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Article: A Study of Elderly Patients' Preference for "Internet + Nursing Service" Based on Discrete Choice Experiments.

Liu, Cui / Zhang, Zhixia / Chen, Qiuxia / He, Fang

Alternative therapies in health and medicine

2024

Abstract: Objective: To investigate the preference of elderly patients for "Internet + Nursing Service", so as to provide reference for accurately matching their service needs.: Methods: Based on discrete choice experiments, the elderly patients' "Internet + ... ...

Abstract	Objective: To investigate the preference of elderly patients for "Internet + Nursing Service", so as to provide reference for accurately matching their service needs. Methods: Based on discrete choice experiments, the elderly patients' "Internet + Nursing Service" choice preference questionnaire was prepared, and 410 elderly patients were interviewed face-to-face. The Conditional Logit Model was used for quantitative analysis of the experimental data. Results: The six attributes included in the study had a significant impact on the elderly patients' preference for "Internet + Nursing Service" (P < .05). Among non-economic attributes, "medical insurance reimbursement ratio -70%" has the highest utility (.263, P < .001), with "hospital size - larger (.205, P < .05)" and "medical insurance reimbursement ratio -50%" (.188, P < .05) ranking second and third, respectively. The relative importance of the attribute of medical insurance reimbursement proportion is the highest (26.44%), and the relative importance of service content is the lowest (9.78%). If the proportion of medical insurance reimbursement increases from 30% to 70%, patients are willing to pay 202.9 yuan, and the probability of choosing "Internet + Nursing Service" increases by 6.1%. Conclusion: Patients prefer to choose a higher proportion of medical insurance reimbursement, a larger medical institution, a higher level of nurses, low single service costs, a basic package, and "Internet + Nursing Service" led by the government and hospitals. Improvement of the price and medical insurance payment policy is recommended, along with the enhancement of the ability of primary nursing services, strengthening of the management of Internet enterprise platforms, and scientific assessment of the needs of patients for personalized nursing services.
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: HDAC7: a promising target in cancer.

Liu, Cui / Zheng, Dan / Pu, Xuan / Li, Sijun

Frontiers in oncology

2024 Volume 14, Page(s) 1327933

Abstract: Histones have a vital function as components of nucleosomes, which serve as the fundamental building blocks of chromatin. Histone deacetylases (HDACs), which target histones, suppress gene transcription by compacting chromatin. This implies that HDACs ... ...

Abstract	Histones have a vital function as components of nucleosomes, which serve as the fundamental building blocks of chromatin. Histone deacetylases (HDACs), which target histones, suppress gene transcription by compacting chromatin. This implies that HDACs have a strong connection to the suppression of gene transcription. Histone deacetylase 7 (HDAC7), a member of the histone deacetylase family, may participate in multiple cellular pathophysiological processes and activate relevant signaling pathways to facilitate the progression of different tumors by exerting deacetylation. In recent years, HDAC7 has been increasingly studied in the pathogenesis of tumors. Studies that are pertinent have indicated that it has a significant impact on the growth and metastasis of tumors, the formation of the vascular microenvironment, and the emergence of resistance to drugs. Therefore, HDAC7 could potentially function as a potent predictor for tumor prognosis and a promising target for mitigating drug resistance in tumors. This review primarily concentrates on elucidating the structure and function of HDAC7, its involvement in the development of various tumors, and its interplay with relevant signaling pathways. Meanwhile, we briefly discuss the research direction and prospect of HDAC7.
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1327933
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Article ; Online: Discrimination of opium from Afghanistan and Myanmar by infrared spectroscopy coupled with machine learning methods.

Liu, Cui-Mei / Liu, Xue-Yan / Du, Yu / Hua, Zhen-Dong

Forensic science international

2024 Volume 357, Page(s) 111974

Abstract: Afghanistan and Myanmar are two overwhelming opium production places. In this study, rapid and efficient methods for distinguishing opium from Afghanistan and Myanmar were developed using infrared spectroscopy (IR) coupled with multiple machine learning ( ...

