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Article ; Online: In vitro

Liu, Aihua / Liu, Chunying

2024 , Page(s) 18717

Abstract: Purpose: Previous research has demonstrated the efficacy of SM in inhibiting tumor growth in various cancer types. The objective of this study was to examine the antineoplastic effects and molecular mechanisms of Solamargine (SM) in colorectal cancer.!## ...

Abstract	Purpose: Previous research has demonstrated the efficacy of SM in inhibiting tumor growth in various cancer types. The objective of this study was to examine the antineoplastic effects and molecular mechanisms of Solamargine (SM) in colorectal cancer. Methods: Colorectal cancer (CRC) cells were treated with different concentrations of SM to evaluate the anticancer concentration for further experimental measurements. Additionally, the antitumor efficacy of SM was assessed in a subcutaneously implanted tumor model of colorectal cancer. RNA-seq and bioinformatics analyses were employed to identify differentially expressed genes (DEGs) and elucidate the underlying molecular mechanisms in LoVo cells. Subsequently, the specific mechanism of SM-mediated anti-tumor activities was analyzed by protein expression methods. Results: The results of in vitro assays demonstrated that SM exhibits significant inhibitory effects on cell proliferation, clone formation, and invasion, while also promoting apoptosis in SW48 and LoVo cells. In a mouse xenograft tumor model, intragastric administration of SM at doses of 5 or 10 mg/kg effectively suppressed tumor volume and weight, and induced cell apoptosis in vivo. SM treatment also down-regulated PCNA and Cyclin E protein expression, contributing to the regulation of apoptosis. Further analysis using RNA-seq, bioinformatics, and experimental measurements revealed that SM treatment upregulates PTEN expression, while significantly reducing the phosphorylation levels of Akt and mTOR in LoVo cells. Conclusion: Our study provides further evidence to support the notion that SM primarily induces apoptosis in colorectal cancer cells through the inhibition of the PI3K/Akt signaling pathway. Additionally, our investigation demonstrated the favorable safety profile of SM in a mouse model of colorectal cancer, thereby suggesting its potential as a promising therapeutic approach for the management of CRC.
Language	English
Publishing date	2024-01-31
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-717
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Article ; Online: Understanding the Roles of Non-coding RNAs and Exosomal Non-Coding RNAs in Diabetic Nephropathy.

Zhu, Yuye / Liu, Chunying / Hallajzadeh, Jamal

Current molecular medicine

2024

Abstract: One of the greatest serious side effects of diabetes is diabetic nephropathy (DN), which is also the key factor in the sometimes-deadly diabetic end-stage renal disease. Progressive renal interstitial fibrosis is closely associated with oxidative stress, ...

Abstract	One of the greatest serious side effects of diabetes is diabetic nephropathy (DN), which is also the key factor in the sometimes-deadly diabetic end-stage renal disease. Progressive renal interstitial fibrosis is closely associated with oxidative stress, and the extracellular matrix is typically a feature of DN. Some RNAs formed by genome transcription that are not translated into proteins are recognized as noncoding RNAs. It has been shown that ncRNAs control apoptosis, inflammatory response, cell proliferation, autophagy, and other pathogenic processes, contributing to the pathogenesis of DN. Exosomes are nano-carriers vesicles that variety in size from 40 to 160 nm. Exosomes are widely present and dispersed in different bodily fluids, plentiful in nucleic acids, lipids, and proteins (microRNA, mRNA, tRNA, lncRNA, circRNA, etc.). Exosomes play a crucial role as messengers for cellular communication. They transport and transmit key signaling molecules, participate in the transfer of information and materials between cells, control cellular physiological processes, and are carefully linked to the beginning and development of many diseases. Herein, we summarized the role of different ncRNAs in DN. Moreover, we highlighted the role of the exosomal form of ncRNAs in the DN pathogenesis.
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064873-X
ISSN	1875-5666 ; 1566-5240
ISSN (online)	1875-5666
ISSN	1566-5240
DOI	10.2174/0115665240287631240321072504
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Article ; Online: Lactate promoted cisplatin resistance in NSCLC by modulating the m6A modification-mediated FOXO3/MAGI1-IT1/miR-664b-3p/IL-6R axis.

