LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 6151

Search options

  1. Article ; Online: Revision of cytogenetic dosimetry in the IAEA manual 2011 based on data about radio-sensitivity and dose-rate findings contributing.

    Liu, Gang

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2022  Volume 36, Issue 11, Page(s) e22621

    Abstract: In order to achieve the goal of rapid response, effective controland protection of life inlarge-scale radiation events, the IAEA Manual 2011 has been revised based on the data of radio-sensitivity, dose-rate findings. Analyze individual differences in ... ...

    Abstract In order to achieve the goal of rapid response, effective controland protection of life inlarge-scale radiation events, the IAEA Manual 2011 has been revised based on the data of radio-sensitivity, dose-rate findings. Analyze individual differences in radiation sensitivity using
    MeSH term(s) Male ; Female ; Humans ; Radiometry/methods ; Cobalt Radioisotopes ; Radiation Tolerance/genetics ; Cytogenetic Analysis
    Chemical Substances Cobalt-60 (5C8182XDPZ) ; Cobalt Radioisotopes
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202200769RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Eosinophilic Asthma: Pathophysiology and Therapeutic Horizons.

    Hussain, Musaddique / Liu, Gang

    Cells

    2024  Volume 13, Issue 5

    Abstract: Asthma is a prevalent chronic non-communicable disease, affecting approximately 300 million people worldwide. It is characterized by significant airway inflammation, hyperresponsiveness, obstruction, and remodeling. Eosinophilic asthma, a subtype of ... ...

    Abstract Asthma is a prevalent chronic non-communicable disease, affecting approximately 300 million people worldwide. It is characterized by significant airway inflammation, hyperresponsiveness, obstruction, and remodeling. Eosinophilic asthma, a subtype of asthma, involves the accumulation of eosinophils in the airways. These eosinophils release mediators and cytokines, contributing to severe airway inflammation and tissue damage. Emerging evidence suggests that targeting eosinophils could reduce airway remodeling and slow the progression of asthma. To achieve this, it is essential to understand the immunopathology of asthma, identify specific eosinophil-associated biomarkers, and categorize patients more accurately based on the clinical characteristics (phenotypes) and underlying pathobiological mechanisms (endotypes). This review delves into the role of eosinophils in exacerbating severe asthma, exploring various phenotypes and endotypes, as well as biomarkers. It also examines the current and emerging biological agents that target eosinophils in eosinophilic asthma. By focusing on these aspects, both researchers and clinicians can advance the development of targeted therapies to combat eosinophilic pathology in severe asthma.
    MeSH term(s) Humans ; Asthma/pathology ; Eosinophils/pathology ; Inflammation/pathology ; Cytokines ; Biomarkers
    Chemical Substances Cytokines ; Biomarkers
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13050384
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: ANGPT1 promotes M1 macrophage polarization and inhibits lung adenocarcinoma progression by inhibiting the TGF-β signalling pathway.

    Liu, Gang / Zhang, Hao

    General physiology and biophysics

    2024  Volume 43, Issue 2, Page(s) 121–138

    Abstract: Immune cells in the immune microenvironment of lung adenocarcinoma (LUAD) are involved in tumour progression. The aim of this study was to investigate the molecular mechanisms of immune infiltration-related genes in LUAD. The GEO, GeneCards, BioGPS and ... ...

    Abstract Immune cells in the immune microenvironment of lung adenocarcinoma (LUAD) are involved in tumour progression. The aim of this study was to investigate the molecular mechanisms of immune infiltration-related genes in LUAD. The GEO, GeneCards, BioGPS and Genehopper databases were utilized to screen for immune infiltration-related differentially expressed genes (DEGs) in LUAD. Protein-protein interaction (PPI) network construction and survival analysis were performed in the Kaplan-Meier database to identify hub genes. The TIMER 2.0 database was used to analyse the correlations between hub gene expression and immune infiltration level. Co-culture of LUAD cells with macrophages and plasmid transfection to overexpress ANGPT1 were performed to investigate the function of the hub genes in LUAD using RT-qPCR, Western blot, CCK-8 assays, cell wound healing assays and transwell assays. A total of 88 immune infiltration-related DEGs were screened. The hub genes ANGPT1, CDH5 and CLDN5 were reduced in LUAD, while COL3A1 was overexpressed. ANGPT1 was significantly correlated with OS, FP and PPS, and ANGPT1 promoted the polarization of M1 macrophages. Further experiments revealed that ANGPT1 inhibited the proliferation, migration and invasion of LUAD cells by inhibiting the TGF-β signalling pathway. ANGPT1 promotes polarization of M1 macrophages and reduces the progression of LUAD by inhibiting the TGF-β signalling pathway. Thus, ANGPT1 could be employed as a predictive biomarker and immunotherapy target for lung cancer.
    MeSH term(s) Humans ; Adenocarcinoma of Lung ; Lung Neoplasms ; Macrophages ; Transforming Growth Factor beta ; Tumor Microenvironment ; Angiopoietin-1
    Chemical Substances Transforming Growth Factor beta ; ANGPT1 protein, human ; Angiopoietin-1
    Language English
    Publishing date 2024-03-13
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 791184-1
    ISSN 0231-5882
    ISSN 0231-5882
    DOI 10.4149/gpb_2024001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1874: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Research on Initialization Algorithm for Visual-Inertial SLAM System

