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  1. Journal ; Online: Life medicine

    Liu, Guang-Hui / Belmonte, Juan Carlos Izpisua

    2022  

    Abstract: Life Medicine' is a fully open access peer-reviewed journal that publishes one volume per year online. 'Life Medicine' is a basic and translational medical research journal. Our mission is to accelerate the translation of life science research from ... ...

    Title variant Statistics in society
    Institution Gao deng jiao yu chu ban she,
    Author's details editor-in-chief, Guang-Hui Liu ; co-editor-in-chief, Juan Carlos Izpisua Belmonte
    Abstract 'Life Medicine' is a fully open access peer-reviewed journal that publishes one volume per year online. 'Life Medicine' is a basic and translational medical research journal. Our mission is to accelerate the translation of life science research from bench to bedside by providing a communication platform for the exchange of cutting-edge knowledge and fresh ideas among medical researchers and clinicians.
    Keywords Medicine ; Medicine/Research
    Subject code 610.5
    Language English
    Dates of publication 2022-
    Size 1 online resource
    Publisher Oxford University Press
    Publishing place Oxford
    Document type Journal ; Online
    Note "Higher Education Press"--Home page. ; Open access.
    ZDB-ID 3158317-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Q&A with Guang-Hui Liu.

    Liu, Guang-Hui

    Cell reports

    2023  Volume 42, Issue 8, Page(s) 112862

    Abstract: We at Cell Reports discuss with Guang-Hui Liu his work with the mechanisms and interventions of aging, in particular, recent work regarding the resurrection of endogenous retroviruses in neurons in primates. ...

    Abstract We at Cell Reports discuss with Guang-Hui Liu his work with the mechanisms and interventions of aging, in particular, recent work regarding the resurrection of endogenous retroviruses in neurons in primates.
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Emergence of Hypervirulent M1T1 Clone of Group A

    Liu, Guanghui

    Current issues in molecular biology

    2019  Volume 32, Page(s) 435–472

    Abstract: Streptococcus ... ...

    Abstract Streptococcus pyogenes
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Clone Cells ; Cytotoxins/genetics ; Cytotoxins/metabolism ; Deoxyribonuclease I/genetics ; Deoxyribonuclease I/metabolism ; Evolution, Molecular ; Exotoxins/genetics ; Exotoxins/metabolism ; Gene Expression Regulation, Bacterial ; Genome, Bacterial ; Host-Pathogen Interactions/genetics ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Pandemics ; Recombination, Genetic ; Selection, Genetic ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcal Infections/pathology ; Streptococcus Phages/genetics ; Streptococcus Phages/metabolism ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/metabolism ; Streptococcus pyogenes/pathogenicity ; Streptococcus pyogenes/virology ; Transduction, Genetic ; Virulence
    Chemical Substances Bacterial Proteins ; Cytotoxins ; Exotoxins ; Membrane Proteins ; SpeA protein, Streptococcus pyogenes ; Deoxyribonuclease I (EC 3.1.21.1) ; Sda1 protein, Streptococcus pyogenes (EC 3.1.21.1)
    Language English
    Publishing date 2019-06-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.21775/cimb.032.435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5122: Show issues Location:
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  4. Article ; Online: Longevity secret: A pluripotent superpower.

    Liu, Guang-Hui / Qu, Jing

    Cell metabolism

    2022  Volume 34, Issue 6, Page(s) 803–804

    Abstract: Mammalian lifespans are dramatically diverse. Identifying the molecular signatures and underlying mechanism of longevity is of keen interest. Using comparative transcriptomics, Lu et al. (2022) showed that genes associated with maximum lifespan are ... ...

