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  1. Article ; Online: Podcast on Lorlatinib as a First-Line Treatment Option for Patients with ALK-Positive Metastatic NSCLC with Brain Metastasis.

    Liu, Geoffrey / Lam, Vincent K

    Advances in therapy

    2023  Volume 40, Issue 10, Page(s) 4117–4126

    Abstract: Brain metastases are especially common in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), with a cumulative incidence of over 50% and associated with a poor prognosis, high symptom burden, and decreased quality of life. ... ...

    Abstract Brain metastases are especially common in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), with a cumulative incidence of over 50% and associated with a poor prognosis, high symptom burden, and decreased quality of life. Lorlatinib is a brain-penetrant, third-generation ALK tyrosine kinase inhibitor (TKI), which has a high potency against resistance mutations seen with earlier generation ALK TKIs. In 2018, lorlatinib was granted accelerated approval in second- and third-line treatment for use in patients with ALK-positive metastatic NSCLC on the basis of phase 1/2 study results. This initial approval was expanded for first-line treatment of patients with ALK-positive metastatic NSCLC on the basis of the interim analysis of the phase 3 CROWN study showing longer progression-free survival, time to intracranial progression, duration of response, and objective response rate compared with crizotinib. This manuscript is a transcript of our podcast, in which we discuss the clinical significance of controlling the onset of brain metastases, considerations in selecting a first-line therapy option, efficacy and safety observed in patients with and without brain metastases, and rationales for using lorlatinib upfront versus reserving for a later line in therapy.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Quality of Life ; Anaplastic Lymphoma Kinase ; Lactams, Macrocyclic/therapeutic use ; Lactams, Macrocyclic/adverse effects ; Protein Kinase Inhibitors ; Brain Neoplasms/drug therapy
    Chemical Substances lorlatinib (OSP71S83EU) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Lactams, Macrocyclic ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Clinical Trial, Phase II ; Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-023-02606-x
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  2. Article ; Online: Re: Response to Letter to the Editor "Respiratory and Cardiometabolic Comorbidities and Stage I-III Non-Small Cell Lung Cancer (NSCLC) Survival: A Pooled Analysis From the International Lung Cancer Consortium".

    García-Pardo, Miguel / Liu, Geoffrey

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 18, Issue 9, Page(s) e96–e97

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/epidemiology ; Lung Neoplasms/epidemiology ; Cardiovascular Diseases/epidemiology
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Meta-Analysis ; Letter ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.06.003
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  3. Article ; Online: Malignant priapism in metastatic adenocarcinoma of gastrointestinal origin: A

    Liu, Geoffrey / Patel, Mihir

    Journal of medical imaging and radiation oncology

    2021  Volume 65, Issue 7, Page(s) 904–906

    Abstract: Priapism is described as a persistent and non-sexual erection. It is a rare presenting complaint with a wide range of aetiologies. Malignant priapism was first used to describe persistent erections secondary to neoplastic infiltration of the penis by ... ...

    Abstract Priapism is described as a persistent and non-sexual erection. It is a rare presenting complaint with a wide range of aetiologies. Malignant priapism was first used to describe persistent erections secondary to neoplastic infiltration of the penis by Peacock in 1938.
    MeSH term(s) Adenocarcinoma/complications ; Adenocarcinoma/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Male ; Penis ; Positron Emission Tomography Computed Tomography ; Priapism/diagnostic imaging ; Priapism/etiology
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-02-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2389687-5
    ISSN 1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
    ISSN (online) 1754-9485 ; 1440-1673
    ISSN 1754-9477 ; 0004-8461
    DOI 10.1111/1754-9485.13163
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  4. Article ; Online: Progression-Free Survival Gain: A Reliable Primary End Point for Drug Registration That Can Accelerate Patient Access to Urgently Needed Therapies.

    Stewart, David J / Ramsay, Tim / Navani, Vishal / Liu, Geoffrey / Jiang, Di Maria / Batist, Gerald

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2024  Volume 42, Issue 8, Page(s) 973–974

    MeSH term(s) Humans ; Progression-Free Survival ; Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Disease-Free Survival
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Letter
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.02259
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  5. Article ; Online: Real-World Treatment Patterns and Survival Among Patients with Stage I-III, Non-Squamous, Non-Small Cell Lung Cancer Receiving Surgery as Primary Treatment.

