LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 114

Search options

  1. Article ; Online: Research on age-friendly garden design in China based on the case study of WANSHOU Park

    Liu Chengyang

    E3S Web of Conferences, Vol 283, p

    2021  Volume 02007

    Abstract: The rate of population aging has reached a high level in China that age-friendly design should be concerned when designing gardens in urban place. Although the generation-skipping guardianship phenomenon always exists in present situation of elderly ... ...

    Abstract The rate of population aging has reached a high level in China that age-friendly design should be concerned when designing gardens in urban place. Although the generation-skipping guardianship phenomenon always exists in present situation of elderly people in China that grandchildren are taken with the elderly and are involved in their daily activities in most family, the needs of children are neglected in urban garden design. The paper generalized guidelines of age-friendly garden design according to LEED, Chinese garden design standard, and the guideline of global age-friendly cities in Europe. Childrenfriendliness have also been included based on the above-mentioned new guidelines. 29 reports have been collected in the case study of WANSHOU Park which can be characterized as an age-friendly garden involving basic information and scoring records on its environment and facilities. Through the increasement of children-friendly features and installments in the park, the design will have great potential to deal with aging problems.
    Keywords Environmental sciences ; GE1-350
    Subject code 710
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Suggestions on home quarantine and recovery of novel coronavirus patients.

    Li, Qiuyu / Liu, Chengyang / Li, Haiyun

    Journal of translational internal medicine

    2023  Volume 11, Issue 2, Page(s) 111–114

    Language English
    Publishing date 2023-07-05
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2861892-0
    ISSN 2224-4018 ; 2450-131X
    ISSN (online) 2224-4018
    ISSN 2450-131X
    DOI 10.2478/jtim-2023-0085
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection.

    Liu, Chengyang / Zheng, Chenyang / Shen, Xipeng / Liang, Ling / Li, Qiuyu

    Frontiers in immunology

    2023  Volume 14, Page(s) 1259381

    Abstract: Serum C-reactive protein (CRP) has been found elevated during COVID-19 infection, and associated with systematic inflammation as well as a poor clinical outcome. However, how did CRP participated in the COVID-19 pathogenesis remains poorly understood. ... ...

    Abstract Serum C-reactive protein (CRP) has been found elevated during COVID-19 infection, and associated with systematic inflammation as well as a poor clinical outcome. However, how did CRP participated in the COVID-19 pathogenesis remains poorly understood. Here, we report that serum C-reactive protein (CRP) levels are correlated with megakaryocyte marker genes and could regulate immune response through interaction with megakaryocytes. Molecular dynamics simulation through ColabFold showed a reliable interaction between monomeric form of CRP (mCRP) and the secreted protein acidic and rich in cysteine (SPARC). The interaction does not affect the physiological activities of SPARC while would be disturbed by pentamerization of CRP. Interplay between SPARC and mCRP results in a more intense immune response which may led to poor prognosis. This study highlights the complex interplay between inflammatory markers, megakaryocytes, and immune regulation in COVID-19 and sheds light on potential therapeutic targets.
    MeSH term(s) Humans ; C-Reactive Protein/metabolism ; Cells, Cultured ; COVID-19 ; Inflammation/metabolism ; Osteonectin/genetics
    Chemical Substances C-Reactive Protein (9007-41-4) ; Osteonectin ; SPARC protein, human ; CRP protein, human
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1259381
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Parameter optimization of unmanned surface vessel propulsion motor based on BAS-PSO

    Li Bian / Xiangqian Che / Liu Chengyang / Dai Jiageng / He Hui

    International Journal of Advanced Robotic Systems, Vol

    2022  Volume 19

    Abstract: Despite advances in modern control theory and artificial intelligence technology, current methods for tuning proportional-integral-derivative (PID) controller parameters based on the traditional particle swarm optimization (PSO) algorithm do not meet the ...

    Abstract Despite advances in modern control theory and artificial intelligence technology, current methods for tuning proportional-integral-derivative (PID) controller parameters based on the traditional particle swarm optimization (PSO) algorithm do not meet the requirements for controlling an unmanned surface vessel (USV) propulsion motor. To overcome the disadvantages of the PSO algorithm, such as low precision and easily falling into a local optimum, the beetle antennae search (BAS) algorithm can be introduced into the PSO algorithm by replacing particles with beetles, and effectively prevents the PSO algorithm from easily falling into the local optimum. At the same time, the BAS algorithm will no longer be limited to single objective parameterization. Herein, we propose a PID parameter optimization method based on the hybrid BAS-PSO algorithm for a USV propulsion motor. The PID parameter optimization of propulsion motor effectively becomes a beetle foraging problem with group optimization. Numerical results show that the method can effectively solve the problems of PSO and greatly improve convergence speed. Compared with the genetic algorithm and standard PSO algorithm, the BAS-PSO algorithm is superior for PID parameter tuning and can improve performance of USV propulsion system.
    Keywords Electronics ; TK7800-8360 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 600
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Photonic jets produced by dielectric micro cuboids.