Bo, Wei / Yu, Ning / Wang, Xiaokai / Wang, Chun / Liu, Chunying

Neoplasia (New York, N.Y.)

2024 Volume 48, Page(s) 100960

Abstract: Background: Cisplatin resistance is one of the major obstacles in non-small cell lung cancer (NSCLC) treatment. Intriguingly, elevated lactate levels were observed in cisplatin-resistant cells, which spurred further investigation into their underlying ... ...

Abstract	Background: Cisplatin resistance is one of the major obstacles in non-small cell lung cancer (NSCLC) treatment. Intriguingly, elevated lactate levels were observed in cisplatin-resistant cells, which spurred further investigation into their underlying biological mechanisms. Methods: Lactate levels were measured by lactate detection kit. Cisplatin-resistance NSCLC cells were established using progressive concentration of cisplatin. Cell viability, proliferation, and apoptosis were detected by CCK-8, EdU, and flow cytometry, respectively. Cell proliferation in vivo was determined by immunohistochemistry of Ki67 and apoptotic cells were calculated by the TUNEL. MeRIP-PCR was used to measure FOXO3 m6A levels. The interactions of genes were analyzed via RIP, ChIP, Dual-luciferase reporter, and RNA pull-down, respectively. Results: Elevated lactate levels were observed in both NSCLC patients and cisplatin-resistance cells. Lactate treatment increased cisplatin-resistance cell viability in vitro and promoted tumor growth in vivo. Mechanistically, lactate downregulated FOXO3 by YTHDF2-mediated m6A modification. FOXO3 transcriptionally reduced MAGI1-IT1 expression. FOXO3 overexpression inhibited the lactate-induced promotion of cisplatin resistance in NSCLC, which were reversed by MAGI1-IT1 overexpression. MAGI1-IT1 and IL6R competitively bound miR-664b-3p. FOXO3 overexpression or MAGI1-IT1 knockdown repressed lactate-mediated cisplatin resistance in vivo. Conclusion: Lactate promoted NSCLC cisplatin resistance through regulating FOXO3/MAGI1-IT1/miR-664b-3p/IL6R axis in YTHDF2-mediated m6A modification.
MeSH term(s)	Humans ; Lactic Acid ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Cisplatin/pharmacology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Transcription Factors ; Cell Proliferation ; MicroRNAs/genetics ; Drug Resistance, Neoplasm/genetics ; Cell Line, Tumor ; Cell Adhesion Molecules ; Adaptor Proteins, Signal Transducing ; Guanylate Kinases ; Forkhead Box Protein O3 ; Adenine/analogs & derivatives
Chemical Substances	Lactic Acid (33X04XA5AT) ; Cisplatin (Q20Q21Q62J) ; 6-methyladenine (W7IBY2BGAX) ; Transcription Factors ; MicroRNAs ; MAGI1 protein, human (EC 2.7.4.8) ; Cell Adhesion Molecules ; Adaptor Proteins, Signal Transducing ; Guanylate Kinases (EC 2.7.4.8) ; FOXO3 protein, human ; Forkhead Box Protein O3 ; Adenine (JAC85A2161)
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2023.100960
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Article: Changes of Vaginal Microecology of Women with Intrauterine Adhesions.

Dun, Sidi / Liu, Chunying / Li, Na

International journal of women's health

2023 Volume 15, Page(s) 857–867

Abstract: Background: Reproductive tract infection is one of the important causes of intrauterine adhesions (IUA). The evaluation of vaginal microecology could provide significant guidance for the treatment of reproductive tract infection. This study aimed to ... ...

Abstract	Background: Reproductive tract infection is one of the important causes of intrauterine adhesions (IUA). The evaluation of vaginal microecology could provide significant guidance for the treatment of reproductive tract infection. This study aimed to investigate the correlation between IUA and vaginal microecology. Methods: Patients who came to the gynecology department of our hospital from March 2020 to February 2022 and were diagnosed with IUA were selected as the research subjects (n=150). Patients with normal uterine cavity were selected as the control group (n=150). All research subjects underwent hysteroscopy and vaginal microecological examination. The vaginal pH, hydrogen peroxide (H Results: The incidence of abnormal vaginal microecological morphological and functional indicators in the IUA group was remarkably higher than that in the control group, mainly manifested as relatively high pH value, reduction of Lactobacillus, increased ratio of flora density I, IV and flora diversity I, IV, higher detection rate of TV and BV. In addition, the increase in the positive rate of H Conclusion: Vaginal microecological imbalance is closely related to the occurrence of IUA, which should cause clinical concern.
Language	English
Publishing date	2023-05-31
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508161-5
ISSN	1179-1411
ISSN	1179-1411
DOI	10.2147/IJWH.S407010
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Article: Calcium signaling facilitates chilling- and GA- induced dormancy release in tree peony.

