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Article ; Online: Photodynamic Effect of Vascular-targeted Polyphenol Nanoparticles on Endothelial Cells.

Yang, Lihua / Liu, Danni / Liu, Lian / Jiang, Xian

2024 , Page(s) 104096

Abstract: Background: Port wine stains (PWS) are vascular malformations, and photodynamic therapy (PDT) is a promising treatment. Emerging drug delivery method employs nanoparticles (NPs) to enhance drug permeability and retention in diseased blood vessels and ... ...

Abstract	Background: Port wine stains (PWS) are vascular malformations, and photodynamic therapy (PDT) is a promising treatment. Emerging drug delivery method employs nanoparticles (NPs) to enhance drug permeability and retention in diseased blood vessels and improving drug bioavailability. (-) -epigallocatechin-3-gallate glycine (EGCG) has anti-angiogenetic effects and boosts photodynamic therapy. Chlorin e6 (Ce6) is capable of efficiently producing singlet oxygen, rendering it a very promising photosensitizer for utilization in nanomedicine. Material and methods: EGCG-Ce6-NPs were synthesized and characterized using various techniques. The photodynamic effects of EGCG-Ce6-NPs on endothelial cells were evaluated. The compatibility and toxicity of the nanoparticle was tested using the CCK-8 assay. The intracellular uptake of the nanoparticle was observed using an inverted fluorescence microscope, and the intracellular fluorescence intensity was detected using flow cytometry. The ROS generation and apoptosis induced by EGCG-Ce6-NPs was observed using confocal laser scanning microscope and flow cytometry respectively. Results: EGCG-Ce6-NPs exhibited stability, spherical shape of uniform size while reducing the particle diameter, low polydisperse profile and retaining the ability to effectively generate singlet oxygen. These characteristics suggest promising potential for enhancing drug permeability and retention. Additionally, EGCG-Ce6-NPs demonstrated good compatibility with endothelial cells and enhanced intracellular uptake of Chlorin e6. Furthermore, EGCG-Ce6-NPs increased activation efficiency, induced significant toxicity, more reactive oxygen species, and higher rate of late apoptosis after laser irradiation. Conclusion: This in vitro study showed the potentials EGCG-Ce6-NPs for the destruction of endothelial cells in vasculature.
Language	English
Publishing date	2024-04-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2024.104096
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Article ; Online: Challenges in the Clinical Management of Proliferative Diabetic Retinopathy: Treatment Choice and Follow-up.

Sun, Jennifer K / Liu, Danni

JAMA ophthalmology

2022 Volume 141, Issue 1, Page(s) 46–47

MeSH term(s)	Humans ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/therapy ; Follow-Up Studies ; Diabetes Mellitus, Type 1
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2022.5057
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Article: Research progress of visual detection in rapid on-site detection of pathogen nucleic acid.

Liu, Dan-Ni / Wu, Hai-Ping / Zhou, Guo-Hua

Yi chuan = Hereditas

2023 Volume 45, Issue 4, Page(s) 306–323

Abstract: Nucleic acid detection is widely used in pathogen screening and detection due to its high sensitivity and specificity. With the increase of detection requirements and the development of amplification technology, nucleic acid detection methods are ... ...

Abstract	Nucleic acid detection is widely used in pathogen screening and detection due to its high sensitivity and specificity. With the increase of detection requirements and the development of amplification technology, nucleic acid detection methods are gradually developing towards simple, fast and low-cost. Quantitative polymerase chain reaction (qPCR), as the "gold standard" for nucleic acid detection, relies on expensive equipment and professional operators, which is not suitable for rapid on-site detection of pathogens. The visual detection method without relying on excitation light source or complex equipment can present the detection results in a more intuitive and portable way after combining with rapid and efficient amplification technology, which has the potential of point-of-care testing (POCT). This paper focuses on the reported application of amplification technology and CRISPR/Cas technology in visual detection and compares their advantages and disadvantages, so as to provide reference for POCT strategy based on pathogen nucleic acid.
MeSH term(s)	Nucleic Acid Amplification Techniques/methods ; Nucleic Acids ; Technology ; CRISPR-Cas Systems
Chemical Substances	Nucleic Acids
Language	English
Publishing date	2023-04-19
Publishing country	China
Document type	Journal Article
ISSN	0253-9772
ISSN	0253-9772
DOI	10.16288/j.yczz.22-323
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Article ; Online: Foam Cell Targeted Liposomes Co-Encapsulating Superoxide Dismutase and Catalase to Attenuate Atherosclerosis by Inhibiting Oxidative Stress.

