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  1. AU="Liu, Changxue"
  2. AU="Spruit, Martijn A"
  3. AU="Zhang, Dai-Gui"
  4. AU="Appelen, Diebrecht"
  5. AU="Moreira, Jânio Cordeiro"

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  1. Article: Testicular metastasis from urothelial carcinoma: case report and literature review.

    Liu, Changxue / Liu, Jing / Yang, Qingbo / Song, Leilei / Ma, Xiaocheng / Wang, Yonghua

    Frontiers in oncology

    2024  Volume 14, Page(s) 1308399

    Abstract: Urothelial carcinoma (UC) with testicular metastasis is extremely rare, and its modes of metastasis, prognosis, and treatment are unclear. In this report, we present an extraordinarily rare case of testicular metastasis arising from UC 8 years after ... ...

    Abstract Urothelial carcinoma (UC) with testicular metastasis is extremely rare, and its modes of metastasis, prognosis, and treatment are unclear. In this report, we present an extraordinarily rare case of testicular metastasis arising from UC 8 years after surgery. The patient underwent left orchiepididymectomy and received immunotherapy postoperatively. After a 6-month follow-up, there were no signs of recurrence. Moreover, the clinical characteristics, metastasis pattern, and treatment plan were also summarized based on 14 earlier reported cases of UC with testicular metastasis.
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1308399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification and validation of a signature based on myofibroblastic cancer-associated fibroblast marker genes for predicting prognosis, immune infiltration, and therapeutic response in bladder cancer.

    Qin, Ruize / Ma, Xiaocheng / Pu, Shi / Shen, Chengquan / Hu, Ding / Liu, Changxue / Wang, Kongjia / Wang, Yonghua

    Investigative and clinical urology

    2024  Volume 65, Issue 3, Page(s) 263–278

    Abstract: Purpose: Myofibroblastic cancer-associated fibroblasts (myCAFs) are important components of the tumor microenvironment closely associated with tumor stromal remodeling and immunosuppression. This study aimed to explore myCAFs marker gene biomarkers for ... ...

    Abstract Purpose: Myofibroblastic cancer-associated fibroblasts (myCAFs) are important components of the tumor microenvironment closely associated with tumor stromal remodeling and immunosuppression. This study aimed to explore myCAFs marker gene biomarkers for clinical diagnosis and therapy for patients with bladder cancer (BC).
    Materials and methods: BC single-cell RNA sequencing (scRNA-seq) data were obtained from the National Center for Biotechnology Information Sequence Read Archive. Transcriptome and clinical data were downloaded from The Cancer Genome Atlas and the Gene Expression Omnibus databases. Subsequently, univariate Cox and LASSO (Least Absolute Shrinkage and Selection Operator regression) regression analyses were performed to construct a prognostic signature. Immune cell activity was estimated using single-sample gene set enrichment analysis whilst the TIDE (tumor immune dysfunction and exclusion) method was employed to assess patient response to immunotherapy. The chemotherapy response of patients with BC was evaluated using genomics of drug sensitivity in cancer. Furthermore, Immunohistochemistry was used to verify the correlation between MAP1B expression and immunotherapy efficacy. The scRNA-seq data were analyzed to identify myCAFs marker genes.
    Results: Combined with bulk RNA-sequencing data, we constructed a two-gene (
    Conclusions: Our findings revealed a typical prognostic signature based on myCAF marker genes, which offers patients with BC a novel treatment target alongside theoretical justification.
    MeSH term(s) Humans ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/therapy ; Urinary Bladder Neoplasms/drug therapy ; Prognosis ; Cancer-Associated Fibroblasts ; Biomarkers, Tumor/genetics ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Male ; Female ; Transcriptome ; Treatment Outcome ; Myofibroblasts
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2024-05-07
    Publishing country Korea (South)
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2923014-7
    ISSN 2466-054X ; 2466-0493
    ISSN (online) 2466-054X
    ISSN 2466-0493
    DOI 10.4111/icu.20230300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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