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Article ; Online: Association between serum homocysteine and postoperative acute kidney injury in patients undergoing cardiac surgery.

Li, Zheng-Rong / Liu, Cun-Fei / Guo, De-Qun / Wei, Yan-Jin

2024 Volume 18, Issue 2, Page(s) 51–57

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/diagnosis ; Cardiac Surgical Procedures/adverse effects ; Risk Factors ; Incidence ; Prevalence ; Postoperative Complications/etiology ; Retrospective Studies
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2023-0611
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Article ; Online: Predictive values of bilirubin for in-hospital adverse events in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention.

Ying, Chen / Liu, Cun-Fei / Guo, De-Qun / Du, Zheng-Ren / Wei, Yan-Jin

Clinics (Sao Paulo, Brazil)

2023 Volume 78, Page(s) 100306

Abstract: Purpose: To investigate the association between serum bilirubin levels and in-hospital Major Adverse Cardiac Events (MACE) in patients with ST-segment Elevation Myocardial Infarction (STEMI) undergoing primary Percutaneous Coronary Intervention (PCI).!## ...

Abstract	Purpose: To investigate the association between serum bilirubin levels and in-hospital Major Adverse Cardiac Events (MACE) in patients with ST-segment Elevation Myocardial Infarction (STEMI) undergoing primary Percutaneous Coronary Intervention (PCI). Methods: A total of 418 patients with STEMI who underwent primary PCI were enrolled from October 1 Results: The incidence of MACE in STEMI patients increased from the lowest to the highest bilirubin tertiles. Multivariate logistic regression analysis showed that increased total bilirubin level was an independent predictor of in-hospital MACE in patients with STEMI (p for trend = 0.02). Compared to the first TB group, the ORs for risk of MACE were 1.58 (95% CI 0.77‒3.26) and 2.28 (95% CI 1.13‒4.59) in the second and third TB groups, respectively. The ROC curve analysis showed that the areas under the curve for TB, DB and IDB in predicting in-hospital MACE were 0.642 (95% CI 0.578‒0.705, p < 0.001), 0.676 (95% CI 0.614‒0.738, p < 0.001), and 0.619 (95% CI 0.554‒0.683, p < 0.001), respectively. Conclusions: The current study showed that elevated TB, DB, and IDB levels are independent predictors of in-hospital MACE in patients with STEMI after primary PCI, and that DB has a better predictive value than TB and IDB.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; ST Elevation Myocardial Infarction/surgery ; ST Elevation Myocardial Infarction/etiology ; Percutaneous Coronary Intervention/adverse effects ; Bilirubin ; Hospitals ; Prognosis ; Treatment Outcome
Chemical Substances	Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182801-5
ISSN	1980-5322 ; 1807-5932
ISSN (online)	1980-5322
ISSN	1807-5932
DOI	10.1016/j.clinsp.2023.100306
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Article ; Online: Association between Uric Acid and In-Hospital Heart Failure in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.

Liu, Cun-Fei / Song, Kai-You / Zhou, Wei-Ning / Wei, Yan-Jin

Disease markers

2021 Volume 2021, Page(s) 7883723

Abstract: Objective: To investigate the association of serum uric acid levels with in-hospital heart failure (HF) in patients with acute myocardial infarction (AMI) who are undergoing percutaneous coronary intervention (PCI).: Methods: Two hundred sixteen ... ...

Abstract	Objective: To investigate the association of serum uric acid levels with in-hospital heart failure (HF) in patients with acute myocardial infarction (AMI) who are undergoing percutaneous coronary intervention (PCI). Methods: Two hundred sixteen patients with AMI who were treated with PCI were enrolled in our study. Univariate and multivariate logistic regression analyses were performed to estimate the associations between uric acid levels and the risk of in-hospital HF in AMI patients. Analyses of the areas under the receiver operating characteristic (ROC) curve were performed to determine the accuracy of uric acid levels in predicting in-hospital HF. Results: A dose-response relationship was found for the incidence of in-hospital HF and levels of uric acid, showing increased HF from the lowest to the highest tertile of uric acid. Compared with subjects in the bottom tertile, the adjusted odds ratio for in-hospital HF was 1.92 (95% CI 0.70-5.24) and 3.33 (95% CI 1.18-9.46) in the second tertile group and the third tertile group, respectively. Every 1 mg/dl increase in the serum uric acid level was associated with a 1.60-fold increased risk of incident in-hospital HF (OR, 1.60; 95% CI 1.22-2.11; Conclusions: Our study showed that the serum uric acid level on admission is an independent predictor of in-hospital heart failure in patients with AMI.
MeSH term(s)	Aged ; Female ; Heart Failure/metabolism ; Humans ; Male ; Middle Aged ; Myocardial Infarction/metabolism ; Myocardial Infarction/surgery ; Percutaneous Coronary Intervention ; Prospective Studies ; Uric Acid/metabolism
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2021/7883723
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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Liver Enzymes and the Risk of Atrial Fibrillation: A Meta-Analysis of Prospective Cohort Studies.

