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  1. Article: Motor neuron replacement therapy for amyotrophic lateral sclerosis.

    Liu, Bochao / Li, Mo / Zhang, Lingyan / Chen, Zhiguo / Lu, Paul

    Neural regeneration research

    2022  Volume 17, Issue 8, Page(s) 1633–1639

    Abstract: Amyotrophic lateral sclerosis is a motor neuron degenerative disease that is also known as Lou Gehrig's disease in the United States, Charcot's disease in France, and motor neuron disease in the UK. The loss of motor neurons causes muscle wasting, ... ...

    Abstract Amyotrophic lateral sclerosis is a motor neuron degenerative disease that is also known as Lou Gehrig's disease in the United States, Charcot's disease in France, and motor neuron disease in the UK. The loss of motor neurons causes muscle wasting, paralysis, and eventually death, which is commonly related to respiratory failure, within 3-5 years after onset of the disease. Although there are a limited number of drugs approved for amyotrophic lateral sclerosis, they have had little success at treating the associated symptoms, and they cannot reverse the course of motor neuron degeneration. Thus, there is still a lack of effective treatment for this debilitating neurodegenerative disorder. Stem cell therapy for amyotrophic lateral sclerosis is a very attractive strategy for both basic and clinical researchers, particularly as transplanted stem cells and stem cell-derived neural progenitor/precursor cells can protect endogenous motor neurons and directly replace the lost or dying motor neurons. Stem cell therapies may also be able to re-establish the motor control of voluntary muscles. Here, we review the recent progress in the use of neural stem cells and neural progenitor cells for the treatment of amyotrophic lateral sclerosis. We focus on MN progenitor cells derived from fetal central nervous system tissue, embryonic stem cells, and induced pluripotent stem cells. In our recent studies, we found that transplanted human induced pluripotent stem cell-derived motor neuron progenitors survive well, differentiate into motor neurons, and extend axons into the host white matter, not only in the rostrocaudal direction, but also along motor axon tracts towards the ventral roots in the immunodeficient rat spinal cord. Furthermore, the significant motor axonal extension after neural progenitor cell transplantation in amyotrophic lateral sclerosis models demonstrates that motor neuron replacement therapy could be a promising therapeutic strategy for amyotrophic lateral sclerosis, particularly as a variety of stem cell derivatives, including induced pluripotent stem cells, are being considered for clinical trials for various diseases.
    Language English
    Publishing date 2022-01-11
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.332123
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  2. Article ; Online: Learning Privacy-Preserving Student Networks via Discriminative-Generative Distillation.

    Ge, Shiming / Liu, Bochao / Wang, Pengju / Li, Yong / Zeng, Dan

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2022  Volume PP

    Abstract: While deep models have proved successful in learning rich knowledge from massive well-annotated data, they may pose a privacy leakage risk in practical deployment. It is necessary to find an effective trade-off between high utility and strong privacy. In ...

    Abstract While deep models have proved successful in learning rich knowledge from massive well-annotated data, they may pose a privacy leakage risk in practical deployment. It is necessary to find an effective trade-off between high utility and strong privacy. In this work, we propose a discriminative-generative distillation approach to learn privacy-preserving deep models. Our key idea is taking models as bridge to distill knowledge from private data and then transfer it to learn a student network via two streams. First, discriminative stream trains a baseline classifier on private data and an ensemble of teachers on multiple disjoint private subsets, respectively. Then, generative stream takes the classifier as a fixed discriminator and trains a generator in a data-free manner. After that, the generator is used to generate massive synthetic data which are further applied to train a variational autoencoder (VAE). Among these synthetic data, a few of them are fed into the teacher ensemble to query labels via differentially private aggregation, while most of them are embedded to the trained VAE for reconstructing synthetic data. Finally, a semi-supervised student learning is performed to simultaneously handle two tasks: knowledge transfer from the teachers with distillation on few privately labeled synthetic data, and knowledge enhancement with tangent-normal adversarial regularization on many triples of reconstructed synthetic data. In this way, our approach can control query cost over private data and mitigate accuracy degradation in a unified manner, leading to a privacy-preserving student model. Extensive experiments and analysis clearly show the effectiveness of the proposed approach.
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2022.3226416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Grafted human-induced pluripotent stem cells-derived oligodendrocyte progenitor cells combined with human umbilical vein endothelial cells contribute to functional recovery following spinal cord injury.