    Seung, Soo Jin / Moldaver, Daniel / Hassan, Shazia / Syed, Iqra / Shanahan, MaryKate / Liu, Geoffrey

    Oncology and therapy

    2024  

    Abstract: Introduction: Approximately half of patients with non-small cell lung cancer (NSCLC) present with early-stage disease at diagnosis. Real-world outcomes data are limited for this population but are of interest given recent and impending results from ... ...

    Abstract Introduction: Approximately half of patients with non-small cell lung cancer (NSCLC) present with early-stage disease at diagnosis. Real-world outcomes data are limited for this population but are of interest given recent and impending results from trials evaluating epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immunotherapies in neoadjuvant, adjuvant, and perioperative settings.
    Methods: A retrospective, longitudinal, population-level study was conducted in patients diagnosed with resected stage I-III non-squamous NSCLC in Ontario, Canada, between April 2010 and March 2019. Study outcomes included patient characteristics and median overall survival (mOS), with stratification by disease stage and treatment exposure. Patients receiving EGFR-TKIs (assumed EGFR mutation-positive by proxy) were a key population of interest.
    Results: Among 8255 cases, 4881 had stage I, 2124 had stage II, and 1250 had stage III NSCLC at diagnosis. The mean patient age was 68 years; 53.5% were female. In the overall cohort, 19.6% received adjuvant chemotherapy. Receipt of adjuvant chemotherapy was associated with significantly longer mOS than not receiving such therapy: stage II (7.6 [95% confidence interval: 6.5-8.5] vs. 4.4 [4.0-4.9] years) or stage III (4.4 [3.6-5.1] vs. 2.7 [2.3-3.3] years), both p < 0.0001. Patients receiving treatment (EGFR-TKIs and chemotherapy) were assumed to have experienced disease recurrence/relapse; mOS was longer among those receiving an EGFR-TKI than among those receiving chemotherapy (2.3 [1.8-3.0] vs. 1.1 [1.0-1.3] years).
    Conclusion: In Ontario, between 2010 and 2019, uptake of adjuvant therapy was low among patients with resected NSCLC, despite such therapy being associated with improved survival. Patients assumed to have recurred/relapsed had markedly reduced mOS, regardless of subsequent therapy, compared with those who did not relapse/recur. Novel peri-adjuvant treatment options are needed to enhance outcomes after lung resection.
    Language English
    Publishing date 2024-03-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2848647-X
    ISSN 2366-1089 ; 2366-1070
    ISSN (online) 2366-1089
    ISSN 2366-1070
    DOI 10.1007/s40487-024-00268-5
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  6. Article ; Online: Correction: Real-World Treatment Patterns and Survival Among Patients with Stage I-III, Non-Squamous, Non-Small Cell Lung Cancer Receiving Surgery as Primary Treatment.

    Seung, Soo Jin / Moldaver, Daniel / Hassan, Shazia / Syed, Iqra / Shanahan, MaryKate / Liu, Geoffrey

    Oncology and therapy

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country New Zealand
    Document type Published Erratum
    ZDB-ID 2848647-X
    ISSN 2366-1089 ; 2366-1070
    ISSN (online) 2366-1089
    ISSN 2366-1070
    DOI 10.1007/s40487-024-00276-5
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  7. Article ; Online: A case of omental torsion and infarct diagnosed on computed tomography.

    Liu, Geoffrey / Patel, Mihir

    Journal of medical imaging and radiation oncology

    2020  Volume 65, Issue 2, Page(s) 219–221

    Abstract: A rare case of omental torsion and infarct diagnosed on CT in a 63-year-old male with undifferentiated abdominal pain. ...