    Liu, Cheng-Yang

    Applied optics

    2015  Volume 54, Issue 29, Page(s) 8694–8699

    Abstract: The formation of photonic jets produced by dielectric micro cuboids is reported. The spatial electromagnetic field has been numerically analyzed on the basis of the finite-difference time-domain calculation. The characteristics of photonic jets, such as ... ...

    Abstract The formation of photonic jets produced by dielectric micro cuboids is reported. The spatial electromagnetic field has been numerically analyzed on the basis of the finite-difference time-domain calculation. The characteristics of photonic jets, such as propagation length and location, can be drastically changed by controlling the cuboid dimensions. Visually three morphological types of photonic jets are introduced for classification. Combining key parameters of photonic jets, the quality criterion is used to describe the jet quality. The super resolution imaging of the dielectric micro cuboid can be expected from the long focal length and small beam waist. The simulation results show that it can be of interest for several potential applications, such as subdiffraction resolution optical microlenses, ultradirectional optical antennae, and nanolithography based on the micro cuboid.
    Language English
    Publishing date 2015-10-10
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.54.008694
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Experimental verification of twin photonic nanojets from a dielectric microcylinder.

    Liu, Cheng-Yang / Yeh, Meng-Ju

    Optics letters

    2019  Volume 44, Issue 13, Page(s) 3262–3265

    Abstract: In this Letter, the direct generation of twin photonic nanojets (PNJs) through two coherent illuminations of a microcylinder is investigated theoretically and experimentally. The dielectric microcylinder (polydimethylsiloxane) with 5 μm diameter and 6 μm ...

    Abstract In this Letter, the direct generation of twin photonic nanojets (PNJs) through two coherent illuminations of a microcylinder is investigated theoretically and experimentally. The dielectric microcylinder (polydimethylsiloxane) with 5 μm diameter and 6 μm height is employed to generate symmetric twin PNJs. The finite-difference time-domain calculation is used to simulate the electric field distributions inside and outside the microcylinder. The scanning optical microscope system is performed for experimental verification of twin photonic nanojets. In both theory and in practice, the intensity null of electric field creates two separate PNJs. Compared to a single PNJ, twin PNJs have a smaller subwavelength waist and more complex intensity distribution. The focal distance, interval, and full width at half-maximum of twin PNJs are a function of the offset angle. The twin PNJs will provide novel applications in nanolithography, optical trapping, biophotonic sensing, and therapy.
    Language English
    Publishing date 2019-06-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.44.003262
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets.

    Patil, Abhijeet R / Schug, Jonathan / Liu, Chengyang / Lahori, Deeksha / Descamps, Hélène C / Naji, Ali / Kaestner, Klaus H / Faryabi, Robert B / Vahedi, Golnaz

    Cell reports. Medicine

    2024  , Page(s) 101535

    Abstract: Type 1 diabetes (T1D) is a chronic condition in which beta cells are destroyed by immune cells. Despite progress in immunotherapies that could delay T1D onset, early detection of autoimmunity remains challenging. Here, we evaluate the utility of machine ... ...

    Abstract Type 1 diabetes (T1D) is a chronic condition in which beta cells are destroyed by immune cells. Despite progress in immunotherapies that could delay T1D onset, early detection of autoimmunity remains challenging. Here, we evaluate the utility of machine learning for early prediction of T1D using single-cell analysis of islets. Using gradient-boosting algorithms, we model changes in gene expression of single cells from pancreatic tissues in T1D and non-diabetic organ donors. We assess if mathematical modeling could predict the likelihood of T1D development in non-diabetic autoantibody-positive donors. While most autoantibody-positive donors are predicted to be non-diabetic, select donors with unique gene signatures are classified as T1D. Our strategy also reveals a shared gene signature in distinct T1D-associated models across cell types, suggesting a common effect of the disease on transcriptional outputs of these cells. Our study establishes a precedent for using machine learning in early detection of T1D.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101535
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing.

    Xie, Gengqiang / Toledo, Maria Pilar / Hu, Xue / Yong, Hyo Jeong / Sanchez, Pamela Sandoval / Liu, Chengyang / Naji, Ali / Irianto, Jerome / Wang, Yue J

    BMC genomics

    2024  Volume 25, Issue 1, Page(s) 427

    Abstract: Background: Current approaches to profile the single-cell transcriptomics of human pancreatic endocrine cells almost exclusively rely on freshly isolated islets. However, human islets are limited in availability. Furthermore, the extensive processing ... ...