    Li, Qian / Liu, Sumei / Zheng, Tianqi / Li, Mo / Qi, Boling / Zhou, Liping / Liu, Bochao / Ma, Dan / Zhao, Chao / Chen, Zhiguo

    Stem cell research & therapy

    2024  Volume 15, Issue 1, Page(s) 35

    Abstract: Background: Spinal cord injury (SCI) is a devastating disease that causes extensive damage to oligodendrocytes and neurons leading to demyelination and axonal degeneration. In this study, we co-transplanted cell grafts containing oligodendrocyte ... ...

    Abstract Background: Spinal cord injury (SCI) is a devastating disease that causes extensive damage to oligodendrocytes and neurons leading to demyelination and axonal degeneration. In this study, we co-transplanted cell grafts containing oligodendrocyte progenitor cells (OPCs) derived from human-induced pluripotent stem cells (iPSCs) combined with human umbilical vein endothelial cells (HUVECs), which were reported to promote OPCs survival and migration, into rat contusion models to promote functional recovery after SCI.
    Methods: OPCs were derived from iPSCs and identified by immunofluorescence at different time points. Functional assays in vitro were performed to evaluate the effect of HUVECs on the proliferation, migration, and survival of OPCs by co-culture and migration assay, as well as on the neuronal axonal growth. A combination of OPCs and HUVECs was transplanted into the rat contusive model. Upon 8 weeks, immunofluorescence staining was performed to test the safety of transplanted cells and to observe the neuronal repairment, myelination, and neural circuit reconstruction at the injured area; also, the functional recovery was assessed by Basso, Beattie, and Bresnahan open-field scale, Ladder climb, SEP, and MEP. Furthermore, the effect of HUVECs on grafts was also determined in vivo.
    Results: Data showed that HUVECs promote the proliferation, migration, and survival of OPCs both in vitro and in vivo. Furthermore, 8 weeks upon engraftment, the rats with OPCs and HUVECs co-transplantation noticeably facilitated remyelination, enhanced functional connection between the grafts and the host and promoted functional recovery. In addition, compared with the OPCs-alone transplantation, the co-transplantation generated more sensory neurons at the lesion border and significantly improved the sensory functional recovery.
    Conclusions: Our study demonstrates that transplantation of OPCs combined with HUVECs significantly enhances both motor and sensory functional recovery after SCI. No significance was observed between OPCs combined with HUVECs group and OPCs-alone group in motor function recovery, while the sensory function recovery was significantly promoted in OPCs combined with HUVECs groups compared with the other two groups. These findings provide novel insights into the field of SCI research.
    MeSH term(s) Rats ; Humans ; Animals ; Oligodendrocyte Precursor Cells/pathology ; Oligodendrocyte Precursor Cells/transplantation ; Human Umbilical Vein Endothelial Cells ; Recovery of Function ; Induced Pluripotent Stem Cells/transplantation ; Spinal Cord Injuries/pathology ; Oligodendroglia ; Spinal Cord/pathology ; Cell Differentiation/physiology
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-024-03651-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Three-Dimensional Printing of Large Objects with High Resolution by Dynamic Projection Scanning Lithography.

    Lin, Chunbo / Xu, Wenbin / Liu, Bochao / Wang, He / Xing, Haiping / Sun, Qiang / Xu, Jia

    Micromachines

    2023  Volume 14, Issue 9

    Abstract: Due to the development of printing materials, light-cured 3D printing is playing an increasingly important role in industrial and consumer markets for prototype manufacturing and conceptual design due to its advantages in high-precision and high-surface ... ...

    Abstract Due to the development of printing materials, light-cured 3D printing is playing an increasingly important role in industrial and consumer markets for prototype manufacturing and conceptual design due to its advantages in high-precision and high-surface finish. Despite its widespread use, it is still difficult to achieve the 3D printing requirements of large volume, high resolution, and high speed. Currently, traditional light-cured 3D printing technologies based on stereolithography, such as regular DLP and SLA, can no longer meet the requirements of the processing size and processing rate. This paper introduces a dynamic projection of 3D printing technology utilizing a digital micro-mirror device (DMD). By projecting the ultraviolet light pattern in the form of "animation", the printing resin is continuously cured in the exposure process to form the required three-dimensional structure. To print large-size objects, the three-dimensional model is sliced into high-resolution sectional images, and each layer of the sectional image is further divided into sub-regional images. These images are dynamically exposed to the light-curing material and are synchronized with the scanning motion of the projection lens to form a static exposure pattern in the construction area. Combined with the digital super-resolution, this system can achieve the layering and fine printing of large-size objects up to 400 × 400 × 200 mm, with a minimum feature size of 45 μm. This technology can achieve large-size, high-precision structural printing in industrial fields such as automobiles and aviation, promoting structural design, performance verification, product pre-production, and final part processing. Its printing speed and material bending characteristics are superior to existing DLP light-curing 3D printing methods.
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14091700
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  5. Article: Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment.

