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  1. Book: Systems biomedicine

    Liu, Edison T.

    [concepts and perspectives]

    2010  

    Author's details ed. by Edison T. Liu
    Keywords Systems biology ; Medical sciences--Computer simulation
    Subject code 610.113
    Language English
    Size X, 438 S. : Ill., graph. Darst., 23 cm
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016132795
    ISBN 978-0-12-372550-9 ; 0-12-372550-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 5605 order for loan Magazin

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  2. Article ; Online: Functional genomics of complex cancer genomes.

    Menghi, Francesca / Liu, Edison T

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 5908

    MeSH term(s) Genome ; Genomics ; Humans ; Neoplasms/genetics
    Language English
    Publishing date 2022-10-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33717-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mouse models for immuno-oncology.

    Bosenberg, Marcus / Liu, Edison T / Yu, Chun I / Palucka, Karolina

    Trends in cancer

    2023  Volume 9, Issue 7, Page(s) 578–590

    Abstract: Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our knowledge of in vivo mechanisms underlying treatment response as well as treatment limiting toxicity. Preclinical in vivo model systems and technologies are required to ... ...

    Abstract Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our knowledge of in vivo mechanisms underlying treatment response as well as treatment limiting toxicity. Preclinical in vivo model systems and technologies are required to address these knowledge gaps and to surmount the challenges faced in the clinical application of immunotherapy. Mice are commonly used for basic and translational research to support development and testing of immune interventions, including for cancer. Here, we discuss the advantages and the limitations of current models as well as future developments.
    MeSH term(s) Animals ; Mice ; Neoplasms/drug therapy ; Medical Oncology ; Disease Models, Animal ; Translational Research, Biomedical ; Immunotherapy
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2023.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tumor Origins Through Genomic Profiles.

    Liu, Edison T / Mockus, Susan M

    JAMA oncology

    2019  Volume 6, Issue 1, Page(s) 33–34

    MeSH term(s) Genes, Neoplasm ; Genomics ; Humans ; Neoplasms/genetics
    Language English
    Publishing date 2019-11-13
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.3981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Grappling with cancer.

    Liu, Edison T

    Science (New York, N.Y.)

    2013  Volume 339, Issue 6127, Page(s) 1493

    MeSH term(s) Humans ; Neoplasms/genetics ; Neoplasms/therapy
    Language English
    Publishing date 2013-03-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1237835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Animals, quality and the pursuit of relevance.

    Svenson, Karen L / Krasinski, Stephen D / Ellis, Michael / Rosenthal, Nadia / Liu, Edison T / Fasman, Kenneth H

    Disease models & mechanisms

    2022  Volume 15, Issue 10

    Abstract: In 2021, the National Institutes of Health Advisory Committee to the Director (ACD) announced recommendations to improve the reproducibility of biomedical research using animals. In response, The Jackson Laboratory faculty and institutional leaders ... ...

    Abstract In 2021, the National Institutes of Health Advisory Committee to the Director (ACD) announced recommendations to improve the reproducibility of biomedical research using animals. In response, The Jackson Laboratory faculty and institutional leaders identified key strategies to further address this important issue. Taking inspiration from the evolution of clinical trials over recent decades in response to similar challenges, we identified opportunities for improvement, including establishment of common standards, use of genetically diverse populations, requirement for robust study design with appropriate statistical methods, and improvement in public databases to facilitate meta-analyses. In this Perspective, we share our response to ACD recommendations, with a specific focus on mouse models, with the aim of promoting continued active dialogue among researchers, using any animal system, worldwide. Such discussion will help to inform the biomedical community about these recommendations and further support their much-needed implementation.
    MeSH term(s) Animals ; Biomedical Research ; Humans ; Laboratories ; Mice ; Reproducibility of Results ; Research Design ; Research Personnel
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adaptive Sentinel Testing in Workplace for COVID-19 Pandemic.