Abstract	Afghanistan and Myanmar are two overwhelming opium production places. In this study, rapid and efficient methods for distinguishing opium from Afghanistan and Myanmar were developed using infrared spectroscopy (IR) coupled with multiple machine learning (ML) methods for the first time. A total of 146 authentic opium samples were analyzed by mid-IR (MIR) and near-IR (NIR), within them 116 were used for model training and 30 were used for model validation. Six ML methods, including partial least squares discriminant analysis (PLS-DA), orthogonal PLS-DA (OPLS-DA), k-nearest neighbour (KNN), support vector machine (SVM), random forest (RF), and artificial neural networks (ANNs) were constructed and compared to get the best classification effect. For MIR data, the average of precision, recall and f1-score for all classification models were 1.0. For NIR data, the average of precision, recall and f1-score for different classification models ranged from 0.90 to 0.94. The comparison results of six ML models for MIR and NIR data showed that MIR was more suitable for opium geography classification. Compared with traditional chromatography and mass spectrometry profiling methods, the advantages of MIR are simple, rapid, cost-effective, and environmentally friendly. The developed IR chemical profiling methodology may find wide application in classification of opium from Afghanistan and Myanmar, and also to differentiate them from opium originating from other opium producing countries. This study presented new insights into the application of IR and ML to rapid drug profiling analysis.
MeSH term(s)	Spectroscopy, Near-Infrared/methods ; Opium ; Afghanistan ; Myanmar ; Spectrophotometry, Infrared ; Discriminant Analysis ; Least-Squares Analysis ; Support Vector Machine
Chemical Substances	Opium (8008-60-4)
Language	English
Publishing date	2024-03-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2024.111974
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Article: Case Report: Pancreaticopleural fistula with an atypical tract in a child with bulging chest.

Shang, Zi Yin / Hong, Chun / Liu, Cui Fen

Frontiers in pediatrics

2023 Volume 11, Page(s) 1278463

Abstract: Pancreaticopleural fistula (PPF) is a rare but serious complication caused by pancreatic lesions that presents primarily with respiratory tract symptoms and pleural effusion. We report a paediatric case of PPF without any respiratory symptoms throughout ... ...

Abstract	Pancreaticopleural fistula (PPF) is a rare but serious complication caused by pancreatic lesions that presents primarily with respiratory tract symptoms and pleural effusion. We report a paediatric case of PPF without any respiratory symptoms throughout the course of the disease, including cough or shortness of breath, with only a bulging chest as the first symptom. Imaging revealed a large left pleural effusion and Magnetic Resonance Cholangiopancreatography (MRCP) revealed a fistula formed between the pancreatic tail and the pleural cavity, which penetrated the diaphragm and opened in the central tendon of the diaphragm. The patient eventually underwent resection of the pancreatic tail lesion and repair of the diaphragmatic fistula and recovered soon thereafter.
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1278463
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Article ; Online: Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer.

Zheng, Le-Wei / Liu, Cui-Cui / Yu, Ke-Da

Journal of hematology & oncology

2023 Volume 16, Issue 1, Page(s) 123

Abstract: Liquid-liquid phase separation (LLPS) is a novel principle for interpreting precise spatiotemporal coordination in living cells through biomolecular condensate (BMC) formation via dynamic aggregation. LLPS changes individual molecules into membrane-free, ...

Abstract	Liquid-liquid phase separation (LLPS) is a novel principle for interpreting precise spatiotemporal coordination in living cells through biomolecular condensate (BMC) formation via dynamic aggregation. LLPS changes individual molecules into membrane-free, droplet-like BMCs with specific functions, which coordinate various cellular activities. The formation and regulation of LLPS are closely associated with oncogenesis, tumor progressions and metastasis, the specific roles and mechanisms of LLPS in tumors still need to be further investigated at present. In this review, we comprehensively summarize the conditions of LLPS and identify mechanisms involved in abnormal LLPS in cancer processes, including tumor growth, metastasis, and angiogenesis from the perspective of cancer hallmarks. We have also reviewed the clinical applications of LLPS in oncologic areas. This systematic summary of dysregulated LLPS from the different dimensions of cancer hallmarks will build a bridge for determining its specific functions to further guide basic research, finding strategies to intervene in LLPS, and developing relevant therapeutic approaches.
MeSH term(s)	Humans ; Phase Separation ; Cell Transformation, Neoplastic ; Carcinogenesis ; Neoplasms ; Medical Oncology
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2429631-4
ISSN	1756-8722 ; 1756-8722
ISSN (online)	1756-8722
ISSN	1756-8722
DOI	10.1186/s13045-023-01522-5
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Article ; Online: Pyroptosis modulation by bacterial effector proteins.