    Liu, Sumei / Liu, Baoguo / Li, Qian / Zheng, Tianqi / Liu, Bochao / Li, Mo / Chen, Zhiguo

    Neural regeneration research

    2023  Volume 19, Issue 2, Page(s) 440–446

    Abstract: Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord, with the expectation that differentiated neurons facilitate recovery. Only a few studies have attempted to use transplanted cells and/or biomaterials as major ... ...

    Abstract Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord, with the expectation that differentiated neurons facilitate recovery. Only a few studies have attempted to use transplanted cells and/or biomaterials as major modulators of the spinal cord injury microenvironment. Here, we aimed to investigate the role of microenvironment modulation by cell graft on functional recovery after spinal cord injury. Induced neural stem cells reprogrammed from human peripheral blood mononuclear cells, and/or thrombin plus fibrinogen, were transplanted into the lesion site of an immunosuppressed rat spinal cord injury model. Basso, Beattie and Bresnahan score, electrophysiological function, and immunofluorescence/histological analyses showed that transplantation facilitates motor and electrophysiological function, reduces lesion volume, and promotes axonal neurofilament expression at the lesion core. Examination of the graft and niche components revealed that although the graft only survived for a relatively short period (up to 15 days), it still had a crucial impact on the microenvironment. Altogether, induced neural stem cells and human fibrin reduced the number of infiltrated immune cells, biased microglia towards a regenerative M2 phenotype, and changed the cytokine expression profile at the lesion site. Graft-induced changes of the microenvironment during the acute and subacute stages might have disrupted the inflammatory cascade chain reactions, which may have exerted a long-term impact on the functional recovery of spinal cord injury rats.
    Language English
    Publishing date 2023-07-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.379049
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  6. Book ; Online: Model Conversion via Differentially Private Data-Free Distillation

    Liu, Bochao / Wang, Pengju / Li, Shikun / Zeng, Dan / Ge, Shiming

    2023  

    Abstract: While massive valuable deep models trained on large-scale data have been released to facilitate the artificial intelligence community, they may encounter attacks in deployment which leads to privacy leakage of training data. In this work, we propose a ... ...

    Abstract While massive valuable deep models trained on large-scale data have been released to facilitate the artificial intelligence community, they may encounter attacks in deployment which leads to privacy leakage of training data. In this work, we propose a learning approach termed differentially private data-free distillation (DPDFD) for model conversion that can convert a pretrained model (teacher) into its privacy-preserving counterpart (student) via an intermediate generator without access to training data. The learning collaborates three parties in a unified way. First, massive synthetic data are generated with the generator. Then, they are fed into the teacher and student to compute differentially private gradients by normalizing the gradients and adding noise before performing descent. Finally, the student is updated with these differentially private gradients and the generator is updated by taking the student as a fixed discriminator in an alternate manner. In addition to a privacy-preserving student, the generator can generate synthetic data in a differentially private way for other downstream tasks. We theoretically prove that our approach can guarantee differential privacy and well convergence. Extensive experiments clearly demonstrate that our approach significantly outperform other differentially private generative approaches.
    Keywords Computer Science - Cryptography and Security
    Subject code 005
    Publishing date 2023-04-24
    Publishing country us
    Document type Book ; Online
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  7. Book ; Online: Learning Differentially Private Probabilistic Models for Privacy-Preserving Image Generation

    Liu, Bochao / Ge, Shiming / Wang, Pengju / Zhuang, Liansheng / Liu, Tongliang

    2023  

    Abstract: A number of deep models trained on high-quality and valuable images have been deployed in practical applications, which may pose a leakage risk of data privacy. Learning differentially private generative models can sidestep this challenge through ... ...