Zhang, Shuang / Liu, Danni / Zhang, Jie / Liu, Siyu / Sun, Ran / Huo, Ran / Cui, Chunying

Discovery medicine

2024 Volume 36, Issue 181, Page(s) 343–354

Abstract: Background: Oxidative stress, propelled by reactive oxygen species (ROS), serves as a significant catalyst for atherosclerosis (AS), a primary contributor to vascular diseases on a global scale. Antioxidant therapy via nanomedicine has emerged as a ... ...

Abstract	Background: Oxidative stress, propelled by reactive oxygen species (ROS), serves as a significant catalyst for atherosclerosis (AS), a primary contributor to vascular diseases on a global scale. Antioxidant therapy via nanomedicine has emerged as a pivotal approach in AS treatment. Nonetheless, challenges such as inadequate targeting, subpar biocompatibility, and limited antioxidant effectiveness have restrained the widespread utilization of nanomedicines in AS treatment. This study aimed to synthesize a specialized peptide-modified liposome capable of encapsulating two antioxidant enzymes, intending to enhance targeted antioxidant therapy for AS. Methods: The film dispersion method was employed for liposome preparation. Fluorescence quantification was conducted to assess the drug encapsulation rate. Characterization of liposome particle size was performed using dynamic light scattering (DLS) and transmission electron microscopy (TEM). Laser confocal microscopy and flow cytometry were utilized to analyze liposome cell uptake and target foam cells. Antioxidant analysis was conducted using 2',7'-Dichlorodihydrofluorescein diacetate (DCFH-DA) staining, while pro-lipid efflux analysis utilized Oil Red O (ORO) staining. Safety evaluation was performed using Hematoxylin and Eosin (H&E) staining. The level of inflammatory factors was determined through enzyme-linked immunosorbent assay (ELISA). The degree of lipid oxidation at the cellular level was assessed using the malonaldehyde (MDA) assay. Results: Our Conclusions: In this study, we effectively synthesized LyP-lip@SOD/CAT and established its efficacy as a straightforward and promising nano-agent for antioxidant therapy targeting atherosclerosis.
MeSH term(s)	Animals ; Foam Cells ; Liposomes/pharmacology ; Superoxide Dismutase/pharmacology ; Catalase/pharmacology ; Antioxidants/therapeutic use ; Antioxidants/pharmacology ; Reactive Oxygen Species ; Oxidative Stress ; Atherosclerosis/drug therapy ; Lipoproteins, LDL/pharmacology ; Plaque, Atherosclerotic
Chemical Substances	Liposomes ; Superoxide Dismutase (EC 1.15.1.1) ; Catalase (EC 1.11.1.6) ; Antioxidants ; Reactive Oxygen Species ; Lipoproteins, LDL
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2415544-5
ISSN	1944-7930 ; 1944-7930
ISSN (online)	1944-7930
ISSN	1944-7930
DOI	10.24976/Discov.Med.202436181.32
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Article ; Online: Influences of carboxymethyl chitosan upon stabilization and gelation of O/W Pickering emulsions in the presence of inorganic salts.

Tong, Qiulan / Yi, Zeng / Ma, Lei / Tan, Yunfei / Cao, Xiaoyu / Liu, Danni / Li, Xudong

Carbohydrate polymers

2024 Volume 331, Page(s) 121902

Abstract: The objective of this study was to investigate the effects of carboxymethyl chitosan (CMCS) on the stabilization and gelation of oil-in-water (O/W) Pickering emulsions (PEs) with polyphenol-amino acid particles in the presence of inorganic salts. The ... ...

Abstract	The objective of this study was to investigate the effects of carboxymethyl chitosan (CMCS) on the stabilization and gelation of oil-in-water (O/W) Pickering emulsions (PEs) with polyphenol-amino acid particles in the presence of inorganic salts. The results revealed that the CMCS-induced depletion interactions contributed to improving the emulsification ability and interfacial adsorption efficiency of polyphenol-amino acid particles as well as constructing the network structures in the continuous phase. These relevant changes collectively resulted in elevating stability, viscosity and moduli of PEs. The additional effects of different inorganic salts with varying additions were further investigated, and the addition-dependent phenomena were observed. At low additions of inorganic salts, the occurrence of the chelation of inorganic salts with CMCS consolidated the constructed network structure, favorable to the gelation of PEs. With increasing additions, this chelation effect became stronger which compromised the CMCS-induced depletion, gradually leading to destabilization of PEs. In terms of ion species, the more pronounced effect on emulsion stability was achieved with calcium ions than with potassium and iron ions. This study expects to provide a new perspective on the extending application of cationic CMCS for improving the stability of O/W PEs in the food industry.
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2024.121902
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Article: A Breeding Plumage in the Making: The Unique Process of Plumage Coloration in the Crested Ibis in Terms of Chemical Composition and Sex Hormones.

Liu, Danni / Tong, Yiwei / Dong, Rong / Ye, Xinping / Yu, Xiaoping

Animals : an open access journal from MDPI

2023 Volume 13, Issue 24

Abstract: The Crested Ibis ( ...