    Abstract Background: Current approaches to profile the single-cell transcriptomics of human pancreatic endocrine cells almost exclusively rely on freshly isolated islets. However, human islets are limited in availability. Furthermore, the extensive processing steps during islet isolation and subsequent single cell dissolution might alter gene expressions. In this work, we report the development of a single-nucleus RNA sequencing (snRNA-seq) approach with targeted islet cell enrichment for endocrine-population focused transcriptomic profiling using frozen archival pancreatic tissues without islet isolation.
    Results: We cross-compared five nuclei isolation protocols and selected the citric acid method as the best strategy to isolate nuclei with high RNA integrity and low cytoplasmic contamination from frozen archival human pancreata. We innovated fluorescence-activated nuclei sorting based on the positive signal of NKX2-2 antibody to enrich nuclei of the endocrine population from the entire nuclei pool of the pancreas. Our sample preparation procedure generated high-quality single-nucleus gene-expression libraries while preserving the endocrine population diversity. In comparison with single-cell RNA sequencing (scRNA-seq) library generated with live cells from freshly isolated human islets, the snRNA-seq library displayed comparable endocrine cellular composition and cell type signature gene expression. However, between these two types of libraries, differential enrichments of transcripts belonging to different functional classes could be observed.
    Conclusions: Our work fills a technological gap and helps to unleash frozen archival pancreatic tissues for molecular profiling targeting the endocrine population. This study opens doors to retrospective mappings of endocrine cell dynamics in pancreatic tissues of complex histopathology. We expect that our protocol is applicable to enrich nuclei for transcriptomics studies from various populations in different types of frozen archival tissues.
    MeSH term(s) Humans ; Islets of Langerhans/metabolism ; Islets of Langerhans/cytology ; Single-Cell Analysis/methods ; Homeobox Protein Nkx-2.2 ; Sequence Analysis, RNA/methods ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Gene Expression Profiling/methods ; Pancreas/metabolism ; Pancreas/cytology ; Transcriptome ; Nuclear Proteins ; Transcription Factors ; Homeodomain Proteins
    Chemical Substances Homeobox Protein Nkx-2.2 ; NKX2-2 protein, human ; Nuclear Proteins ; Transcription Factors ; Homeodomain Proteins
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-024-10335-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: The role of RNA epigenetic modification in normal and malignant hematopoiesis.

    Vasic, Radovan / Gao, Yimeng / Liu, Chengyang / Halene, Stephanie

    Current stem cell reports

    2020  Volume 6, Issue 4, Page(s) 144–155

    Abstract: Purpose of review: RNA epigenetic modifications have been identified as novel, dynamic regulators of gene expression, with important impacts on stem cell fate decisions. Here we examine the functions of RNA modifications, with a focus on : Recent ... ...

    Abstract Purpose of review: RNA epigenetic modifications have been identified as novel, dynamic regulators of gene expression, with important impacts on stem cell fate decisions. Here we examine the functions of RNA modifications, with a focus on
    Recent findings: The m
    Summary: The RNA modification m
    Language English
    Publishing date 2020-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2808623-5
    ISSN 2198-7866
    ISSN 2198-7866
    DOI 10.1007/s40778-020-00178-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Magnetic Concentric Hot-Circle Generation at Optical Frequencies in All-Dielectric Mesoscale Janus Particles.

    Minin, Oleg V / Zhou, Song / Liu, Cheng-Yang / Kong, Jelene Antonicole Ngan / Minin, Igor V

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 19

    Abstract: The development of all-dielectric structures with high magnetic response at optical frequencies has become a matter of intense study in past years. However, magnetic effects are weak at optical frequencies due to the small value of the magnetic ... ...

    Abstract The development of all-dielectric structures with high magnetic response at optical frequencies has become a matter of intense study in past years. However, magnetic effects are weak at optical frequencies due to the small value of the magnetic permeability of natural materials. To this end, natural dielectric materials are unemployable for practical “magnetic” applications in optics. We have shown for the first time that it is possible to induce intense magnetic concentric subwavelength “hot circles” in a dielectric mesoscale Janus particle. The basis of the Janus particle is a combination of the effects of a photonic jet, whispering-gallery waves, and the concept of solid immersion. Simulations show an (H/H0)2/(E/E0)2 contrast of more than 10, and maximal magnetic field intensity enhancement is more than 1000 for a wavelength-scaled particle with a refractive index n < 2 and a size parameter in the order of 30. This work may provide a new way to realize precise magnetic devices for integrated photonic circuits and light−matter interaction.
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12193428
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top