    LIU Gang, GE Hongwei

    Jisuanji kexue yu tansuo, Vol 15, Iss 8, Pp 1546-

    2021  Volume 1554

    Abstract: Monocular vision and inertial simultaneous localization and mapping (SLAM) system is becoming more and more popular in practical engineering applications because it can achieve the complementarity in use scenarios and lower hardware cost. Recent results ... ...

    Abstract Monocular vision and inertial simultaneous localization and mapping (SLAM) system is becoming more and more popular in practical engineering applications because it can achieve the complementarity in use scenarios and lower hardware cost. Recent results have shown that optimization-based fusion strategies outperform filtering strategies. However, the optimization-based SLAM algorithm of vision inertial navigation fusion is highly nonlinear, and its performance highly depends on the accuracy of the estimation of the initial parameters of the system state. The inertial measurement unit needs acceleration excitation, which means that it cannot start from the static state, but must start from the unknown motion state. Therefore, accurate estimation of the initial state is the key to the high robustness of the algorithm and the first step of the vision inertial fusion algorithm. By analyzing the pre integration algorithm of inertial measurement unit, an initialization estimation system based on convex optimization is derived, and the initial states are solved jointly considering the constraints of the gravity acceleration. More importantly, a novel method is proposed to determine the termination condition of the initialization algorithm by measuring the estimation effect with Fisher information, which improves the accuracy of the algorithm and shortens the initialization time. Experiments on Euroc dataset show that the new algorithm has a more precise and robust initial state.
    Keywords simultaneous localization and mapping (slam) ; visual inertial alignment ; preintegration ; inertial navigation ; fisher information ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 006
    Language Chinese
    Publishing date 2021-08-01T00:00:00Z
    Publisher Journal of Computer Engineering and Applications Beijing Co., Ltd., Science Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Current advancement in the application of prime editing.

    Huang, Zhangrao / Liu, Gang

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1039315

    Abstract: Prime editing (PE) is a precise genome manipulation technology based on the "search and replace" approach of the CRISPR-Cas9 system, while it does not require the exogenous donor DNA and the DNA double-strand breaks (DSBs). Comparing the base editing ... ...

    Abstract Prime editing (PE) is a precise genome manipulation technology based on the "search and replace" approach of the CRISPR-Cas9 system, while it does not require the exogenous donor DNA and the DNA double-strand breaks (DSBs). Comparing the base editing technology, the editing scope of prime editing has been widely expanded. Prime editing has been successfully applied in a variety of plant cells, animal cells and the model microorganism
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1039315
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Reclaiming the Balance: Blocking Glutamine Uptake to Restrain Pulmonary Fibrosis.

    Liu, Gang / Summer, Ross

    American journal of respiratory cell and molecular biology

    2023  Volume 69, Issue 4, Page(s) 378–379

    MeSH term(s) Humans ; Glutamine/metabolism ; Pulmonary Fibrosis/drug therapy ; Biological Transport ; Ion Transport ; Minor Histocompatibility Antigens ; Amino Acid Transport System ASC
    Chemical Substances Glutamine (0RH81L854J) ; SLC1A5 protein, human ; Minor Histocompatibility Antigens ; Amino Acid Transport System ASC
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2023-0189ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: The Entrepreneur's Multiple Identities Dynamic Interaction and Strategic Entrepreneurial Behavior: A Case Study Based on Grounded Theory.

    Yin, Qing / Liu, Gang

    Behavioral sciences (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Family firms face many uncertainties in a dynamic entrepreneurial context. Previous studies have shown strategic entrepreneurship can help firms effectively cope with uncertainties. There are few studies on how family-firm entrepreneurs make strategic ... ...