Liu, Cun-Fei / Zhou, Wei-Ning / Guo, Tang-Meng / Hou, An-Cheng / Wei, Yan-Jin

Genetic testing and molecular biomarkers

2019 Volume 23, Issue 12, Page(s) 865–870

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Alanine Transaminase/analysis ; Alanine Transaminase/metabolism ; Aspartate Aminotransferases/analysis ; Aspartate Aminotransferases/metabolism ; Atrial Fibrillation/etiology ; Cohort Studies ; Female ; Humans ; Liver/enzymology ; Male ; Prospective Studies ; Risk Assessment/methods ; Risk Factors ; gamma-Glutamyltransferase/analysis ; gamma-Glutamyltransferase/metabolism
Chemical Substances	gamma-Glutamyltransferase (EC 2.3.2.2) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2019-12-10
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2486664-7
ISSN	1945-0257 ; 1945-0265
ISSN (online)	1945-0257
ISSN	1945-0265
DOI	10.1089/gtmb.2019.0142
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Article: Association Between Uric Acid and Metabolic Syndrome in Elderly Women.

Wang, Hui-Juan / Shi, Lei-Zhi / Liu, Cun-Fei / Liu, Shi-Min / Shi, Song-Tao

Open medicine (Warsaw, Poland)

2018 Volume 13, Page(s) 172–177

Abstract: Objective: To investigate the relationship between uric acid and metabolic syndrome (MetS) in elderly women.: Methods: A total of 468 women aged ≥60 years participating in a health examination were enrolled. The association between uric acid and MetS ...

Abstract	Objective: To investigate the relationship between uric acid and metabolic syndrome (MetS) in elderly women. Methods: A total of 468 women aged ≥60 years participating in a health examination were enrolled. The association between uric acid and MetS and its individual variables was evaluated by univariate and multivariate logistic regression models. Results: A dose-response relationship was observed for the prevalence of MetS and uric acid quartiles. Subjects in the second, third and fourth quartile of uric acid had a 2.23-fold, 2.25-fold and 4.41-fold increased risk, respectively, of MetS than those in the first uric acid quartile (p for trend <0.001). Furthermore, each 1 mg/dl increment of serum uric acid level had a 1.38-fold increased risk of MetS (OR 1.38; 95% CI, 1.14-1.69; p=0.001). Conclusions: Our present study demonstrated that elevated uric acid was positively associated with the prevalence of MetS in elderly women. Further random control trials are needed to elucidate the effectiveness of treatment of hyperuricaemia in reducing the incidence of MetS in elderly women.
Language	English
Publishing date	2018-05-09
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2829380-0
ISSN	2391-5463
ISSN	2391-5463
DOI	10.1515/med-2018-0027
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Article ; Online: The associations between liver enzymes and the risk of metabolic syndrome in the elderly.

Liu, Cun-Fei / Zhou, Wei-Ning / Lu, Zheng / Wang, Xue-Ting / Qiu, Zhao-Hui

Experimental gerontology

2018 Volume 106, Page(s) 132–136

Abstract: Background: Studies have demonstrated that liver enzymes are associated with metabolic syndrome (MetS). However, little information is available regarding these relationships in elderly populations. Our present study aimed to explore the associations ... ...

Abstract	Background: Studies have demonstrated that liver enzymes are associated with metabolic syndrome (MetS). However, little information is available regarding these relationships in elderly populations. Our present study aimed to explore the associations between liver enzymes and the risk of MetS in elderly populations. Methods: This cross-sectional study included 1444 elder participants (970 men and 474 women) who attended annual physical examinations. Univariate and multivariate logistic regressions were performed to estimate the associations between liver enzymes and the risk of MetS and its components according to quartiles of the concentration of each liver enzyme. Results: The prevalence of MetS and its components increased remarkably with increasing quartiles of alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) but not with aspartate aminotransferase (AST) in the elderly. Compared with subjects in the bottom quartile, the adjusted odds ratio for MetS in the highest ALT, GGT and ALP quartiles were 1.78 (95% CI 1.21-2.61), 2.58 (95% CI 1.77-3.78) and 1.85 (95%CI 1.27-2.70) respectively. No statistically significant increases in the odds ratio for MetS according to increased quartiles of AST were found in either the univariate or multivariate logistic regression analyses. Conclusions: Elevated liver enzymes levels (mainly ALT, GGT and ALP but not AST) are positively associated with the prevalence of MetS in elderly populations.
MeSH term(s)	Aged ; Alanine Transaminase/metabolism ; Alkaline Phosphatase/metabolism ; Aspartate Aminotransferases/metabolism ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Liver/enzymology ; Liver Function Tests ; Logistic Models ; Male ; Metabolic Syndrome/epidemiology ; Middle Aged ; Multivariate Analysis ; Prevalence ; Risk Factors ; gamma-Glutamyltransferase/metabolism
Chemical Substances	gamma-Glutamyltransferase (EC 2.3.2.2) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2018-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2018.02.026
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Article ; Online: Association between uric acid and metabolic syndrome in elderly women