Chai, Qiyao / Lei, Zehui / Liu, Cui Hua

Seminars in immunology

2023 Volume 69, Page(s) 101804

Abstract: Pyroptosis is a proinflammatory form of programmed cell death featured with membrane pore formation that causes cellular swelling and allows the release of intracellular inflammatory mediators. This cell death process is elicited by the activation of the ...

Abstract	Pyroptosis is a proinflammatory form of programmed cell death featured with membrane pore formation that causes cellular swelling and allows the release of intracellular inflammatory mediators. This cell death process is elicited by the activation of the pore-forming proteins named gasdermins, and is intricately orchestrated by diverse regulatory factors in mammalian hosts to exert a prompt immune response against infections. However, growing evidence suggests that bacterial pathogens have evolved to regulate host pyroptosis for evading immune clearance and establishing progressive infection. In this review, we highlight current understandings of the functional role and regulatory network of pyroptosis in host antibacterial immunity. Thereafter, we further discuss the latest advances elucidating the mechanisms by which bacterial pathogens modulate pyroptosis through adopting their effector proteins to drive infections. A better understanding of regulatory mechanisms underlying pyroptosis at the interface of host-bacterial interactions will shed new light on the pathogenesis of infectious diseases and contribute to the development of promising therapeutic strategies against bacterial pathogens.
MeSH term(s)	Animals ; Humans ; Pyroptosis ; Inflammasomes ; Bacterial Proteins ; Apoptosis ; Inflammation Mediators ; Bacteria/metabolism ; Mammals/metabolism
Chemical Substances	Inflammasomes ; Bacterial Proteins ; Inflammation Mediators
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1018141-6
ISSN	1096-3618 ; 1044-5323
ISSN (online)	1096-3618
ISSN	1044-5323
DOI	10.1016/j.smim.2023.101804
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Article: [Input Characteristics of Dry Deposition of Atmospheric Particulates and Metals in Farmland in the Suburb of Nanjing].

Liu, Cui-Ying / Jin, Hao / Fan, Jian-Ling

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 4, Page(s) 1873–1881

Abstract: The dry deposition of heavy metals in atmospheric particulates is one of the important sources of heavy metals in agricultural areas, but there are few observational studies on the atmospheric deposition of heavy metals in agricultural areas. In this ... ...

Abstract	The dry deposition of heavy metals in atmospheric particulates is one of the important sources of heavy metals in agricultural areas, but there are few observational studies on the atmospheric deposition of heavy metals in agricultural areas. In this study, the concentrations of atmospheric particulates with different particle sizes and ten kinds of metal elements in them were analyzed by sampling a typical rice-wheat rotation area in the suburb of Nanjing for one year, and the dry deposition fluxes were estimated using the big leaf model, so as to understand the input characteristics of particulates and heavy metals. The results showed that the particulate concentrations and dry deposition fluxes were high in winter and spring but low in summer and autumn. In winter and spring, coarse particulates (2.1-9.0 μm) and fine particulates (<2.1 μm) had dual effects on particulate pollution, whereas in summer and autumn, particulate pollution was mainly attributed to the fine particulates. The concentrations of metal elements were the lowest in giant particulates (>9.0 μm) and were similar in coarse particulates and fine particulates, whereas Pb, Mn, As, and Cd elements were relatively high in fine particulates. The average annual dry deposition fluxes[g·(m
Language	Chinese
Publishing date	2023-04-11
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202206224
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Book ; Online ; E-Book: Landscape change and resource utilization in East Asia

Liu, Cuirong / Janku, Andrea / Pietz, David A.

perspectives from environmental history

(Academia Sinica on East Asia)

2018

Author's details	edited by Ts'ui-jung Liu, Andrea Janku and David Pietz
Series title	Academia Sinica on East Asia
Keywords	Landscape changes/History ; Land use/History ; Human ecology/History ; Landscape assessment/Methodology ; Landscapes/Social aspects ; East Asia
Subject code	304.20951
Language	English
Size	1 Online Ressource (224 Seiten), Illustrationen
Publisher	Routledge
Publishing place	London ; New York
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Note	Includes bibliographical references and index
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019729673
ISBN	978-1-351-18290-4 ; 978-1-351-18292-8 ; 9780815396048 ; 978-1-351-1829-11 ; 9781351182898 ; 1-351-18290-0 ; 1-351-18292-7 ; 081539604X ; 1-351-1829-1-9 ; 1351182897
DOI	10.4324/9781351182928
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The functional divergence of homologous GPAT9 genes contributes to the erucic acid content of Brassica napus seeds.

