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  1. Article ; Online: Acinetobacter baumannii infection in intensive care unit: analysis of distribution and drug resistance.

    Zhao, Siyang / Zhang, Bing / Liu, Conghai / Sun, Xiaodong / Chu, Yanpeng

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 120

    Abstract: Background: The isolation rate and drug resistance rate of Acinetobacter baumannii (A.baumannii) have increased over the years, which has become one of the main causes of infection and death in intensive care unit (ICU) patients. Analysis of the ... ...

    Abstract Background: The isolation rate and drug resistance rate of Acinetobacter baumannii (A.baumannii) have increased over the years, which has become one of the main causes of infection and death in intensive care unit (ICU) patients. Analysis of the distribution characteristics, drug resistance and influencing factors of A.baumannii in ICU could provide basis and reference for the infection prevention and clinical treatment.
    Methods and results: In this study, patients diagnosed with A.baumannii infection in ICU from January 2020 to December 2021 were selected. Samples of patients were collected for bacterial culture, drug sensitivity test analysis and drug resistant gene detection of A.baumannii. A total of 197 strains of A.baumannii were cultured in 2021, which was 18 strains more than in 2020. The specimens were mainly from lower respiratory tract secretions, and the isolated strains were multi-drug resistant. The resistance of isolates to tobramycin, gentamicin, and trimethoprim-sulfamethoxazole in 2021 showed a significant increase compared to 2020, while there were no significant differences observed in other resistance changes. The prevalence of multi-drug resistant A.baumannii in ICU remains high. Among them, all imipenem-resistant A.baumannii strains carried OXA-23 gene.
    Conclusion: Clinical treatment should use antibiotics reasonably based on the characteristics of bacterial resistance, and strengthen the prevention and control of hospital infection, pay more attention to the disinfection and isolation to reduce the risk of cross infection.
    MeSH term(s) Humans ; Acinetobacter baumannii/genetics ; Intensive Care Units ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Drug Resistance
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-09144-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review

    Wei, Zhicheng / Chen, Jing / Zuo, Fang / Guo, Julie / Sun, Xiaodong / Liu, Deming / Liu, Conghai

    Journal of ethnopharmacology. 2022 Sept. 19,

    2022  

    Abstract: With high mortality and morbidity rates, lung cancer (LC) has become one of the major threats to human health. The treatment strategies for LC currently face issues, such as drug resistance and body tolerance. Traditional Chinese medicine (TCM) is ... ...

    Abstract With high mortality and morbidity rates, lung cancer (LC) has become one of the major threats to human health. The treatment strategies for LC currently face issues, such as drug resistance and body tolerance. Traditional Chinese medicine (TCM) is characterized by novel pharmacological mechanisms, low toxicity, and limited side effects. TCM includes a substantial number of biologically active ingredients, several of which are effective monomeric agents against LC. An increasing number of researchers are focusing their efforts on the discovery of active anti-cancer ingredients in TCM. In this review, we summarized the anti-LC mechanisms of five types of TCM monomeric compounds. Our goal is to provide research ideas for the identification of new prospective medication candidates for the treatment of LC. We collected reports on the anti-LC effects of TCM monomers from web databases, including PubMed, Science Direct, Web of Science, and Europe PubMed Central. Among the keywords used were “lung cancer,” “traditional Chinese medicine,” “pharmacology,” and their combinations thereof. Then, we systematically summarized the anti-LC efficacy and related mechanisms of TCM monomers. Based on the available literature, this paper reviewed the therapeutic effects and mechanisms of five types of TCM monomers on LC. The characteristics of TCM monomers include the capabilities to suppress the tumor cell cycle, inhibit proliferation, induce apoptosis, promote autophagy, inhibit tumor cell invasion and metastasis, and enhance efficacy or reduce drug resistance when combined with cytotoxic agents and other methods to arrest the progression of LC and prolong the survival of patients. TCM contains numerous flavonoids, alkaloids, terpenoids, polyphenols, and other active compounds that are effective against LC. Given their chemical structure and pharmacological properties, these monomers are suitable as candidate drugs for the treatment of LC.
    Keywords Oriental traditional medicine ; apoptosis ; autophagy ; cell cycle ; chemical structure ; cytotoxicity ; drug resistance ; drug therapy ; flavonoids ; human health ; lung neoplasms ; metastasis ; morbidity ; mortality ; neoplasm cells ; polyphenols ; terpenoids ; Europe
    Language English
    Dates of publication 2022-0919
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115748
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review.

    Wei, Zhicheng / Chen, Jing / Zuo, Fang / Guo, Julie / Sun, Xiaodong / Liu, Deming / Liu, Conghai

    Journal of ethnopharmacology

    2022  Volume 300, Page(s) 115748

    Abstract: Ethnopharmacological relevance: With high mortality and morbidity rates, lung cancer (LC) has become one of the major threats to human health. The treatment strategies for LC currently face issues, such as drug resistance and body tolerance. Traditional ...

    Abstract Ethnopharmacological relevance: With high mortality and morbidity rates, lung cancer (LC) has become one of the major threats to human health. The treatment strategies for LC currently face issues, such as drug resistance and body tolerance. Traditional Chinese medicine (TCM) is characterized by novel pharmacological mechanisms, low toxicity, and limited side effects. TCM includes a substantial number of biologically active ingredients, several of which are effective monomeric agents against LC. An increasing number of researchers are focusing their efforts on the discovery of active anti-cancer ingredients in TCM.
    Aim of the review: In this review, we summarized the anti-LC mechanisms of five types of TCM monomeric compounds. Our goal is to provide research ideas for the identification of new prospective medication candidates for the treatment of LC.
    Materials and methods: We collected reports on the anti-LC effects of TCM monomers from web databases, including PubMed, Science Direct, Web of Science, and Europe PubMed Central. Among the keywords used were "lung cancer," "traditional Chinese medicine," "pharmacology," and their combinations thereof. Then, we systematically summarized the anti-LC efficacy and related mechanisms of TCM monomers.
    Results: Based on the available literature, this paper reviewed the therapeutic effects and mechanisms of five types of TCM monomers on LC. The characteristics of TCM monomers include the capabilities to suppress the tumor cell cycle, inhibit proliferation, induce apoptosis, promote autophagy, inhibit tumor cell invasion and metastasis, and enhance efficacy or reduce drug resistance when combined with cytotoxic agents and other methods to arrest the progression of LC and prolong the survival of patients.
    Conclusions: TCM contains numerous flavonoids, alkaloids, terpenoids, polyphenols, and other active compounds that are effective against LC. Given their chemical structure and pharmacological properties, these monomers are suitable as candidate drugs for the treatment of LC.
    MeSH term(s) Cytotoxins ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Flavonoids ; Humans ; Lung Neoplasms/drug therapy ; Medicine, Chinese Traditional ; Prospective Studies ; Terpenes
    Chemical Substances Cytotoxins ; Drugs, Chinese Herbal ; Flavonoids ; Terpenes
    Language English
    Publishing date 2022-09-24
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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