    Abstract Mammalian lifespans are dramatically diverse. Identifying the molecular signatures and underlying mechanism of longevity is of keen interest. Using comparative transcriptomics, Lu et al. (2022) showed that genes associated with maximum lifespan are regulated by circadian and pluripotency networks, which shed light on natural strategies for controlling lifespan.
    MeSH term(s) Animals ; Longevity/genetics ; Mammals/genetics ; Transcriptome
    Language English
    Publishing date 2022-06-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6169: Show issues Location:
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  5. Article ; Online: Emerging epigenetic insights into aging mechanisms and interventions.

    Wu, Zeming / Zhang, Weiqi / Qu, Jing / Liu, Guang-Hui

    Trends in pharmacological sciences

    2024  Volume 45, Issue 2, Page(s) 157–172

    Abstract: Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although still an evolving field with much to explore, it has rapidly gained significance by providing valuable insights into the mechanisms of aging and potential ... ...

    Abstract Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although still an evolving field with much to explore, it has rapidly gained significance by providing valuable insights into the mechanisms of aging and potential therapeutic opportunities for age-related diseases. Recent years have witnessed remarkable strides in our understanding of the epigenetic landscape of aging, encompassing pivotal elements, such as DNA methylation, histone modifications, RNA modifications, and noncoding (nc) RNAs. Here, we review the latest discoveries that shed light on new epigenetic mechanisms and critical targets for predicting and intervening in aging and related disorders. Furthermore, we explore burgeoning interventions and exemplary clinical trials explicitly designed to foster healthy aging, while contemplating the potential ramifications of epigenetic influences.
    MeSH term(s) Humans ; Epigenesis, Genetic ; DNA Methylation ; Aging/genetics ; Protein Processing, Post-Translational
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1513: Show issues Location:
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  6. Article ; Online: Daphnetin alleviates silica-induced pulmonary inflammation and fibrosis by regulating the PI3K/AKT1 signaling pathway in mice.

    Yang, Tianye / Pan, Qian / Yue, Rujing / Liu, Guanghui / Zhou, Yuanyuan

    International immunopharmacology

    2024  Volume 133, Page(s) 112004

    Abstract: Silicosis is a hazardous occupational disease caused by inhalation of silica, characterized by persistent lung inflammation that leads to fibrosis and subsequent lung dysfunction. Moreover, the complex pathophysiology of silicosis, the challenges ... ...

    Abstract Silicosis is a hazardous occupational disease caused by inhalation of silica, characterized by persistent lung inflammation that leads to fibrosis and subsequent lung dysfunction. Moreover, the complex pathophysiology of silicosis, the challenges associated with early detection, and the unfavorable prognosis contribute to the limited availability of treatment options. Daphnetin (DAP), a natural lactone, has demonstrated various pharmacological properties, including anti-inflammatory, anti-fibrotic, and pulmonary protective effects. However, the effects of DAP on silicosis and its molecular mechanisms remain uncover. This study aimed to evaluate the therapeutic effects of DAP against pulmonary inflammation and fibrosis using a silica-induced silicosis mouse model, and investigate the potential mechanisms and targets through network pharmacology, proteomics, molecular docking, and cellular thermal shift assay (CETSA). Here, we found that DAP significantly alleviated silica-induced lung injury in mice with silicosis. The results of H&E staining, Masson staining, and Sirius red staining indicated that DAP effectively reduced the inflammatory response and collagen deposition over a 28-day period following lung exposure to silica. Furthermore, DAP reduced the number of TUNEL-positive cells, increased the expression levels of Bcl-2, and decreased the expression of Bax and cleaved caspase-3 in the mice with silicosis. More importantly, DAP suppressed the expression levels of NLRP3 signaling pathway-related proteins, including NLRP3, ASC, and cleaved caspase-1, thereby inhibiting silica-induced lung inflammation. Further studies demonstrated that DAP possesses the ability to inhibit the epithelial mesenchymal transition (EMT) induced by silica through the inhibition of the TGF-β1/Smad2/3 signaling pathway. The experimental results of proteomic analysis found that the PI3K/AKT1 signaling pathway was the key targets of DAP to alleviate lung injury induced by silica. DAP significantly inhibited the activation of the PI3K/AKT1 signaling pathway induced by silica in lung tissues. The conclusion was also verified by the results of molecular and CETSA. To further verify this conclusion, the activity of PI3K/AKT1 signaling pathway was inhibited in A549 cells using LY294002. When the A549 cells were pretreated with LY294002, the protective effect of DAP on silica-induced injury was lost. In conclusion, the results of this study suggest that DAP alleviates pulmonary inflammation and fibrosis induced by silica by modulating the PI3K/AKT1 signaling pathway, and holds promise as a potentially effective treatment for silicosis.
    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.112004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5408: Show issues Location:
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  7. Article ; Online: Additional Findings of 18 F-AIF-FAPI-42 PET/CT in a Patient With Mycosis Fungoides-Type Cutaneous T-Cell Lymphoma : Comparisons With 18 F-FDG PET/CT.