Liu, Hongbo / Zhu, Jinbo / Zhang, Bingxin / Li, Qingyang / Liu, Cui / Huang, Qian / Cui, Peng

BMC plant biology

2024 Volume 24, Issue 1, Page(s) 69

Abstract: Background: The early allopolyploid Brassica napus was a hybrid of two Brassica species, that had undergone a whole genome duplication event followed by genome restructuring, including deletions and small scale duplications. A large number of homologous ...

Abstract	Background: The early allopolyploid Brassica napus was a hybrid of two Brassica species, that had undergone a whole genome duplication event followed by genome restructuring, including deletions and small scale duplications. A large number of homologous genes appeared functional divergence during species domestication. Due to the high conservation of de novo glycerolipid biosynthesis, multiple homologues of glycerol-3-phosphate acyltransferases (GPATs) have been found in B. napus. Moreover, the functional variances among these homologous GPAT-encoding genes are unclear. Results: In this study, four B. napus homologous genes encoding glycerol-3-phosphate acyltransferase 9 (BnaGPAT9) were characterized. Although a bioinformatics analysis indicated high protein sequence similarity, the homologues demonstrated tissue-specific expression patterns and functional divergence. Yeast genetic complementation assays revealed that BnaGPAT9-A1/C1 homologues but not BnaGPAT9-A10/C9 homologues encoded functional GPAT enzymes. Furthermore, a single nucleotide polymorphism of BnaGPAT9-C1 that occurred during the domestication process was associated with enzyme activity and contributed to the fatty acid composition. The seed-specific expression of BnGPAT9-C1 Conclusions: This study revealed that BnaGPAT9 gene homologues evolved into functionally divergent forms with important roles in erucic acid biosynthesis.
MeSH term(s)	Brassica napus ; Glycerol ; Glycerol-3-Phosphate O-Acyltransferase ; Saccharomyces cerevisiae ; Seeds ; Phosphates ; Erucic Acids
Chemical Substances	erucic acid (075441GMF2) ; Glycerol (PDC6A3C0OX) ; Glycerol-3-Phosphate O-Acyltransferase (EC 2.3.1.15) ; Phosphates ; Erucic Acids
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-024-04734-0
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Article ; Online: Dipole-multipole plasmonic coupling between gold nanorods and titanium nitride nanoparticles for enhanced photothermal conversion.

Xi, Min / Xu, Chenyang / Zhong, Li / Liu, Cui / Li, Nian / Zhang, Shudong / Wang, Zhenyang

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 7, Page(s) 6196–6207

Abstract: The plasmonic photothermal conversion efficiency can be enhanced by coupling among plasmonic atoms or plasmonic molecules due to the amplified local electric field and extinction cross-section. Recently, it has been theoretically proved that ... ...

Abstract	The plasmonic photothermal conversion efficiency can be enhanced by coupling among plasmonic atoms or plasmonic molecules due to the amplified local electric field and extinction cross-section. Recently, it has been theoretically proved that hybridization between dipolar modes and higher order modes can provide higher enhancement than that among dipolar modes in terms of both near- and far-field, which may lead to a higher photothermal conversion rate. In this work, we systematically investigated the photothermal conversion enhancement of plasmonic coupling between a dipolar mode of a titanium nitride nanoparticle (TiN NP) and a higher order mode of a gold nanorod (Au NR), which was compared to that of coupling among TiN NPs' dipolar modes. We evaluated the photothermal conversion efficiency of dipole-dipole coupling and dipole-multipole coupling in the nanocluster under the illumination of a monochromatic laser of 808 nm wavelength and simulated solar light, respectively. Both experimental tests and numerical simulations suggested that the plasmonic dipole-multipole coupling exhibited higher enhancement in photothermal conversion than dipole-dipole plasmonic coupling.
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp05933b
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