    Abstract A number of deep models trained on high-quality and valuable images have been deployed in practical applications, which may pose a leakage risk of data privacy. Learning differentially private generative models can sidestep this challenge through indirect data access. However, such differentially private generative models learned by existing approaches can only generate images with a low-resolution of less than 128x128, hindering the widespread usage of generated images in downstream training. In this work, we propose learning differentially private probabilistic models (DPPM) to generate high-resolution images with differential privacy guarantee. In particular, we first train a model to fit the distribution of the training data and make it satisfy differential privacy by performing a randomized response mechanism during training process. Then we perform Hamiltonian dynamics sampling along with the differentially private movement direction predicted by the trained probabilistic model to obtain the privacy-preserving images. In this way, it is possible to apply these images to different downstream tasks while protecting private information. Notably, compared to other state-of-the-art differentially private generative approaches, our approach can generate images up to 256x256 with remarkable visual quality and data utility. Extensive experiments show the effectiveness of our approach.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Cryptography and Security
    Subject code 006
    Publishing date 2023-05-17
    Publishing country us
    Document type Book ; Online
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  8. Article ; Online: Structure of human BCCIP and implications for binding and modification of partner proteins.

    Choi, Woo Suk / Liu, Bochao / Shen, Zhiyuan / Yang, Wei

    Protein science : a publication of the Protein Society

    2021  Volume 30, Issue 3, Page(s) 693–699

    Abstract: BCCIP was isolated based on its interactions with tumor suppressors BRCA2 and p21. Knockdown or knockout of BCCIP causes embryonic lethality in mice. BCCIP deficient cells exhibit impaired cell proliferation and chromosome instability. BCCIP also plays a ...

    Abstract BCCIP was isolated based on its interactions with tumor suppressors BRCA2 and p21. Knockdown or knockout of BCCIP causes embryonic lethality in mice. BCCIP deficient cells exhibit impaired cell proliferation and chromosome instability. BCCIP also plays a key role in biogenesis of ribosome 60S subunits. BCCIP is conserved from yeast to humans, but it has no discernible sequence similarity to proteins of known structures. Here we report two crystal structures of an N-terminal truncated human BCCIPβ, consisting of residues 61-314. Structurally BCCIP is similar to GCN5-related acetyltransferases (GNATs) but contains different sequence motifs. Moreover, both acetyl-CoA and substrate-binding grooves are altered in BCCIP. A large 19-residue flap over the putative CoA binding site adopts either an open or closed conformation in BCCIP. The substrate binding groove is significantly reduced in size and is positively charged despite the acidic isoelectric point of BCCIP. BCCIP has potential binding sites for partner proteins and may have enzymatic activity.
    MeSH term(s) Acetyltransferases ; Binding Sites ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Escherichia coli/genetics ; Humans ; Models, Molecular ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Binding ; Protein Conformation ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
    Chemical Substances BCCIP protein, human ; Calcium-Binding Proteins ; Cell Cycle Proteins ; Nuclear Proteins ; Recombinant Proteins ; Acetyltransferases (EC 2.3.1.-)
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3407: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
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  9. Article ; Online: A Helper Antibody-Based Competitive Fluorescence Immunochromatographic Assay for Quantitative Detection of Florfenicol in Poultry Eggs.

    Zhang, Enhui / Liu, Bochao / Lu, Jinhui / Liang, Chaolan / Zhao, Fang / Li, Jinfeng / Li, Tingting / Li, Chengyao / Zhang, Ling

    Journal of AOAC International

    2023  Volume 106, Issue 4, Page(s) 837–845

    Abstract: Background: Florfenicol (FF) is a chloramphenicol analogue used in animals, and florfenicol amine (FFA) is the main metabolite of FF. However, their residues in agricultural products are harmful to human health. A highly specific and sensitive assay for ...