    Abstract A rare case of omental torsion and infarct diagnosed on CT in a 63-year-old male with undifferentiated abdominal pain.
    MeSH term(s) Humans ; Infarction/diagnostic imaging ; Male ; Middle Aged ; Omentum/diagnostic imaging ; Peritoneal Diseases/diagnostic imaging ; Tomography, X-Ray Computed ; Torsion Abnormality/diagnostic imaging ; Torsion Abnormality/surgery
    Language English
    Publishing date 2020-11-30
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2389687-5
    ISSN 1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
    ISSN (online) 1754-9485 ; 1440-1673
    ISSN 1754-9477 ; 0004-8461
    DOI 10.1111/1754-9485.13129
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  8. Article: Two words.

    Liu, Geoffrey

    Connecticut medicine

    2014  Volume 78, Issue 7, Page(s) 432–433

    MeSH term(s) Delivery of Health Care/ethics ; Delivery of Health Care/standards ; Health Personnel/psychology ; Humanism ; Physician-Patient Relations
    Language English
    Publishing date 2014-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412600-2
    ISSN 0010-6178
    ISSN 0010-6178
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    Zs.B 288: Show issues Location:
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  9. Article ; Online: Two-stage multivariate Mendelian randomization on multiple outcomes with mixed distributions.

    Deng, Yangqing / Tu, Dongsheng / O'Callaghan, Chris J / Liu, Geoffrey / Xu, Wei

    Statistical methods in medical research

    2023  Volume 32, Issue 8, Page(s) 1543–1558

    Abstract: In clinical research, it is important to study whether certain clinical factors or exposures have causal effects on clinical and patient-reported outcomes such as toxicities, quality of life, and self-reported symptoms, which can help improve patient ... ...

    Abstract In clinical research, it is important to study whether certain clinical factors or exposures have causal effects on clinical and patient-reported outcomes such as toxicities, quality of life, and self-reported symptoms, which can help improve patient care. Usually, such outcomes are recorded as multiple variables with different distributions. Mendelian randomization (MR) is a commonly used technique for causal inference with the help of genetic instrumental variables to deal with observed and unobserved confounders. Nevertheless, the current methodology of MR for multiple outcomes only focuses on one outcome at a time, meaning that it does not consider the correlation structure of multiple outcomes, which may lead to a loss of statistical power. In situations with multiple outcomes of interest, especially when there are mixed correlated outcomes with different distributions, it is much more desirable to jointly analyze them with a multivariate approach. Some multivariate methods have been proposed to model mixed outcomes; however, they do not incorporate instrumental variables and cannot handle unmeasured confounders. To overcome the above challenges, we propose a two-stage multivariate Mendelian randomization method (MRMO) that can perform multivariate analysis of mixed outcomes using genetic instrumental variables. We demonstrate that our proposed MRMO algorithm can gain power over the existing univariate MR method through simulation studies and a clinical application on a randomized Phase III clinical trial study on colorectal cancer patients.
    MeSH term(s) Humans ; Genetic Variation ; Mendelian Randomization Analysis/methods ; Quality of Life ; Causality ; Computer Simulation
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1136948-6
    ISSN 1477-0334 ; 0962-2802
    ISSN (online) 1477-0334
    ISSN 0962-2802
    DOI 10.1177/09622802231181220
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  10. Article: Subdural hemorrhage post obstetric epidural: An MRI Case Report.

    Liu, Geoffrey / Lee, Allan / Withanawasam, Neoma / Tara, Sanyogita

    Radiology case reports

    2020  Volume 15, Issue 9, Page(s) 1584–1586

    Abstract: Epidural and spinal anesthesia is a routine anesthetic procedure and considered the standard of care for intrapartum analgesia. Complications of epidurals vary greatly from temporary hypotension to meningitis and intracranial bleeds. Intracranial ... ...

    Abstract Epidural and spinal anesthesia is a routine anesthetic procedure and considered the standard of care for intrapartum analgesia. Complications of epidurals vary greatly from temporary hypotension to meningitis and intracranial bleeds. Intracranial subdural hemorrhages are considered a rare but serious complication that may have significant long-term morbidity, particularly for postpartum women. The most common complication is a postdural puncture headache and patients with intracranial subdural hemorrhage present with similar symptoms.
    Language English
    Publishing date 2020-07-09
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2020.06.030
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