Wang Hui-Juan / Shi Lei-Zhi / Liu Cun-Fei / Liu Shi-Min / Shi Song-Tao

Open Medicine, Vol 13, Iss 1, Pp 172-

2018 Volume 177

Abstract: To investigate the relationship between uric acid and metabolic syndrome (MetS) in elderly women. ...

Abstract	To investigate the relationship between uric acid and metabolic syndrome (MetS) in elderly women.
Keywords	uric acid ; metabolic syndrome ; elderly women ; Medicine ; R
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gamma-glutamyltransferase level and risk of hypertension: a systematic review and meta-analysis.

Liu, Cun-Fei / Gu, Yu-Ting / Wang, Hai-Ya / Fang, Ning-Yuan

PloS one

2012 Volume 7, Issue 11, Page(s) e48878

Abstract: Background: Several prospective observational studies suggest that gamma-glutamyltransferase(GGT) level is positively associated with risk of hypertension. However, these studies draw inconsistent conclusions. Therefore, we conducted a systematic review ...

Abstract	Background: Several prospective observational studies suggest that gamma-glutamyltransferase(GGT) level is positively associated with risk of hypertension. However, these studies draw inconsistent conclusions. Therefore, we conducted a systematic review and meta-analysis to evaluate the exact association between GGT level and subsequent development of hypertension. Methods: We searched Pubmed, Embase, and Science Citation Index (ISI Web of Science) for prospective cohort studies examining the association between GGT level and hypertension. Then, pooled effect estimates (RRs) for the association between GGT level and hypertension were calculated. Results: A total of 13 prospective cohort studies including 43314 participants and 5280 cases of hypertension were included. The pooled RR of hypertension was 1.94(95%CI: 1.55-2.43; P<0.001) when comparing the risk of hypertension between the highest versus lowest category of GGT levels. Moreover, the risk of hypertension increased by 23% (summary RR: 1.23; 95%CI: 1.13-1.32; P<0.001) per 1 SD logGGT increment. Subgroup analyses showed significant positive associations in each subgroup except in ≧160/95 subgroup (RR: 2.56, 95%CI: 0.87-7.54; P = 0.088) and nondrinkers subgroup (RR: 1.76, 95%CI: 0.88-3.53; P = 0.113). Sensitivity analyses showed no single study significantly affects the pooled RRs. No publication bias was found in our meta-analysis. Conclusions: GGT level is positively associated with the development of hypertension. Further studies are needed to confirm our findings and elucidate the exact mechanisms between GGT level and the incidence of hypertension.
MeSH term(s)	Biomarkers/blood ; Humans ; Hypertension/blood ; Male ; Odds Ratio ; Prospective Studies ; Risk ; Risk Factors ; gamma-Glutamyltransferase/blood
Chemical Substances	Biomarkers ; gamma-Glutamyltransferase (EC 2.3.2.2)
Language	English
Publishing date	2012-11-07
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0048878
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Article ; Online: Apolipoprotein a5 gene polymorphism and risk for metabolic syndrome: a meta-analysis.

Liu, Cun-Fei / Yang, Qun-Fang / Chen, Xing-Lin / Liu, Cheng-Yun

Genetic testing and molecular biomarkers

2012 Volume 16, Issue 10, Page(s) 1241–1245

Abstract: Background: Many studies have focused on the association between the apolipoprotein A5 (ApoA5) polymorphism and the risk of metabolic syndrome (MetS). However, these studies drew inconsistent conclusions. The aim of this study was to evaluate the exact ... ...