    Abstract Background: Florfenicol (FF) is a chloramphenicol analogue used in animals, and florfenicol amine (FFA) is the main metabolite of FF. However, their residues in agricultural products are harmful to human health. A highly specific and sensitive assay for FF/FFA detection needs to be developed since the traditional detection methods are low in sensitivity.
    Objective: In this study, a new method for rapid quantification of FF/FFA in poultry eggs by helper antibody-based fluorescent immunochromatographic assay (HAFIA) was established.
    Methods: Triple antibodies including a primary monoclonal antibody (mAb) specific to the targets FF and FFA, a secondary polyclonal antibody (pAb) labeled with europium nanoparticles (EuNPs), and a helper monoclonal antibody (hAb), reacting with pAb but not with the mAb or the target antigen, are designed, which can form structural aggregation complexes in microwells with a single step of reactions. By loading the reaction sample solution, the triple-antibodies (mAb-pAb-hAb)-EuNPs complexes migrate to the test (T) line on the nitrocellulose membrane of testing strip and are competitively captured by the immobilized FF-bovine serum album (BSA) conjugates on the membrane and the FF/FFA targets in the sample solution.
    Results: Fluorescence on the T line is read by a portable fluorescent strip reader in 10 min, and the result is given as the ratio of fluorescent intensities on the T and control (C) lines. This new fluorescent testing strip, with amplified signal from the triple-antibody complex, has 50-fold higher sensitivity than conventional colloidal gold-lateral flow immunoassays (CG-LFIAs), and can detect as low as 0.01 ng/mL FF and 0.1 ng/mL FFA targets from egg samples.
    Conclusion: The developed competitive fluorescent immunochromatography method based on auxiliary antibodies has the advantages of high sensitivity and specificity for the rapid and quantitative detection of FF/FFA in poultry eggs.
    Highlights: Newly designed helper antibody and portable device were applied to quantitative detection. HAFIA tests egg samples and results can be obtained in 10 minutes. HAFIA has the advantages of being more convenient, faster and does not require professional laboratory personnel.
    MeSH term(s) Animals ; Humans ; Poultry ; Europium ; Metal Nanoparticles ; Immunoassay ; Antibodies, Monoclonal/chemistry ; Chromatography, Affinity/methods
    Chemical Substances florfenicol (9J97307Y1H) ; Europium (444W947O8O) ; florfenicol amine (76639-93-5) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1103149-9
    ISSN 1944-7922 ; 1060-3271
    ISSN (online) 1944-7922
    ISSN 1060-3271
    DOI 10.1093/jaoacint/qsad044
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1229: Show issues Location:
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  10. Article ; Online: A novel photosensitizer DTPP-mediated photodynamic therapy induces oxidative stress and apoptosis through mitochondrial pathways in LA795 cells.

    Zheng, Liqing / Li, Ze / Wang, Ruibo / Wang, Jing / Liu, Bochao / Wang, Yiying / Qin, Shihao / Yang, Junying / Liu, Jianhua

    Photodiagnosis and photodynamic therapy

    2023  Volume 45, Page(s) 103894

    Abstract: Objective: Investigation of the effects of 5-5- (4-N, N-diacetoxylphenyl)-10,15,20- tetraphenylporphyrin (DTPP)-mediated photodynamic therapy (PDT) on oxidative stress and mitochondrial apoptosis in LA795 lung cancer cells.: Methods: Proteomics was ... ...

    Abstract Objective: Investigation of the effects of 5-5- (4-N, N-diacetoxylphenyl)-10,15,20- tetraphenylporphyrin (DTPP)-mediated photodynamic therapy (PDT) on oxidative stress and mitochondrial apoptosis in LA795 lung cancer cells.
    Methods: Proteomics was used to identify differentially expressed proteins after PDT treatment. The apoptosis rate was determined by flow cytometry. Morphologic observation of apoptosis, reactive oxygen species (ROS) levels, antioxidant indices, nitric oxide (NO) content, mitochondrial membrane potential (MMP), and Caspase- 9 and Caspase-3 were determined by assays; apoptosis-related protein levels of Cytochrome (Cyto) c, Bcl- 2, Bax were determined by Western blot.
    Results: Typical apoptosis morphology of LA795 cells was observed after PDT. The cells were mainly in the apoptosis death pathway with high cell apoptosis rates. The proteomics study observed the apoptosis-associated proteins, oxidative stress proteins, antioxidant proteins, the cytoskeletal protein and mitochondrial dysfunction in LA 795 cells. Additional results indicated that PDT could increase levels of ROS, NO; decrease glutathione (GSH) content and MMP; upregulated Bax, Cyto c, and Caspase-3 protein expression, inhibited Bcl-2 protein expression, and further induced cell apoptosis. The effect of DTPP-PDT on lung cancer was: first, mitochondrial Cyto c is released into the cytoplasm, then Caspase- 9 / Caspase-3 was activated, Bcl-2 decreased/Bax increased, initiating cell apoptosis.
    Conclusion: DTPP-PDT could induce oxidative stress and apoptosis via mitochondrial pathways in LA795 cells.
    MeSH term(s) Humans ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Caspase 3/metabolism ; Photochemotherapy/methods ; bcl-2-Associated X Protein/metabolism ; Reactive Oxygen Species ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Apoptosis ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Oxidative Stress ; Lung Neoplasms/drug therapy ; Organophosphorus Compounds
    Chemical Substances Photosensitizing Agents ; DTPP (37107-08-7) ; Caspase 3 (EC 3.4.22.-) ; bcl-2-Associated X Protein ; Reactive Oxygen Species ; Antioxidants ; Proto-Oncogene Proteins c-bcl-2 ; Organophosphorus Compounds
    Language English
    Publishing date 2023-11-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103894
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