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Article ; Online: Synthesis, Characterization, X-Ray Crystal Structures and Antibacterial Activity of Zinc(II) and Vanadium(V) Complexes Derived from 5-Bromo-2-((2-(methylamino)ethylimino)methyl)phenol.

Liu, Cheng

2022 Volume 69, Issue 1, Page(s) 157–166

Abstract: Three new zinc(II) and one vanadium(V) complexes, [Zn2Cl2L2] (1), [Zn2I2L2] (2), [ZnCl2(HL)] (3), and [V2O2(μ-O)2L2] (4), where L is 5-bromo-2-((2-(methylamino)ethylimino)methyl)phenolate, have been synthesized and characterized by elemental analyses, IR ...

Abstract	Three new zinc(II) and one vanadium(V) complexes, [Zn2Cl2L2] (1), [Zn2I2L2] (2), [ZnCl2(HL)] (3), and [V2O2(μ-O)2L2] (4), where L is 5-bromo-2-((2-(methylamino)ethylimino)methyl)phenolate, have been synthesized and characterized by elemental analyses, IR and UV-Vis spectra, as well as molar conductivity. Structures of the complexes were confirmed by single crystal X-ray diffraction. Complexes 1 and 2 are isostructural dinuclear zinc compounds, with the Zn atoms in square pyramidal coordination. The Zn atoms in the mononuclear complex 3 are in tetrahedral coordination. Complex 4 is a dinuclear vanadium(V) compound, with the V atoms in octahedral coordination. The complexes were assayed for antibacterial activities by MTT method.
MeSH term(s)	Anti-Bacterial Agents ; Ligands ; Phenols/pharmacology ; Vanadium/chemistry ; Vanadium/pharmacology ; X-Rays ; Zinc/chemistry ; Zinc/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Ligands ; Phenols ; Vanadium (00J9J9XKDE) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-03-15
Publishing country	Slovenia
Document type	Journal Article
ZDB-ID	2029709-9
ISSN	1580-3155 ; 1318-0207
ISSN (online)	1580-3155
ISSN	1318-0207
DOI	10.17344/acsi.2021.7167
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Article ; Online: Synthesis, Characterization, X-Ray Crystal Structures and Antibacterial Activity of Cobalt(III) Complexes Derived from 5-Bromo-2-((2-(phenylamino)ethylimino)methyl)phenol.

Liu, Cheng

Acta chimica Slovenica

2021 Volume 68, Issue 4, Page(s) 983–989

Abstract: Two new and similar cobalt(III) complexes, [CoL2]·NO3 (1) and [CoL2]·Cl (2), where L is 5-bromo-2-((2-(phenylamino)ethylimino)methyl)phenolate, have been synthesized and characterized by IR and UV-Vis spectra. Structures of the complexes were confirmed ... ...

Abstract	Two new and similar cobalt(III) complexes, [CoL2]·NO3 (1) and [CoL2]·Cl (2), where L is 5-bromo-2-((2-(phenylamino)ethylimino)methyl)phenolate, have been synthesized and characterized by IR and UV-Vis spectra. Structures of the complexes were confirmed by single crystal X-ray determination. The Co atoms in the complexes are in octahedral coordination, with the donor atoms come from the two Schiff base ligands, viz. phenolate oxygen, and imino and amino nitrogen. The anions of the cobalt salts crystallized as counteranions in the complexes. The complexes were assayed for antibacterial activities by MTT method.
MeSH term(s)	Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cobalt/chemistry ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Crystallography, X-Ray ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Microbial Sensitivity Tests ; Molecular Conformation ; Phenols/chemistry ; Schiff Bases/chemistry
Chemical Substances	Anti-Bacterial Agents ; Coordination Complexes ; Phenols ; Schiff Bases ; Cobalt (3G0H8C9362)
Language	English
Publishing date	2021-12-15
Publishing country	Slovenia
Document type	Journal Article
ZDB-ID	2029709-9
ISSN	1580-3155 ; 1318-0207
ISSN (online)	1580-3155
ISSN	1318-0207
DOI	10.17344/acsi.2021.6979
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Book: Biosimilars of monoclonal antibodies

Liu, Cheng / Morrow, K. John Jr

a practical guide to manufacturing, preclinical and clinical development

2017

Author's details	ed. by Cheng Liu ; K. John Morrow, Jr
Keywords	Antibodies, Monoclonal ; Biosimilar Pharmaceutical
Language	English
Size	LII, 652 S. : Ill., graph. Darst.
Publisher	Wiley
Publishing place	Hoboken
Publishing country	United States
Document type	Book
HBZ-ID	HT018747498
ISBN	978-1-118-66231-1 ; 9781118940631 ; 9781118940624 ; 1-118-66231-8 ; 1118940636 ; 1118940628
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2017 A 148	available for loan (reading room)	Lesesaal EG

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Article: Serum Uric Acid: A Murderer or Bystander for Cardiac-related Mortality?