Abstract	The Crested Ibis (
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13243820
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Article ; Online: Cost-effectiveness of Aflibercept Monotherapy vs Bevacizumab First Followed by Aflibercept If Needed for Diabetic Macular Edema.

Hutton, David W / Glassman, Adam R / Liu, Danni / Sun, Jennifer K

JAMA ophthalmology

2023 Volume 141, Issue 3, Page(s) 268–274

Abstract: Importance: The DRCR Retina Network Protocol AC showed no significant difference in visual acuity outcomes over 2 years between treatment with aflibercept monotherapy and bevacizumab first with switching to aflibercept for suboptimal response in ... ...

Abstract	Importance: The DRCR Retina Network Protocol AC showed no significant difference in visual acuity outcomes over 2 years between treatment with aflibercept monotherapy and bevacizumab first with switching to aflibercept for suboptimal response in treating diabetic macular edema (DME). Understanding the estimated cost and cost-effectiveness of these approaches is important. Objective: To evaluate the cost and cost-effectiveness of aflibercept monotherapy vs bevacizumab-first strategies for DME treatment. Design, setting, and participants: This economic evaluation was a preplanned secondary analysis of a US randomized clinical trial of participants aged 18 years or older with center-involved DME and best-corrected visual acuity of 20/50 to 20/320 enrolled from December 15, 2017, through November 25, 2019. Interventions: Aflibercept monotherapy or bevacizumab first, switching to aflibercept in eyes with protocol-defined suboptimal response. Main outcomes and measures: Between February and July 2022, the incremental cost-effectiveness ratio (ICER) in cost per quality-adjusted life-year (QALY) over 2 years was assessed. Efficacy and resource utilization data from the randomized clinical trial were used with health utility mapping from the literature and Medicare unit costs. Results: This study included 228 participants (median age, 62 [range, 34-91 years; 116 [51%] female and 112 [49%] male; 44 [19%] Black or African American, 60 [26%] Hispanic or Latino, and 117 [51%] White) with 1 study eye. The aflibercept monotherapy group included 116 participants, and the bevacizumab-first group included 112, of whom 62.5% were eventually switched to aflibercept. Over 2 years, the cost of aflibercept monotherapy was $26 504 (95% CI, $24 796-$28 212) vs $13 929 (95% CI, $11 984-$15 874) for the bevacizumab-first group, a difference of $12 575 (95% CI, $9987-$15 163). The aflibercept monotherapy group gained 0.015 (95% CI, -0.011 to 0.041) QALYs using the better-seeing eye and had an ICER of $837 077 per QALY gained compared with the bevacizumab-first group. Aflibercept could be cost-effective with an ICER of $100 000 per QALY if the price per dose were $305 or less or the price of bevacizumab was $1307 per dose or more. Conclusions and relevance: Variability in individual needs will influence clinician and patient decisions about how to treat specific eyes with DME. While the bevacizumab-first group costs still averaged approximately $14 000 over 2 years, this approach, as used in this study, may confer substantial cost savings on a societal level without sacrificing visual acuity gains over 2 years compared with aflibercept monotherapy.
MeSH term(s)	Male ; Aged ; Female ; Humans ; United States ; Middle Aged ; Bevacizumab/therapeutic use ; Macular Edema/diagnosis ; Macular Edema/drug therapy ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/drug therapy ; Ranibizumab/therapeutic use ; Angiogenesis Inhibitors ; Cost-Benefit Analysis ; Vascular Endothelial Growth Factor A ; Medicare ; Receptors, Vascular Endothelial Growth Factor/therapeutic use ; Recombinant Fusion Proteins/therapeutic use ; Diabetes Mellitus/drug therapy
Chemical Substances	Bevacizumab (2S9ZZM9Q9V) ; aflibercept (15C2VL427D) ; Ranibizumab (ZL1R02VT79) ; Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) ; Recombinant Fusion Proteins
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2022.6142
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Article ; Online: Associations of resilience and respiratory sinus arrhythmia with alienation among college students.

Lin, Shanyan / Liu, Danni / Zhang, Hui / Longobardi, Claudio

Journal of affective disorders

2022 Volume 322, Page(s) 24–30

Abstract: Background: Although the sense of alienation is harmful and causes many developmental problems, very few studies have focused on its antecedent variables and when these variables are related to alienation. The purpose of this study was to examine the ... ...