Gai, Weiling / Liu, Chunying / Yang, Mengjie / Li, Feng / Xin, Hua / Gai, Shupeng

Frontiers in plant science

2024 Volume 15, Page(s) 1362804

Abstract: Calcium plays a crucial role in plant growth and development, yet little is known about its function in endodormancy regulation. Tree peony ( ...

Abstract	Calcium plays a crucial role in plant growth and development, yet little is known about its function in endodormancy regulation. Tree peony (
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2024.1362804
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Article: PsmiR159b-

Zhang, Tao / Wang, Xinyu / Yuan, Yanchao / Zhu, Shoujie / Liu, Chunying / Zhang, Yuxi / Gai, Shupeng

Horticulture research

2024 Volume 11, Issue 4, Page(s) uhae052

Abstract: Bud endodormancy in perennial plants is a sophisticated system that adapts to seasonal climatic changes. Growth-promoting signals such as low temperature and gibberellins (GAs) are crucial for facilitating budbreak following endodormancy release (EDR). ... ...

Abstract	Bud endodormancy in perennial plants is a sophisticated system that adapts to seasonal climatic changes. Growth-promoting signals such as low temperature and gibberellins (GAs) are crucial for facilitating budbreak following endodormancy release (EDR). However, the regulatory mechanisms underlying GA-mediated budbreak in tree peony (
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ISSN	2662-6810
ISSN	2662-6810
DOI	10.1093/hr/uhae052
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Article ; Online: Overexpression of circZNF720 Inhibits Hepatocellular Carcinoma Progression by Regulating miR-421/MAPK9.

Yang, Feifei / Zhuang, Zhenjuan / Liu, Chunying / Li, Fuliang / Zhou, Jingjing

Molecular biotechnology

2023

Abstract: Hepatocellular carcinoma (HCC) is characterized by high incidence, high death rate and poor long term prognosis. Abnormal expression of circular RNA (circRNA) has been demonstrated to be closely associated with malignant progression of HCC. However, the ... ...

Abstract	Hepatocellular carcinoma (HCC) is characterized by high incidence, high death rate and poor long term prognosis. Abnormal expression of circular RNA (circRNA) has been demonstrated to be closely associated with malignant progression of HCC. However, the effect of circZNF720 on HCC is largely incompletely understood. This study sought to explore the effect of circZNF720 on the progression of HCC by CCK-8, transwell, and flow cytometry experiments. The prognosis of circZNF720 on patients was analyzed by Kaplan-Meier curve. Then, the regulatory mechanisms among circZNF720, miR-421, and MAPK9 were identified by qRT-PCR, dual-luciferase reporter assay, and RIP analysis, respectively. The outcomes of this study disclosed that circZNF720 was lowly expressed in HCC, and this low expression was strongly linked with a poor prognosis for HCC patients. Overexpression of circZNF720 inhibited the proliferation, migration, and invasion of cells, and increased the apoptosis of cells. Mechanistic studies revealed that circZNF720 targeted miR-421 and regulated the development of HCC by acting as a sponge for miRNAs. In addition, MAPK9 was a downstream target of miR-421, and circZNF720 introduction hampered HCC progression by upregulating MAPK9 expression through sponging miR-421. In conclusion, circZNF720 restrained HCC progression by targeting miR-421/MAPK9. This study provides a novel target for the treatment of HCC.
Language	English
Publishing date	2023-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-023-01016-2
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Article ; Online: Response of macrofaunal assemblages to different pollution pressures of two types of ports

Zhang, Mingwei / Liu, Chunying / Zhang, Caijie / Zhu, Haiyun / Wan, Jiteng / Liu, Xiaoshou

Ecological Indicators. 2023 Feb., v. 146 p.109858-

2023

Abstract: Pollution status and benthic ecological quality of the two types of ports were assessed based on heavy metals and macrofaunal assemblages. Macrofaunal abundance and biomass in the industrial port were significantly higher than those in the fishing port. ... ...