    Liu, Guanghui / Li, Yaming / Du, Bulin / Cui, Yan / Li, Xuena

    Clinical nuclear medicine

    2024  Volume 49, Issue 5, Page(s) e199–e201

    Abstract: Abstract: A 44-year-old woman presented with extensive skin patches and pruritus persisting for 3 years. Histopathological examination of the skin from the right abdomen confirmed mycosis fungoides-type cutaneous T-cell lymphoma. Staging PET with 18 F- ... ...

    Abstract Abstract: A 44-year-old woman presented with extensive skin patches and pruritus persisting for 3 years. Histopathological examination of the skin from the right abdomen confirmed mycosis fungoides-type cutaneous T-cell lymphoma. Staging PET with 18 F-FDG PET/CT) showed increased uptake in the skin on the right abdomen and left hip. Subsequently 18 F-FAPI-42 PET/CT revealed additional foci of abnormal uptake on the skin of the chest and back.
    MeSH term(s) Female ; Humans ; Adult ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Mycosis Fungoides/diagnostic imaging ; Lymphoma, T-Cell, Cutaneous/diagnostic imaging ; Skin Neoplasms/diagnostic imaging ; Gallium Radioisotopes
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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  8. Article ; Online: Deciphering RNA m

    Wu, Zeming / Ren, Jie / Liu, Guang-Hui

    Aging cell

    2023  Volume 22, Issue 10, Page(s) e13972

    Abstract: ... ...

    Abstract N
    MeSH term(s) Cellular Senescence/genetics ; RNA
    Chemical Substances RNA (63231-63-0) ; N-methyladenosine (CLE6G00625)
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6581: Show issues Location:
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  9. Article ; Online: Potential approaches for intervening aging

    Shen Jianghua / Liu Guang-Hui / Song Moshi

    National Science Open, Vol

    2022  Volume 1

    Keywords Science ; Q ; Engineering (General). Civil engineering (General) ; TA1-2040
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Science Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Biosynthesis of palladium nanoparticles using

    Liu, Guanghui / Bai, Xuefeng

    IET nanobiotechnology

    2021  Volume 11, Issue 3, Page(s) 310–316

    Abstract: A green route for the synthesis of palladium (Pd) nanoparticles (Pd NPs) ... ...

    Abstract A green route for the synthesis of palladium (Pd) nanoparticles (Pd NPs) employing
    MeSH term(s) Biological Products/chemistry ; Boronic Acids/chemistry ; Green Chemistry Technology/methods ; Materials Testing ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/ultrastructure ; Palladium/chemistry ; Particle Size ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Populus/chemistry ; Toluene/analogs & derivatives ; Toluene/chemistry
    Chemical Substances Biological Products ; Boronic Acids ; Plant Extracts ; Toluene (3FPU23BG52) ; Palladium (5TWQ1V240M) ; 4-bromotoluene (9E349GQ7EU)
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2264529-9
    ISSN 1751-875X ; 1751-8741
    ISSN (online) 1751-875X
    ISSN 1751-8741
    DOI 10.1049/iet-nbt.2016.0117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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