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  1. Journal ; Online: Life medicine

    Liu, Guang-Hui / Belmonte, Juan Carlos Izpisua

    2022  

    Abstract: Life Medicine' is a fully open access peer-reviewed journal that publishes one volume per year online. 'Life Medicine' is a basic and translational medical research journal. Our mission is to accelerate the translation of life science research from ... ...

    Title variant Statistics in society
    Institution Gao deng jiao yu chu ban she,
    Author's details editor-in-chief, Guang-Hui Liu ; co-editor-in-chief, Juan Carlos Izpisua Belmonte
    Abstract 'Life Medicine' is a fully open access peer-reviewed journal that publishes one volume per year online. 'Life Medicine' is a basic and translational medical research journal. Our mission is to accelerate the translation of life science research from bench to bedside by providing a communication platform for the exchange of cutting-edge knowledge and fresh ideas among medical researchers and clinicians.
    Keywords Medicine ; Medicine/Research
    Subject code 610.5
    Language English
    Dates of publication 2022-
    Size 1 online resource
    Publisher Oxford University Press
    Publishing place Oxford
    Document type Journal ; Online
    Note "Higher Education Press"--Home page. ; Open access.
    ZDB-ID 3158317-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Q&A with Guang-Hui Liu.

    Liu, Guang-Hui

    Cell reports

    2023  Volume 42, Issue 8, Page(s) 112862

    Abstract: We at Cell Reports discuss with Guang-Hui Liu his work with the mechanisms and interventions of aging, in particular, recent work regarding the resurrection of endogenous retroviruses in neurons in primates. ...

    Abstract We at Cell Reports discuss with Guang-Hui Liu his work with the mechanisms and interventions of aging, in particular, recent work regarding the resurrection of endogenous retroviruses in neurons in primates.
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Longevity secret: A pluripotent superpower.

    Liu, Guang-Hui / Qu, Jing

    Cell metabolism

    2022  Volume 34, Issue 6, Page(s) 803–804

    Abstract: Mammalian lifespans are dramatically diverse. Identifying the molecular signatures and underlying mechanism of longevity is of keen interest. Using comparative transcriptomics, Lu et al. (2022) showed that genes associated with maximum lifespan are ... ...

    Abstract Mammalian lifespans are dramatically diverse. Identifying the molecular signatures and underlying mechanism of longevity is of keen interest. Using comparative transcriptomics, Lu et al. (2022) showed that genes associated with maximum lifespan are regulated by circadian and pluripotency networks, which shed light on natural strategies for controlling lifespan.
    MeSH term(s) Animals ; Longevity/genetics ; Mammals/genetics ; Transcriptome
    Language English
    Publishing date 2022-06-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Artificial intelligence for the detection of glaucoma with SD-OCT images: a systematic review and Meta-analysis.

    Shi, Nan-Nan / Li, Jing / Liu, Guang-Hui / Cao, Ming-Fang

    International journal of ophthalmology

    2024  Volume 17, Issue 3, Page(s) 408–419

    Abstract: Aim: To quantify the performance of artificial intelligence (AI) in detecting glaucoma with spectral-domain optical coherence tomography (SD-OCT) images.: Methods: Electronic databases including PubMed, Embase, Scopus, ScienceDirect, ProQuest and ... ...

    Abstract Aim: To quantify the performance of artificial intelligence (AI) in detecting glaucoma with spectral-domain optical coherence tomography (SD-OCT) images.
    Methods: Electronic databases including PubMed, Embase, Scopus, ScienceDirect, ProQuest and Cochrane Library were searched before May 31, 2023 which adopted AI for glaucoma detection with SD-OCT images. All pieces of the literature were screened and extracted by two investigators. Meta-analysis, Meta-regression, subgroup, and publication of bias were conducted by Stata16.0. The risk of bias assessment was performed in Revman5.4 using the QUADAS-2 tool.
    Results: Twenty studies and 51 models were selected for systematic review and Meta-analysis. The pooled sensitivity and specificity were 0.91 (95%CI: 0.86-0.94,
    Conclusion: There is a high accuracy for the detection of glaucoma with AI with SD-OCT images. The application of AI-based algorithms allows together with "doctor+artificial intelligence" to improve the diagnosis of glaucoma.
    Language English
    Publishing date 2024-03-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2024.03.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Emerging epigenetic insights into aging mechanisms and interventions.

    Wu, Zeming / Zhang, Weiqi / Qu, Jing / Liu, Guang-Hui

    Trends in pharmacological sciences

    2024  Volume 45, Issue 2, Page(s) 157–172

    Abstract: Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although still an evolving field with much to explore, it has rapidly gained significance by providing valuable insights into the mechanisms of aging and potential ... ...