Abstract	Background: Although the sense of alienation is harmful and causes many developmental problems, very few studies have focused on its antecedent variables and when these variables are related to alienation. The purpose of this study was to examine the relationship between resilience and sense of alienation among college students, and the moderating role of baseline respiratory sinus arrhythmia (RSA) in this association. Method: Physiological data were collected during a resting condition in the laboratory from 109 college students aged from 17 to 21 years (M = 18.94, SD = 0.92). Questionnaires that captured demographic information, resilience, and sense of alienation, were also completed. Results: Results indicated that resilience was negatively related to the sense of alienation. Moreover, this negative relationship was moderated by baseline RSA such that it was significant only among students with low levels of baseline RSA. Conclusion: Our findings revealed that individuals with low resilience tend to have a higher level of alienation if their baseline RSA is relatively low. Discussion: The current study sheds light on the psychological and biological characteristics of these individuals who tend to have higher levels of alienation, which may be useful for intervention program developers and practitioners.
MeSH term(s)	Humans ; Respiratory Sinus Arrhythmia/physiology ; Emotions ; Students/psychology ; Behavior Therapy
Language	English
Publishing date	2022-11-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2022.10.050
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Article ; Online: Information Dissemination Model in Rural Live Broadcasting under Blockchain in the Era of Artificial Intelligence.

Liu, Jie / Yu, Yahui / Ji, Peng / Liu, Danni

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 4590578

Abstract: This work aims to improve the information dissemination atmosphere of rural live broadcasting and ensure its long-term development. First, it studies and analyzes the current situation and characteristics of rural live broadcasting. Then, it discusses ... ...

Abstract	This work aims to improve the information dissemination atmosphere of rural live broadcasting and ensure its long-term development. First, it studies and analyzes the current situation and characteristics of rural live broadcasting. Then, it discusses the blockchain (BC) technology and information dissemination mode in the era of artificial intelligence (AI). Finally, the characteristics of BC technology (BT) and the information dissemination model are discussed. A BT-optimized susceptible exposed infected recovered (SEIR) information dissemination model is proposed. The results show that the BT-optimized SEIR model has no effect on the traditional information transmission characteristics and can ensure the conventional transmission of all information. Additionally, BT can effectively improve the overall transmission efficiency of the SEIR model for false information and accurate information and effectively shorten the duration. Specifically, the BT-optimized SEIR model's maximum false information transmission proportion is reduced by about 13%. The duration is reduced by 15 days over the traditional model. By comparison, in positive information dissemination, the maximum transmission proportion of the proposed BT-optimized SEIR model is about 19% higher than the traditional model. The duration is about 30 days longer. The research provides technical support for controlling and improving the current situation and atmosphere of rural live broadcasting information dissemination.
MeSH term(s)	Artificial Intelligence ; Blockchain ; Information Dissemination ; Technology
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/4590578
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Article: Correlation of Tryptophan Metabolic Pathway with Immune Activation and Chemosensitivity in Patients with Lung Adenocarcinoma.

Wang, Zheng / Liu, Danni / Yang, Rongjie

Journal of oncology

2022 Volume 2022, Page(s) 2158525

Abstract: Lung adenocarcinoma (LUAD) is the most common type of lung cancer with high malignancy and easy metastasis in the early stage. In this study, we aimed to figure out the role of tryptophan metabolic pathway in LUAD prognosis and treatment. Different ... ...

Abstract	Lung adenocarcinoma (LUAD) is the most common type of lung cancer with high malignancy and easy metastasis in the early stage. In this study, we aimed to figure out the role of tryptophan metabolic pathway in LUAD prognosis and treatment. Different molecular subtypes were constructed based on tryptophan metabolism-related genes. Significant prognostic genes and clinical prognostic characteristics, immune infiltration level, and pathway activity in different subtypes were determined by algorithms, such as the least absolute shrinkage and selection operator (Lasso), CIBERSORT, Tumor Immune Dysfunction and Exclusion (TIDE), and gene set enrichment analysis (GSEA). The effect of different gene mutation types on the prognosis of patients with LUAD was explored. The clinical prognosis model was constructed and its reliability was verified. Of the 40 genes in the tryptophan metabolism pathway, 13 had significant prognostic significance. Based on these 13 genes, three molecular subtypes (C1, C2, and C3) were established. Among them, C1 had the worst prognosis and the lowest enrichment score of tryptophan metabolism. At the same time, C1 had the most genetic variation, the highest level of immune infiltration, and significantly activated pathways related to tumor development. The high-risk and low-risk groups had significant differences in prognosis, immune infiltration and pathway enrichment, which was consistent with the results of subtype analysis. Mutation in tryptophan metabolism-related genes leads to abnormal tryptophan metabolism, immune deficiency, and activation of cancer-promoting pathways. This results in high malignancy, poor prognosis, and failure of traditional clinical treatments. Through the establishment of risk score (RS) clinical prognosis model, we determined that RS could reliably predict the prognosis of patients with LUAD.
Language	English
Publishing date	2022-09-21
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2461349-6
ISSN	1687-8469 ; 1687-8450
ISSN (online)	1687-8469
ISSN	1687-8450
DOI	10.1155/2022/2158525
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