    Li, Yi / Chen, Mandy / George, Joshy / Liu, Edison T / Karuturi, R Krishna Murthy

    Journal of computational biology : a journal of computational molecular cell biology

    2022  Volume 30, Issue 4, Page(s) 376–390

    Abstract: Testing and isolation of infectious employees is one of the critical strategies to make the workplace safe during the pandemic for many organizations. Adaptive testing frequency reduces cost while keeping the pandemic under control at the workplace. ... ...

    Abstract Testing and isolation of infectious employees is one of the critical strategies to make the workplace safe during the pandemic for many organizations. Adaptive testing frequency reduces cost while keeping the pandemic under control at the workplace. However, most models aimed at estimating test frequencies were structured for municipalities or large organizations such as university campuses of highly mobile individuals. By contrast, the workplace exhibits distinct characteristics: employee positivity rate may be different from the local community because of rigorous protective measures at workplace, or self-selection of co-workers with common behavioral tendencies for adherence to pandemic mitigation guidelines. Moreover, dual exposure to COVID-19 occurs at work and home that complicates transmission modeling, as does transmission tracing at the workplace. Hence, we developed
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics/prevention & control ; SARS-CoV-2 ; Workplace
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2030900-4
    ISSN 1557-8666 ; 1066-5277
    ISSN (online) 1557-8666
    ISSN 1066-5277
    DOI 10.1089/cmb.2022.0291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.

    Gong, Zheng / Li, Qing / Shi, Jiayuan / Liu, Edison T / Shultz, Leonard D / Ren, Guangwen

    Cell metabolism

    2022  Volume 34, Issue 12, Page(s) 1960–1976.e9

    Abstract: While the distant organ environment is known to support metastasis of primary tumors, its metabolic roles in this process remain underdetermined. Here, in breast cancer models, we found lung-resident mesenchymal cells (MCs) accumulating neutral lipids at ...

    Abstract While the distant organ environment is known to support metastasis of primary tumors, its metabolic roles in this process remain underdetermined. Here, in breast cancer models, we found lung-resident mesenchymal cells (MCs) accumulating neutral lipids at the pre-metastatic stage. This was partially mediated by interleukin-1β (IL-1β)-induced hypoxia-inducible lipid droplet-associated (HILPDA) that subsequently represses adipose triglyceride lipase (ATGL) activity in lung MCs. MC-specific ablation of the ATGL or HILPDA genes in mice reinforced and reduced lung metastasis of breast cancer respectively, suggesting a metastasis-promoting effect of lipid-laden MCs. Mechanistically, lipid-laden MCs transported their lipids to tumor cells and natural killer (NK) cells via exosome-like vesicles, leading to heightened tumor cell survival and proliferation and NK cell dysfunction. Blockage of IL-1β, which was effective singly, improved the efficacy of adoptive NK cell immunotherapy in mitigating lung metastasis. Collectively, lung MCs metabolically regulate tumor cells and anti-tumor immunity to facilitate breast cancer lung metastasis.
    MeSH term(s) Animals ; Mice ; Killer Cells, Natural ; Lung Neoplasms ; Lung ; Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Cellos

    Mukashyaka, Patience / Kumar, Pooja / Mellert, David J / Nicholas, Shadae / Noorbakhsh, Javad / Brugiolo, Mattia / Anczukow, Olga / Liu, Edison T / Chuang, Jeffrey H

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Three-dimensional (3D) culture models, such as organoids, are flexible systems to interrogate cellular growth and morphology, multicellular spatial architecture, and cell interactions in response to drug treatment. However, new computational methods to ... ...

    Abstract Three-dimensional (3D) culture models, such as organoids, are flexible systems to interrogate cellular growth and morphology, multicellular spatial architecture, and cell interactions in response to drug treatment. However, new computational methods to segment and analyze 3D models at cellular resolution with sufficiently high throughput are needed to realize these possibilities. Here we report
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.03.531019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reply to Watkins et al.: Whole-genome sequencing-based identification of diverse tandem duplicator phenotypes in human cancers.

    Menghi, Francesca / Liu, Edison T

    Proceedings of the National Academy of Sciences of the United States of America

    2016  Volume 113, Issue 36, Page(s) E5259–60

    Language English
    Publishing date 2016-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1610624113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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