Abstract	Background: Many studies have focused on the association between the apolipoprotein A5 (ApoA5) polymorphism and the risk of metabolic syndrome (MetS). However, these studies drew inconsistent conclusions. The aim of this study was to evaluate the exact association between the ApoA5 polymorphism and MetS in a large-scale meta-analysis. Methods: The PubMed, Embase, and Science Citation Index (ISI Web of Science) databases were searched to collect all publications on the association between the ApoA5 polymorphism and MetS. Two common variants of ApoA5 (namely -1131T>C in the promoter region and c.56C>G in the coding region) with the risk of MetS were analyzed. The overall odd ratios (ORs) and 95% confidence intervals (CIs) for -1131T>C (CC+TC) versus TT genotype and c.C56G (GG+GC) versus CC were assessed between the MetS and control group. Subgroup analysis was further performed by ethnicity. The meta-analysis was performed by Stata11.0. Results: Twelve studies from 10 publications were chosen in our meta-analysis. The combined results showed that C allele carriers (CC+TC) of -1131T>C had a significantly higher risk of MetS for the overall (OR=1.32; 95% CI: 1.14-1.53; p=0.000) with moderate heterogeneity (I2=54.9%, p=0.014). Subgroup analysis was further performed according to ethnicity, and the association was still significant in Asians (OR=1.42; 95% CI: 1.25-1.62; p=0.000), but not in white populations (OR=1.25; 95% CI: 0.97-1.61; p=0.087). When analyzing the association between c.C56G and MetS, the G allele carrier (GG+GC) genotype significantly increased the risk of MetS (OR=1.32; 95% CI: 1.15-1.50; p=0.000) in white populations. No significant publication bias was observed in either -1131T>C or c.C56G. Conclusions: Our study suggested that the ApoA5 -1131T>C polymorphism was significantly associated with the risk of MetS in Asians, but not in white populations. However, the c.C56G polymorphism was significantly associated with MetS in white populations.
MeSH term(s)	Adult ; Aged ; Apolipoprotein A-V ; Apolipoproteins A/genetics ; Asian Continental Ancestry Group/genetics ; European Continental Ancestry Group/genetics ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Metabolic Syndrome/genetics ; Middle Aged ; Polymorphism, Genetic
Chemical Substances	APOA5 protein, human ; Apolipoprotein A-V ; Apolipoproteins A
Language	English
Publishing date	2012-10
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2486664-7
ISSN	1945-0257 ; 1945-0265
ISSN (online)	1945-0257
ISSN	1945-0265
DOI	10.1089/gtmb.2012.0183
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Article ; Online: Adventitial gene transfer of catalase attenuates angiotensin II-induced vascular remodeling.

Liu, Cun-Fei / Zhang, Jia / Shen, Kai / Gao, Ping-Jin / Wang, Hai-Ya / Jin, Xin / Meng, Chao / Fang, Ning-Yuan

Molecular medicine reports

2015 Volume 11, Issue 4, Page(s) 2608–2614

Abstract: Vascular adventitia and adventitia‑derived reactive oxygen species (ROS) contribute to vascular remodeling following vascular injury. A previous ex vivo study in adventitial fibroblasts showed that catalase, one of most important anti‑oxide enzymes, was ... ...

Abstract	Vascular adventitia and adventitia‑derived reactive oxygen species (ROS) contribute to vascular remodeling following vascular injury. A previous ex vivo study in adventitial fibroblasts showed that catalase, one of most important anti‑oxide enzymes, was downregulated by angiotensin II (AngII). The aim of the present study was to investigate whether adventitial gene transfer of catalase affects AngII‑induced vascular remodeling in vivo. Adenoviruses co‑expressing catalase and enhanced green fluorescent protein (eGFP) or expressing eGFP only were applied to the adventitial surface of common carotid arteries of Sprague‑Dawley rats. Alzet minipumps administering AngII (0.75 mg/kg/day) were then implanted subcutaneously for 14 days. Systolic blood pressure and biological parameters of vascular remodeling were measured in each group. Adventitial fibroblasts were cultured and p38 mitogen‑activated protein kinase (MAPK) phosphorylation was measured using western blot analysis. The results showed that adventitial gene transfer of catalase had no effect on AngII‑induced systolic blood pressure elevation. However, catalase adenovirus transfection significantly inhibited AngII‑induced media hypertrophy compared with that of the control virus (P<0.05). In addition, catalase transfection significantly attenuated AngII‑induced ROS generation, macrophage infiltration, collagen deposition and adventitial α‑smooth muscle actin expression. Furthermore, catalase transfection significantly inhibited the AngII‑induced increase in p38MAPK phosphorylation. In conclusion, the results of the present study demonstrated that adventitial gene transfer of catalase significantly attenuated AngII‑induced vascular remodeling in rats via inhibition of adventitial p38MAPK phosphorylation.
MeSH term(s)	Adenoviridae/genetics ; Adventitia/drug effects ; Adventitia/metabolism ; Angiotensin II/pharmacology ; Animals ; Catalase/genetics ; Catalase/metabolism ; Collagen/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Expression ; Gene Transfer Techniques ; Genes, Reporter ; Genetic Vectors/genetics ; Macrophages/pathology ; Male ; Phosphorylation/drug effects ; Rats ; Reactive Oxygen Species/metabolism ; Transduction, Genetic ; Transfection ; Vascular Remodeling/drug effects ; Vascular Remodeling/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Reactive Oxygen Species ; Angiotensin II (11128-99-7) ; Collagen (9007-34-5) ; Catalase (EC 1.11.1.6) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2015-04
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2014.3069
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