Abstract	Pollution status and benthic ecological quality of the two types of ports were assessed based on heavy metals and macrofaunal assemblages. Macrofaunal abundance and biomass in the industrial port were significantly higher than those in the fishing port. The dominant species of the two ports were Echinocardium cordatum and Nephtys oligobranchia. The AZTI marine biotic index (AMBI), multivariate AMBI, and Shannon-Wiener diversity index demonstrated that the benthic ecological quality of the two ports was moderate to good. The benthic ecological quality of the distant port sites was better than those of the nearby port sites. The geoaccumulation index and the Hakanson potential ecological risk index indicated that mercury posed a serious threat to port sediment pollution. AMBI, multivariate AMBI, and Shannon-Wiener diversity index were not good indicators for heavy metal pollution. The dominant species and Pielou's evenness index were significantly correlated with heavy metal pollution and were good biological indicators.
Keywords	Nephtys ; biomass ; dominant species ; fauna ; heavy metals ; mercury ; risk ; sediment contamination ; Macrofauna ; Ports ; Biotic index ; Pollution assessment
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2036774-0
ISSN	1872-7034 ; 1470-160X
ISSN (online)	1872-7034
ISSN	1470-160X
DOI	10.1016/j.ecolind.2022.109858
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Spatiotemporal distribution and environmental control factors of halocarbons in the Yangtze River Estuary and its adjacent marine area during autumn and spring.

Zou, Yawen / He, Zhen / Liu, Chunying / Yang, Gui-Peng

Environmental pollution (Barking, Essex : 1987)

2022 Volume 304, Page(s) 119244

Abstract: The oceanic production and release of volatile halocarbons (VHCs) to the atmosphere play a vital role in regulating the global climate. In this study, seasonal and spatial variations in VHCs, including trichlorofluoromethane (CFC-11), methyl iodide ( ... ...

Abstract	The oceanic production and release of volatile halocarbons (VHCs) to the atmosphere play a vital role in regulating the global climate. In this study, seasonal and spatial variations in VHCs, including trichlorofluoromethane (CFC-11), methyl iodide (CH
MeSH term(s)	China ; Environmental Monitoring ; Estuaries ; Hydrocarbons, Halogenated/analysis ; Hydrogen-Ion Concentration ; Rivers/chemistry ; Seasons ; Seawater/chemistry ; Water
Chemical Substances	Hydrocarbons, Halogenated ; Water (059QF0KO0R)
Language	English
Publishing date	2022-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119244
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Article: PsRGL1 negatively regulates chilling- and gibberellin-induced dormancy release by PsF-box1-mediated targeting for proteolytic degradation in tree peony.

Gao, Linqiang / Niu, Demei / Chi, Tianyu / Yuan, Yanchao / Liu, Chunying / Gai, Shupeng / Zhang, Yuxi

Horticulture research

2023 Volume 10, Issue 5, Page(s) uhad044

Abstract: Tree peony bud endodormancy is a common survival strategy similar to many perennial woody plants in winter, and the activation of the GA signaling pathway is the key to breaking endodormancy. GA signal transduction is involved in many physiological ... ...

Abstract	Tree peony bud endodormancy is a common survival strategy similar to many perennial woody plants in winter, and the activation of the GA signaling pathway is the key to breaking endodormancy. GA signal transduction is involved in many physiological processes. Although the GA-GID1-DELLA regulatory module is conserved in many plants, it has a set of specific components that add complexity to the GA response mechanism. DELLA proteins are key switches in GA signaling. Therefore, there is an urgent need to identify the key DELLA proteins involved in tree peony bud dormancy release. In this study, the prolonged chilling increased the content of endogenously active gibberellins. PsRGL1 among three DELLA proteins was significantly downregulated during chilling- and exogenous GA
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ISSN	2662-6810
ISSN	2662-6810
DOI	10.1093/hr/uhad044
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