Liu, Cheng-Wei

The Journal of rheumatology

2021 Volume 48, Issue 11, Page(s) 1639–1640

MeSH term(s)	Heart ; Humans ; Hyperuricemia ; Risk Factors ; Uric Acid
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2021-08-15
Publishing country	Canada
Document type	Editorial
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.210695
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article: Potential benefits of vitamin D supplementation on pregnancy.

Liu, Cheng-Chiang / Huang, Jian-Pei

Journal of the Formosan Medical Association = Taiwan yi zhi

2023 Volume 122, Issue 7, Page(s) 557–563

Abstract: Background: The level of vitamin D in pregnant women and the effect of vitamin D supplementation are lack in Taiwan.: Objective: To investigate the vitamin D serum level and the effect of its supplementation on pregnancy.: Methods: We included ... ...

Abstract	Background: The level of vitamin D in pregnant women and the effect of vitamin D supplementation are lack in Taiwan. Objective: To investigate the vitamin D serum level and the effect of its supplementation on pregnancy. Methods: We included 1048 pregnant women who underwent prenatal exam with known serum 25-hydroxyvitamin D3 [25(OH)D3] levels and delivery at the Mackay Memorial Hospital, Taipei, Taiwan during 2015-2018. A daily dose 2000 IU of vitamin D was given, starting at 12-16 weeks of pregnancy, to reach the level of 20 ng/mL, and then a maintenance dose of 800 IU/day was given. The other 3654 women without vitamin D supplementation delivered in 2018 served as control group. Pregnancy outcomes were recorded for analysis. Results: Over 80% of the 1048 pregnant women were vitamin D deficiency. There was an inverse correlation between serum vitamin D levels and maternal body mass index (p = 0.0366). We compared 375 women with serum vitamin D levels increased above 30 ng/mL after supplementation with control group. The rates of preterm birth, low birth weight, and postpartum hemorrhage between these 2 groups were 6.67% vs. 11.19% (p = 0.007), 6.40% vs. 10.0% (p = 0.025), and 1.33% vs. 3.20% (p = 0.04), respectively. Conclusion: Vitamin D deficiency is very prevalent in pregnant women, especially those with high BMI, in Taiwan. It can be corrected by adequate vitamin D supplementation, which may decrease the risk of pregnancy complications and bring benefits to the fetus.
MeSH term(s)	Female ; Pregnancy ; Infant, Newborn ; Humans ; Dietary Supplements ; Premature Birth/prevention & control ; Vitamin D ; Vitamins ; Pregnancy Outcome ; Vitamin D Deficiency/drug therapy ; Pregnancy Complications/prevention & control
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-03-14
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2023.02.004
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Article: Sustainable digital transformation path for manufacturing outwards foreign direct investment firms: Gradual or leapfrogging.

Yang, Xiaohua / Liu, Cheng / Wei, Qiancheng

Heliyon

2024 Volume 10, Issue 3, Page(s) e24889

Abstract: Digital transformation plays an important role in improving the efficiency of production of enterprises and can provide strong support for green and sustainable development. Compared with domestic enterprises, outward foreign direct investment (OFDI) ... ...

Abstract	Digital transformation plays an important role in improving the efficiency of production of enterprises and can provide strong support for green and sustainable development. Compared with domestic enterprises, outward foreign direct investment (OFDI) enterprises have greater access to advanced digital technology. This paper aims to analyze the path selection of green and sustainable production for the digital transformation of manufacturing outward foreign direct investment (OFDI) companies, whether gradual or leapfrogging. However, there is a lack of systemic game mechanisms and numerical simulation methods for heterogeneous enterprises. Based on the analysis of reverse technology spillover intensity of outward foreign direct investment (OFDI) and differences in the absorptive capacity of enterprises, we have proposed the evolutionary game model for different path selection of digital transformation of manufacturing enterprises, due to heterogeneous enterprises under different spillover degrees with numerical analysis methods. The research results show that: (i) Under low reverse technology spillover intensity, all enterprises evolve to a gradual transformation path, and enterprises with weaker absorptive capacity converge faster; (ii) There is a certain threshold for reverse technology spillover. When reverse technology spillover intensity exceeds the threshold, enterprises with stronger absorptive capacity converge to a leapfrog transformation path, but enterprises with weak absorptive capacity converge to a gradual transformation path; (iii) With high reverse technology spillover intensity, all enterprises evolve toward a leapfrog transformation path, and faster convergence happens to enterprises with higher absorptive capacity. The evolutionary game path of digital transformation in manufacturing enterprises is illustrated in Fig. 1.
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24889
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Article ; Online: Bifocal photon sieve imaging in the hard x-ray region.

Bai, Xiaojun / Zhang, Junyong / Liu, Huiya / Liu, Cheng

Optics letters

2024 Volume 49, Issue 7, Page(s) 1713–1716

Abstract: Hard x-rays are widely used for plasma diagnosis, nondestructive inspection, and high-resolution x-ray imaging. A typical x-ray source is a tabletop micro-focus x-ray source. Here, a bifocal photon sieve (PS) with the smallest diameter of 59.6 nm was ... ...