    Abstract Family firms face many uncertainties in a dynamic entrepreneurial context. Previous studies have shown strategic entrepreneurship can help firms effectively cope with uncertainties. There are few studies on how family-firm entrepreneurs make strategic decisions and engage in strategic entrepreneurial behavior. This may prevent managers lacking the necessary action guidelines from effectively implementing entrepreneurial behavior. we aim to explore the micro-behavioral mechanisms of strategic entrepreneurship in family firms. A longitudinal single case study based on grounded theory was conducted to explore these issues. Results show that (i) the entrepreneur's identity will constantly evolve to adapt to the entrepreneurial context during the life cycle of the corporation; (ii) entrepreneurs influence strategic entrepreneurial activities through the dynamic evolution and interaction of their identities; (iii) different entrepreneurial emotional states affect the strategic entrepreneurial behavior mechanisms. As a result, dynamic interactions between entrepreneurial identities have a significant impact on emotional states such as entrepreneurial well-being, which may significantly affect the implementation pattern of strategic entrepreneurial behaviors and the sustainable development of the firm. This paper provides a novel theoretical perspective on the path and behavioral choices of strategic entrepreneurship in firms, and also provides action guidelines and theoretical references for family business managers to implement strategic entrepreneurial behavior.
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs13020167
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Technological Modalities in the Assessment and Treatment of Disorders of Consciousness.

    Liu, Gang / Chi, Bradley

    Physical medicine and rehabilitation clinics of North America

    2023  Volume 35, Issue 1, Page(s) 109–126

    Abstract: Over the last 10 years, there have been rapid advances made in technologies that can be utilized in the diagnosis and treatment of patients with a disorder of consciousness (DoC). This article provides a comprehensive review of these modalities including ...

    Abstract Over the last 10 years, there have been rapid advances made in technologies that can be utilized in the diagnosis and treatment of patients with a disorder of consciousness (DoC). This article provides a comprehensive review of these modalities including the evidence supporting their potential use in DoC. This review specifically addresses diagnostic, non-invasive therapeutic, and invasive therapeutic technological modalities except for neuroimaging, which is discussed in another article. While technologic advances appear promising for both assessment and treatment of patients with a DoC, high-quality evidence supporting widespread clinical adoption remains limited.
    MeSH term(s) Humans ; Consciousness Disorders/diagnosis ; Consciousness Disorders/therapy ; Consciousness ; Neuroimaging
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196791-2
    ISSN 1558-1381 ; 1047-9651
    ISSN (online) 1558-1381
    ISSN 1047-9651
    DOI 10.1016/j.pmr.2023.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 1374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: ASO Author Reflections: Which is the Better Choice for Patients with PC Who Underwent Diaphragm Resection: HIPEC or HITAC.

    Liu, Gang / Li, Yan

    Annals of surgical oncology

    2023  Volume 31, Issue 2, Page(s) 1069–1070

    MeSH term(s) Humans ; Hyperthermic Intraperitoneal Chemotherapy ; Diaphragm/surgery ; Hyperthermia, Induced ; Peritoneal Neoplasms/surgery ; Patients ; Cytoreduction Surgical Procedures
    Language English
    Publishing date 2023-11-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-14548-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Cathepsin B Responsive Peptide-Purpurin Conjugates Assembly-Initiated in Situ Self-Aggregation for Cancer Sonotheranostics.

    Dai, Qixuan / Xie, Lisi / Ren, En / Liu, Gang

    Nano letters

    2024  Volume 24, Issue 3, Page(s) 950–957

    Abstract: Sonodynamic therapy (SDT) was hampered by the sonosensitizers with low bioavailability, tumor accumulation, and therapeutic efficiency. In situ responsive sonosensitizer self-assembly strategy may provide a promising route for cancer sonotheranositics. ... ...

    Abstract Sonodynamic therapy (SDT) was hampered by the sonosensitizers with low bioavailability, tumor accumulation, and therapeutic efficiency. In situ responsive sonosensitizer self-assembly strategy may provide a promising route for cancer sonotheranositics. Herein, an intelligent sonotheranostic peptide-purpurin conjugate (P18-P) is developed that can self-assemble into supramolecular structures via self-aggregation triggered by rich enzyme cathepsin B (CTSB). After intravenous injection, the versatile probe could achieve deep tissue penetration because of the penetration sequence of P18-P. More importantly, CTSB-triggered self-assembly strongly prolonged retention time, amplified photoacoustic imaging signal for sensitive CTSB detection, and boosted reactive oxygen species for advanced SDT, evoking specific CTSB responsive sonotheranostics. This peptide-purpurin conjugate may serve as an efficient sonotheranostic platform for the early diagnosis of CTSB activity and effective cancer therapy.
    MeSH term(s) Humans ; Cathepsin B ; Ultrasonic Therapy/methods ; Neoplasms/drug therapy ; Peptides/therapeutic use ; Reactive Oxygen Species ; Cell Line, Tumor ; Nanoparticles/chemistry
    Chemical Substances Cathepsin B (EC 3.4.22.1) ; Peptides ; Reactive Oxygen Species
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04371
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top