    Abstract Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although still an evolving field with much to explore, it has rapidly gained significance by providing valuable insights into the mechanisms of aging and potential therapeutic opportunities for age-related diseases. Recent years have witnessed remarkable strides in our understanding of the epigenetic landscape of aging, encompassing pivotal elements, such as DNA methylation, histone modifications, RNA modifications, and noncoding (nc) RNAs. Here, we review the latest discoveries that shed light on new epigenetic mechanisms and critical targets for predicting and intervening in aging and related disorders. Furthermore, we explore burgeoning interventions and exemplary clinical trials explicitly designed to foster healthy aging, while contemplating the potential ramifications of epigenetic influences.
    MeSH term(s) Humans ; Epigenesis, Genetic ; DNA Methylation ; Aging/genetics ; Protein Processing, Post-Translational
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Deciphering RNA m

    Wu, Zeming / Ren, Jie / Liu, Guang-Hui

    Aging cell

    2023  Volume 22, Issue 10, Page(s) e13972

    Abstract: ... ...

    Abstract N
    MeSH term(s) Cellular Senescence/genetics ; RNA
    Chemical Substances RNA (63231-63-0) ; N-methyladenosine (CLE6G00625)
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6581: Show issues Location:
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  7. Article ; Online: Potential approaches for intervening aging

    Shen Jianghua / Liu Guang-Hui / Song Moshi

    National Science Open, Vol

    2022  Volume 1

    Keywords Science ; Q ; Engineering (General). Civil engineering (General) ; TA1-2040
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Science Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Targeting aging and age-related diseases with vaccines.

    Wu, Ruochen / Sun, Fei / Zhang, Weiqi / Ren, Jie / Liu, Guang-Hui

    Nature aging

    2024  Volume 4, Issue 4, Page(s) 464–482

    Abstract: Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising strategy to combat these age-related diseases by targeting specific antigens and inducing immune responses. Here, we provide a comprehensive overview of recent ... ...

    Abstract Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising strategy to combat these age-related diseases by targeting specific antigens and inducing immune responses. Here, we provide a comprehensive overview of recent advances in vaccine-based interventions targeting these diseases, including Alzheimer's disease, type II diabetes, hypertension, abdominal aortic aneurysm, atherosclerosis, osteoarthritis, fibrosis and cancer, summarizing current approaches for identifying disease-associated antigens and inducing immune responses against these targets. Further, we reflect on the recent development of vaccines targeting senescent cells, as a strategy for more broadly targeting underlying causes of aging and associated pathologies. In addition to highlighting recent progress in these areas, we discuss important next steps to advance the therapeutic potential of these vaccines, including improving and robustly demonstrating efficacy in human clinical trials, as well as rigorously evaluating the safety and long-term effects of these vaccine strategies.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2 ; Vaccines/therapeutic use ; Aging ; Vaccination ; Neoplasms
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-024-00597-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coal Tar Pitch-Based Porous Carbon Loaded MoS

    Bai, Rui / Cao, Yuan-Jia / Lu, Cui-Ying / Liu, Guang-Hui

    ACS omega

    2023  Volume 8, Issue 38, Page(s) 34471–34480

    Abstract: In this paper, with coal tar pitch as the carbon source, porous carbon (PC) was prepared by one-step carbonization. To improve the energy density of coal tar pitch-based porous carbon, ... ...

    Abstract In this paper, with coal tar pitch as the carbon source, porous carbon (PC) was prepared by one-step carbonization. To improve the energy density of coal tar pitch-based porous carbon, MoS
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c02610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Stress, epigenetics, and aging: Unraveling the intricate crosstalk.

    Wu, Zeming / Qu, Jing / Zhang, Weiqi / Liu, Guang-Hui

    Molecular cell

    2023  Volume 84, Issue 1, Page(s) 34–54

    Abstract: Aging, as a complex process involving multiple cellular and molecular pathways, is known to be exacerbated by various stresses. Because responses to these stresses, such as oxidative stress and genotoxic stress, are known to interplay with the epigenome ... ...

    Abstract Aging, as a complex process involving multiple cellular and molecular pathways, is known to be exacerbated by various stresses. Because responses to these stresses, such as oxidative stress and genotoxic stress, are known to interplay with the epigenome and thereby contribute to the development of age-related diseases, investigations into how such epigenetic mechanisms alter gene expression and maintenance of cellular homeostasis is an active research area. In this review, we highlight recent studies investigating the intricate relationship between stress and aging, including its underlying epigenetic basis; describe different types of stresses that originate from both internal and external stimuli; and discuss potential interventions aimed at alleviating stress and restoring epigenetic patterns to combat aging or age-related diseases. Additionally, we address the challenges currently limiting advancement in this burgeoning field.
    MeSH term(s) Epigenesis, Genetic ; DNA Methylation ; Epigenome ; Oxidative Stress
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
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