Abstract	Hard x-rays are widely used for plasma diagnosis, nondestructive inspection, and high-resolution x-ray imaging. A typical x-ray source is a tabletop micro-focus x-ray source. Here, a bifocal photon sieve (PS) with the smallest diameter of 59.6 nm was designed and fabricated by electron-beam lithography to focus hard x-rays on variable-resolution array images. An imaging experiment at 8.39 keV demonstrates that the designed and fabricated PS has two different focal lengths. The numerous pinholes that can be optimized provide richer degrees of freedom to realize considerably more functionalities. A multi-focal PS provides the possibility of splitting x-rays and further extends interferometry from visible light to hard x-rays.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.519852
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Article ; Online: Unveiling the Causal Association between Non-Infectious Respiratory Disorders and Sepsis through Mendelian Randomization Analysis.

Liu, Cheng / He, Li / Zheng, Xiangde

Shock (Augusta, Ga.)

2024

Abstract: Background: The association between sepsis and non-infectious respiratory diseases is well-documented, yet the specific causal link between the two remains unclear. In order to explore this relationship further, we employed a Mendelian randomization (MR) ...

Abstract	Background: The association between sepsis and non-infectious respiratory diseases is well-documented, yet the specific causal link between the two remains unclear. In order to explore this relationship further, we employed a Mendelian randomization (MR) analysis utilizing data from the UK Biobank and FinnGen Biobank. Methods: We analyzed the summary statistics of a genome-wide association study (GWAS) summary statistics for chronic obstructive pulmonary disease (COPD), asthma, pulmonary embolism (PE), idiopathic pulmonary fibrosis (IPF), obstructive sleep apnea (OSA), lung cancer, sepsis, and sepsis-related mortality. We employed the inverse-variance weighted (IVW) method and four additional MR methods. Heterogeneity and horizontal pleiotropy were assessed using the Cochrane's Q test, MR-Egger intercept, and MR-PRESSO test. A sensitivity analysis was also performed. Results: MR analysis showed associations between COPD and lung cancer with increased sepsis risk (odds ratio (OR)IVW 1.138, P = 0.006; (OR)IVW 1.123, P = 0.031; respectively) and sepsis mortality ((OR)IVW 1.350, P = 0.022; (OR)IVW 1.312, P = 0.022; respectively). Asthma exhibited a potential protective effect against sepsis mortality((OR)IVW = 0.300, P = 0.039), while PE demonstrated a risk effect ((OR)IVW = 1.148, P = 0.032). No causal association was observed between asthma, PE, and sepsis (P > 0.05). IPF and OSA were not significantly associated with sepsis or sepsis-related mortality (P > 0.05). Heterogeneity and horizontal pleiotropy were not evident for asthma or lung cancer (P > 0.05). However, horizontal pleiotropy was suggested for COPD by the MR-Egger regression (P < 0.05), but not by the MR-PRESSO test (P > 0.05). IPF and OSA were not significantly associated with sepsis or sepsis-related mortality (P > 0.05). Conclusions: Our MR analysis offers new insights into potential links between noninfectious respiratory diseases and the risk of sepsis. However, additional investigation into the underlying mechanisms and clinical studies are necessary to confirm these findings.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000002358
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Zs.A 3985: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Persistent Hyperkeratotic Plaques on a Man's Genitogluteal Area.

Zhang, Qian / Liu, Cheng-Cheng / Li, Jiu-Hong

JAMA dermatology

2024 Volume 160, Issue 4, Page(s) 466–467

MeSH term(s)	Male ; Humans ; Porokeratosis
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2023.4624
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Article ; Online: Redox signaling and oxidative stress in systemic acquired resistance.

Liu, Cheng / Liu, Qingcai / Mou, Zhonglin

Journal of experimental botany

2024

Abstract: Plants fully depend on their immune systems to defend against pathogens. Upon pathogen attack, plants not only activate immune responses at the infection site but also trigger a defense mechanism known as systemic acquired resistance (SAR) in distal ... ...

Abstract	Plants fully depend on their immune systems to defend against pathogens. Upon pathogen attack, plants not only activate immune responses at the infection site but also trigger a defense mechanism known as systemic acquired resistance (SAR) in distal systemic tissues to prevent subsequent infections by a broad-spectrum of pathogens. SAR is induced by mobile signals produced at the infection site. Accumulating evidence suggests that reactive oxygen species (ROS) play a central role in SAR signaling. ROS burst at the infection site is one of the earliest cellular responses following pathogen infection and can spread to systemic tissues through membrane-associated NADPH oxidase-dependent relay-production of ROS. It is well known that ROS ignite redox signaling and when in excess, cause oxidative stress damaging cellular components. In this review, we summarize current knowledge on redox regulation of several SAR signaling components. We discuss the ROS amplification loop in systemic tissues involving multiple SAR mobile signals. Moreover, we highlight the essential role of oxidative stress in generating SAR signals including azelaic acid and extracellular NAD(P) [eNAD(P)]. Finally, we propose that eNAD(P) is a damage-associated molecular pattern serving as a converging point of SAR mobile signals in systemic tissues.
Language	English
Publishing date	2024-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/erae193
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