 0022-1147
ISSN (online)	1750-3841
ISSN	0022-1147
DOI	10.1111/1750-3841.16038
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fault Detection and Exclusion for Tightly Coupled GNSS/INS System Considering Fault in State Prediction.

Wang, Shizhuang / Zhan, Xingqun / Zhai, Yawei / Liu, Baoyu

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 3

Abstract: To ensure navigation integrity for safety-critical applications, this paper proposes an efficient Fault Detection and Exclusion (FDE) scheme for tightly coupled navigation system of Global Navigation Satellite Systems (GNSS) and Inertial Navigation ... ...

Abstract	To ensure navigation integrity for safety-critical applications, this paper proposes an efficient Fault Detection and Exclusion (FDE) scheme for tightly coupled navigation system of Global Navigation Satellite Systems (GNSS) and Inertial Navigation System (INS). Special emphasis is placed on the potential faults in the Kalman Filter state prediction step (defined as "filter fault"), which could be caused by the undetected faults occurring previously or the Inertial Measurement Unit (IMU) failures. The integration model is derived first to capture the features and impacts of GNSS faults and filter fault. To accommodate various fault conditions, two independent detectors, which are respectively designated for GNSS fault and filter fault, are rigorously established based on hypothesis-test methods. Following a detection event, the newly-designed exclusion function enables (a) identifying and removing the faulty measurements and (b) eliminating the effect of filter fault through filter recovery. Moreover, we also attempt to avoid wrong exclusion events by analyzing the underlying causes and optimizing the decision strategy for GNSS fault exclusion accordingly. The FDE scheme is validated through multiple simulations, where high efficiency and effectiveness have been achieved in various fault scenarios.
Language	English
Publishing date	2020-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20030590
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: New PTX-HS15/T80 Mixed Micelles: Cytotoxicity, Pharmacokinetics and Tissue Distribution.

Liu, Baoyu / Gao, Wei / Wu, Hui / Liu, Hong / Pan, Hongchun

AAPS PharmSciTech

2021 Volume 22, Issue 2, Page(s) 56

Abstract: Compared with single micelle, the new PTX-HS15/T80 mixed micelle system (PTX-HS15/T80 MMs) had achieved better results in solubilization, stability, and sensitization before. Therefore, we intend to further verify the potential advantages of the mixed ... ...

Abstract	Compared with single micelle, the new PTX-HS15/T80 mixed micelle system (PTX-HS15/T80 MMs) had achieved better results in solubilization, stability, and sensitization before. Therefore, we intend to further verify the potential advantages of the mixed micelle delivery system through in vitro cytotoxicity test and animal test to understand the anticancer effect and in vivo pharmaceutical behavior of the system. In vitro cytotoxicity test showed that the new PTX-HS15/T80 MMs had a stronger ability to inhibit the proliferation of cancer cells. The results of in vivo pharmacokinetics showed that the micelle had shorter half-life, higher clearance rate, and lower blood concentration and had good blood clearance characteristics. The results of in vivo tissue distribution showed that, compared with the single micelle Taxol
MeSH term(s)	Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Cell Line, Tumor ; Drug Delivery Systems/methods ; Female ; Male ; Micelles ; Paclitaxel/administration & dosage ; Paclitaxel/pharmacokinetics ; Paclitaxel/pharmacology ; Polyethylene Glycols/chemistry ; Polysorbates/chemistry ; Rats ; Rats, Sprague-Dawley ; Stearic Acids/chemistry ; Tissue Distribution
Chemical Substances	Antineoplastic Agents, Phytogenic ; Micelles ; Polysorbates ; Stearic Acids ; Polyethylene Glycols (3WJQ0SDW1A) ; Solutol HS 15 (61909-81-7) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2021-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-021-01929-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Structures of the SARS-CoV-2 spike glycoprotein and applications for novel drug development.

Liu, Xiao-Huan / Cheng, Ting / Liu, Bao-Yu / Chi, Jia / Shu, Ting / Wang, Tao

Frontiers in pharmacology

2022 Volume 13, Page(s) 955648

Abstract: COVID-19 caused by SARS-CoV-2 has raised a health crisis worldwide. The high morbidity and mortality associated with COVID-19 and the lack of effective drugs or vaccines for SARS-CoV-2 emphasize the urgent need for standard treatment and prophylaxis of ... ...

Abstract	COVID-19 caused by SARS-CoV-2 has raised a health crisis worldwide. The high morbidity and mortality associated with COVID-19 and the lack of effective drugs or vaccines for SARS-CoV-2 emphasize the urgent need for standard treatment and prophylaxis of COVID-19. The receptor-binding domain (RBD) of the glycosylated spike protein (S protein) is capable of binding to human angiotensin-converting enzyme 2 (hACE2) and initiating membrane fusion and virus entry. Hence, it is rational to inhibit the RBD activity of the S protein by blocking the RBD interaction with hACE2, which makes the glycosylated S protein a potential target for designing and developing antiviral agents. In this study, the molecular features of the S protein of SARS-CoV-2 are highlighted, such as the structures, functions, and interactions of the S protein and ACE2. Additionally, computational tools developed for the treatment of COVID-19 are provided, for example, algorithms, databases, and relevant programs. Finally, recent advances in the novel development of antivirals against the S protein are summarized, including screening of natural products, drug repurposing and rational design. This study is expected to provide novel insights for the efficient discovery of promising drug candidates against the S protein and contribute to the development of broad-spectrum anti-coronavirus drugs to fight against SARS-CoV-2.
Language	English
Publishing date	2022-08-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.955648
Database	MEDical Literature Analysis and Retrieval System OnLINE

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